| 研究課題/領域番号 |
19K24194
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| 研究種目 |
研究活動スタート支援
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| 配分区分 | 基金 |
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| 審査区分 |
0908:社会医学、看護学およびその関連分野
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| 研究機関 | 東京大学 |
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研究代表者 |
KOUDOUNAS SOFOKLIS 東京大学, 大学院医学系研究科(医学部), 特任助教 (70849968)
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| 研究期間 (年度) |
2019-08-30 – 2022-03-31
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| 研究課題ステータス |
完了 (2021年度)
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| 配分額 *注記 |
2,860千円 (直接経費: 2,200千円、間接経費: 660千円)
2020年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
2019年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
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| キーワード | IAD / skin barrier / incontinence / older patients / infected urine / urinary-incontinence / dermatitis / bacteria / rat |
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| 研究開始時の研究の概要 |
IAD is a painful complication among elderly patients, leading to a reduced quality of life. Physiological urine does not lead to the development of IAD; however, infected urine is severely irritating and increases the risk of skin damage. How infected urine leads to the development of IAD has never been investigated. Therefore, this study aims to elucidate the histopathological/molecular mechanisms of IAD caused by infected urine in order to develop new nursing interventions for complete prevention of IAD and ultimately improve the patients’ quality of life.
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| 研究成果の概要 |
My research with this JSPS grant aimed at understanding the mechanisms of incontinence-associated dermatitis (IAD) induced by urine and bacteria. In the first year, my research showed that after a specific time point urine promotes the growth of bacteria.
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| 研究成果の学術的意義や社会的意義 |
My research findings are important for the development of new innovative prevention/treatment strategies for IAD. The animal model I have established can serve as the basis for future studies to test the effectiveness of novel strategies to prevent the development of IAD.
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