心腎連関の基盤たる分子機序の解明

• 研究課題/領域番号: 20390227
• 研究種目: 基盤研究(B)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 循環器内科学
• 研究機関: 奈良県立医科大学
• 研究代表者: 斎藤 能彦 奈良県立医科大学, 医学部, 教授 (30250260)
• 研究期間 (年度): 2008 – 2010
• 研究課題ステータス: 完了 (2010年度)
• 配分額: 18,980千円 (直接経費: 14,600千円、間接経費: 4,380千円); 2010年度: 910千円 (直接経費: 700千円、間接経費: 210千円); 2009年度: 8,060千円 (直接経費: 6,200千円、間接経費: 1,860千円); 2008年度: 10,010千円 (直接経費: 7,700千円、間接経費: 2,310千円)
• キーワード: 心腎連関 / 腎不全 / 心不全 / sFlt / Klotho / sFLT / 可溶型Flt-1 / 動脈硬化 / ApoE欠損マウス / FGF23 / PIGF

研究概要

心腎連関が大変注目されているが、分子機序は不明である。今回、我々は、腎機能の低下に伴い可溶型Flt-1の体内での発現が減少し、相対的にPlGF/Flt-1系が活性化することにより動脈硬化が増悪すること、また、糖尿病性腎症でKlotho遺伝子の発現が特異的に低下し、尿中Ca排泄が増加し、動脈硬化の増悪に関連する可能性を示した。

研究成果

• [雑誌論文] Roles of Guanylyl Cyclase-A Signaling in Cardiovascular System. (2011)
  • 著者名/発表者名: Saito Y, Kishimoto I, Nakao K
  • 雑誌名: Canadian J Physiology and Pharmacology in press
• [雑誌論文] for the Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) Trial Investigators. Differential Effect of Low-Dose Aspirin for Primary Prevention of Atherosclerotic Events in Diabetic Management : A Subanalysis of the JPAD Trial. (2011)
  • 著者名/発表者名: Okada S, Morimoto T, Ogawa H, Kanauchi M, Nakayama M, Uemura S, Doi N, Jinnouchi H, Waki M, Soejima H, Sakuma M, Saito Y
  • 雑誌名: Diabetes Care. in press
• [雑誌論文] Rare Concurrence of Apical Hypertrophic Cardiomyopathy and Effusive Constrictive Pericarditis. (2011)
  • 著者名/発表者名: Okayama S, Soeda T, Seno A, Watanabe M, Nakajima T, Uemura S, Saito Y
  • 雑誌名: The Open Cardiovascular Medicine Journal. in press
• [雑誌論文] Myocardial hypoperfusion detected by cardiac computed tomography in an adult patient with heart failure after classic repair for corrected transposition of the great arteries. (2011)
  • 著者名/発表者名: Okayama S, Seno A, Soeda T, Takami Y, Horii M, Uemura S, Saito Y
  • 雑誌名: Acta Cardiologica. in press
• [雑誌論文] Atrial right-to-left shunt without pulmonary hypertension in a patient with biventricular non-compaction cardiomyopathy accompanied by ventricular and atrial septal defects. (2011)
  • 著者名/発表者名: Sakan H, Okayama S, Uemura S, Somekawa S, Ishigami K, Takeda Y, Kawata H, Horii M, Fujimoto S, Saito Y
  • 雑誌名: Internal Medicine. in press
  • NAID: 130000969381
• [雑誌論文] Feasibility of evaluating epicardial fat using dual gradient-echo in-phase and opposed-phase magnetic resonance imaging. (2011)
  • 著者名/発表者名: Okayama S, Somekawa S, Uemura S, Kubota Y, Saito Y
  • 雑誌名: Acta Radiologica. in press
• [雑誌論文] Low-dose Aspirin Therapy in Patients With Type 2 Diabetes Mellitus and Reduced Glomerular Filtration Rate : Subanalysis from the JPAD Trial. (2011)
  • 著者名/発表者名: Saito Y, Morimoto T, Ogawa H, Nakayama M, Uemura S, Doi N, Jinnouchi H, Waki M, Soejima H, Sugiyama S, Okada S, Akai Y
  • 雑誌名: Diabetes Care. 34 ページ: 280-285
• [雑誌論文] Clinical significance of papillary muscle late enhancement detected via cardiac magnetic resonance imaging in patients with single old myocardial infarction. (2011)
  • 著者名/発表者名: Okayama S, Uemura S, Soeda T, Onoue K, Somekawa S, Ishigami K, Watanabe M, Nakajima T, Fujimoto S, Saito Y
  • 雑誌名: Int J Cardiol. 7;146(Epub 2010 May 14) ページ: 73-79
• [雑誌論文] Vasodilator therapy with hydralazine induces angiotensin AT receptor-mediated cardiomyocyte growth in mice lacking guanylyl cyclase-A. (2010)
  • 著者名/発表者名: Li Y, Saito Y, Kuwahara K, Rong X, Kishimoto I, Harada M, Horiuchi M, Murray M, Nakao K
  • 雑誌名: Br J Pharmacol. 159 ページ: 1133-1142
• [雑誌論文] Adipose tissue-specific dysregulation of angiotensinogen by oxidative stress in obesity. (2010)
  • 著者名/発表者名: Okada S, Kozuka C, Masuzaki H, Yasue S, Ishii-Yonemoto T, Tanaka T, Yamamoto Y, Noguchi M, Kusakabe T, Tomita T, Fujikura J, Ebihara K, Hosoda K, Sakaue H, Kobori H, Ham M, Lee YS, Kim JB, Saito Y, Nakao K
  • 雑誌名: Metabolism. 59 ページ: 1241-1251
• [雑誌論文] An ultrasound-responsive nano delivery system of tissue-type plasminogen activator for thrombolytic therapy. (2010)
  • 著者名/発表者名: Uesugi Y, Kawata H, Jo J, Saito Y, Tabata Y
  • 雑誌名: J Control Release. 15;147 ページ: 269-277
• [雑誌論文] Letter by Di Marco and Brand regarding article, "Reduction of circulating soluble fms-like tyrosine kinase-1 plays a significant role in renal dysfunction-associated aggravation of atherosclerosis". (2010)
  • 著者名/発表者名: Uemura S, Onoue K, Saito Y
  • 雑誌名: Circulation. 122
• [雑誌論文] Resolution of mesangial light chain deposits 3 years after high-dose melphalan with autologous peripheral blood stem cell transplantation. (2010)
  • 著者名/発表者名: Harada K, Akai Y, Sakan H, Yamaguchi Y, Nakatani K, Iwano M, Saito Y
  • 雑誌名: Clin Nephrol. 74 ページ: 384-388
• [雑誌論文] Still Searching for a New Therapeutic Strategy for Acute Myocardial Infarction. (2010)
  • 著者名/発表者名: Saito Y
  • 雑誌名: Circ J. 25;74 ページ: 2290-2292
  • NAID: 10026972513
• [雑誌論文] Aspirin for the primary prevention of cardiovascular events in patients with peripheral artery disease or diabetes mellitus. Analyses from the JPAD, POPADAD and AAA trials. (2010)
  • 著者名/発表者名: Soejima H, Morimoto T, Saito Y, Ogawa H
  • 雑誌名: Thromb Haemost. 104 ページ: 1085-1088
• [雑誌論文] Roles of atrial natriuretic peptide and its therapeutic use. (2010)
  • 著者名/発表者名: Saito Y
  • 雑誌名: J Cardiol. 56 ページ: 262-2670
  • NAID: 10028189387
• [雑誌論文] Contrast-enhanced computed tomographic and echocardiographic detection of intra-aortic free floating thrombus causing acute myocardial infarction (2010)
  • 著者名/発表者名: Soeda T, Okayama S, Seno A, Kawakami R, Somekawa S, Takeda Y, Uemura S, Saito Y
  • 雑誌名: J Cardiovasc Comput Tomogr. (Epub ahead of print)
• [雑誌論文] Establishment of sandwich ELISA for soluble alpha-Klotho measurement : Age-dependent change of soluble alpha-Klotho levels in healthy subjects. (2010)
  • 著者名/発表者名: Yamazaki Y, Imura A, Urakawa I, Shimada T, Murakami J, Aono Y, Hasegawa H, Yamashita T, Nakatani K, Saito Y, Okamoto N, Kurumatani N, Namba N, Kitaoka T, Ozono K, Sakai T, Hataya H, Ichikawa S, Imel EA, Econs MJ, Nabeshima Y.
  • 雑誌名: Biochem Biophys Res Commun. 30;398 ページ: 513-518
• [雑誌論文] Imaging Mass Spectrometry to Accurately Diagnose Fabry's Disease. (2010)
  • 著者名/発表者名: Onoue K, Zaima N, Sugiura Y, Isojima T, Okayama S, Horii M, Akai Y, Uemura S, Takemura G, Sakuraba H, Sakaguchi Y, Setou M, Saito Y
  • 雑誌名: Circ J. 24;75 ページ: 221-223
• [雑誌論文] Dual Gradient-echo In-phase and Opposed-phase Magnetic Resonance Imaging to Evaluate Lipomatous Metaplasia in Patients with Old Myocardial Infarction. (2010)
  • 著者名/発表者名: Okayama S, Uemura S, Sugimoto H, Enomoto S, Onoue K, Omori S, Soeda T, Somekawa S, Ishigami K, Watanabe M, Nakajima T, Kubota Y, Saito Y
  • 雑誌名: Magn Reson Med Sci. 9 ページ: 85-89
  • NAID: 10026930486
• [雑誌論文] Congenital isolated biventricular diverticula evaluated by cardiac computed tomography and magnetic resonance imaging. (2010)
  • 著者名/発表者名: Okayama S, Uemura S, Soeda T, Seno A, Onoue K, Ishigami K, Horii M, Saito Y
  • 雑誌名: Heart Lung Circ. 19 ページ: 630-632
• [雑誌論文] A pediatric case of hypertrophic cardiomyopathy with mid-ventricular obstruction incidentally detected by electrocardiography. (2010)
  • 著者名/発表者名: Okayama S, Fujimoto S, Tsutsumi T, Onoue K, Horii M, Uemura S, Sakaguchi Y, Saito Y
  • 雑誌名: Journal of Cardiology Cases. in press
• [雑誌論文] Fractalkine expression and CD16+ monocyte accumulation in glomerular lesions: association with their severity and diversity in lupus models. (2010)
  • 著者名/発表者名: Nakatani K, Yoshimoto S, Iwano M, Asai O, Samejima K, Sakan H, Terada M, Hasegawa H, Nose M, Saito Y
  • 雑誌名: Am J Physiol Renal Physiol. 299
• [雑誌論文] The Homeobox Gene HEX Regulates Hepatocyte Differentiation from ES cell-Derived Endoderm. (2010)
  • 著者名/発表者名: Kubo A, Kim Y. H, Irion S, Kasuda S, Takeuchi M, Ohashi K, Iwano M, Dohi Y, Saito Y, Snodgrass R, Keller G
  • 雑誌名: Hepatology. 51 ページ: 633-641
• [雑誌論文] A novel Thr56Met mutation of the autosomal recessive hypercholesterolemia gene associated with hypercholesterolemia. (2010)
  • 著者名/発表者名: Harada K, Miyamoto Y, Morisaki H, Ohta N, Yamanaka I, Kokubo Y, Makino H, Harada-Shiba M, Okayama A, Tomoike H, Okamura T, Saito Y, Yoshimasa Y, Morisaki T
  • 雑誌名: J Atheroscler Thromb. 26;17 ページ: 131-140
  • NAID: 130004444401
• [雑誌論文] Role of cardiac computed tomography in planning and evaluating percutaneous transluminal septal myocardial ablation for hypertrophic obstructive cardiomyopathy. (2010)
  • 著者名/発表者名: Okayama S, Uemura S, Soeda T, Horii M, Saito Y
  • 雑誌名: J Cardiovasc Comput Tomogr. 4 ページ: 62-65
• [雑誌論文] Novel application of black-blood echo-planar imaging to the assessment of myocardial infarction. (2010)
  • 著者名/発表者名: Okayama S, Uemura S, Watanabe M, Morikawa Y, Onoue K, Soeda T, Iwama H, Somekawa S, Takeda Y, Uramoto H, Kobayashi Y, Saito Y
  • 雑誌名: Heart and Vessel. 25 ページ: 104-112
• [雑誌論文] Dual-single photon emission computed tomography and contrast-enhanced magnetic resonance imaging to evaluate dissimilar features of apical hypertrophic cardiomyopathy. (2010)
  • 著者名/発表者名: Okayama S, Kawata H, Sung JH, Okada S, Nishida T, Onoue K, Soeda T, Uemura S, Saito Y
  • 雑誌名: Cardiol J. 17 ページ: 306-311
• [雑誌論文] An ultrasound-responsive nano delivery system of tissue-type plasminogen activator for thrombolytic therapy. (2010)
  • 著者名/発表者名: Uesugi Y, Kawata H, et al.
  • 雑誌名: J Control Release. 巻: 15 ページ: 269-77
  • 査読あり
• [雑誌論文] Still Searching for a New Therapeutic Strategy for Acute Myocardial Infarction. (2010)
  • 著者名/発表者名: Saito Y.
  • 雑誌名: Circ J. 巻: 25 ページ: 2290-2
  • NAID: 10026972513
  • 査読あり
• [雑誌論文] The Homeobox Gene HEX Regulates Hepatocyte Differentiation from ES cell-Derived Endoderm. (2010)
  • 著者名/発表者名: Kubo A, Kim Y.H, et al.
  • 雑誌名: Hepatology 巻: 51 ページ: 633-41
  • 査読あり
• [雑誌論文] A novel Thr56Met mutation of the autosomal recessive hypercholesterolemia gene associated with hypercholesterolemia. (2010)
  • 著者名/発表者名: Harada K, Miyamoto Y, et al.
  • 雑誌名: J Atheroscler Thromb. 巻: 26 ページ: 131-40
  • 査読あり
• [雑誌論文] Non-contrast MRI for the evaluation of hydronephrotic and dysfunctioning kidney secondary to testicular cancer. (2009)
  • 著者名/発表者名: Okayama S, Matsui M, Somekawa S, Iwano M, Saito Y.
  • 雑誌名: Ren Fail. 31 ページ: 153-158
• [雑誌論文] Coronary spasm preferentially occurs at branch points : An angiographic comparison with atherosclerotic plaque. (2009)
  • 著者名/発表者名: Nakagawa H, Morikawa Y, Mizuno Y, Harada E, Ito T, Matsui K, Saito Y, Yasue H.
  • 雑誌名: Circ Cardiovasc Intervent. 2 ページ: 97-104
• [雑誌論文] Treatment with recombinant placental growth factor (PlGF) enhances both angiogensis and arteriogenesis and improves survival after myocardial infarction. (2009)
  • 著者名/発表者名: Takeda Y, Uemura S, Iwama H, Imagawa K, Nishida T, Onoue K, Takemoto Y, Soeda T, Okayama S, Somekawa S, Ishigami K, Takaoka M, Kawata H, Kubo A, Horii M, Nakajima T, Saito Y.
  • 雑誌名: Circ J. 73 ページ: 1674-1682
• [雑誌論文] Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor. (2009)
  • 著者名/発表者名: Somekawa S, Imagawa K, Naya N, Takemoto Y, Onoue K, Okayama S, Takeda Y, Kawata H, Horii M, Nakajima T, Uemura S, Mochizuki N, Saito Y.
  • 雑誌名: Endocrinology. 50 ページ: 3110-3117
• [雑誌論文] Human placental ectonucleoside triphosphate diphosphohydrolase gene transfer via gelatin-coated stents prevents in-stent thrombosis. (2009)
  • 著者名/発表者名: Takemoto Y, Kawata H, Soeda T, Imagawa K, Somekawa S, Takeda Y, Uemura S, Matsumoto M, Fujimura Y, Jo J, Kimura Y, Tabata Y, Saito Y.
  • 雑誌名: Arterioscler Thromb Vasc Biol. 29 ページ: 857-862
• [雑誌論文] Guanylyl cyclase-A inhibits angiotensin II type 2 receptor-mediated pro-hypertrophic signaling in the heart. (2009)
  • 著者名/発表者名: Li Y, Saito Y, Kuwahara K, Rong X, Kishimoto I, Harada M, Adachi Y, Nakanishi M, Kinoshita H, Horiuchi M, Murray M, Nakao K.
  • 雑誌名: Endocrinology. 150 ページ: 3759-3765
• [雑誌論文] Epithelial-mesenchymal transition as an explanation for podocyte depletion in diabetic nephropathy. (2009)
  • 著者名/発表者名: Yamaguchi Y, Iwano M, Suzuki D, Nakatani K, Kimura K, Harada K, Kubo A, Akai Y, Toyoda M, Kanauchi M, Eric G Neilson, Saito Y.
  • 雑誌名: Am J Kidney Dis. 54 ページ: 653-664
• [雑誌論文] Morphological features of coronary arteries in patients with coronary spastic angina : Assessment with intracoronary optical coherence tomography. (2009)
  • 著者名/発表者名: Morikawa Y, Uemura S, Ishigami K, Soeda T, Okayama S, Takemoto Y, Onoue K, Somekawa S, Nishida T, Takeda Y, Kawata H, Horii M, Saito Y.
  • 雑誌名: Int J Cardiol. (Epub ahead of print)
• [雑誌論文] Long term follow-up of neointimal coverage of sirolimus-eluting stents: Evaluation with optical coherencetomography. (2009)
  • 著者名/発表者名: Ishigami K, Uemura S, Morikawa Y, Soeda T, Okayama S, Nishida T, Takemoto Y, Onoue K, Somekawa S, Takeda Y, Kawata H, Horii M, Saito Y.
  • 雑誌名: Circ J. 3 ページ: 2300-2307
• [雑誌論文] Usefulness of soluble Fms-like tyrosine kinase 1 as a biomarker of acute severe heart failure in patients with acute myocardial infarction. (2009)
  • 著者名/発表者名: Onoue K, Uemura S, Takeda Y, Somekawa S, Iwama H, Nishida T, Morikawa Y, Nakagawa H, Tsutsumi T, Sung J. H, Takemoto Y, Soeda T, Okayama S, Ishigami K, Kawata H, Horii M, Nakajima T, Saito Y.
  • 雑誌名: Am J Cardiol. 104 ページ: 1478-1483
• [雑誌論文] Periadventitial adipose tissue plays a critical role in vascular remodeling. (2009)
  • 著者名/発表者名: Takaoka M, Nagata D, Kihara S, Shimomura I, Kimura Y,Tabata Y, Saito Y, Nagai R, Sata M.
  • 雑誌名: Circ Res. 105 ページ: 906-911
• [雑誌論文] Reduction of circulating soluble fms-like tyrosine kinase-1 plays a significant role in renal dysfunction-associated aggravation of atherosclerosis. (2009)
  • 著者名/発表者名: Onoue K, Uemura S, Takeda Y, Somekawa S, Iwama H, Imagawa K, Nishida T, Morikawa Y, Takemoto Y, Asai O, Soeda T, Okayama S, Ishigami K, Nakatani K, Kawata H, Horii M, Nakajima T, Akai Y, Iwano M, Saito Y.
  • 雑誌名: Circulation. 15;120 ページ: 2470-2477
• [雑誌論文] Reduction of circulating soluble fms-like tyrosine kinase-1 plays a significant role in renal dysfunction-associated aggravation of atherosclerosis (2009)
  • 著者名/発表者名: Onoue K, Uemura S, Saito Y, et al.
  • 雑誌名: Circulation 15 ページ: 2470-2477
  • 査読あり
• [雑誌論文] Usefulness of soluble Fms-like tyrosine kinase 1 as a biomarker of acute severe heart failure in patients with acute myocardial infarction (2009)
  • 著者名/発表者名: Onoue K, Uemura S, Saito Y, et al.
  • 雑誌名: Am J Cardiol 104 ページ: 1478-1483
  • 査読あり
• [雑誌論文] Prediction of corticosteroid responsiveness based on fibroblast-specific protein 1 (FSP1) in patients with IgA nephropathy. (2008)
  • 著者名/発表者名: Harada K, Akai Y, Yamaguchi Y, Kimura K, Nishitani Y, Nakatani K, Iwano M, Saito Y.
  • 雑誌名: Nephrol Dial Transplant. 23 ページ: 3152-3159
• [雑誌論文] A case of autoimmune hepatitis exacerbated by the administration of etanercept in the patient with rheumatoid arthritis. (2008)
  • 著者名/発表者名: Harada K, Akai Y, Koyama S, Ikenaka Y, Saito Y.
  • 雑誌名: Clin Rhrumatol. 27 ページ: 1063-1066
• [雑誌論文] Continuing improvement of cardiac sympathetic activity on 123I-MIBG scintigraphy in a patient with hypertrophic obstructive cardiomyopathy after percutaneous transluminal septal myocardial ablation. (2008)
  • 著者名/発表者名: Okayama S, Uemura S, Kawata H, Horii M, Saito Y.
  • 雑誌名: J Nucl Cardiol. 15
• [雑誌論文] The Specific Mineralocorticoid Receptor Blocker Eplerenone Attenuates Left Ventricular Remodeling in Mice Lacking the Gene Encoding Guanylyl Cyclase-A. (2008)
  • 著者名/発表者名: Q Zhang, Saito Y, Naya N, Imagawa K, Somekawa S, Kawata H, Takeda Y, Uemura S, Kishimoto I, Nakao K.
  • 雑誌名: Hypertens Res. 31 ページ: 1251-1256
  • NAID: 10021936878
• [雑誌論文] Effects of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, fluvastatin, on coronary spasm after withdrawal of calcium-channel blockers. (2008)
  • 著者名/発表者名: Yasue H, Mizuno Y, Harada E, Itoh T, Nakagawa H, Nakayama M, Ogawa H, Tayama S, Honda T, Hokimoto S, Ohshima S, Hokamura Y, Kugiyaama K, Horie M, Yoshimura M, Harada M, Uemura S, Y. Saito.
  • 雑誌名: J Am Coll Cardiol. 51 ページ: 1742-1748
• [雑誌論文] Long-term clinical outcome after intramuscular implantation of bone marrow mononuclear cells (Therapeutic Angiogenesis by Cell Transplantation [TACT] trial) in patients with chronic limb ischemia. (2008)
  • 著者名/発表者名: Matoba S, Tatsumi T, Murohara T, Imaizumi T, Katsuda Y, Ito M, Saito Y, Uemura S, H Suzuki, Fukumoto S, Yamamoto Y, Onodra R, Fukushima S, Matsubara H.
  • 雑誌名: Am Heart J. 156 ページ: 1010-1018
• [雑誌論文] Establishment of embryonic stem cells secreting human factor VIII for cell-based treatment of hemophilia A. (2008)
  • 著者名/発表者名: Kasuda S, Kubo A, Sakurai Y, Irion S, Ohashi K, Tatsumi K, Nakajima Y, Saito Y, Hakake K, Pipe SW, Shima M, Yoshioka A.
  • 雑誌名: J Thromb Haemost. 6 ページ: 1352-1359
• [雑誌論文] Progression of non-culprit coronary artery atherosclerosis after acute myocardial infarction in comparison with stable angina pectoris. (2008)
  • 著者名/発表者名: Okayama S, Uemura S, Nishida T, Morikawa Y, Onoue K, Takemoto Y, Soeda T, Somekawa S, Ishigami K, Takeda Y, Horii M, Kawata H, Takaoka M, Nakajima T, Saito Y.
  • 雑誌名: J Atheroscler Thromb 15 ページ: 228-234
  • NAID: 10024363253
• [雑誌論文] Acute myocardial infarction as a systemic prothrombotic condition evidenced by increased von willebrand factor protein over ADAMTS13 activity in coronary and systemic circulation. (2008)
  • 著者名/発表者名: Horii M, Uemura S, Uemura M, Matsumoto M,Ishizashi H, Imagawa K, Iwama H, Takeda Y, Kawata H, Nakajima T, Fujimura Y, Saito Y.
  • 雑誌名: Heart and Vessel. 23 ページ: 301-307
• [雑誌論文] On behalf of the Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes (JPAD) Trial Investigators*. (2008)
  • 著者名/発表者名: Ogawa H, Nakayama M, Morimoto T, Uemura S, Kanauchi,M, Doi N, Jinnouchi H, Sugiyama S, Saito Y.
  • 雑誌名: JAMA 300 ページ: 2134-2141
• [雑誌論文] Differential Effect of Low-Dose Aspirin for Primary Prevention of Atherosclerotic Events in Diabetic Management : A Subanalysis of the JPAD Trial.
  • 著者名/発表者名: Okada S, Morimoto T, et al.
  • 雑誌名: Diabetes Care. 巻: (in press)
  • 査読あり
• [雑誌論文] Treatment with Recombinant Placental Growth Factor (PIGF) Enhances both Angiogensis and Arteriogenesis and Improves Survival after Myocardial Infarction.
  • 著者名/発表者名: Takeda Y, Uemura S, Iwama H, Imagawa K, Nishida T, Onoue K, Takemoto Y, et al.
  • 雑誌名: Circ. J. (In press)
  • 査読あり
• [雑誌論文] Human placental ectonucleoside triphosphate diphosphohy drolase gene transter via gelatin-coated stents prevents in-stent thrombosis.
  • 著者名/発表者名: Takemoto Y, Kawata H, Soeda T, Imagawa K, Somekawa, et al.
  • 雑誌名: Arterioscler Thromb Vase Biol. (In press)
  • 査読あり
• [雑誌論文] Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor.
  • 著者名/発表者名: Somekawa S, Imagawa K, Naya N, Takemoto Y, Onoue, et al
  • 雑誌名: Endocrinology. (In press)
  • 査読あり
• [学会発表] Optical Coherence Tomography-Based Complex Plaque Characteristics Predict the Subsequent Progression of Non-culprit Lesion in Patients with Percutaneous Coronary Intervention. (2010)
  • 著者名/発表者名: Uemura S, Ishigami K, et al.
  • 学会等名: American Heart Association Scientific Session 2010
  • 発表場所: Chicago, USA
  • 年月日: 2010-11-17
• [学会発表] Efficacy of Low-dose Aspirin Therapy for Primary Prevention of Atheros clerotic Events Depends on the Severity of Diabetes : a subanalysis of JPAD trial. (2010)
  • 著者名/発表者名: Okada S, Morimoto T, et al.
  • 学会等名: American Heart Association Scientific Session 2010
  • 発表場所: Chicago, USA
  • 年月日: 2010-11-17
• [学会発表] Better Neointimal Formation of Paclitaxel Eluting Stent of the Patient with Multiple Risk Factor -Optical coherence tomography study. (2010)
  • 著者名/発表者名: Ishigami K, Uemura S, et al.
  • 学会等名: American Heart Association Scientific Session 2010
  • 発表場所: Chicago, USA
  • 年月日: 2010-11-15
• [学会発表] Cardio-renal interaction in heart failure (2010)
  • 著者名/発表者名: Saito Y.
  • 学会等名: the XX ISHR World Congress
  • 発表場所: Kyoto, Japan
  • 年月日: 2010-05-13
• [学会発表] Optical Coherence Tomography-Based Complex Plaque Characteristics Predict the Subsequent Progression of Non-culprit Lesion in Patients with Percutaneous Coronary Intervention. (2010)
  • 著者名/発表者名: Uemura S, Ishigami K, Soeda T, Sung J, Nakagawa H, Tsutsumi T, Okayama S, Kawata H, Horii M, Saito Y
  • 学会等名: American Heart Association Scientific Session
  • 発表場所: Chicago, USA
• [学会発表] Development of the New Drug Delivery System with Ultrasound for Coronary Thrombosis. (2010)
  • 著者名/発表者名: Kawata H, Soeda T, Takemoto Y, Sung J, Uemura S, Uesugi Y, Jo J, Tabata Y, Umaki K, Kato K, Saito Y
  • 学会等名: American Heart Association Scientific Session 2010
  • 発表場所: Chicago, USA
• [学会発表] Better Neointimal Formation of Paclitaxel Eluting Stent of the Patient with Multiple Risk Factor -Optical coherence tomography study-. (2010)
  • 著者名/発表者名: Ishigami K, Uemura S, Sung J, Soeda T, Okayama S, Kawata H, Horii M, Saito Y
  • 学会等名: American Heart Association Scientific Session 2010
  • 発表場所: Chicago, USA
• [学会発表] Efficacy of Low-dose Aspirin Therapy for Primary Prevention of Atherosclerotic Events Depends on the Severity of Diabetes : a subanalysis of JPAD trial. (2010)
  • 著者名/発表者名: Okada S, Morimoto T, Ogawa H, Nakayama H, Sakuma M, Uemura S, Kanauchi M, Doi N, Jinnouchi H, Soejima H, Sugihara S, Waki M, Kawano T, Saito Y
  • 学会等名: American Heart Association Scientific Session 2010 November
  • 発表場所: Chicago, USA
• [学会発表] Diffuse Intimal Thickness without Lipid or Calcium Content at Branch Points is a Characteristic Feature of Coronary Artery in Patitents with Coronary Spastic Angina : Optical Coherence Tomography Analysis. (2010)
  • 著者名/発表者名: Nakagawa H, Uemura S, Horii M, Ishigami K, Soeda T, Sung J, Somekawa S, Okayama S, Morikawa Y, Mizuno Y, Harada E, Yasue H, Saito Y
  • 学会等名: American Heart Association Scientific Session 2010
  • 発表場所: Chicago, USA
• [学会発表] New Biomarker for Cardio-renal Connection (2009)
  • 著者名/発表者名: Saito Y.
  • 学会等名: 5^<th> China- Japan Cardiovascular Forum
  • 発表場所: Bejing, China
  • 年月日: 2009-10-11
• [備考] ホームページ等
  • URL: http://www.naramed-u.ac.jp/~1int/
• [備考]
  • URL: http://www.naramed-u.ac.jp/~lint/
• [備考]
  • URL: http://www.naramed-u.ac.jp/~lint/
• [備考]
  • URL: http://www.naramed-u.ac.jp/~lint/
• [産業財産権] 血栓溶解酵素含有複合体 (2010)
  • 発明者名: 斎藤能彦・川田 啓之・田畑泰彦
  • 権利者名: 公立大学法人奈良県立医科大学・国立大学法人京都大学
  • 出願年月日: 2010-05-26
• [産業財産権] 血栓溶解酵素含有複合体 (2010)
  • 発明者名: 斎藤能彦, 川田啓之, 田畑泰彦
  • 権利者名: 公立大学法人奈良県立医科大学, 国立大学法人京都大学
  • 産業財産権番号: 2010-120535
  • 出願年月日: 2010-05-26