革新的な大動脈瘤診断・治療法の開発:テネイシンCによる分子病態制御機構の解明

• 研究課題/領域番号: 20390348
• 研究種目: 基盤研究(B)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 外科学一般
• 研究機関: 独立行政法人国立国際医療研究センター
• 研究代表者: 廣江 道昭 独立行政法人国立国際医療研究センター, 循環器科, 部長 (80101872)
• 研究分担者: 木村 壮介 国立国際医療研究センター(研究所), 戸山病院, 院長 (30118450) ; 重松 宏 東京医科大学, 医学部, 教授 (40134556) ; 小櫃 由樹生 東京医科大学, 医学部, 准教授 (10233610) ; 吉田 恭子 (今中 恭子) 三重大学, 大学院・医学系研究科, 准教授 (00242967) ; 青木 浩樹 久留米大学, 循環器病研究所, 准教授 (60322244) ; 吉村 耕一 山口大学, 医学部, 准教授 (00322248)
• 研究期間 (年度): 2008 – 2010
• 研究課題ステータス: 完了 (2010年度)
• 配分額: 19,500千円 (直接経費: 15,000千円、間接経費: 4,500千円); 2010年度: 1,690千円 (直接経費: 1,300千円、間接経費: 390千円); 2009年度: 7,020千円 (直接経費: 5,400千円、間接経費: 1,620千円); 2008年度: 10,790千円 (直接経費: 8,300千円、間接経費: 2,490千円)
• キーワード: 大動脈瘤 / バイオマーカー / 病態生理 / 分子病態 / テネイシンC / C aC 12 / TN-Cノックアウトマウス / アンジオテンシンII / 炎症 / ノックアウトマウス

研究概要

大動脈瘤は大動脈の局所的な脆弱化と拡張が進行し、破裂・突然死に至る原因不明の疾患である。本研究では種々のストレスが加わった時に発現する細胞外マトリックス分子であるテネイシンC(TN-C)が、大動脈組織を保護していることを見いだした。また、TN-Cは大動脈瘤組織で発現しており、血管内治療後の血清TN-C 値は高い方が良好な経過を辿ることから、TN-Cが予後を予測する病態診断マーカーである可能性が示された。

研究成果

• [雑誌論文] Tenascin-C is expressed in abdominal aortic aneurysm tissue withactive degradation process. (2011)
  • 著者名/発表者名: Kimura T., Yoshimura K., Aoki H., Imanaka-Yoshida K., Yoshida T., Ikeda Y., Morikage N., Endo H., Hamano K., Imaizumi T., Hiroe M., Aonuma K., Matsuzaki M.
  • 雑誌名: Pathol Intern (in press)
• [雑誌論文] Tenascin C may regulate the recruitment of smooth muscle cells during coronary artery development. (2011)
  • 著者名/発表者名: Ando K., Takahashi M., Yamagishi T., Miyagawa-Tomita S., Imanaka-Yoshida, Toshimichi Yoshida K., Nakajima Y.
  • 雑誌名: Differentiation (in press)
• [雑誌論文] Matricelular proteins-New molecular targets to prevent heart failure. (2011)
  • 著者名/発表者名: Okamoto H., Imanaka-Yoshida K.
  • 雑誌名: Cardiovasc.Ther. (in press)
• [雑誌論文] Hepatocyte growth factor promotes an anti-inflammatory cytokine profile in human abdominal aortic aneurysm tissue. (2011)
  • 著者名/発表者名: Shintani Y., Nishihara M., Ohno S., Furusho A., Aoki H., Hiromatsu S.-i., Akashi, H., Imaizumi, T., Aoyagi S.
  • 雑誌名: Atherosclerosis (in press)
• [雑誌論文] Role of vascular endothelial growth factor-A in development of abdominal aortic aneurysm. (2011)
  • 著者名/発表者名: Kaneko H., Anzai T., Takahashi T., Kohno T., Shimoda M., Sasaki A., Shimizu H., Nagai T., Maekawa Y., Yoshimura K., Aoki H., Yoshikawa T., Okada Y., Yozu R., Ogawa S., Fukuda K.
  • 雑誌名: Cardiovasc Res (in press)
• [雑誌論文] Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylation in human breast cancer cells. (2011)
  • 著者名/発表者名: Nagaharu K., Zhang X., Yoshida T., Katoh D., Hanamura N., Kozuka Y., Ogawa T., Shiraishi T., Imanaka-Yoshida K.
  • 雑誌名: Am J Pathol. 178 ページ: 754-63
• [雑誌論文] Developmental defects of coronary vasculature in rat embryos administered bis-diamine. (2011)
  • 著者名/発表者名: Hanato T., Nakagawa M., Okamoto N., Nishijima S., Fujino H., Shimada M., Takeuchi Y., Imanaka-Yoshida K.
  • 雑誌名: Birth Defects Res B Dev Reprod Toxicol. 92 ページ: 10-6
• [雑誌論文] Transfection of human HGF plasmid DNA improves limb salvage in Buerger's disease patients with critical limb ischemia. (2011)
  • 著者名/発表者名: Shigematsu H., Yasuda K., Sasajima T., Takano T., Miyata T., Ohta T., Tanemoto K., Obitsu Y., Iwai T., Ozaki S., et al.
  • 雑誌名: Int Angiol 30 ページ: 140-149
• [雑誌論文] Obstructive sleep apnea as a potential risk factor for aortic disease. (2011)
  • 著者名/発表者名: Saruhara H., Takata Y., Usui Y., Shiina K., Hashimura Y., Kato K., Asano K., Kawaguchi S., Obitsu Y., Shigematsu H., et al.
  • 雑誌名: Heart Vessels. (in press)
• [雑誌論文] Staged hybrid repair using telescoped stent graft fixation for aortic arch and descending aortic aneurysms. (2011)
  • 著者名/発表者名: Koizumi N., Obitsu Y., Saiki N., lida Y., Kawaguchi S., Shigematsu H.
  • 雑誌名: J Vasc Surg.
• [雑誌論文] Tenascin-Cenhances crosstalk signaling of integrin alphavbeta3/PDGFR-beta complex by SRC recruitment promoting PDGF-induced proliferation and migration in smooth muscle cells. (2010)
  • 著者名/発表者名: Ishigaki T., Imanaka-Yoshida K., Shimojo N., Matsushima S., Taki W., Yoshida T.
  • 雑誌名: J Cell Physiol(Epub ahesd of prints) 28
• [雑誌論文] Dynamic expression of tenascin-C after myocardial ischemia and reperfusion : assessment by 1251-anti-tenascin-C antibody imaging. (2010)
  • 著者名/発表者名: Taki J., Inaki A., Wakabayashi H., Imanaka-Yoshida K., Ogawa K., Hiroe M., Shiba K., Yoshida T., Kinuya S.
  • 雑誌名: J Nucl Med. 51 ページ: 1116-22
• [雑誌論文] Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice. (2010)
  • 著者名/発表者名: Nishioka T., Onishi K., Shimojo N., Nagano Y., Matsusaka H., Ikeuchi M., Ide T., Tsutsui H., Hiroe M., Yoshida T., Imanaka-Yoshida K.
  • 雑誌名: Am J Physiol Heart Circ Physiol. 298
• [雑誌論文] Helicobacter pylori CagA inhibits endocytosis of cytotoxin VacA in host cells. (2010)
  • 著者名/発表者名: Akada J.K., Aoki H., Torigoe Y., Kitagawa T., Kurazono H., Hoshida H., Nishikawa J., Terai S., Matsuzaki M., Hirayama T., Nakazawa T., Akada R., Nakamura K.
  • 雑誌名: Dis Model Mech 3 ページ: 605-617
• [雑誌論文] Isoform Specific Roles of Protein Phosphatase 1 Catalytic Subunits in Sarcoplasmic Reticulum-Mediated Ca2+ Cycling. (2010)
  • 著者名/発表者名: Aoyama H., Ikeda Y., Miyazaki Y., Yoshimura K., Nishino S., Yamamoto T., Yano M., Inui M., Aoki H., Matsuzaki M.
  • 雑誌名: Cardiovasc Res 89 ページ: 79-88
• [雑誌論文] Celiac artery coverage after occlusion test during endovascular stent grafting for thoracoabdominal aortic aneurysm. (2010)
  • 著者名/発表者名: Shimazaki T., Kawaguchi S., Yokoi Y., Koide K., Matsumoto M., Shigematsu, H.
  • 雑誌名: J Thorac Cardiovasc Surg 139
• [雑誌論文] Randomized, double-blind, placebo-controlled clinical trial of hepatocyte growth factor plasmid for critical limb ischemia. (2010)
  • 著者名/発表者名: Shigematsu H., Yasuda K., Iwai T., Sasajima T., Ishimaru S., Ohashi Y., Yamaguchi T., Ogihara T., Morishita R.
  • 雑誌名: Gene Ther 17 ページ: 1152-1161
• [雑誌論文] Three-year cardiovascular events and disease progress in patients with peripheral arterial disease : results from the Japan Medication Therapy for Peripheral Arterial Disease (J-METHOD). (2010)
  • 著者名/発表者名: Shigematsu H., Nishibe T., Obitsu Y., Matsuzaki K., Ishida A., Miyata T., Shindo S., Hida K., Ohta T., Ando M., et al.
  • 雑誌名: Int Angiol 29 ページ: 2-13
• [雑誌論文] Long-term result of hybrid procedure for an extensive thoracic aortic aneurysm in Takayasu arteritis : a case report. (2010)
  • 著者名/発表者名: Obitsu Y., Koizumi N., Saiki N., Kawaguchi S., Shigematsu H.
  • 雑誌名: J Cardiothorac Surg 5 ページ: 28-28
• [雑誌論文] Surgical repair for aortic dissection accompanying a right-sided aortic arch. (2010)
  • 著者名/発表者名: Obitsu Y., Koizumi N., Iwahashi T., Saiki N., Shigematsu H.
  • 雑誌名: J Cardiothorac Surg 5 ページ: 35-35
• [雑誌論文] Long-term results of second-stage thoracic endovascular aortic repair following total aortic arch replacement. (2010)
  • 著者名/発表者名: Obitsu Y., Koizumi N., lida Y., Iwahashi T., Saiki N., Watanabe Y., Takae H., Kawaguchi S., Shigematsu H.
  • 雑誌名: Gen Thorac Cardiovasc Surg 58 ページ: 501-505
  • NAID: 10027470444
• [雑誌論文] The education system to master endovascular aortic repair in Japan-the Japanese Committee for Stentgraft Management. (2010)
  • 著者名/発表者名: Obitsu Y., Ishimaru S., Shigematsu H.
  • 雑誌名: Fur J Vasc Endovasc Surg 39Suppl 1
• [雑誌論文] Expression and localization of vascular endothelial growth factor in normal abdominal aorta and abdominal aortic aneurysm. (2010)
  • 著者名/発表者名: Nishibe T., Dardik A., Kondo Y., Kudo F., Muto A., Nishi M., Nishibe M., Shigematsu H.
  • 雑誌名: Int Angiol 29 ページ: 260-265
• [雑誌論文] Left atrial myxoma associated with acute myocardial infarction and multiple cerebral infarctions: Report of a case. (2010)
  • 著者名/発表者名: Konagai N., Cho M., Shigematsu H.
  • 雑誌名: Surg Today 40 ページ: 1159-1163
  • NAID: 10027657467
• [雑誌論文] Left atrial myxoma as a cause of acute myocardial infarction. (2010)
  • 著者名/発表者名: Konagai N., Cho M., Nakamura K., Shigematsu H.
  • 雑誌名: Tex Heart Inst J 37 ページ: 125-126
• [雑誌論文] Successful treatment of multiple mycotic aortic aneurysms, using a hybrid procedure. (2010)
  • 著者名/発表者名: Iida Y., Obitsu Y., Yokoi Y., Komai H., Kawaguchi S., Shigematsu H.
  • 雑誌名: J Vasc Surg 51 ページ: 1521-1524
• [雑誌論文] A case of abdominal aortic aneurysm associated with L-shaped crossed-fused renal ectopia. (2010)
  • 著者名/発表者名: Iida Y., Obitsu Y., Sugimoto T., Yamamoto K., Yoshii S., Shigematsu, H.
  • 雑誌名: Ann Vasc Surg 24
• [雑誌論文] Surgical technique of total arch replacement for failed thoracic endovascular aortic repair. (2010)
  • 著者名/発表者名: Iida Y., Obitsu Y., Koizumi N., Yokoi Y., Kawaguchi S., Shigematsu H.
  • 雑誌名: Ann Thorac Surg 90 ページ: 677-678
• [雑誌論文] Novel Role of Antioxidant-1 (Atoxl) as a Copper-dependent Transcription Factor Involved in Cell Proliferation. (2010)
  • 著者名/発表者名: Itoh S., Kim H.W., Nakagawa O., Ozumi K., Lessner S.M., Aoki H., Akram K., McKinney R.D., Ushio-Fukai,M., Fukai T
  • 雑誌名: J Biol Chem 283 ページ: 9157-9167
• [雑誌論文] Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylatbn in human breast cancer cells. (2010)
  • 著者名/発表者名: Nagaharu, K., Zhang, X., Yoshida, T., Katoh, D., Hanamura, N., Kozuka, Y., Ogawa, T., Shiraishi T., Imanaka-Yoshida, K.
  • 雑誌名: Am J Pathol 巻: 178 ページ: 754-763
  • 査読あり
• [雑誌論文] Developmental defects of coronary vasculature in rat embryos adm in istered bis-diamine. (2010)
  • 著者名/発表者名: Hanato, T., Nakagawa, M., Okamoto, N., Nishijima, S., Fujino, H., Shimada, M., Takeuchi Y., Imanaka-Yoshida, K.
  • 雑誌名: Birth Defects Res B Dev Reprod Toxicol 巻: 92 ページ: 10-16
  • 査読あり
• [雑誌論文] Tenascin-C enhances crosstalk signaling of integrin alphavbe ta3/PDGFR-beta complex by SRC recruitment promoting PDGF-induced proliferation and migration in smooth muscle cells. (2010)
  • 著者名/発表者名: Ishigaki T., Imanaka-Yoshida, K., Shimojo, N., Matsushima, S., Taki W., Yoshida, T.
  • 雑誌名: J Cell Physiol 巻: Dec 28(Epub ahead of print)
  • 査読あり
• [雑誌論文] Dynamic expression of tenascin-C after myocardial ischemia and reperfusion : assessment by 125I-anti-tenascin-C antibody imaging (2010)
  • 著者名/発表者名: Taki J., Inaki A., Wakabayashi H., Imanaka-Yoshida, K., Ogawa, K., Hiroe, M., Shiba, K., Yoshida, T., Kinuya, S.
  • 雑誌名: J Nucl Med. 巻: 51 ページ: 1116-1122
  • 査読あり
• [雑誌論文] Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarctbn in mice. (2010)
  • 著者名/発表者名: Nishioka, T., Onishi K., Shimojo, N., Nagano, Y., Matsusaka, H., Ikeuchi M., Ide, T., Tsutsui, H., Hiroe, M., Yoshida, T., Imanaka-Yoshida, K.
  • 雑誌名: Am J Physiol Heart Circ Physiol 巻: 298
  • 査読あり
• [雑誌論文] Helicobacter pylori CagA inhibits endocytosis of cytotoxin VacA in host cells. (2010)
  • 著者名/発表者名: Akada, J.K., Aoki H., Torigoe, Y., Kitagawa, T., Kurazono, H., Hoshida, H., Nishikawa, J., Terai S., Matsuzaki M., Hirayama, T., Nakazawa, T., Akada, R., Nakamura, K.
  • 雑誌名: Dis Model Mech 巻: 3 ページ: 605-617
  • 査読あり
• [雑誌論文] Isoform-Specific Roles of Protein Phosphatase 1 Catalytic Subunits in Sarcoplasm is Reticulum-Mediated Ca2+ Cycling. (2010)
  • 著者名/発表者名: Aoyama, H., Ikeda, Y., Miyazaki, Y., Yoshimura, K., Nishino, S., Yamamoto, T., Yano, M., Inui, M., Aoki, H., Matsuzaki, M.
  • 雑誌名: Cardiovasc Res 巻: 89 ページ: 79-88
  • 査読あり
• [雑誌論文] Celiac artery coverage after occlusion test during endovascular stent grafting for thoracoabdomn ial aortic aneurysm. (2010)
  • 著者名/発表者名: Shimazaki, T., Kawaguchi, S., Yokoi, Y., Koide, K., Matsumoto, M., Shigematsu, H.
  • 雑誌名: J Thorac Cardiovasc Surg 巻: 139
  • 査読あり
• [雑誌論文] Randomized, double-blind, placebo-controlled clinical trial of hepatocyte growth factor plasmid for critical limb ischemia (2010)
  • 著者名/発表者名: Shigematsu, H., Yasuda, K., Iwai, T., Sasajina, T., Ishimaru, S., Ohashi Y., Yamaguchi T., Ogihara, T., Morishita, R.
  • 雑誌名: Gene Ther 巻: 17 ページ: 1152-1161
  • 査読あり
• [雑誌論文] Three-year cardiovascular events and disease progress in patients with peripheral arterial disease : results from the Japan Medication Therapy for Peripheral Arterial Disease (J-METHOD). (2010)
  • 著者名/発表者名: Shigematsu, H., Nishibe, T., Obitsu, Y., Matsuzaki, K., Ishida, A., Miyata, T., Shindo, S., Hida, K., Ohta, T., Ando, M
  • 雑誌名: Int Angiol 巻: 29 ページ: 2-13
  • 査読あり
• [雑誌論文] Long-term result of hybrid procedure for an extensive thoracic aortic aneurysm in Takayasu arteritis : a case report (2010)
  • 著者名/発表者名: Obitsu, Y., Koizumi, N., Saiki, N., Kawaguchi, S., Shigematsu, H.
  • 雑誌名: J Candothorac Surg 巻: 5 ページ: 28-28
  • 査読あり
• [雑誌論文] Surgical repair for aortic dissection accompanying a right-sided aortic arch (2010)
  • 著者名/発表者名: Obitsu, Y., Koizumi, N., Iwahashi, T., Saiki, N., Shigematsu, H.
  • 雑誌名: Cardbthorac Surg 巻: 5 ページ: 35-35
  • 査読あり
• [雑誌論文] Long-term results of second-stage thoracic endovascular aortic repair following total aortic arch replacement (2010)
  • 著者名/発表者名: Obitsu, Y., Koizumi, N., Iida, Y., Iwahashi, T., Saki, N., Watanabe, Y., Takae, H., Kawaguchi, S, Shigematsu, H
  • 雑誌名: Gen Thorac Cardiovasc Surg 巻: 58 ページ: 501-505
  • NAID: 10027470444
  • 査読あり
• [雑誌論文] The education system to master endovascular aortic repair in Japan-the Japanese Committee for Stentgraft Management. (2010)
  • 著者名/発表者名: Obitsu, Y., Ishimaru, S., Shigematsu, H.
  • 雑誌名: Eur J Vasc Endovasc Surg 巻: 39
  • 査読あり
• [雑誌論文] Expression and localization of vascular endothelial growth factor in normal abdominal aorta and abdominal aortic aneurysm. (2010)
  • 著者名/発表者名: Nishibe, T., Dardik, A., Kondo, Y., Kudo, F., Muto, A., Nishim, M., Nishibe, M., Shigematsu, H.
  • 雑誌名: Int Angiol 巻: 29 ページ: 260-265
  • 査読あり
• [雑誌論文] Successful treatment of multiple mycotic aortic aneurysms, using a hybrid procedure. (2010)
  • 著者名/発表者名: ida, Y., Obitsu, Y., Yokoi, Y., Komai, H., Kawaguchi, S., Shigematsu, H
  • 雑誌名: J Vasc Surg 巻: 51 ページ: 1521-1524
  • 査読あり
• [雑誌論文] A case of abdominal aortic aneurysm associated with L-shaped crossed-fused renal ectopia. (2010)
  • 著者名/発表者名: Iida, Y., Obitsu, Y., Sugimoto, T., Yamamoto, K., Yoshii, S., Shigematsu, H.
  • 雑誌名: Ann Vasc Surg 巻: 24
  • 査読あり
• [雑誌論文] Surgical technique of total arch replacement for failed thoracic endovascular aortic repair. (2010)
  • 著者名/発表者名: Iida, Y., Obitsu, Y., Koizumi, N. Yokoi, Y., Kawaguchi, S., Shigematsu, H.
  • 雑誌名: Ann Thorac Surg 巻: 90 ページ: 677-678
  • 査読あり
• [雑誌論文] Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice (2010)
  • 著者名/発表者名: Nishioka T, Onishi K, Shimojo N, Nagano Y, Matsusaka H, Ikeuchi M, Ide T, Tsutsui H, HIroe M, Yoshida T, Imanaka-Yoshida K
  • 雑誌名: Am J Physiol Heart Circ Physiol 298
  • 査読あり
• [雑誌論文] Incremental prognostic values of serum tenascin-C levels with blood B-type natriuretic peptide testing at discharge in patients with dilated cardiomyopathy and decompensated heart failure. (2009)
  • 著者名/発表者名: Fujimoto N., Onishi K., Sato A., Terasaki F., Tsukada B., Nozato T., Yamada T., Imanaka-Yoshida K., Yoshida T., Ito M., Hiroe M.
  • 雑誌名: J Card Fail. 15 ページ: 898-905
• [雑誌論文] Deficiency of tenascin-C delays articular cartilage repair in mice. (2009)
  • 著者名/発表者名: Okamura N., Hasegawa M., Nakoshi Y., Iino T., Sudo A., Imanaka-Yoshida K., Yoshida T., Uchida A.
  • 雑誌名: Osteoarthritis Cartilage. 18 ページ: 839-48
• [雑誌論文] T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgfbeta2 expression and endocardial cushion formation. (2009)
  • 著者名/発表者名: Shirai M., Imanaka-Yoshida K., Schneider M.D., Schwartz R.J., Morisaki T.
  • 雑誌名: Proc Natl Acad Sci U S A. 106 ページ: 18604-9
• [雑誌論文] Tenascin-C is induced in cerebral vasospasm after subarachnoid hemorrhage in rats and humans : a pilot study. (2009)
  • 著者名/発表者名: Suzuki H., Kanamaru K., Suzuki Y., Aimi Y., Matsubara N., Araki T., Takayasu M., Kinoshita N., Imanaka-Yoshida K., Yoshida T., Taki W.
  • 雑誌名: Neurol Res. 32 ページ: 179-84
• [雑誌論文] High prevalence of chronic myocarditis in dilated cardiomyopathy referred for left ventriculoplasty : expression of tenascin C as a possible marker for inflammation. (2009)
  • 著者名/発表者名: Tsukada B., Terasaki F., Shimomura H., Otsuka K., Katashima T., Fujita S., Imanaka-Yoshida K., Yoshida T., Hiroe M., Kitaura Y.
  • 雑誌名: Hum Pathol. 40 ページ: 1015-22
• [雑誌論文] RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cells. (2009)
  • 著者名/発表者名: Oda H., Fujimoto M., Patrick M.S., Chida D., Sato Y., Azuma Y., Aoki H., Abe T., Suzuki H., Shirai
  • 雑誌名: J Immunol 182 ページ: 957-962
• [雑誌論文] Lysyl oxidase resolves inflammation by reducing monocyte chemoattractant protein-1 in abdominal aortic aneurysm. (2009)
  • 著者名/発表者名: Onoda M., Yoshimura K., Aoki H., Ikeda Y., Morikage N., Furutani A., Matsuzaki M., Hamano K.
  • 雑誌名: Atherosclerosis 208 ページ: 366-369
• [雑誌論文] Clinical comparison of two different types of bifurcated graft for postoperative baPWV and ABI. (2009)
  • 著者名/発表者名: Iwahashi T., Obitsu Y., Koizumi N., Shiraishi Y., Shigematsu H.
  • 雑誌名: Int Angiol 28 ページ: 232-237
• [雑誌論文] Successful coil embolization for rupture of the subclavian artery associated with Ehlers-Danlos syndrome type IV. (2009)
  • 著者名/発表者名: Iida Y., Obitsu Y., Komai H., Shigematsu H.
  • 雑誌名: J Vase Surg 50 ページ: 1191-1195
• [雑誌論文] Prevalence of coronary heart disease in patients with aortic aneurysm and/or peripheral artery disease. (2009)
  • 著者名/発表者名: Hirose K., Chikamori T., Hida S., Tanaka H., Igarashi Y., Watanabe Y., Koizumi N., Kawaguchi S., Obitsu Y., Shigematsu H., et al.
  • 雑誌名: Am J Cardiol 103 ページ: 1215-1220
  • NAID: 120005340984
• [雑誌論文] Thoracic endovascular aneurysm repair in Japan : Experience with fenestrated stent grafts in the treatment of distal arch aneurysms. (2009)
  • 著者名/発表者名: Kawaguchi S., Yokoi Y., Shimazaki T., Koide K., Matsumoto M., Shigematsu H.
  • 雑誌名: J Vase Surg(discussion 29S) 48
• [雑誌論文] Incremental prognostic values of serum tenascin-C levels with blood B-type natriuretic peptide testing at discharge in patients with dilated cardiomyopathy and decompensated heart failure (2009)
  • 著者名/発表者名: Fujimoto N, Onishi K, Sato A, Terasaki F, Tsukada B, Nozato T, Yamada T, Imanaka-Yoshida K, Yoshida T, Ito M, Hiroe M
  • 雑誌名: J Card Fail 15 ページ: 898-905
  • 査読あり
• [雑誌論文] High prevalence of chronic myocarditis in dilated cardiomyopathy referred for left ventriculoplasty : expression of tenascinC as a possible market for inflammation (2009)
  • 著者名/発表者名: Tsukada B, Terasaki F, Shimomura H, Otsuka K, Katashima T, Fujita S, Imanaka-Yoshida K, Yoshida T, Hiroe M, Kitaura T
  • 雑誌名: Human Pathol 40 ページ: 1015-1022
  • 査読あり
• [雑誌論文] Role of stromal tenascin-C in mouse prostatic development and epithelial cell differentiation. (2008)
  • 著者名/発表者名: Ishii K., Imanaka-Yoshida K., Yoshida T., Sugimura Y.
  • 雑誌名: Dev Biol. 324 ページ: 310-9
• [雑誌論文] Basic fibroblast growth factor slow release stent graft for endovascular aortic aneurysm repair : a canine model experiment. (2008)
  • 著者名/発表者名: Kajimoto M., Shimono T., Hirano K., Miyake Y., Kato N., Imanaka-Yoshida K., Shimpo H., Miyamoto K.
  • 雑誌名: J Vase Surg. 48 ページ: 1306-14
• [雑誌論文] Conventional therapy with an ACE inhibitor diminishes left ventricular dyssynchrony during the progression of heart failure. (2008)
  • 著者名/発表者名: Kurita T., Onishi K., Dohi K., Takamura T., Fujimoto N., Tanigawa T., Imanaka-Yoshida K., Wada H., Nobori T., Ito M.
  • 雑誌名: Int J Cardiol. 140 ページ: 48-54
• [雑誌論文] Atrial natriuretic peptide gene transfection with a novel envelope vector system ameliorates pulmonary hypertension in rats. (2008)
  • 著者名/発表者名: Mitani Y., Maruyama J., Jiang B.H., Sawada H., Shimpo H., Imanaka-Yoshida K., Kaneda Y., Komada Y., Maruyama K.
  • 雑誌名: J Thorac Cardiovasc Surg. 136 ページ: 142-9
• [雑誌論文] Identification of cardiac-specific myosin light chain kinase. (2008)
  • 著者名/発表者名: Chan J.Y., Takeda M., Briggs L.E., Graham M.L., Lu,J.T., Horikoshi N., Weinberg E.O., Aok, H., Sato N., Chien K.R., Kasahara H.
  • 雑誌名: Circ Res 102 ページ: 571-580
• [雑誌論文] Role of NonO-histone interaction in TNFalpha-suppressed prolyl-4-hydroxylase alphal. (2008)
  • 著者名/発表者名: Zhang C., Zhang M.X., Shen Y.H., Burks J.K., Li X.N., LeMaire S.A., Yoshimura K., Aoki H., Matsuzaki M., An F.S., Engler D.A., Matsunami R.K., Coselli J.S., Zhang Y., Wang X.L.
  • 雑誌名: Biochim Biophys Acta 1783 ページ: 1517-1528
• [雑誌論文] Noninvasive detection of cardiac repair after acute myocardial infarction in rats by 111 In Fab fragment of monoclonal antibody specific for tenascin-C. (2008)
  • 著者名/発表者名: Odaka K., Uehara T., Arano Y., Adachi S., Tadokoro H., Yoshida K., Hasegawa H., Imanaka-Yoshida K., Yoshida T., Hiroe M., Irie T., Tanada S., Komuro I.
  • 雑誌名: Int Heart J. 49 ページ: 481-92
• [雑誌論文] Cerebrospinal fluid tenascin-C increases preceding the development of chronic shunt-dependent hydrocephalus after subarachnoid hemorrhage. (2008)
  • 著者名/発表者名: Suzuki H., Kinoshita N., Imanaka-Yoshida K., Yoshida T., Taki W.
  • 雑誌名: Stroke. 39 ページ: 1610-2
• [雑誌論文] Noninvasive detection of cardiac repair after acute myocardial infarction in rats by 111 In Fab fragment of monoclonal antibody specific for tenascin-C (2008)
  • 著者名/発表者名: Odaka, K, et al
  • 雑誌名: Int Heart J 49 ページ: 481-492
  • 査読あり
• [雑誌論文] Stunned myocardium in transient left ventricular apical ballooning : a serial study of dual I-123 BMIPP and T1-201 SPECT (2008)
  • 著者名/発表者名: Sato A, et al
  • 雑誌名: J Nucl Cardiol 15 ページ: 671-679
  • 査読あり
• [雑誌論文] Quantitative measures of coronary stenosis severity by 64-Slice CT angiography and relation to physiologic significance of perfusion in nonobese patients : comparison with stress myocardial perfusion imaging (2008)
  • 著者名/発表者名: Sato A, et al
  • 雑誌名: J Nucl Med 49 ページ: 564-572
  • 査読あり
• [雑誌論文] Early validation study of 64-slice multidetector computed tomography for the assessment of myocardial viability and the prediction of left ventricular remodeling after acute myocardial infarction (2008)
  • 著者名/発表者名: Sato A, et al
  • 雑誌名: Eur Heart 29 ページ: 490-498
  • 査読あり
• [雑誌論文] Role of NonO-histone interaction in TNFalpha-suppressed prolyl-4-hydrixylase alphal (2008)
  • 著者名/発表者名: Zhang C, et al
  • 雑誌名: Biochim Biophys Acta 1783 ページ: 1517-1528
  • 査読あり
• [雑誌論文] Novel Role of Antioxidant-1(Atoxl) as a Copper-dependent Transcription Involved in Cell Proliferation (2008)
  • 著者名/発表者名: Itoh S, et al
  • 雑誌名: J Biol Chem 283 ページ: 9157-9167
  • 査読あり
• [雑誌論文] Identification of cardiac-specific myosin light chain kinase (2008)
  • 著者名/発表者名: Chan J, et al
  • 雑誌名: Circ Res 102 ページ: 571-580
  • 査読あり
• [雑誌論文] Stromal tenascin-C regulates epithelial cell deifferentiation in mouse prostate (2008)
  • 著者名/発表者名: Ishii, K, et al
  • 雑誌名: Dev Biol 324 ページ: 310-319
  • 査読あり
• [雑誌論文] Basic fibroblast growth factor slow release stent graft for endovascular aortic aneurysm repair : a canine mode 1 experiment (2008)
  • 著者名/発表者名: Kajimoto M, et al
  • 雑誌名: J Vase Surg 48 ページ: 1306-1314
  • 査読あり
• [雑誌論文] High prevalence of chronic myocarditis in dilated cardiomyopathy referred for left ventriculoplastry : Expression of tenascin-C as a possible marker for inflammation
  • 著者名/発表者名: Tsukada B, et al
  • 雑誌名: Human Pathol 2009(印刷中)
  • 査読あり
• [学会発表] シンポジウム14新規疾患関連分子Molecular network for the homeostasis of aortic tissue (2010)
  • 著者名/発表者名: Aoki H, Kimura T, Yoshimura K, Imanaka-Yoshida K, Yoshida T, Aonuma K, Hiroe M, Imaizumi T, Matsuzaki M
  • 学会等名: 第18回日本血管生物医学会
  • 発表場所: 大阪
  • 年月日: 2010-12-03
• [学会発表] シンポジウム14新規疾患関連分子Mocular network for the homeostasis of aortic tissue (2010)
  • 著者名/発表者名: Aoki H, Kimura T, Yoshimura K, Imanaka-Yoshida K, Yoshida T, Aonuma K, Hiroe M, Imaizumi T, Matsuzaki M.
  • 学会等名: 第18回日本血管生物医学会
  • 発表場所: 大阪市
  • 年月日: 2010-12-03
• [学会発表] Tenascin-C Protects Aortic Tissue from The Development of Aortic Dissection (2010)
  • 著者名/発表者名: Kimura T, Yoshimura K, Aoki H, Imanaka-Yoshida K, Yoshida T, Aonuma K, Hiroe M, Imaizumi T, Matsuzaki M
  • 学会等名: Cell Symposia : Cell Inflammation and Disease Symposium
  • 発表場所: Lisbon, Portugal
• [学会発表] Tenascin-C Is a Molecular Shock-Absorber That Protects Aorta from Dissection (2010)
  • 著者名/発表者名: Aoki H, Kimura T, Yoshimura K, Imanaka-Yoshida K, Yoshida T, Aonuma K, Hiroe M, Imaizumi T, Matsuzaki M
  • 学会等名: American Society for Cell Biology Annual Meeting 2010
  • 発表場所: Philadelphia, PA, USA.
• [学会発表] Tenascin-C may regulate recruitment of mural cells during coronary arterial development. (2010)
  • 著者名/発表者名: Imanaka-Yoshida K, Ando K., Yamagishi T, Yoshida T, Nakajima Y, Miyagawa-Tomita S
  • 学会等名: Weinstein Cardiovascular Development Conference
  • 発表場所: Amsterdam, The Nederlands
• [学会発表] Cardiovascular Development and Repair. Tenascin C as a Target for Regulation of Cardiac Remodeling. (2010)
  • 著者名/発表者名: 今中一吉田恭子
  • 学会等名: Keystone Symposia
  • 発表場所: Keystone, Colorado, アメリカ合衆国
• [学会発表] シンポジウム「大動脈疾患治療UP to DATE」Molecular Network of Abdominal Aortic Aneurysm (2010)
  • 著者名/発表者名: Aoki H, Yoshimura K, Kimura T, Imanaka-Yoshida K, Aonuma K, Hiroe M, Shigematsu H, Matsuzaki M, Imaizumi T
  • 学会等名: 第74回日で撮器学会
  • 発表場所: 京都
• [学会発表] A Novel Hybrid Device for Personalized and Minimally Invasive Treatment of Aortic Aneurysms (2010)
  • 著者名/発表者名: Yoshimura K, Aoki H, Ikeda Y, Matsuzaki M, Hamano K
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
• [学会発表] Tenascin-C Protects Aortic Tissue From Multiple Insults Against The Development of Aortic Aneurysm (2010)
  • 著者名/発表者名: Kimura T, Yoshimura K, Aoki H, Ikeda Y, Imanaka-Yoshida K, Hiroe M, Imaizumi T, Aonuma K, Matsuzaki M
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
• [学会発表] シンポジウム「大動脈疾患治療UP to DATE」Molecular Network of Abdominal Aortic Aneurysm (2010)
  • 著者名/発表者名: Aoki H, Yoshimura K, Kimura T, Imanaka-Yoshida K, Aonuma K, Hiroe M, Shigematsu H, Matsuzaki M, Imaizumi T
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
• [学会発表] ヒト大動脈瘤組織におけるマトリクス・メタロプロテアーゼ系の発現パターン解析 (2010)
  • 著者名/発表者名: 西原通秀、青木浩樹、大野聡子、今泉勉
  • 学会等名: 第33回日本高血圧学会
  • 発表場所: 福岡市
• [学会発表] JAK/STAT系による大動脈瘤のサイトカインネットワーク制御 (2010)
  • 著者名/発表者名: 大野聡子、青木浩樹、西原通秀、今泉勉
  • 学会等名: 第33回日本高血圧学会
  • 発表場所: 福岡市
• [学会発表] Tenascin-C Protects Aortic Tissue from The Development of Aortic Dissection (2010)
  • 著者名/発表者名: Kimura T, Yoshimura K, Aoki H, Imanaka-Yoshida K, Yoshida T, Aonuma K, Hiroe M, Imaizumi T, Matsuzaki M.
  • 学会等名: Cell Symposia : Cell Inflammation and Disease Symposilm
  • 発表場所: L isbon, Portugal
• [学会発表] Tenascin-C Is a Molecular Shock-Absorber That Protects Aorta from Dissection (2010)
  • 著者名/発表者名: Aoki H, Kimura T, Yoshinura K, Imanaka-Yoshida K, Yoshida T, Aonuma K, Hiroe M, Imaizumi T, Matsuzaki M.
  • 学会等名: American Society for Cell Biology Annual Meetiig
  • 発表場所: Philadelphia, PA, USA
• [学会発表] Tenascin-C may regulate recruitment of mural cells during coronaryarterial development. (2010)
  • 著者名/発表者名: Imanaka-Yoshida K., Ando K., Yamagishi T, Yoshida T, Nakajima Y, Miyagawa-Tomita S
  • 学会等名: Weinstein Cardiovascular Development Conference
  • 発表場所: Amsterdam, The Nederlands
• [学会発表] Tenascin-C is Tissue Protective during the Development of Abdominal Aortic Aneurysm in Mice (2009)
  • 著者名/発表者名: 木村泰三, 他
  • 学会等名: 第73回日本循環器学会総会・学術集会
  • 発表場所: 大阪
  • 年月日: 2009-03-22
• [学会発表] Stage-Specific Molecular Therapy for Abdominal Aortic Aneurysm (2009)
  • 著者名/発表者名: 青木浩樹, 他
  • 学会等名: 第73回日本循環器学会総会・学術集会
  • 発表場所: 大阪
  • 年月日: 2009-03-22
• [学会発表] Tenascin C Protects Aortic Tissue From Multiple Insults Against The Development of Aortic Aneurysm (2009)
  • 著者名/発表者名: Kimura T, Yoshimura K, Aoki H, Imanaka-Yoshida K, Yoshida T, Aonuma K, Hiroe M, Imaizumi T, Matsuzaki M
  • 学会等名: American Society for Cell Biology Annual Meeting 2009
  • 発表場所: San Diego, CA, USA
• [学会発表] Tenascin-C Has A Protective Role during The Development of Aortic Aneurysm (2009)
  • 著者名/発表者名: Kimura T, Yoshimura K, Aoki H, Ikeda Y, Hamano K, Imanaka-Yoshida K, Yoshida T, Hiroe M, Aonuma K, Matsuzaki M
  • 学会等名: American Heart Association Scientific Sessions 2009
  • 発表場所: Orlando, FL, USA
• [学会発表] Critical role of JNK2 for development of abdominal aortic aneurysm in a murine model (2009)
  • 著者名/発表者名: Koichi Yoshimura, Hiroki Aoki, Akira Furutani, Masunori Matsuzaki, Kimikazu Hamano, Yoshimura K, Aoki H, Furutani A, Matsuzaki M, HHamano K
  • 学会等名: Asian Society for Vascular Surgery Annual Congress 2009
  • 発表場所: Busan, Korea
• [学会発表] Tenascin C regulates recruitment of smooth muscle cells during coronary arterial development. (2009)
  • 著者名/発表者名: Ando K, Yamagishi T, Miyagawa-Tomita S, Imanaka-Yoshida K, Yoshida T, Nakajima Y
  • 学会等名: American Society for Cell Biology Meeitng 49th Annual Meeting.
  • 発表場所: San Diego, California, アメリカ合衆国
• [学会発表] Symposium "Recent advances in pathobiology and treatment of aortic aneurysms" Molecular Pathogenesis of Abdominal Aortic Aneurysm. (2009)
  • 著者名/発表者名: Aoki H. Yoshimura H. Shigematsu T. Imaizumi M. Matsuzaki
  • 学会等名: 第41回回日本動脈硬化学会
  • 発表場所: 下関
• [学会発表] 細胞外マトリクステネイシンCによる線維化・炎症・免疫反応の制御 (2009)
  • 著者名/発表者名: 今中恭子、廣江道昭
  • 学会等名: 第13回日本心不全学会学術集会
  • 発表場所: 福岡
• [学会発表] シンポジウム「大動脈疾患の新しい診断と治療」Stage-Specific Molecular Therapy for Abdominal Aortic Aneurysm:病態解明への挑戦 (2009)
  • 著者名/発表者名: 青木浩樹
  • 学会等名: 第73回日本循環器学会
  • 発表場所: Osaka,Japan
• [学会発表] ワークショップ「慢性炎症:生活習慣病・癌に共通する基盤病態」炎症のタイムカプセル:大動脈瘤をモデル疾患とした慢性炎症の病態解明 (2009)
  • 著者名/発表者名: 青木浩樹,吉村耕一,木村泰三,宮本貴宣,今中一吉田恭子,吉田利通,浜本義彦,青沼和隆,廣江道昭,重松宏,松崎益徳,今泉勉
  • 学会等名: 第32回日本分子生物学会
  • 発表場所: 横浜
• [学会発表] Incremental Utility of Serum Tenascin-C and Plasma BNP Levels as Cardiac Biomarkers for Predicting Prognosis and Cardiac Events After Acute Myocardial Infarction and Successful Coronary Intervention (2009)
  • 著者名/発表者名: Hiroe M, Satoh A, Aonuma K, Imanaka-Yoshida K, Yoshida T
  • 学会等名: Basic Cardiovascular Science Conference 2009
  • 発表場所: Lake Las Vegas, Nevada アメリカ合衆国
• [学会発表] Serum Tenascin-C Levels Might be a Novel Biomarker for Predicting Short-term Prognosis of Type B Acute Aortic Dissection (2009)
  • 著者名/発表者名: Nozato T, Sato A, Hiroe M, Aonuma K, Imanaka-Yoshida K
  • 学会等名: America Heart Association Conference 2009
  • 発表場所: Orlando, Florida アメリカ合衆国
• [学会発表] Protective Role of Tenascin-C during The Development of Aortic Aneurysm in Mice (2008)
  • 著者名/発表者名: 木村泰三, 他
  • 学会等名: 2008 stanford AAA Summit : Strategies for Multidisciplinary Research
  • 発表場所: 米国, スタンフォード
  • 年月日: 2008-09-05
• [学会発表] Protective Role of Tenascin-C during The Development of Aortic Aneurysm in Mice (2008)
  • 著者名/発表者名: Kimura K, Yoshimura K, Aoki H, Ikeda Y, Imanaka-Yoshida K, Yoshida T, Hiroe M, Aonuma K, Matsuzaki M
  • 学会等名: 2008 Stanford AAA Summit : Strategies for Multidisciplinary Research
  • 発表場所: Stanford, CA, USA
• [学会発表] The Vascular Smooth Muscle Cell-Autonomous Role of Id2 in Phenotypic Modulation In Vitro And Atherogenesis In Vivo (2008)
  • 著者名/発表者名: Aoki H, Yoshimura K, Ikeda Y, Matsuzaki M
  • 学会等名: The American Heart Association Scientific Sessions 2008
  • 発表場所: New Orleans, LA, USA
• [学会発表] Tenascin-C may play a significant role in maturation of coronary arteries in mouse. (2008)
  • 著者名/発表者名: 今中一吉田恭子
  • 学会等名: Weinstein Cardiovascular Development Conference
  • 発表場所: Houston, Texas, アメリカ合衆国
• [学会発表] Incremental value of tenascin-C and BNP levels for predicting prognosis in patients with dilated cardiomyopathy and decompensated heart failure. (2008)
  • 著者名/発表者名: Hiroe M, Onishi K, Fujimoto N, Sato A, Yoshida T, Imanaka-Yoshida K
  • 学会等名: Basic Cardiovascular Science Conference 2008
  • 発表場所: Keystone Colorado, アメリカ合衆国
• [学会発表] Tenascin-C may accelerate adverse cardiac remodeling and cardiac failure. (2008)
  • 著者名/発表者名: Yoshida T, Nagaharu K, Imanaka-Yoshida K,Imanaka-Yoshida K, Nishioka T, Nagano Y, Onishi K, Yoshida T
  • 学会等名: The American Society for Cell Biology 48^<th> Annual Meeting
  • 発表場所: San Francisco CA, アメリカ合衆国