C型肝炎における代謝異常と肝疾患進展への影響

• 研究課題/領域番号: 20390204
• 研究種目: 基盤研究(B)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 消化器内科学
• 研究機関: 東京大学
• 研究代表者: 小池 和彦 東京大学, 医学部附属病院, 教授 (80240703)
• 研究分担者: 四柳 宏 東京大学, 医学部附属病院, 准教授 (30251234) ; 藤江 肇 東京大学, 医学部附属病院, 助教 (90332577)
• 研究期間 (年度): 2008 – 2010
• 研究課題ステータス: 完了 (2010年度)
• 配分額: 18,980千円 (直接経費: 14,600千円、間接経費: 4,380千円); 2010年度: 3,640千円 (直接経費: 2,800千円、間接経費: 840千円); 2009年度: 5,330千円 (直接経費: 4,100千円、間接経費: 1,230千円); 2008年度: 10,010千円 (直接経費: 7,700千円、間接経費: 2,310千円)
• キーワード: ウイルス肝炎 / 癌 / 肝線維化 / 脂質代謝 / インスリン抵抗性 / C型肝炎 / 脂質代謝異常 / 酸化ストレス / 脂肪酸 / ミトコンドリア / C型肝炎ウイルス / 肝細胞癌

研究概要

肝炎患者とマウスモデルを対象として、C型肝炎において脂質代謝異常やインスリン抵抗性が高率に発生することを明らかにし、その機序を解明してきた。C型肝炎ウイルス(HCV)は転写因子SREBP-1c発現、シグナル・タンパク質のリン酸化、脂質代謝酵素発現、アポリポタンパク分泌、等の制御を修飾して代謝異常を引き起こすこと、また、活性酸素産生と宿主抗酸化系に影響を与えC型肝炎最大の特徴である酸化ストレスの過剰産生をもたらし、肝疾患を進行させることが明らかになった。

研究成果

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• [雑誌論文] Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer. (2011)
  • 著者名/発表者名: Hayakawa Y, Hirata Y, Nakagawa H, Sakamoto K, Hikiba Y, Kinoshita H, Nakata W, Takahashi R, Tateishi K, Tada M, Akanuma M, Yoshida H, Takeda K, Ichijo H, Omata M, Maeda S, Koike K.
  • 雑誌名: Proc Natl Acad Sci USA 108 ページ: 780-785
• [雑誌論文] Intrahepatic bile duct dilatation after percutaneous radiofrequency ablation for hepatocellular carcinoma: impact on patient's prognosis. (2011)
  • 著者名/発表者名: Kondo Y, Shiina S, Tateishi R, Arano T, Uchino K, Enooku K, Goto E, Nakagawa H, Masuzaki R, Asaoka Y, Fujie H, Goto T, Omata M, Yoshida H, Koike K.
  • 雑誌名: Liver Int 31 ページ: 197-205
• [雑誌論文] Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated MAPK (2011)
  • 著者名/発表者名: Nakagawa H, Hirata Y, Iakeda K, Hayakawa Y, Sato T, Kinoshita H, Sakamoto K, Nakata W, Hikiba Y, Omata M, Yoshida H, Koike K, Ichijo H, Maeda S.
  • 雑誌名: Hepatology 巻: 右記参照
  • 査読あり
• [雑誌論文] Direct differentiation of hepatic cells from human induced pluripotent stem cells using a limited number of cytokines (2011)
  • 著者名/発表者名: Takata A, Otsuka M, Kogiso T, Kojima K, Yoshikawa T, Tateishi R, Kato N, Shiina S, Yoshida H, Omata M, Koike K.
  • 雑誌名: Hepatol Int 巻: 右記参照
  • 査読あり
• [雑誌論文] Hepatocellular carcinoma with extrahepatic metastasis : Clinical features and prognostic factors (2011)
  • 著者名/発表者名: Uchino K, Tateishi R, Shiina S, Kanda M, Masuzaki R, Kondo Y, Goto T, Omata M, Yoshida H, Koike K.
  • 雑誌名: Cancer 巻: 右記参照
  • 査読あり
• [雑誌論文] Autotaxin as a novel serum marker of liver fibrosis (2011)
  • 著者名/発表者名: Nakagawa H, Ikeda H, Nakamura K, Ohkawa R, Masuzaki R, Tateishi R, Yoshida H, Watanabe N, Tejima K, Kume Y, Iwai T, Suzuki A, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Omata M, Igarashi K, Aoki, J, Koike K, Yatomi Y.
  • 雑誌名: Clin Chim Acta 巻: 右記参照
  • 査読あり
• [雑誌論文] Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma (2011)
  • 著者名/発表者名: Yasui K, Hashimoto E, Komorizono Y, Koike K, Arii S, Imai Y, Shima T, Kanhara Y, Saihara T, Mori T, Kawata S, Uto H, Takami S, Sumida Y, Takamura T, Kawanaka M, Okanoue T
  • 雑誌名: Clin Gastroenterol Hepatol 巻: 右記参照
  • 査読あり
• [雑誌論文] Effect of treatment with polynsatured fatty acids on HCV-or diet-induced fatty liver (2011)
  • 著者名/発表者名: Koike K, Miyoshi H, Yotsyanagi H, Moriya K.
  • 雑誌名: J Hepatol 巻: 右記参照
  • 査読あり
• [雑誌論文] Intrahepatic bile duct dilatation after percutaneous radiofrequency ablation for hepatocellular carcinoma : impact on patient's prognosis (2011)
  • 著者名/発表者名: Kondo Y, Shiina S, Tateishi R, Arano T, Uchino K, Enooku K, Goto E, Nakagawa H, Masuzaki R, Asaoka Y, Fujie H, Goto T, Omata M, Yoshida H, Koike K.
  • 雑誌名: Liver Int 巻: 31 ページ: 197-205
  • 査読あり
• [雑誌論文] Pathogenesis of lipid metabolism disorder in hepatitis C : polyunsaturated fatty acids counteract lipid alterations induced by the core protein. (2011)
  • 著者名/発表者名: Miyoshi H, Moriya K, Tsutsumi T, Shinzawa S, Fujie H, Shintani Y, Fujinaga H, Goto K, Todoroki T, Suzuki T, Miyamura T, Matsuura Y, Yotsuyanagi H, Koike K.
  • 雑誌名: J Hepatol 巻: 54 ページ: 432-438
  • 査読あり
• [雑誌論文] Serum level of adiponectin and the risk of liver cancer development in chronic hepatitis C patients. (2010)
  • 著者名/発表者名: Arano T, Nakagawa H, Tateishi R, Ikeda H, Uchino K, Enooku K, Goto E, Masuzaki R, Asaoka Y, Kondo Y, Goto T, Shiina S, Omata M, Yoshida H, Koike K.
  • 雑誌名: Int J Cancer, [Epub ahead of print] PubMed PMID ページ: 21170963-21170963
• [雑誌論文] Impact of Changes in Obesity Parameters on Glucose Metabolism and Insulin Resistance Over a One-Year Period. (2010)
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  • 雑誌名: J Atheroscler Thromb 17 ページ: 1246-1255
  • NAID: 130004444393
• [雑誌論文] Expression of alpha-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor. (2010)
  • 著者名/発表者名: Ohtomo N, Tomiya T, Tanoue Y, Inoue Y, Nishikawa T, Ikeda H, Seyama Y, Kokudo N, Shibahara J, Fukayama M, Koike K, Shirataki H, Fujiwara K.
  • 雑誌名: Int J Oncol 37 ページ: 1417-1423
• [雑誌論文] Lipid metabolism and pathogenesis of liver disease in hepatitis C viral infection. (2010)
  • 著者名/発表者名: Koike K, Tsutsumi T, Yotsuyanagi H, Moriya K.
  • 雑誌名: Oncology 78 Suppl 1 ページ: 24-30
• [雑誌論文] Thrombocytopenia is more severe in advanced chronic hepatitis C than B with the same grade of splenomegaly. (2010)
  • 著者名/発表者名: Tejima K, Masuzaki R, Ikeda H, Yoshida H, Tateishi R, Sugioka Y, Kume Y, Okano T, Iwai T, Gotoh H, Katoh S, Suzuki S, Yatomi Y, Omata M, Koike K.
  • 雑誌名: J Gastroeterol 45 ページ: 876-884
• [雑誌論文] Cryptococcus gattii Genotype VGIIa Infection in Man, Japan (2010)
  • 著者名/発表者名: Okamoto K, Hatakeyama S, Itoyama S, Nukui Y, Yoshino Y, Kitazawa T, Yotsuyanagi H, Reiko Ikeda, SugitaT, Koike K.
  • 雑誌名: 2007.Emerg Infect Dis 16 ページ: 1155-1157
• [雑誌論文] Association between gamma-glutamyl transferase levels and insulin resistance according to alcohol consumption and number of cigarettes smoked. (2010)
  • 著者名/発表者名: Ishizaka N, Ishizaka Y, Toda E, Yamakado M, Koike K, Nagai R.
  • 雑誌名: J Atheroscler Thromb 17 ページ: 476-485
  • NAID: 130004845307
• [雑誌論文] Plasma sphingosine 1-phosphate level is reduced in patients with chronic liver disease caused by hepatitis C. (2010)
  • 著者名/発表者名: Ikeda H, Ohkawa R, Watanabe N, Nakamura K, Kume Y, OkuboS, Yokota H, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Koike K, Yatomi Y.
  • 雑誌名: Clin Chim Acta 411 ページ: 765-770
• [雑誌論文] Effect of nucleoside analogue-interferon sequential therapy on patients with acute exacerbation of chronic hepatitis B. (2010)
  • 著者名/発表者名: Okuse C, Yotsuyanagi H, Yamada N, Okamoto M, Ikeda H, Kobayashi M, Fukuda Y, Takahashi H, Nagase Y, Suzuki Y, Matsunaga K, Ishii T, Matsumoto N, Koike K, Suzuki M, Itoh F.
  • 雑誌名: Hepatol Res 40 ページ: 461-469
• [雑誌論文] RNA dependent RNA polymerase of hepatitis C virus binds to its coding region RNA stem-loop structure, 5BSL3.2, and its negative strand. (2010)
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• [雑誌論文] Hepatitis C virus core protein compromises iron-induced activation of antioxidants in mice and HepG2 cells. (2010)
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• [雑誌論文] Animal models for hepatitis C and related liver disease. (2010)
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  • NAID: 10027406832
• [雑誌論文] Changes in waist circumference and body mass index in relation to changes in serum uric acid in Japanese individuals. (2010)
  • 著者名/発表者名: Ishizaka N, Ishizaka Y, Toda A, Tani M, Toda E, Koike K, Yamakado M, Nagai R.
  • 雑誌名: J Rheumatol 37 ページ: 410-416
• [雑誌論文] Serum level of adiponectin and the risk of liver cancer development in chronic hepatitis C patients (2010)
  • 著者名/発表者名: Arano T, Nakagawa H, Tateishi R, Ikeda H, Uchino K, Enooku K, Goto E, Masuzaki R, Asaoka Y, Kondo Y, Goto T, Shiina S, Omata M, Yoshida H, Koike K.
  • 雑誌名: Int J Cancer 巻: 右記参照
  • 査読あり
• [雑誌論文] Utility of contrast enhanced ultrasonography with sonazoid in radiofre quency ablation for hepatocellular carcinoma (2010)
  • 著者名/発表者名: Masuzaki R, Shiina S, Tateishi R, Yoshida H, Goto E, Sugioka Y, Kondo Y, Goto T, Ikeda H, Omata M, Koike K.
  • 雑誌名: J Gastroenterol Hepatol 巻: 右記参照
  • 査読あり
• [雑誌論文] Usefulness of multi-detector helical CT with multiplanar reconstruction for depicting the duodenal varices with multiple collateral shunt vessels (2010)
  • 著者名/発表者名: Yoshida S, Watahe H, Akahane M, Kyoden Y. Ishikawa H, Yamada A. Sugimoto T, Ohta M, Ogura K, Yamaji Y, Ohtomo K, Kokudo N, Koike K, Omata M.
  • 雑誌名: Hepatol Int 巻: 4 ページ: 775-778
  • 査読あり
• [雑誌論文] Impact of changes in obesity parameters on glucose metabolism and insulin resistance over a one-year period. (2010)
  • 著者名/発表者名: Sakamoto A, Ishizaka Y, Toda EI, Nagai R, Koike K, Yamakado M, Ishizaka N.
  • 雑誌名: J Atheroscler Thromb 巻: 右記参照
  • NAID: 130004444393
  • 査読あり
• [雑誌論文] Lipid metabolism and pathogenesis of liver disease in hepatitis C viral infection. (2010)
  • 著者名/発表者名: Koike K, Tsutsumi T, Yotsuyanagi H, Moriya K.
  • 雑誌名: Oncology 巻: 78 ページ: 24-30
  • 査読あり
• [雑誌論文] Thrombocytopenia is more severe in advanced chronic hepatitis C than B with the same grade of splenomegaly. (2010)
  • 著者名/発表者名: Tejima K, Masuzaki R, Ikeda H, Yoshida H, Tateishi R, Sugioka Y, Kume Y, Okano T, Iwai T, Gotoh H, Katoh S, Suzuki S, Yatomi Y, Omata M, Koike K.
  • 雑誌名: J Gastroeterol 巻: 45 ページ: 876-884
  • 査読あり
• [雑誌論文] Association between gamma-glutamyl transferase levels and insulin resistance according to alcohol consumption and number of cigarettes smoked. (2010)
  • 著者名/発表者名: Ishizaka N, Ishizaka Y, Toda E, Yamakado M, Koike K, Nagai R.
  • 雑誌名: J Atheroscler Thromb 巻: 17 ページ: 476-485
  • NAID: 130004845307
  • 査読あり
• [雑誌論文] Expression of alpha-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor. (2010)
  • 著者名/発表者名: Ohtomo N, Tomiya T, Tanoue Y, Inoue Y, Nishikawa T, Ikeda H, Seyama Y, Kokudo N, Shibahara J, Fukayama M, Koike K, Shirataki H, Fujiwara K.
  • 雑誌名: Int J Oncol 巻: 37 ページ: 1417-1423
  • 査読あり
• [雑誌論文] Plasma sphingosine 1-phosphate level is reduced in patients with chronic liver disease caused by hepatitis C (2010)
  • 著者名/発表者名: Ikeda H, Ohkawa R, Watanahe N, Nakamura K, Kume Y, Okubo S, Yokota H, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Koike K, Yatomi Y.
  • 雑誌名: Clin Chim Acta 巻: 411 ページ: 765-770
  • 査読あり
• [雑誌論文] Effect of nucleoside analogue-interferon sequential therapy on patients with acute exacerbation of chronic hepatitis B (2010)
  • 著者名/発表者名: Okuse C, Yotsuyanagi H, Yamada N, Okamoto M, Ikeda H, Kobayashi M, Fukuda Y, Takahashi H, Nagase Y, Suzuki Y, Malsunaga K, Ishii T, Matsumoto N, Koike K, Suzuki M, Itoh F.
  • 雑誌名: Hepatol Res 巻: 40 ページ: 461-469
  • 査読あり
• [雑誌論文] RNA dependent RNA polymerase of hepatitis C virus binds to its coding region RNA stem-loop structure, 5BSL3.2, and its negative strand (2010)
  • 著者名/発表者名: Kanamori H, Yuhashi K, Ohnishi S, Koike K, Kodama T.
  • 雑誌名: J Gen Virol 巻: 91 ページ: 1207-1212
  • 査読あり
• [雑誌論文] Hepatitis C virus core protein compromises iron-induced activation of antioxidants in mice and HepG2 cells (2010)
  • 著者名/発表者名: Moriya K, Miyoshi H, Shinzawa S, Tsutsumi T, Fujie H, Goto K, Shintani Y, Yotsuyanagi H, Koike K.
  • 雑誌名: J Med Virol 巻: 82 ページ: 776-792
  • 査読あり
• [雑誌論文] Expression of pituitary tumor transforming gene 1 (PTTG1)/securin in hepatitis B virus-associated liver diseases : Evidence for a hepatitis B virus X protein-mediated inhibition of PTTG1 ubiquitination and degradation (2010)
  • 著者名/発表者名: Molina-Jimenez F, Benedicto I, Murata M, Martin-Vilchez S, Seki T, Pintor-Toro JA, Tortotero M, Moreno-Otero R, Okazaki K, Koike K, Barbero JL, Matsuzaki K, Majano PL, Lopez-Cabrera M
  • 雑誌名: Hepatology 巻: 51 ページ: 777-787
  • 査読あり
• [雑誌論文] Identification of hepatitis C virus genotype 2a replicon variants with reduced susceptibility to ribavirin. (2010)
  • 著者名/発表者名: Hmwe SS, Aizakia H, Date T, Murakami K, Ishii K, Miyamura T, Koike K, Wakita T, Suzuki T.
  • 雑誌名: Antiviral Res 巻: 85 ページ: 520-524
  • 査読あり
• [雑誌論文] Prolonged treatment with PEG-IFN a-2b and ribavirin can improve SVR in chronic hepatitis C genotype 1 patients with late response in a clinical real-life setting in Japan (2010)
  • 著者名/発表者名: Watanabe S, Enomoto N, Koike K, Izumi N, Takikawa H, Hashimoto E, Moriyasu F, Kumada H, Imawari M, PERFECT STUDY GROUP
  • 雑誌名: Hepatol Res 巻: 40 ページ: 135-144
  • 査読あり
• [雑誌論文] Animal models for hepatitis C and related liver disease (2010)
  • 著者名/発表者名: Koike K, Moriya K, Matsuura Y
  • 雑誌名: Hepatol Res 巻: 40 ページ: 69-82
  • NAID: 10027406832
  • 査読あり
• [雑誌論文] Impact of changes in waist circumference and BMI over one-year period on serum lipid data in Japanese individuals. (2009)
  • 著者名/発表者名: Ishizaka N, Ishizaka Y, Toda E, Koike K, Nagai R, Yamakado M.
  • 雑誌名: J Atheroscler Thromb 16 ページ: 764-771
  • NAID: 10026144211
• [雑誌論文] Impacts of changes in obesity parameters for the prediction of blood pressure change in Japanese individuals. (2009)
  • 著者名/発表者名: Ishizaka N, Ishizaka Y, Toda E, Koike K, Yamakado M, Nagai R.
  • 雑誌名: Kidney Blood Press Res 32 ページ: 421-427
• [雑誌論文] Tacrolimus ameliorates metabolic disturbance and oxidative stress caused by hepatitis C virus core protein: Analysis using mouse model and cultured cells. (2009)
  • 著者名/発表者名: Moriya K, Miyoshi H, Tsutsumi T, Shinzawa S, Fujie H, Shintani Y, Yotsuyanagi H, Moriishi K, Matsuura Y, Suzuki T, Miyamura T, Koike K.
  • 雑誌名: Am J Pathol 175 ページ: 1515-1524
• [雑誌論文] Proteomics analysis of mitochondrial proteins reveals overexpression of a mitochondrial protein chaperone, prohibitin, in cells expressing hepatitis C virus core protein. (2009)
  • 著者名/発表者名: Tsutsumi T, Matsuda M, Aizaki H, Moriya K, Miyoshi H, Fujie H, Shintani Y, Yotsuyanagi H, Miyamura T, Suzuki T, Koike K.
  • 雑誌名: Hepatology 50 ページ: 378-386
• [雑誌論文] Chronic hepatitis C in patients coinfected with human immunodeficiency virus in Japan: a retrospective multicenter analysis. (2009)
  • 著者名/発表者名: Yotsuyanagi H, Kikuchi Y, Tsukada K, Nishida K, Kato M, Sakai H, Takamatsu J, Hige S, Chayama K, Moriya K, Koike K.
  • 雑誌名: Hepatol Res 39 ページ: 657-663
  • NAID: 10025326580
• [雑誌論文] Association between changes in obesity parameters and incidence of chronic kidney disease in Japanese individuals. (2009)
  • 著者名/発表者名: Ishizaka Y, Ishizaka N, Tani M, Toda A, Toda EI, Koike K, Nagai R, Yamakado M.
  • 雑誌名: Kidney Blood Press Res 32 ページ: 141-149
• [雑誌論文] Hepatitis B virus X protein shifts hepatic Smad3-mediated signaling from tumor-suppression to oncogenesis in chronic hepatitis B. (2009)
  • 著者名/発表者名: Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Uemura Y, Sakaida N, Fujisawa J, Seki T, Koike K, Okazaki K.
  • 雑誌名: Hepatology 49 ページ: 1203-1217
• [雑誌論文] Administration of angiotensin II, but not catecholamines, induces accumulation of lipids in the rat heart. (2009)
  • 著者名/発表者名: Hongo M, Ishizaka N, Furuta K, Yahagi N, Saito K, Sakurai R, Matsuzaki G, Koike K, Nagai R.
  • 雑誌名: Eur J Pharmacol 604 ページ: 87-92
• [雑誌論文] A single amino acid of toll-like receptor 4 that is pivotal for its signaltransduction and subcellular localization. (2009)
  • 著者名/発表者名: Yanagimoto S, Tatsuno K, Okugawa S, Kitazawa T, Tsukada K, Koike K, Kodama T, Kimura S, Shibasaki Y, Ota Y.
  • 雑誌名: J Biol Chem 284 ページ: 3513-3520
• [雑誌論文] Association between metabolic syndrome and carotid atherosclerosis in individuals without diabetes based on the oral glucose tolerance test. (2009)
  • 著者名/発表者名: Ishizaka N, Ishizaka Y, Yamakado M, Toda E, Koike K, Nagai R.
  • 雑誌名: Atherosclerosis 204 ページ: 619-623
• [雑誌論文] Identification of a novel mutation for phytosterolemia.Genetic analysis of two cases. (2009)
  • 著者名/発表者名: Togo M, Hashimoto Y, Iso-O N, Kurano M, Hara M, Kadowaki T, Koike K, Tsukamoto K.
  • 雑誌名: Clin Chim Acta 401 ページ: 165-169
• [雑誌論文] Steatosis, Liver injury and hepatocarcinogenesis in hepatitis C viral infection. (2009)
  • 著者名/発表者名: Koike K.
  • 雑誌名: J Gastroenterol 44supl ページ: 82-88
  • NAID: 10025177272
• [雑誌論文] Limitation of immunoaffinity column for the removal of abundant proteins from plasma in quantitative plasma proteomics. (2009)
  • 著者名/発表者名: Ichibangase T, Moriya K, Koike K, Imai K.
  • 雑誌名: BiomedChromatogr 23 ページ: 480-487
• [雑誌論文] Proteomics analysis of mitochondrial proteins reveals overexpression of a mitochondrial protein chaperone, prohibitin, in cells expressing hepatitis C virus core protein (2009)
  • 著者名/発表者名: Tsutsumi T, Matsuda M, Koike K
  • 雑誌名: Hepatology 50 ページ: 378-386
  • 査読あり
• [雑誌論文] Tacrolimus ameliorates metabolic disturbance and oxidative stress caused by hepatitis Cvirus core protein : Analysis using mouse model and cultured cells (2009)
  • 著者名/発表者名: Moriya K, Miyoshi H, Koike K.
  • 雑誌名: Am J Pathol 175 ページ: 1515-1524
  • 査読あり
• [雑誌論文] Hepatitis B virus X protein shifts hepatic Smad3-mediated signaling from tumor-suppression to oncogenesis in chronic hepatitis B (2009)
  • 著者名/発表者名: Murata M, Matsuzaki K, Koike K
  • 雑誌名: Hepatology 49 ページ: 1203-1217
  • 査読あり
• [雑誌論文] Colonization and/or infection with methicillin-resistant Staphylococcus aureus after living donor liver transplantation: a case control study. (2008)
  • 著者名/発表者名: Hashimoto M, Sugawara Y, Tamura S, Kaneko J, Matsui Y, Togashi J, Moriya K, Koike K, Makuuchi M.
  • 雑誌名: BMC Infectious Diseases 8 ページ: 155-155
• [雑誌論文] PPAR-alpha is essential for severe hepatic steatosis and hepatocellular carcinoma induced by HCV core protein. (2008)
  • 著者名/発表者名: Tanaka N, Moriya K, Kiyosawa K, Koike K, Gonzalez FJ, Aoyama T.
  • 雑誌名: J Clin Invest 118 ページ: 683-694
• [雑誌論文] Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: Implications for HCV-associated hepatocarcinogenesis. (2008)
  • 著者名/発表者名: Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T.
  • 雑誌名: Int J Cancer 122 ページ: 124-131
• [雑誌論文] Prevalence of hepatitis B virus infection in patients with human immunodeficiency virus in Japan. (2008)
  • 著者名/発表者名: Koike K, Kikuchi Y, Kato M, Takamatsu J, Shintani Y, Tsutsumi T, Fujie H, Miyoshi H, Moriya K, Yotsuyanagi H.
  • 雑誌名: Hepatol Res 38 ページ: 310-314
• [雑誌論文] Are serum carcinoembryonic antigen levels associated with carotid atherosclerosis in Japanese men? (2008)
  • 著者名/発表者名: Ishizaka N, Ishizaka Y, Toda EI, Koike K, Yamakado M, Nagai R.
  • 雑誌名: Arterioscler Thromb Vasc Biol 28 ページ: 160-165
• [雑誌論文] Effect of treatment with interferon alpha-2b and ribavirin in patients infected with genotype 2 hepatitis C virus. (2008)
  • 著者名/発表者名: Nagase Y, Yotsuyanagi H, Okuse C, Yasuda K, Kato T, Koike K, Suzuki M, Nishioka K, Iino S, Itoh F.
  • 雑誌名: Hepatol Res 38 ページ: 252-258
• [雑誌論文] Methicillin-resistant Staphylococcus aureus infection after living-donor liver transplantation in adults. (2008)
  • 著者名/発表者名: Hashimoto M, Sugawara Y, Tamura S, Kaneko J, Matsui Y, Moriya K, Koike K, Makuuchi M.
  • 雑誌名: Transpl Infect Dis 10 ページ: 110-116
• [雑誌論文] Molecular basis for the synergy between alcohol and hepatitis C virus in hepatocarcinogenesis. (2008)
  • 著者名/発表者名: Koike K, Tsutsumi T, Miyoshi H, Shinzawa S, Shintani Y, Fujie H, Yotsuyanagi H, Moriya K.
  • 雑誌名: J Gastroenterol Hepatol 23
• [雑誌論文] Experimental models of hepatocellular carcinoma. (2008)
  • 著者名/発表者名: Newell P, Villanueva A, Friedman SL, Koike K, Llovet JM.
  • 雑誌名: J Hepatol 48 ページ: 858-879
• [雑誌論文] Association between cigarette smoking and chronic kidney disease in Japanese men. (2008)
  • 著者名/発表者名: Ishizaka N, Ishizaka Y, Toda E, Shimomura H, Koike K, Seki G, Nagai R, Yamakado M.
  • 雑誌名: Hypertens Res 31 ページ: 485-92
  • NAID: 10021933819
• [雑誌論文] Relationship between Albuminuria, Low eGFR, and Carotid Atherosclerosis in Japanese Women. (2008)
  • 著者名/発表者名: Ishizaka Y, Ishizaka N, Tani M, Toda A, Toda EI, Koike K, Yamakado M.
  • 雑誌名: Kidney Blood Press Res 31 ページ: 164-170
• [雑誌論文] Association between hepatitis B/C viral infection, chronic kidney disease and insulin resistance in individuals undergoing general health screening. (2008)
  • 著者名/発表者名: Ishizaka N, Ishizaka Y, Seki G, Nagai R, Yamakado M, Koike K.
  • 雑誌名: Hepatol Res 38 ページ: 775-783
  • NAID: 10021945875
• [雑誌論文] PPAR-α is essential for severe hepatic steatosis and hepatocellular carcinoma induced by HCV core protein. (2008)
  • 著者名/発表者名: Tanaka N, et al.
  • 雑誌名: J Clin Invest 118 ページ: 683-694
  • 査読あり
• [雑誌論文] Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator?activated receptor alpha in transgenic mice: Implications for HCV-associated hepatocarcinogenesis. (2008)
  • 著者名/発表者名: Tanaka N, et al.
  • 雑誌名: Int J Cancer 122 ページ: 124-131
  • 査読あり
• [雑誌論文] Experimental models of hepatocellular carcinoma (2008)
  • 著者名/発表者名: Newell P, et al.
  • 雑誌名: J Hepatol 48 ページ: 858-879
  • 査読あり
• [雑誌論文] MicroRNA122 is a key regulator of α-fetoprotein expression and biologically aggressive behavior of hepatocellular carcinoma.
  • 著者名/発表者名: Kojima K, Takata A, Vadnais C, Otsuka M, Yoshikawa T, Akanuma M, Kondo Y, Kang YJ, Kishikawa T, Kato N, Xie Z, Zhang WJ, Yoshida H, Omata M, Nepveu A, Koike K.
  • 雑誌名: Nat Commun in press
• [学会発表] Association of the substitution of amino acid 75 in the hepatitis virus core region with IL-8 upregulation and hepatocarcinogenesis (2010)
  • 著者名/発表者名: Tsutsumi T, Miyoshi H, Goto Koji, Moriya K, Koike K.
  • 学会等名: 17th International Meeting on Hepatitis C Virus and Related Viruses
  • 発表場所: Yokohama
  • 年月日: 2010-09-17
• [学会発表] Animal models in HCC research (2009)
  • 著者名/発表者名: Koike K.
  • 学会等名: 3rd International Kobe Liver Symposium on HCC with a JSH-ILCA Joint Scientific Session
  • 発表場所: Kobe
  • 年月日: 2009-05-28
• [学会発表] Steatosis, liver injury and hepatocarcinogenesis in HCV infection. (2008)
  • 著者名/発表者名: Koike K.
  • 学会等名: Inflammation and Immunity 2008
  • 発表場所: Galveston, TX, USA
  • 年月日: 2008-01-20
• [図書] 肥満と消化器疾患 (2010)
  • 著者名/発表者名: 小池和彦(共著)
  • 総ページ数: 224
  • 出版者: 金原出版
• [図書] 肝臓病診療Q&A (2009)
  • 著者名/発表者名: 小池和彦, 他
  • 総ページ数: 312
  • 出版者: 中外医学社
• [図書] NASH診療best approach (2008)
  • 著者名/発表者名: 小池和彦、他
  • 総ページ数: 264
  • 出版者: 中外医学社
• [産業財産権] 肝細胞癌発生予測因子としての血中ADAMTS13 (2010)
  • 発明者名: 池田均、矢冨裕、建石良介、小池和彦、小野智子
  • 権利者名: 東京大学
  • 出願年月日: 2010-11-11
• [産業財産権] 肝細胞癌発生予測因子としての血中ADAMTS13 (2010)
  • 発明者名: 池田均、矢冨裕、建石良介、小池和彦、小野智子
  • 権利者名: 東京大学
  • 出願年月日: 2010-11-05