| 研究課題/領域番号 |
19K07526
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| 研究種目 |
基盤研究(C)
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| 配分区分 | 基金 |
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| 応募区分 | 一般 |
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| 審査区分 |
小区分49040:寄生虫学関連
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| 研究機関 | 愛媛大学 (2020-2021)
長崎大学 (2019) |
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研究代表者 |
カレトン リチャード 愛媛大学, プロテオサイエンスセンター, 教授 (10503782)
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| 研究期間 (年度) |
2019-04-01 – 2022-03-31
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| 研究課題ステータス |
完了 (2021年度)
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| 配分額 *注記 |
4,290千円 (直接経費: 3,300千円、間接経費: 990千円)
2021年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円)
2020年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円)
2019年度: 1,690千円 (直接経費: 1,300千円、間接経費: 390千円)
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| キーワード | Malaria / Genetics / Genomics / malaria / P. vinckei / vaccine / LGS / RMP / Plasmodium vinckei / WGS / genetics / crossing / Vaccine / Genetic linkage analysis |
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| 研究開始時の研究の概要 |
In order to design new vaccines for malaria, proteins that play crucial roles in inducing protective host immunity must be identified. I propose to identify targets of host immunity using Linkage Group Selection (LGS) and the experimental rodent malaria parasite system, Plasmodium vinckei. I propose systematically test the ability of combinations of strains of P. vinckei to induce strain specific immunity in mice, then apply LGS to attempt to identify the genes that encode protective antigens.
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| 研究成果の概要 |
We have described here in detail the phenotypic, structural, copy number and nucleotide-level variations among several P. vinckei isolates. We hope that these efforts would greatly aid genetic linkage studies in the future to resolve genotype-phenotype relationships.
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| 研究成果の学術的意義や社会的意義 |
Plasmodium vinckei isolates display a large degree of phenotypic and genotypic diversity and could serve as a resource to study parasite virulence and immunogenicity. Amenability to genetic crossing and transfection make them also suitable for classical and functional genetics to study malaria.
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