腎臓膜輸送体を制御する新規細胞内刺激伝達系の解明

• 研究課題/領域番号: 20249047
• 研究種目: 基盤研究(A)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 腎臓内科学
• 研究機関: 東京医科歯科大学
• 研究代表者: 内田 信一 東京医科歯科大学, 大学院・医歯学総合研究科, 准教授 (50262184)
• 研究期間 (年度): 2008 – 2012
• 研究課題ステータス: 完了 (2012年度)
• 配分額: 47,710千円 (直接経費: 36,700千円、間接経費: 11,010千円); 2012年度: 9,360千円 (直接経費: 7,200千円、間接経費: 2,160千円); 2011年度: 9,360千円 (直接経費: 7,200千円、間接経費: 2,160千円); 2010年度: 9,360千円 (直接経費: 7,200千円、間接経費: 2,160千円); 2009年度: 9,360千円 (直接経費: 7,200千円、間接経費: 2,160千円); 2008年度: 10,270千円 (直接経費: 7,900千円、間接経費: 2,370千円)
• キーワード: 水・電解質代謝学 / 塩分感受性高血圧 / 遺伝子改変マウス / リン酸化酵素 / 高血圧 / リン酸化 / 輸送体 / 膜輸送体 / WNKキナーゼ / 腎臓 / 遺伝子改変動物 / キナーゼ / WNK4ノックアウトマウス / SGKノックアウトマウス / アルドステロン / 細胞容積調節

研究概要

我々は、遺伝性高血圧症である偽性低アルドステロン症II(PHAII)の原因遺伝子であるWNKキナーゼのシグナル伝達系を、Wnk4D561A/+PHAII病態モデルを用いて明らかにした(CellMetab2007)。本研究は、PHAII以外にこの新規WNKキナーゼシグナルカスケードが生体内でもつ病態生理学的意義を明らかにすることを目的として行われた。その結果、WNKキナーゼを制御する液性因子や下流で制御される新たな輸送体を同定し、生体内におけるWNKキナーゼの血圧調整における重要な役割とその制御機構を明らかにした。

研究成果

• [雑誌論文] ImpairedKLHL3-Mediated Ubiquitination of WNK4 Causes Human Hypertension (2013)
  • 著者名/発表者名: Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, Chiga M, Kikuchi E, NomuraN, Mori Y, Matsuo H, Murata T, Nomura S, Asano T, Kawaguchi H, Nonoyama S, Rai T, Sasaki S, Uchida S
  • 雑誌名: Cell Rep 巻: 3(3) ページ: 858-68
  • 査読あり
• [雑誌論文] Characterization of AQP-2 gene mutation (R254Q) in a family with dominant nephrogenic DI.. (2013)
  • 著者名/発表者名: Shida Y
  • 雑誌名: Pediatr Int. 巻: 55 号: 1 ページ: 105-107
  • DOI: 10.1111/j.1442-200x.2012.03614.x
  • 査読あり
• [雑誌論文] Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension. (2013)
  • 著者名/発表者名: Wakabayashi M
  • 雑誌名: Cell Rep. 巻: 28 号: 3 ページ: 858-868
  • DOI: 10.1016/j.celrep.2013.02.024
  • 査読あり
• [雑誌論文] Involvement of aquaporin-7 inthe cutaneous primary immune response through modulation of antigen uptake and migration in dendritic cells (2012)
  • 著者名/発表者名: Hara-Chikuma M, Sugiyama Y, Kabashima K, Sohara E, Uchida S, Sasaki S, Inoue S, Miyachi Y
  • 雑誌名: FASEB J 巻: 26 ページ: 211-8
  • 査読あり
• [雑誌論文] Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination (2012)
  • 著者名/発表者名: Hossain Khan MZ, Sohara E, Ohta A, ChigaM, Inoue Y, Isobe K, Wakabayashi M, Oi K, Rai T, Sasaki S, Uchida S
  • 雑誌名: Biochem. Biophys. Res. Commun 巻: 425 ページ: 456-61
  • 査読あり
• [雑誌論文] A new role for aquaporin 7 in insulin secretion (2012)
  • 著者名/発表者名: Louchami K, Best L, Brown P, Virreira M, Hupkens E, Perret J, Devuyst O, Uchida S, Delporte C, Malaisse WJ, Beauwens R, SenerA
  • 雑誌名: Cell Physiol. Biochem 巻: 29 ページ: 65-74
  • 査読あり
• [雑誌論文] ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney (2012)
  • 著者名/発表者名: Naguro I, Umeda T, Kobayashi Y, MaruyamaJ, Hattori K, Shimizu Y, Kataoka K,Kim-Mitsuyama S, Uchida S, Vandewalle A, Noguchi T, Nishitoh H, Matsuzawa A, Takeda K, Ichijo H
  • 雑誌名: Nat. Commun 巻: 3 ページ: 1285-1285
  • 査読あり
• [雑誌論文] Phosphatidylinositol 3-kinase/Akt signaling pathway activates theWNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice (2012)
  • 著者名/発表者名: Nishida H, Sohara E, Nomura N, Chiga M, Alessi DR, Rai T, Sasaki S, Uchida S
  • 雑誌名: Hypertension 巻: 60 ページ: 981-90
  • 査読あり
• [雑誌論文] Accumulation of autofluorescent storage material in brain is accelerated byischemia in chloride channel 3gene-deficient mice (2012)
  • 著者名/発表者名: Ohtaki H, Ohara K, Song D, Miyamoto K, Tsumuraya T, Yofu S, Dohi K, Tanabe S, Sasaki S, Uchida S, Matsunaga M, Shioda S
  • 雑誌名: J. Neurosci. Res 巻: 90 ページ: 2163-72
  • 査読あり
• [雑誌論文] A minor role of WNK3 in regulating phosphorylation ofrenal NKCC2 and NCC co-transporters in vivo (2012)
  • 著者名/発表者名: Oi K, Sohara E, Rai T, Misawa M, Chiga M, Alessi DR, Sasaki S, Uchida S
  • 雑誌名: Biol.Open 巻: 1 ページ: 120-7
  • 査読あり
• [雑誌論文] Effect of heterozygousdeletion of WNK1 on the WNK-OSR1/SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels (2012)
  • 著者名/発表者名: Susa K, Kita S, Iwamoto T, Yang SS, LinSH, Ohta A, Sohara E, Rai T, Sasaki S, Alessi DR, Uchida S
  • 雑誌名: Clin. Exp. Nephrol 巻: 16 ページ: 530-8
  • 査読あり
• [雑誌論文] WNK-OSR1/SPAK-NCC signal cascade has circadian rhythmdependent on aldosterone (2012)
  • 著者名/発表者名: Susa K, Sohara E, Isobe K, Chiga M, Rai T, Sasaki S, Uchida S
  • 雑誌名: Biochem. Biophys. Res. Commun 巻: 427 ページ: 743-7
  • 査読あり
• [雑誌論文] Does a β2-adrenergicreceptor-WNK4-Na-Cl co-transporter signal cascade exist in the in vivo kidney? (2012)
  • 著者名/発表者名: Uchida S, Chiga M, Sohara E, Rai T, Sasaki S
  • 雑誌名: Nat.Med 巻: 18 ページ: 1324-5
  • 査読あり
• [雑誌論文] Involvement of aquaporin-7 in the cutaneous primary immune response through modulation of antigen uptake and migration in dendritic cells. (2012)
  • 著者名/発表者名: Hara-Chikuma M
  • 雑誌名: FASEB J. 巻: 26 号: 1 ページ: 211-218
  • DOI: 10.1096/fj.11-186627
  • 査読あり
• [雑誌論文] Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination. (2012)
  • 著者名/発表者名: Hossain Khan MZ
  • 雑誌名: Biochem. Biophys. Res. Commun. 巻: 425 号: 2 ページ: 456-461
  • DOI: 10.1016/j.bbrc.2012.07.124
  • 査読あり
• [雑誌論文] A new role for aquaporin 7 in insulin secretion. (2012)
  • 著者名/発表者名: Louchami K
  • 雑誌名: Cell Physiol. Biochem. 巻: 29 号: 1-2 ページ: 65-74
  • DOI: 10.1159/000337588
  • 査読あり
• [雑誌論文] ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney. (2012)
  • 著者名/発表者名: Naguro I., et al.
  • 雑誌名: Nature Communications 巻: 3 号: 1 ページ: 1285-1285
  • DOI: 10.1038/ncomms2283
  • 査読あり
• [雑誌論文] Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice. (2012)
  • 著者名/発表者名: Nishida H
  • 雑誌名: Hypertension 巻: 60 号: 4 ページ: 981-990
  • DOI: 10.1161/hypertensionaha.112.201509
  • 査読あり
• [雑誌論文] Accumulation of autofluorescent storage material in brain is accelerated by ischemia in chloride channel 3 gene-deficient mice. (2012)
  • 著者名/発表者名: Ohtaki H
  • 雑誌名: J. Neurosci. Res. 巻: 90 号: 11 ページ: 2163-2172
  • DOI: 10.1002/jnr.23110
  • 査読あり
• [雑誌論文] A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo (2012)
  • 著者名/発表者名: Oi K
  • 雑誌名: Biology Open 巻: Vol.1 号: 2 ページ: 120-127
  • DOI: 10.1242/bio.2011048
  • 査読あり
• [雑誌論文] Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels. (2012)
  • 著者名/発表者名: Susa K
  • 雑誌名: Clin. Exp. Nephrol. 巻: 16 ページ: 530-538
  • 査読あり
• [雑誌論文] WNK-OSR1/SPAK-NCC signal cascade has circadian rhythm dependent on aldosterone. (2012)
  • 著者名/発表者名: Susa K
  • 雑誌名: Biochem. Biophys. Res. Commun. 巻: 427 号: 4 ページ: 743-747
  • DOI: 10.1016/j.bbrc.2012.09.130
  • 査読あり
• [雑誌論文] Does a β2-adrenergic receptor-WNK4-Na-Cl co-transporter signal cascade exist in the in vivo kidney? (2012)
  • 著者名/発表者名: Uchida S
  • 雑誌名: Nat. Med. 巻: 18 号: 9 ページ: 1324-1325
  • DOI: 10.1038/nm.2809
  • 査読あり
• [雑誌論文] Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on theWNK-OSR1/SPAK kinase cascade (2011)
  • 著者名/発表者名: Chiga M, Rafiqi FH, Alessi DR, Sohara E, Ohta A, Rai T, Sasaki S, Uchida S
  • 雑誌名: J. Cell Sci 巻: 124 ページ: 1391-5
  • 査読あり
• [雑誌論文] Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1deficiency manifests hypotension and Bartter-like syndrome (2011)
  • 著者名/発表者名: Lin SH, Yu IS, Jiang ST, Lin SW, Chu P, Chen A, Sytwu HK, Sohara E, Uchida S, Sasaki S, Yang SS
  • 雑誌名: Proc. Natl. Acad. Sci. U S A 巻: 108 ページ: 17538-43
  • 査読あり
• [雑誌論文] Regulation of WNK1 kinase by extracellular potassium (2011)
  • 著者名/発表者名: Naito S, Ohta A, Sohara E, Ohta E, Rai T, Sasaki S, Uchida S
  • 雑誌名: Clin. Exp. Nephrol 巻: 15 ページ: 195-202
  • NAID: 10029005115
  • 査読あり
• [雑誌論文] Generation and analyses of R8L barttin knockin mouse (2011)
  • 著者名/発表者名: Nomura N, Tajima M, Sugawara N, Morimoto T, Kondo Y, Ohno M, Uchida K, Mutig K, Bachmann S, Soleimani M, Ohta E, Ohta A, Sohara E, Okado T, Rai T, Jentsch TJ, Sasaki S, UchidaS
  • 雑誌名: Am. J. Physiol. Renal. Physiol 巻: 301
  • 査読あり
• [雑誌論文] Dexamethasone increases the phosphorylation of nephrin in cultured podocytes (2011)
  • 著者名/発表者名: Ohashi T, Uchida K, Uchida S, Sasaki S, Nitta K
  • 雑誌名: Clin. Exp. Nephrol 巻: 15 ページ: 688-93
  • NAID: 10030340996
  • 査読あり
• [雑誌論文] Immunolocalization of WNK4 in mouse kidney (2011)
  • 著者名/発表者名: Ohno M, Uchida K, Ohashi T, Nitta K, Ohta A, Chiga M, Sasaki S, UchidaS
  • 雑誌名: Histochem. Cell Biol 巻: 136 ページ: 25-35
  • 査読あり
• [雑誌論文] Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney (2011)
  • 著者名/発表者名: Sohara E, Rai T, Yang SS, Ohta A, NaitoS, Chiga M, Nomura N, Lin SH, Vandewalle A, Ohta E, Sasaki S, Uchida S
  • 雑誌名: PLoS One 巻: 6
  • 査読あり
• [雑誌論文] Severe hyperparathyroidism in a pre-dialysis chronic kidney disease patient treated with a very low protein diet (2011)
  • 著者名/発表者名: Ohta E
  • 雑誌名: J. Bone Miner. Metab. 巻: (published online) 号: 2 ページ: 238-242
  • DOI: 10.1007/s00774-011-0320-6
  • 査読あり
• [雑誌論文] Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade (2011)
  • 著者名/発表者名: Chiga M
  • 雑誌名: J. Cell Sci. 巻: Vol.124 号: 9 ページ: 1391-5
  • DOI: 10.1242/jcs.084111
  • 査読あり
• [雑誌論文] Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome (2011)
  • 著者名/発表者名: Lin SH
  • 雑誌名: Proc. Natl. Acad. Sci. USA. 巻: Vol.108 号: 42 ページ: 17538-43
  • DOI: 10.1073/pnas.1107452108
  • 査読あり
• [雑誌論文] Regulation of WNK1 kinase by extracellular potassium (2011)
  • 著者名/発表者名: Naito S
  • 雑誌名: Clin. Exp. Nephrol. 巻: Vol.15 号: 2 ページ: 195-202
  • DOI: 10.1007/s10157-010-0378-9
  • 査読あり
• [雑誌論文] Generation and analyses of R8L barttin knockin mouse (2011)
  • 著者名/発表者名: Nomura N
  • 雑誌名: Am. J. Physiol. Renal. Physiol. 巻: Vol.301 号: 2 ページ: F297-F307
  • DOI: 10.1152/ajprenal.00604.2010
  • 査読あり
• [雑誌論文] Dexamethasone increases the phosphorylation of nephrin in cultured podocytes (2011)
  • 著者名/発表者名: Ohashi T
  • 雑誌名: Clin. Exp. Nephrol. 巻: Vol.15 号: 5 ページ: 688-93
  • DOI: 10.1007/s10157-011-0479-0
  • 査読あり
• [雑誌論文] Immunolocalization of WNK4 in mouse kidney (2011)
  • 著者名/発表者名: Ohno M
  • 雑誌名: Histochem. Cell Biol. 巻: Vol.136 号: 1 ページ: 25-35
  • DOI: 10.1007/s00418-011-0827-x
  • 査読あり
• [雑誌論文] Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney (2011)
  • 著者名/発表者名: Sohara E
  • 雑誌名: PLoS One 巻: Vol.6 号: 8 ページ: e24277-e24277
  • DOI: 10.1371/journal.pone.0024277
  • 査読あり
• [雑誌論文] Phosphorylation of aquaporin-2 regulates its water permeability (2010)
  • 著者名/発表者名: Eto K, Noda Y, Horikawa S, Uchida S, Sasaki S
  • 雑誌名: J. Biol. Chem 巻: 285 ページ: 40777-84
  • 査読あり
• [雑誌論文] Short-term stimulation of the thiazide-sensitive Na+-Cl- cotransporter by vasopressin involves phosphorylation and membrane translocation (2010)
  • 著者名/発表者名: Mutig K, Saritas T, Uchida S, Kahl T,Borowski T, Paliege A, Bohlick A, Bleich M, Shan Q, Bachmann S
  • 雑誌名: Am. J. Physiol. Renal Physiol 巻: 298 ページ: 502-9
  • 査読あり
• [雑誌論文] Calcium and calcimimetics regulate paracellular Na+ transport in the thin ascending limb of Henle's loop in mouse kidney (2010)
  • 著者名/発表者名: Sugawara N, Morimoto T, Farajov EI, Kumagai N, Aslanova UF, Rai T, Uchida S, Sasaki S, Tsuchiya S, Kondo Y
  • 雑誌名: Pflugers Arch 巻: 460 ページ: 197-205
  • 査読あり
• [雑誌論文] Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney (2010)
  • 著者名/発表者名: Talati G, Ohta A, Rai T, Sohara E, Naito S, Vandewalle A, Sasaki S, Uchida S
  • 雑誌名: Biochem. Biophys. Res. Commun 巻: 393 ページ: 844-8
  • 査読あり
• [雑誌論文] Generation and analysis of the thiazide-sensitive Na+ -Cl- cotransporter (Ncc/Slc12a3) Ser707X knockin mouse as a model of Gitelman syndrome (2010)
  • 著者名/発表者名: Yang SS, Lo YF, Yu IS, Lin SW, Chang TH, Hsu YJ, Chao TK, Sytwu HK, Uchida S, Sasaki S, Lin SH
  • 雑誌名: Hum. Mutat 巻: 31 ページ: 1304-15
  • 査読あり
• [雑誌論文] SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction (2010)
  • 著者名/発表者名: Yang SS, Lo YF, Wu CC, Lin SW, Yeh CJ, Chu P, Sytwu HK, Uchida S, Sasaki S, Lin SH
  • 雑誌名: J. Am. Soc. Nephrol 巻: 21 ページ: 1868-77
  • 査読あり
• [雑誌論文] Mechanisms for hypercalciuria in pseudohypoaldosteronism type II-causing WNK4 knock-in mice (2010)
  • 著者名/発表者名: Yang SS, Hsu YJ, Chiga M, Rai T, Sasaki S, Uchida S, Lin SH
  • 雑誌名: Endocrinology 巻: 151 ページ: 1829-36
  • 査読あり
• [雑誌論文] Pathophysiological roles of WNK kinases in the kidney (2010)
  • 著者名/発表者名: Uchida S
  • 雑誌名: Pflugers Arch 巻: 460 ページ: 695-702
  • 査読あり
• [雑誌論文] Pathophysiological roles of WNK kinases in the kidney. (2010)
  • 著者名/発表者名: Uchida S.
  • 雑誌名: Pflugers Arch. 460 ページ: 695-702
• [雑誌論文] Phosphorylation of aquaporin-2 regulates its water permeability. (2010)
  • 著者名/発表者名: Eto K, Noda Y, Horikawa S, Uchida S, Sasaki S.
  • 雑誌名: J.Biol.Chem. 285 ページ: 40777-40784
• [雑誌論文] Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney. (2010)
  • 著者名/発表者名: Talati G, Ohta A, Rai T, Sohara E, Naito S, Vandewalle A, Sasaki S, Uchida S.
  • 雑誌名: Biochem. Biophys. Res.Commun. 393 ページ: 844-848
• [雑誌論文] Regulation of WNK1 kinase by extracellular potassium. (2010)
  • 著者名/発表者名: Naito S, et al.
  • 雑誌名: Clinical.Experimental.Nephrology. 巻: (Epub ahead of print)
  • 査読あり
• [雑誌論文] Phosphorylation of aquaporin-2 regulates its water permeability. (2010)
  • 著者名/発表者名: Eto K, et al.
  • 雑誌名: J.Biol.Chem. 巻: 285 ページ: 40777-40784
  • 査読あり
• [雑誌論文] Short-term stimulation of the thiazide-sensitive Na+-CI- cotransporter byvasopressin involves phosphorylation and membrane translocation. (2010)
  • 著者名/発表者名: Mutig K, et al
  • 雑誌名: Am.J.Physiol.Renal Physiol 巻: 298
  • 査読あり
• [雑誌論文] Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney. (2010)
  • 著者名/発表者名: Talati G, et al
  • 雑誌名: Biochem.Biophys.Res.Commun. 巻: 393 ページ: 844-848
  • 査読あり
• [雑誌論文] Generation and analysis of the thiazide-sensitive Na+ -Cl- cotransporterNcc/Slc12a3) Ser707X knockin mouse as a model of Gitelman syndrome. (2010)
  • 著者名/発表者名: Yang SS, et al
  • 雑誌名: Hum.Mutat. 巻: 31 ページ: 1304-1315
  • 査読あり
• [雑誌論文] SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction. (2010)
  • 著者名/発表者名: Yang SS, et al
  • 雑誌名: J Am.Soc.Nephrol. 巻: 21 ページ: 1868-1877
  • 査読あり
• [雑誌論文] Mechanisms for hypercalciuria in pseudohypoaldosteronism type II-causing WNK4 knock-in mice. (2010)
  • 著者名/発表者名: Yang SS, et al
  • 雑誌名: Endocrinology. 巻: 151 ページ: 1829-1836
  • 査読あり
• [雑誌論文] Pathophysiological roles of WNK kinases in the kidney. (2010)
  • 著者名/発表者名: Uchida s
  • 雑誌名: Pflugers Arch. 巻: 460 ページ: 695-702
  • 査読あり
• [雑誌論文] Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney. (2010)
  • 著者名/発表者名: Talati Gulibaha
  • 雑誌名: Biochem Biophys Res Commun. (Epub ahead of print)
  • 査読あり
• [雑誌論文] Mechanisms for hypercalciuria in pseudohypoaldosteronism type II-causing WNK4 knock-in mice. (2010)
  • 著者名/発表者名: Sung-seng Yang
  • 雑誌名: Endocrinology (Epub ahead of print)
  • 査読あり
• [雑誌論文] Aquaporin-2 regulates cell volume recovery via tropomyosin (2009)
  • 著者名/発表者名: Li YH, Eto K, Horikawa S, Uchida S, Sasaki S, Li XJ, Noda Y
  • 雑誌名: Int. J. Biochem. Cell Biol 巻: 41 ページ: 2466-2476
  • 査読あり
• [雑誌論文] Targeted disruption of the Wnk4 genedecreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure (2009)
  • 著者名/発表者名: Ohta A, Rai T, Yui N, Chiga M, Yang SS, Lin SH, Sohara E, Sasaki S, Uchida S
  • 雑誌名: Hum. Mol. Genet 巻: 18 ページ: 3978-86
  • 査読あり
• [雑誌論文] Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis (2009)
  • 著者名/発表者名: Ohta E, Itoh T, Nemoto T, Kumagai J, Ko SB, Ishibashi K, Ohno M, Uchida K, Ohta A, Sohara E, Uchida S, Sasaki S, Rai T
  • 雑誌名: Am. J. Physiol. Cell Physiol 巻: 297 ページ: 1368-78
  • 査読あり
• [雑誌論文] FAPP2 is required for aquaporin-2 apical sorting attrans-Golgi network in polarized MDCK cells (2009)
  • 著者名/発表者名: Yui N, Okutsu R, Sohara E, Rai T, OhtaA, Noda Y, Sasaki S, Uchida S
  • 雑誌名: Am. J. Physiol. Cell Physiol 巻: 297 ページ: 1389-1396
  • 査読あり
• [雑誌論文] Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo isregulated by dietary salt, potassium, and SGK1 (2009)
  • 著者名/発表者名: Vallon V, Schroth J, Lang F, Kuhl D, Uchida S
  • 雑誌名: Am. J. Physiol. Renal Physiol 巻: 297 ページ: 704-12
  • 査読あり
• [雑誌論文] Function of aquaporin-7 in the kidney and the male reproductive system (2009)
  • 著者名/発表者名: Sohara E, Uchida S, Sasaki S
  • 雑誌名: Handb ExpPharmacol ページ: 219-31
  • 査読あり
• [雑誌論文] Expression and phosphorylation of the Na^+-Clcotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1. Am. J.Physiol. (2009)
  • 著者名/発表者名: Vallon V, Schroth J, Lang F, Kuhl D, Uchida S.
  • 雑誌名: Renal Physiol. 297 ページ: 704-712
• [雑誌論文] FAPP2 is required for aquaporin-2 apical sorting at trans-Golgi network in polarized MDCK cells. (2009)
  • 著者名/発表者名: Yui N, Okutsu R, Sohara E, Rai T, Ohta A, Noda Y, Sasaki S, Uchida S.
  • 雑誌名: Am.J.Physiol.Cell Physiol. 297 ページ: 1389-1396
• [雑誌論文] Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. (2009)
  • 著者名/発表者名: Ohta A, Rai T, Yui N, Chiga M, Yang SS, Lin SH, Sohara E, Sasaki S, Uchida S.
  • 雑誌名: Hum.Mol.Genet. 18 ページ: 3978-86
• [雑誌論文] Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. (2009)
  • 著者名/発表者名: Akihito Ohta
  • 雑誌名: Hum Mol Genet 18 ページ: 3978-3986
  • 査読あり
• [雑誌論文] FAPP2 is required for aquaporin-2 apical sorting at trans-Golgi network in polarized MDCK cells. (2009)
  • 著者名/発表者名: Naofumi Yui
  • 雑誌名: Am J Physiol Cell Physiol 297
  • 査読あり
• [雑誌論文] Expression and phosphorylation of the Na^+-Cl^- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1. (2009)
  • 著者名/発表者名: Vallon V
  • 雑誌名: Am J Physiol Renal 297
  • 査読あり
• [雑誌論文] Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis. (2009)
  • 著者名/発表者名: Eriko Ohta
  • 雑誌名: Am J Physiol Cell Physiol 297
  • 査読あり
• [雑誌論文] Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone (2008)
  • 著者名/発表者名: Chiga M, Rai T, Yang SS, Ohta A, Takizawa T, Sasaki S, Uchida S
  • 雑誌名: Kidney Int 巻: 74 ページ: 1403-9
  • 査読あり
• [雑誌論文] Intracellular ClC-3 chloride channels promote bone resorption in vitro through organelle acidification in mouse osteoclasts (2008)
  • 著者名/発表者名: Okamoto F, Kajiya H, Toh K, Uchida S, Yoshikawa M, Sasaki S, Kido MA, Tanaka T, Okabe K
  • 雑誌名: Am. J .Physiol. Cell Physiol 巻: 294
  • 査読あり
• [雑誌論文] AKAP220 colocalizes with AQP2 in the inner medullary collecting ducts (2008)
  • 著者名/発表者名: Okutsu R, Rai T, Kikuchi A, Ohno M, Uchida K, Sasaki S, Uchida S
  • 雑誌名: Kidney Int 巻: 74 ページ: 1429-33
  • 査読あり
• [雑誌論文] Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone. (2008)
  • 著者名/発表者名: Chiga M, Rai T, Yang SS, Ohta A, Takizawa T, Sasaki S, Uchida S.
  • 雑誌名: Kidney Int. 74 ページ: 1403-1409
• [雑誌論文] AKAP220 colocalizes with AQP2 in the inner medullary collecting ducts. (2008)
  • 著者名/発表者名: Okutsu R, Rai T, Kikuchi A, Ohno M, Uchida K, Sasaki S, Uchida S.
  • 雑誌名: Kidney Int. 74 ページ: 1429-1433
• [雑誌論文] Dietary salt regulates the phosphorylation of OSRl/SPAK kinases and the sodium chloride cotransporter through aldosterone. (2008)
  • 著者名/発表者名: Chiga M
  • 雑誌名: Kidney Int. 74 ページ: 1403-1409
  • 査読あり
• [雑誌論文] AKAP220 colocalizes with AQP2 in the inner medullary collecting ducts (2008)
  • 著者名/発表者名: Okutsu R
  • 雑誌名: Kidney Int. 74 ページ: 1429-1433
  • 査読あり
• [学会発表] Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates itsubiquitination (2012)
  • 著者名/発表者名: Hossain Khan MZ, Sohara E, Ohta A, Chiga M, Inoue Y, Isobe K, Wakabayashi M, Naito S, Oi K, Rai T, Sasaki S, Uchida S
  • 学会等名: The 45th Annual meeting of American Society of Nephrology
  • 発表場所: San Diego (USA)
• [学会発表] Development of sandwich enzyme linked immunosorbent assay (ELISA) for measurement of urinary total and phosphorylated Na-Clcotransporter (NCC) protein (2012)
  • 著者名/発表者名: Isobe K, Sohara E, Rai T, Sasaki S,Uchida S
  • 学会等名: The 45th Annual meeting of American Society of Nephrology
  • 発表場所: San Diego (USA)
• [学会発表] Chemical library screening for direct SPAK inhibitors by a newly developed ELISA system (2012)
  • 著者名/発表者名: Kikuchi E, Mori T, Isobe K, Sohara E, Rai T, Sasaki S, Uchida S
  • 学会等名: The 45th Annual Meeting of American Society of Nephrology
  • 発表場所: San Diego (USA)
• [学会発表] Generation and analysis of WT-WNK4 transgenic mice revealed the physiological role of WNK4 (2012)
  • 著者名/発表者名: Mori T, Sohara E, Rai T, Sasaki S, Uchida S
  • 学会等名: The 45th Annual Meeting of American Society of Nephrology
  • 発表場所: San Diego (USA)
• [学会発表] Hereditary nephrogenic diabetes insipidus (NDI) in Japanese patients: Analysis of 73 families (2012)
  • 著者名/発表者名: Sasaki S, Chiga M, Kikuchi E, Uchida S
  • 学会等名: The 45th Annual Meeting of American Society of Nephrology
  • 発表場所: San Diego (USA)
• [学会発表] WNK4-OSR1/SPAK-NCC signal cascade has circadian rhythm dependent on aldosterone (2012)
  • 著者名/発表者名: Susa K, Sohara E, Isobe K, Chiga M, Rai T, Sasaki S, Uchida S
  • 学会等名: The 45th Annual Meeting of American Society of Nephrology
  • 発表場所: San Diego (USA)
• [学会発表] Dietary salt intake and angiotensin II regulates WNK-SPAK-NKCC1 phosphorylation cascade in mouse aorta (2012)
  • 著者名/発表者名: Zeniya M, Sohara E, Oi K, Chiga M, SusaK, Mori T, Rai T, Sasaki S, Uchida S
  • 学会等名: The 45th Annual Meeting of American Society of Nephrology
  • 発表場所: San Diego (USA)
• [学会発表] Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination. (2012)
  • 著者名/発表者名: Hossain Khan MZ
  • 学会等名: The 45th Annual meeting of American Society of Nephrology
  • 発表場所: San Diego Convention Center
• [学会発表] Impaired trafficking of polycystin-1 may be a key mechanism of cyst formation in the aquaporin-11 knockout mouse. (2012)
  • 著者名/発表者名: Inoue Y
  • 学会等名: The 45th Annual meeting of American Society of Nephrology
  • 発表場所: San Diego Convention Center
• [学会発表] Development of sandwich enzyme linked immunosorbent assay (ELISA) for measurement of urinary total and phosphorylated Na-Clcotransporter (NCC) protein. (2012)
  • 著者名/発表者名: Isobe K
  • 学会等名: The 45th Annual meeting of American Society of Nephrology
  • 発表場所: San Diego Convention Center
• [学会発表] Chemical library screening for direct SPAK inhibitors by a newly developed ELISA system. (2012)
  • 著者名/発表者名: Kikuchi E
  • 学会等名: The 45th Annual meeting of American Society of Nephrology
  • 発表場所: San Diego Convention Center
• [学会発表] Generation and analysis of WT-WNK4 transgenic mice revealed the physiological role of WNK4. (2012)
  • 著者名/発表者名: Mori T
  • 学会等名: The 45th Annual meeting of American Society of Nephrology
  • 発表場所: San Diego Convention Center
• [学会発表] Hereditary nephrogenic diabetes insipidus (NDI) in Japanese patients: Analysis of 73 families. (2012)
  • 著者名/発表者名: Sasaki S
  • 学会等名: The 45th Annual meeting of American Society of Nephrology
  • 発表場所: San Diego Convention Center
• [学会発表] WNK4-OSR1/SPAK-NCC signal cascade has circadian rhythm dependent on aldosterone. (2012)
  • 著者名/発表者名: Susa K
  • 学会等名: The 45th Annual meeting of American Society of Nephrology
  • 発表場所: San Diego Convention Center
• [学会発表] Dietary salt intake and angiotensin II regulates WNK-SPAK-NKCC1 phosphorylation cascade in mouse aorta. (2012)
  • 著者名/発表者名: Zeniya M
  • 学会等名: The 45th Annual meeting of American Society of Nephrology
  • 発表場所: San Diego Convention Center
• [学会発表] Chemical library screening for drugs to correct intracellular mislocalization of R8L mutant barttin. (2012)
  • 著者名/発表者名: Uchida S
  • 学会等名: 2012 International Ion Channel Conference.
  • 発表場所: Shilla Hotel
  • 招待講演
• [学会発表] Role of WNK kinases in the blood pressure regulation. (2012)
  • 著者名/発表者名: Uchida S
  • 学会等名: Taiwan Society of Nephrology 2012
  • 発表場所: China Medical University
  • 招待講演
• [学会発表] Generation and analyses of AQP11 BAC transgenic mice (2011)
  • 著者名/発表者名: Inoue Y, Sohara E, Kobayashi K, Rai T,Ishibashi K, Sasaki S, Uchida S
  • 学会等名: The 44th Annual Meeting of American Society of Nephrology
  • 発表場所: Philadelphia (USA)
• [学会発表] Development of new systems to measure total and phosphorylated Na-Cl cotransporter(NCC)protein in human urine (2011)
  • 著者名/発表者名: Isobe K, Ohta A, Sohara E, Rai T, SasakiS, Uchida S
  • 学会等名: The 44th Annual Meeting of American Society of Nephrology
  • 発表場所: Philadelphia (USA)
• [学会発表] Urinary excretion of Na-ClCotransporter in exosomes is increased by high salt diet as well as low salt diet (2011)
  • 著者名/発表者名: Kahn MZH, Sohara E, Ohta A, Naito S, Chiga M, Rai T, Sasaki S, Uchida S
  • 学会等名: The 44th Annual Meeting of American Society of Nephrology
  • 発表場所: Philadelphia (USA)
• [学会発表] CFTR is highly expressed in the cyst-lining epithelial cells of the AQP11 knockout mouse kidney (2011)
  • 著者名/発表者名: Kobayashi K, Uchida S, Sasaki S
  • 学会等名: The 44th Annual Meeting of American Society of Nephrology
  • 発表場所: Philadelphia (USA)
• [学会発表] High throughput screening of drugs that inhibit WNK-OSR1/SPAK signaling cascade (2011)
  • 著者名/発表者名: Mori T, Ohta A, Sohara E, Rai T, Sasaki S, Uchida S
  • 学会等名: The 44th Annual Meeting of American Society of Nephrology
  • 発表場所: Philadelphia (USA)
• [学会発表] Increased Na-Cl cotransporter phosphorylation in hyperinsulinemic db/db mice is regulated by insulin/PI3K pathway (2011)
  • 著者名/発表者名: Nishida H, Sohara E, Alessi DR, Nomura N, Rai T, Sasaki S, Uchida S
  • 学会等名: The 44th Annual Meeting of American Society of Nephrology
  • 発表場所: Philadelphia (USA)
• [学会発表] Chemical library screening for drugs to correct intracellular mislocalization of R8L mutant barttin (2011)
  • 著者名/発表者名: Nomura N, Naito S, Sohara E, Rai T, Sasaki S, Uchida S
  • 学会等名: The 44th Annual Meeting of American Society of Nephrology
  • 発表場所: Philadelphia (USA)
• [学会発表] Renal phenotype of WNK3 knockout mouse (2011)
  • 著者名/発表者名: Oi K, Sohara E, Rai T, Chiga M, Alessi DR, Sasaki S, Uchida S
  • 学会等名: The 44th Annual Meeting of American Society of Nephrology
  • 発表場所: Philadelphia (USA)
• [学会発表] Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney (2011)
  • 著者名/発表者名: Sohara E, Rai T, Yang SS, Ohta A, Chiga M, Nomura N, Lin SH, Vandewalle A, Sasaki S, Uchida S
  • 学会等名: The 44th Annual Meeting of American Society of Nephrology
  • 発表場所: Philadelphia (USA)
• [学会発表] WNK-OSR1/SPAK-SLC12A phosphorylation cascade in the WNK1 (+/-) mice (2011)
  • 著者名/発表者名: Susa K, Ohta A, Sohara E, Rai T, Kita S, Iwamoto T, Alessi DR, Sasaki S, Uchida S
  • 学会等名: The 44th Annual Meeting of American Society ofNephrology
  • 発表場所: Philadelphia (USA)
• [学会発表] Increased protein abundance of the mutant WNK4 may be a cause of the increased WNK4 kinase activity inthe mouse model of pseudohypoaldosteronism type II (2011)
  • 著者名/発表者名: Wakabayashi M, Naito S, Sohara E, Rai T, Sasaki S, Uchida S
  • 学会等名: The 44th Annual Meeting of American Society of Nephrology
  • 発表場所: Philadelphia (USA)
• [学会発表] Generation and analyses of AQP11 BAC transgenic mice (2011)
  • 著者名/発表者名: Inoue Y
  • 学会等名: The 44^<th> Annual Meeting of American Society of Nephrology
  • 発表場所: Pennsylvania Convention Center, Philadelphia, U.S.A.
• [学会発表] Development of new systems to measure total and phosphorylated Na-Cl cotransporter (NCC) protein in human urine (2011)
  • 著者名/発表者名: Isobe K
  • 学会等名: The 44^<th> Annual Meeting of American Society of Nephrology
  • 発表場所: Pennsylvania Convention Center, Philadelphia, U.S.A.
• [学会発表] Urinary excretion of Na-Cl Cotransporter in exosomes is increased by high salt diet as well as low salt diet (2011)
  • 著者名/発表者名: Kahn MZH
  • 学会等名: The 44^<th> Annual Meeting of American Society of Nephrology
  • 発表場所: Pennsylvania Convention Center, Philadelphia, U.S.A.
• [学会発表] High throughput screening of drugs that inhibit WNK-OSR1/SPAK signaling cascade (2011)
  • 著者名/発表者名: Mori T
  • 学会等名: The 44^<th> Annual Meeting of American Society of Nephrology
  • 発表場所: Pennsylvania Convention Center, Philadelphia, U.S.A.
• [学会発表] Increased Na-Cl cotransporter phosphorylation in hyperinsulinemic db/db mice is regulated by insulin/PI3K pathway (2011)
  • 著者名/発表者名: Nishida H
  • 学会等名: The 44^<th> Annual Meeting of American Society of Nephrology
  • 発表場所: Pennsylvania Convention Center, Philadelphia, U.S.A.
• [学会発表] Chemical library screening for drugs to correct intracellular mislocalization of R8L mutant barttin (2011)
  • 著者名/発表者名: Nomura N
  • 学会等名: The 44^<th> Annual Meeting of American Society of Nephrology
  • 発表場所: Pennsylvania Convention Center, Philadelphia, U.S.A.
• [学会発表] Renal phenotype of WNK3 knockout mouse (2011)
  • 著者名/発表者名: Oi K
  • 学会等名: The 44^<th> Annual Meeting of American Society of Nephrology
  • 発表場所: Pennsylvania Convention Center, Philadelphia, U.S.A.
• [学会発表] Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney (2011)
  • 著者名/発表者名: Sohara E
  • 学会等名: The 44^<th> Annual Meeting of American Society of Nephrology
  • 発表場所: Pennsylvania Convention Center, Philadelphia, U.S.A.
• [学会発表] WNK-OSR1/SPAK-SLC12A phosphorylation cascade in the WNK1 (+/-)mice (2011)
  • 著者名/発表者名: Susa K
  • 学会等名: The 44^<th> Annual Meeting of American Society of Nephrology
  • 発表場所: Pennsylvania Convention Center, Philadelphia, U.S.A.
• [学会発表] A new signal cascade in kidney regulating blood pressure and ion homeostasis (2011)
  • 著者名/発表者名: Uchida S
  • 学会等名: The 23^<rd> Annual Meeting of the Korean Society for Molecular and Cellular Biology
  • 発表場所: COEX, Seoul, Korea
• [学会発表] Increased protein abundance of the mutant WNK4 may be a cause of the increased WNK4 kinase activity in the mouse model of pseudohypoaldosteronism type II (2011)
  • 著者名/発表者名: Wakabayashi M
  • 学会等名: The 44^<th> Annual Meeting of American Society of Nephrology
  • 発表場所: Pennsylvania Convention Center, Philadelphia, U.S.A.
• [学会発表] Treatment of Bartter syndrome type IV caused by R8L barttin mutation (2010)
  • 著者名/発表者名: Nomura N, Masato T, Ohta E, Ohta A, Sohara E, Rai T, Sasaki S, Uchida S
  • 学会等名: The 43nd Annual Meeting of American Society of Nephrology
  • 発表場所: Denver (USA)
• [学会発表] 腎臓でのNaCl およびK 出納調節におけるWNK キナーゼの役割 (2010)
  • 著者名/発表者名: 内田信一
  • 学会等名: 第87回日本生理学会大会
  • 発表場所: 盛岡
• [学会発表] 腎臓でのNaClおよびK出納調節におけるWNKキナーゼの役割. (2010)
  • 著者名/発表者名: 内田信
  • 学会等名: 第87回日本生理学会大会
  • 発表場所: 盛岡
• [学会発表] よくわかるシリーズ(遺伝子改変動物を用いた腎臓病研究). (2010)
  • 著者名/発表者名: 内田信
  • 学会等名: 第53回日本腎臓学会学術総会
  • 発表場所: 神戸
• [学会発表] Increased phosphorylation of Na-Cl cotransporter (NCC) in the mouse model of pseudohypoaldosteronism type II was dependent on both OSR1 and SPAK kinase activity (2009)
  • 著者名/発表者名: Chiga M, Ohta A, Rai T, Sohara E, Ohta E, Rafiqi FH, Alessi DR, Sasaki S, Uchida S
  • 学会等名: The 42nd Annual Meeting ofAmerican Society of Nephrology
  • 発表場所: San Diego(USA)
• [学会発表] Regulation of WNK1 activation by extracellular ionic conditions (2009)
  • 著者名/発表者名: Naito S, Ohta A, Ohta E, Sohara E, Rai T, Sasaki S, Uchida S
  • 学会等名: The 42nd Annual Meeting of American Society of Nephrology
  • 発表場所: San Diego(USA)
• [学会発表] Generation and analysis of the BsndR8L/R8L knockin mice (2009)
  • 著者名/発表者名: Nomura N, Masato T, Morimoto T, Kondo Y, Ohta E, Ohta A, Sohara E, Rai T, Sasaki S, Uchida S
  • 学会等名: The 42nd Annual Meeting of American Society of Nephrology
  • 発表場所: San Diego (USA)
• [学会発表] Investigation of the localization of mouse WNK3 in kidney (2009)
  • 著者名/発表者名: Oi K, Sohara E, Ohta A, Ohta E, Rai T, Sasaki S, Uchida S
  • 学会等名: The 42nd Annual Meeting of American Society of Nephrology
  • 発表場所: San Diego (USA)
• [学会発表] Novel insulin-WNK4-NCC phosphorylation cascade is involved in pathogenesis of PHA II caused by WNK4R1185C mutation (2009)
  • 著者名/発表者名: Sohara E, Rai T, Ohta A, Ohta E, Sasaki S and Uchida S
  • 学会等名: The 42nd Annual Meeting of American Society of Nephrology
  • 発表場所: San Diego (USA)
• [学会発表] Effect of angiotensin II on WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney (2009)
  • 著者名/発表者名: Talati G, Ohta A, Rai T, Sohara E, Naito S, Vandewalle A, Sasaki S, Uchida S
  • 学会等名: The 42st Annual Meetingof American Society of Nephrology
  • 発表場所: SanDiego (USA)
• [学会発表] (2009)
  • 学会等名: The 36th International Congress ofPhysiological Sciences (IUPS2009)
  • 発表場所: Kyoto
• [学会発表] Molecular pathogenesis of Bartter syndrome caused by R8L barttin mutation (2009)
  • 著者名/発表者名: Uchida S, Nomura N, Sugawara N, Morimoto T, Kondo Y, Naito S, Yui N, Oi K, Talat G , KMZ Hossain, Wakabayashi M, Nishida H, Ohta E, Ohta A, Sohara E, Rai T, Sasaki S
  • 学会等名: The 40th NIPS International Symposium & Physiology of anion transport and cell volume regulation (PAT-CVR 2009)
  • 発表場所: Okazaki
• [学会発表] シンポジウム 輸送体研究の新展開:新しい解析技術による創薬標的の実体と病態の解明.疾患起因性変異ノックインマウスの解析による腎臓の水・電解質輸送機構の解明 (2009)
  • 著者名/発表者名: 内田信一
  • 学会等名: 第82回日本薬理学会年会
  • 発表場所: 横浜
• [学会発表] 教育講演 WNK キナーゼによる腎臓での新たな塩分出納調節機構 (2009)
  • 著者名/発表者名: 内田信一
  • 学会等名: 第44回日本小児腎臓病学会学術総会
  • 発表場所: 東京
• [学会発表] シンポジウム トランスポーター研究のパラダイムシフト:ヒトシステムの理解を目指して.ヒト遺伝性高血圧症原因遺伝子の機能解析から明らかになった腎臓での新たなNaCl 出納調節系 (2009)
  • 著者名/発表者名: 内田信一
  • 学会等名: 第82回日本生化学会大会
  • 発表場所: 神戸
• [学会発表] WNK キナーゼの腎尿細管における役割 (2009)
  • 著者名/発表者名: 内田信一
  • 学会等名: 第31回腎臓セミナー
  • 発表場所: 東京
• [学会発表] WNKキナーゼによる腎臓での新たな塩分出納調節機構 (2009)
  • 著者名/発表者名: 内田信一
  • 学会等名: 第44回日本小児腎臓病学会学術総会
  • 発表場所: 東京
• [学会発表] トランスポーター研究のパラダイムシフト:ヒトシステムの理解を目指して.ヒト遺伝性高血圧症原因遺伝子の機能解析から明らかになった腎臓での新たなNaCl出納調節系 (2009)
  • 著者名/発表者名: 内田信一
  • 学会等名: 第82回日本生化学会大会
  • 発表場所: 神戸
• [学会発表] The primary cilia of the AQP11 knockout mouse kidney (2008)
  • 著者名/発表者名: Kobayashi K, Uchida S, Sasaki S
  • 学会等名: The 41st Annual Meeting of American Society of Nephrology
  • 発表場所: Philadelphia (USA)
• [学会発表] Targeted disruption of the Wnk4 gene reduced the phospholylation of OSR1/SPAK and Na-Cl cotransporter in mice (2008)
  • 著者名/発表者名: Ohta A, Chiga M, Tajima M, Yang SS, Naito S, Rai T, Uchida S, Sasaki S
  • 学会等名: The 41st Annual Meeting of American Society of Nephrology
  • 発表場所: Philadelphia (USA)
• [学会発表] Analysis of pancreatic exocrine function ofaquaporin-12 knockout mice (2008)
  • 著者名/発表者名: Ohta E, Itoh T, Nemoto T, Kumagai J, Ko SBH, Ishibashi K, Ohno M, Uchida K, Ohta A, Rai T, Uchida S, Sasaki S
  • 学会等名: The 41st Annual meeting of American Society of Nephrology
  • 発表場所: Philadelphia (USA)
• [学会発表] Basic and Clinical Science Symposium, "Transport regulation by phosphorylation"Phosphorylation-dependent regulation of NCC by WNKs (2008)
  • 著者名/発表者名: Uchida S
  • 学会等名: The 41st Annual meeting of American Society of Nephrology
  • 発表場所: Philadelphia (USA)
• [学会発表] Basic and Clinical Science Symposium, "Transport regulation by phosphorylation" Phosphorylation-dependent regulation of NCC by WNKs. (2008)
  • 著者名/発表者名: Uchida S.
  • 学会等名: The 41st Annual meeting of American Society of Nephrology
  • 発表場所: Philadelphia
• [学会発表] "Transport regulation by phosphorylation" Phosphorylation- dependent regulation of NCC by WNKs. (2008)
  • 著者名/発表者名: Uchida S
  • 学会等名: The 41^<st> Annual meeting of AmericanSociety of Nephrology
  • 発表場所: フィラデルフィア
• [学会発表] Analysis of pancreatic exocrine function of aquaporin-12 knockout mice. (2008)
  • 著者名/発表者名: Ohta E
  • 学会等名: The 41^<st> Annual meeting of AmericanSociety of Nephrology
  • 発表場所: フィラデルフィア
• [学会発表] Targeted disruption of the Wnk4 gene reduced the phospholylation of OSRl/SPAK and Na-Cl cotransporter in mice. (2008)
  • 著者名/発表者名: Ohta A
  • 学会等名: The 41^<st> Annual meeting of AmericanSociety of Nephroiogy
  • 発表場所: フィラデルフィア
• [学会発表] WNKl activity to OSRl in COS cells is regulated not by hypotonicity but by low chloride. (2008)
  • 著者名/発表者名: Naito S
  • 学会等名: The 41^<st> Annual meeting of AmericanSociety of Nephrology
  • 発表場所: フィラデルフィア
• [学会発表] The primary cilia of the AQP11 knockout mouse kidney. (2008)
  • 著者名/発表者名: Kobayashi K
  • 学会等名: The 41^<st> Annual meeting of AmericanSocietv of Nephrology
  • 発表場所: フィラデルフィア
• [学会発表] FAPP2 Is required for AQP2 apical sorting in polarized MDCK cells. (2008)
  • 著者名/発表者名: Yui N
  • 学会等名: The 41^<st> Annual meeting of AmericanSociety of Nephrology
  • 発表場所: フィラデルフィア
• [学会発表] Epithelial transport: bridges between molecules and function
  • 著者名/発表者名: Uchida S
  • 学会等名: WNK kinases and cation-chloride cotransporters, novel transportsomes regulating blood pressure
• [図書] 2-2膜電位とイオンチャネル2-2-4「膜電位とチャネル」クロライド.トランスポートソームの世界.金井好克/竹島浩/森泰生/久保義弘編著 (2011)
  • 著者名/発表者名: 内田信一, 野村尚弘
  • 出版者: 京都廣川書店
• [図書] 2-6非興奮性細胞(非興奮性組織)のイオンチャネル2-6-2上皮.トランスポートソームの世界.金井好克/竹島浩/森泰生/久保義弘編著 (2011)
  • 著者名/発表者名: 日比野浩, 内田信一, 野村尚弘
  • 出版者: 京都廣川書店
• [図書] 今日の治療指針2011 急性腎不全 (2011)
  • 著者名/発表者名: 内田信
  • 出版者: 医学書院
• [図書] 腎疾患・透析 最新の治療2011-2013(尿崩症) (2011)
  • 著者名/発表者名: 内田信
  • 出版者: 南江堂
• [図書] 電解質輸送体の調節機構についての新たな進展Anuual Reciew 腎臓2010 (2010)
  • 著者名/発表者名: 太田哲人、内田信一
  • 出版者: 中外医学社
• [図書] Annual Review 腎臓2010(電解質輸送体の調節機構についての新たな進展) (2010)
  • 著者名/発表者名: 太田哲人、内田信
  • 出版者: 中外医学社
• [図書] 医学スーパラーニングシリーズ 腎臓内科学 (内分泌機能、水電解質の代謝) (2010)
  • 著者名/発表者名: 内田信
  • 出版者: シュプリンガー・ジャパン
• [図書] Neural roles of CLC chloride channels.(Handbook of Neurochemistry and Molecular Neurobiology.)(3rd Edition.)(Editor : Abel Lajha) (2009)
  • 著者名/発表者名: Uchida S, Sasaki S.
  • 出版者: Springer
• [図書] 尿細管の生理,SIADH.専門医のための腎臓病学第2版 (2009)
  • 著者名/発表者名: 大井克征
  • 総ページ数: 640
  • 出版者: 医学書院
• [備考] 東京医科歯科大学腎臓内科学
  • URL: http://www.tmd.ac.jp/grad/kid/kid-J.htm
• [備考] 腎臓内科ホームページ
  • URL: http://www.tmd.ac.jp/grad/kid/kid-J.htm
• [備考]
  • URL: http://www.tmd.ac.jp/grad/kid/kid-J.htm
• [備考] ホームページ
  • URL: http://www.tmd.ac.jp/grad/kid/kid-J.htm
• [備考]
  • URL: http://www.tmd.ac.jp/grad/kid/kid-J.htm
• [備考]
  • URL: http://www.tmd.ac.jp/grad/kid/kid-J.htm
• [備考]
  • URL: http://www.tmd.ac.jp/grad/kid/kid-j/htm