| 研究課題/領域番号 |
19J22546
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| 研究種目 |
特別研究員奨励費
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| 配分区分 | 補助金 |
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| 応募区分 | 国内 |
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| 審査区分 |
小区分90110:生体医工学関連
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| 研究機関 | 東京大学 |
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研究代表者 |
寿 景文 東京大学, 工学系研究科, 特別研究員(DC1)
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| 研究期間 (年度) |
2019-04-25 – 2022-03-31
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| 研究課題ステータス |
完了 (2021年度)
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| 配分額 *注記 |
2,500千円 (直接経費: 2,500千円)
2021年度: 800千円 (直接経費: 800千円)
2020年度: 800千円 (直接経費: 800千円)
2019年度: 900千円 (直接経費: 900千円)
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| キーワード | super-multiplex / super-resolution / stimulated Raman / fluorescence / high-speed / Super-multiplex / Stimulated Raman / Fluorescence / High-speed |
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| 研究開始時の研究の概要 |
Biological systems are subject to the complicated and dynamic interplay. The organelle contacts play a vital role in diverse cellular function. In this research, high-speed super-multiplexed imaging will be developed and exploited for the co-localization imaging and interactome anlysis.
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| 研究実績の概要 |
This year, we have worked on the theme of ‘ super-multiplex biological imaging’ mainly towards super-multiplex super-resolution imaging. Via applying the technology of photoswitchable stimulated Raman scattering microscopy developed before which is also a part of this project, we successfully demonstrate super-resolution stimulated Raman scattering imaging with high chemical specificity. Meanwhile, the newly developed photoswitchable Raman probe enable us to target certain kind of intracellular organelle for meaningful biological imaging. The evaluated spatial resolution has broken the diffraction limitation in the circumstance of vibrational imaging. Both the narrow linewidth and super-resolution property shows the developed technique as an important step towards final super-multiplex super-resolution imaging.
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| 現在までの達成度 (段落) |
令和3年度が最終年度であるため、記入しない。
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| 今後の研究の推進方策 |
令和3年度が最終年度であるため、記入しない。
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