低エネルギー超音波を利用した新しい非侵襲的癌治療システムの確立

• 研究課題/領域番号: 20500432
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 医用システム
• 研究機関: 福岡大学
• 研究代表者: ロリト Bフェリル (LORETO B Feril / LORETO B FerIl) 福岡大学, 医学部, 講師 (10435109)
• 研究分担者: 立花 克郎 福岡大学, 医学部, 教授 (40271605) ; 遠藤 日富美 福岡大学, 医学部, 講師 (00435108)
• 研究期間 (年度): 2008 – 2010
• 研究課題ステータス: 完了 (2010年度)
• 配分額: 4,550千円 (直接経費: 3,500千円、間接経費: 1,050千円); 2010年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円); 2009年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円); 2008年度: 1,820千円 (直接経費: 1,400千円、間接経費: 420千円)
• キーワード: Ultrasound / Sonotransfection / Cancer Therapy / Sonoporation / Bioeffect / Bioeffects / Low-intensity ultrasound / low-intensity

研究概要

1.がん細胞と正常細胞の成長に対するverylow-intensity超音波の影響、2.メラノーマ細胞内への遺伝子のsonotransfection効果。3.ソノポレーション法における細胞膜への影響を検討した。メラノーマ細胞における反復的な超音波照射により、細胞の成長と増殖に影響が認められ、Gene-chip解析、Cellcycleassayでもこれを裏付けるデータが得られた。また、ソノポレーション法によりインターフェロンγを誘導して細胞増殖の抑制に成功した。ソノポレーション法における細胞膜への損傷はその後の薬物の細胞内への流入に影響することを定量的な実験方法で証明でき、動物実験でも同様の実験結果が得られた。

研究成果

• [雑誌論文] Synergistic inhibition of malignant melanoma proliferation by melphalan combined with ultrasound and microbubbles. (2011)
  • 著者名/発表者名: Matsuo M, Yamaguchi K, Feril LB Jr, Endo H, Ogawa K, Tachibana K, Nakayama J.
  • 雑誌名: Ultrasonics Sonochemistry 18 ページ: 1218-1224
  • 査読あり
• [雑誌論文] Synergistic Effect of Ultrasound and Antibiotics against Chlamydia trachomatis-infected Human Epithelial cells in vitro. (2011)
  • 著者名/発表者名: Ikeda-Dantsuji Y, Feril LB Jr, Tachibana K, Ogawa K, Endo H, Harada Y, Suzuki R, Maruyama K.
  • 雑誌名: Ultrasonics Sonochemistry 18(1) ページ: 425-430
  • 査読あり
• [雑誌論文] Ultrasound activation of TiO(2) in melanoma tumors. (2011)
  • 著者名/発表者名: Harada Y, Ogawa K, Endo H, Feril LB Jr, Uemura T, Tachibana K.
  • 雑誌名: J Control Release 149(2) ページ: 190-195
  • 査読あり
• [雑誌論文] Differential Cytotoxicity and sonosensitization by sanazole : Effect of cell type and acoustic parameters. (2011)
  • 著者名/発表者名: Hassan MA, Furusawa Y, Zhao Q-L, Takasaki I, Feril LB Jr, Tachibana K, Kudo N, Minemura M, Sugiyama T, Kondo T.
  • 雑誌名: J Med.Ultrasonics 38(2) ページ: 65-72
  • NAID: 10029031195
  • 査読あり
• [雑誌論文] Synergistic Effect of Ultrasound and Antibiotics against Chlamydia trachomatis-infected Human Epithelial cells in vitro. (2011)
  • 著者名/発表者名: Ikeda-Dantsuji Y, Feril LB Jr, Tachibana K, Ogawa K, Endo H, Harada Y, Suzuki R, Maruyama K.
  • 雑誌名: Ultrasonics Sonochemistry 巻: 18 ページ: 425-430
  • 査読あり
• [雑誌論文] Ultrasound activation of TiO(2) in melanoma tumors. (2011)
  • 著者名/発表者名: Harada Y, Ogawa K, Endo H, Feril LB Jr, Uemura T, Tachibana K.
  • 雑誌名: J Control Release 巻: 149 ページ: 190-195
  • 査読あり
• [雑誌論文] Differential Cytotoxicity and sonosensitization by sanazole : Effect of cell type and acoustic parameters. (2011)
  • 著者名/発表者名: Hassan MA, Furusawa Y, Zhao Q-L, Takasaki I, Feril LB Jr, Tachibana K, Kudo N, Minemura M, Sugiyama T, Kondo T.
  • 雑誌名: Journal of Medical Ultrasonics 巻: 38 ページ: 65-72
  • NAID: 10029031195
  • 査読あり
• [雑誌論文] The sonochemical and biological effects of three clinically-used contrast agents. (2011)
  • 著者名/発表者名: Hassan MA, Feril LB Jr, Kudo N, Tachibana K, Kondo T, Riesz P.
  • 雑誌名: Journal of Medical Ultrasonics
  • 査読あり
• [雑誌論文] Synergistic inhibition of malignant melanoma proliferation by melphalan combined with ultrasound and microbubbles. (2011)
  • 著者名/発表者名: Matsuo M, Yamaguchi K, Feril LB Jr, Endo H, Ogawa K, Tachibana K, Nakayama J.
  • 雑誌名: Ultrasonics Sonochemistry
  • 査読あり
• [雑誌論文] Hypotonia-induced cell swelling enhances ultrasound-induced mechanical damage on cancer cells. (2010)
  • 著者名/発表者名: Feril LB Jr, Tachibana K, Kondo T, Ogawa R, Zhao QL, Yamaguchi Ogawa K, Endo H, Irie Y, Harada Y.
  • 雑誌名: J.Med.Ultrasonics 37 ページ: 3-8
  • NAID: 130004496931
  • 査読あり
• [雑誌論文] Therapeutic high intensity focused ultrasound. (2010)
  • 著者名/発表者名: Feril LB Jr., Tachibana K, Kondo T.
  • 雑誌名: Philippine Physics J. 32 ページ: 47-52
  • 査読あり
• [雑誌論文] The sonochemical and biological effects of three clinically-used contrast agents. (2010)
  • 著者名/発表者名: Hassan MA, Feril LB Jr, Kudo N, Tachibana K, Kondo T, Riesz P.
  • 雑誌名: Japanese Journal of Applied Physics 49
  • 査読あり
• [雑誌論文] Hypotonia-induced cell swelling enhances ultrasound-induced mechanical damage on cancer cells. (2010)
  • 著者名/発表者名: Feril LB Jr.Tachibana K, Kondo T, Ogawa R, Zhao QL, Yamaguchi K, Ogawa K, Endo H, Irie Y, Harada Y.
  • 雑誌名: Journal of Medical Ultrasonics 巻: 37 ページ: 3-8
  • NAID: 130004496931
  • 査読あり
• [雑誌論文] Therapeutic high intensity focused ultrasound. (2010)
  • 著者名/発表者名: Feri LB Jr., Tachibana K, Kondo T.
  • 雑誌名: Philippine Physics Journal 巻: 32 ページ: 47-52
  • 査読あり
• [雑誌論文] Hypotonia-induced cell swelling enhances ultrasound-induced mechanical damage on cancer cells (2010)
  • 著者名/発表者名: Feril LB Jr, Tachibana K, Kondo T, Ogawa R, Zhao QL, Yamaguchi K, Ogawa K, Endo H, Irie Y, Harada Y.
  • 雑誌名: Journal of Medical Ultrasonics 37 ページ: 3-8
  • NAID: 130004496931
  • 査読あり
• [雑誌論文] Therapeutic high intensity focused ultrasound (2010)
  • 著者名/発表者名: Feril LB Jr, Tachibana K, Kondo T
  • 雑誌名: Philippine Journal of Physics 32
  • 査読あり
• [雑誌論文] Growth inhibition of neurofibroma by ultrasound-mediated interferon gamma transfection. (2009)
  • 著者名/発表者名: Yamaguchi K, Feril LB Jr, Harada Y, Endo H, Irie Y, Nakayama J, Tachibana K.
  • 雑誌名: J.Medical Ultrasonics 36 ページ: 3-8
  • 査読あり
• [雑誌論文] Influence of Changing Pulse Repetition Frequency on Chemical and Biological Effects Induced by Low Intensity Ultrasound In-vitro. (2009)
  • 著者名/発表者名: Buldakov MA, Hassan MA, Zhao Q-L, Feril LB Jr, Kudo N, Kondo T, Litvyakov NV, Bolshakov MA, Rostov VV, Cherdyntseva NV
  • 雑誌名: Riesz P.Ultrasonics Sonochemistry 16 ページ: 392-7
  • 査読あり
• [雑誌論文] Low-intensity ultrasound adjuvant therapy : The enhancement of doxorubicin-induced cytotoxicity and the acoustic mechanisms involved. (2009)
  • 著者名/発表者名: Kondo T, Yoshida T, Ogawa R, Hasaan MA, Furusawa Y, Zhao QL, Watanabe A, Morii A, Feril LB Jr, Tachibana K, Kitagawa H, Tabuchi Y, Takasaki I, Shehata MH, Kudo N, Tsukada K.
  • 雑誌名: J.Med.Ultrasonics 36 ページ: 61-68
  • NAID: 10025327909
  • 査読あり
• [雑誌論文] Gene transfection through microbubble-aided sonication in cancer cells. (2009)
  • 著者名/発表者名: Moreno DC, Feril LB Jr, Tachibana K, Irie Y.
  • 雑誌名: Philippine Physics J. 31 ページ: 1-7
  • 査読あり
• [雑誌論文] Jr (2009)
  • 著者名/発表者名: Ogawa R, Lee S, Izumi H, Kagiya G, Yoshida T, Watanabe A, Morii A, Kakutani S, Kondo T, Feril LB Enhancement of artificial promoter activity by ultrasound-induced oxidative stress.
  • 雑誌名: Utrason Sonochem 16 ページ: 379-386
  • 査読あり
• [雑誌論文] Evaluation and comparison of three novel microbubbles : Enhancement of ultrasound-induced cell death and free radicals production. (2009)
  • 著者名/発表者名: Hassan MA, Feril LB Jr, Suzuki K, Kudo N, Tachibana K, Kondo T.
  • 雑誌名: Ultrasonics Sonochemistry 16 ページ: 372-8
  • 査読あり
• [雑誌論文] Enhancement of artificial promoter activity by ultrasound-induced oxidative stress (2009)
  • 著者名/発表者名: Ogawa R, Lee S, Izumi H, Kagiya G, Yoshida T, Watanabe A, Morii A, Kakutani S, Kondo T, Feril LB Jr, Ishimoto T.
  • 雑誌名: Utrasonics Sonochemistry 16 ページ: 379-386
  • 査読あり
• [雑誌論文] Low-intensity ultrasound adjuvant therapy : The enhancement of doxorubicin-induced cytotoxicity and the acoustic mechanisms involved (2009)
  • 著者名/発表者名: Kondo T, Yoshida T, Ogawa R, Hasaan MA, Furusawa Y, Zhao QL, Watanabe A, Morii A, Feril LB Jr, Tachibana K, Kitagawa H, Tabuchi Y, Takasaki I, Shehata MH, Kudo N, Tsukada K.
  • 雑誌名: Journal of Medical Ultrasonics 36 ページ: 61-68
  • NAID: 10025327909
  • 査読あり
• [雑誌論文] (2009)
  • 著者名/発表者名: Feril, LB Jr.
  • 雑誌名: Ultrasound-mediated gene transfection, Chapter 10, Gene Therapy of Cancer 2^<nd> Edition, Methods in molecular biology(Humana Press, Hatfield, Hertfordshire, AL10 9AB, UK.) ページ: 179-194
• [雑誌論文] Evaluation and comparison of three novel microbubbles : Enhancement of ultrasound-induced cell death and free radicals production. (2009)
  • 著者名/発表者名: Hassan MA
  • 雑誌名: Ultrasonics Sonochemistry 16 ページ: 372-378
  • 査読あり
• [雑誌論文] Influence of Changing Pulse Repetition Frequency on Chemical and Biological Effects Induced by Low Intensity Ultrasound In-vitro. (2009)
  • 著者名/発表者名: Buldakov MA
  • 雑誌名: Ultrasonics Sonochemistry 16 ページ: 392-397
  • 査読あり
• [雑誌論文] Construction of artificial promoters sensitively responsive to sonication in vitro. (2009)
  • 著者名/発表者名: Watanabe A
  • 雑誌名: Journal of Medical Ultrasonics 36 ページ: 9-17
  • 査読あり
• [雑誌論文] Growth inhibition of neurofibroma by ultrasound-mediated interferon gamma transfection (2009)
  • 著者名/発表者名: Yamaguchi K
  • 雑誌名: Journal of Medical Ultrasonics 36 ページ: 3-8
  • 査読あり
• [雑誌論文] Gene Transfection through microbubble-aided sonication in cancer cells (2009)
  • 著者名/発表者名: Dickerson C. Moreno
  • 雑誌名: Philippine Physics Journal 31 ページ: 1-6
  • 査読あり
• [雑誌論文] Sonodynamic therapy. (2008)
  • 著者名/発表者名: Tachibana K, FeFeril LB Jr, Ikeda-Dantsuji Y.
  • 雑誌名: Ultrasonics 48 ページ: 253-259
  • 査読あり
• [雑誌論文] Cancer Letters (2008)
  • 著者名/発表者名: Tabuchi Y, Takasaki I, Zhao Q-L, Wada S, Hori T, Feril LB Jr, Tachibana K, Nomura Kondo T.
  • 雑誌名: Genetic networks responsive to low-intensity pulsed ultrasound in human lymphoma U937 cells. 270(2) ページ: 286-94
  • 査読あり
• [雑誌論文] Dual role of low-dose ionizing radiation. (2008)
  • 著者名/発表者名: Buldakov AM, Feril LB Jr.
  • 雑誌名: Philippine Physics J. 30 ページ: 1-6
  • 査読あり
• [雑誌論文] Therapeutic potential of low-intensity ultrasound (part 1) : thermal and sonodynamic effects. (2008)
  • 著者名/発表者名: Feril LB Jr, Tachibana K, Ogawa K, Yamaguchi K, Solano I, Irie Y.
  • 雑誌名: J.Medical Ultrasonics 35 ページ: 153-60
  • 査読あり
• [雑誌論文] J.Medical Ultrasonics (2008)
  • 著者名/発表者名: Feril LB Jr, Tachibana K, Ikeda-Dantsuji Y, Endo H, Harada Y, Kondo T, Ogawa R.
  • 雑誌名: Therapeutic potential of low-intensity ultrasound (part 2) : biomolecular effects, sonotransfection, and sonoporation. 35 ページ: 161-67
  • 査読あり
• [雑誌論文] Combination of doxorubicin and low-intensity ultrasound causes a synergistic enhancement in cell killing and an additive enhancement in apoptosis induction in human lymphoma U937 cells. (2008)
  • 著者名/発表者名: Yoshida T
  • 雑誌名: Cancer Chemotherapy and Pharmacology 61 ページ: 559-567
  • 査読あり
• [雑誌論文] Effects of ultrasound on apoptosis induced by anti-CD20 antibody in CD20-positive B lymphoma cells. (2008)
  • 著者名/発表者名: Danno D
  • 雑誌名: Ultrasonics Sonochemistry 15 ページ: 463-471
  • 査読あり
• [雑誌論文] Sonodynamic therapy (2008)
  • 著者名/発表者名: Tachibana K
  • 雑誌名: Ultrasonics 48 ページ: 253-259
  • 査読あり
• [雑誌論文] Genetic networks responsive to low-intensity pulsed ultrasound in human lymphoma U937 cells. (2008)
  • 著者名/発表者名: Tabuchi Y
  • 雑誌名: Cancer Letters 270 ページ: 286-294
  • 査読あり
• [雑誌論文] Therapeutic potential of low-intensity ultrasound (part 1) : thermal and sonodynamic effects. (2008)
  • 著者名/発表者名: Feril LB Jr
  • 雑誌名: Journal of Medical Ultrasonics 35 ページ: 153-160
  • 査読あり
• [雑誌論文] Therapeutic potential of low-intensity ultrasound (part 2) : biomolecular effects, sonotransfection, and sonoporation. (2008)
  • 著者名/発表者名: Feril LB Jr
  • 雑誌名: Journal of Medical Ultrasonics 35 ページ: 161-167
  • 査読あり
• [雑誌論文] Dual role of low-dose ionizing radiation. (2008)
  • 著者名/発表者名: Buldakov AM
  • 雑誌名: Philippine Physics Journal 30 ページ: 1-6
  • 査読あり
• [学会発表] Inhibition of melanoma growth when subcultured with melanocytes sonotransfected interferon-beta gene. (2011)
  • 著者名/発表者名: Feril LB Jr., Tachibana K, Yamaguchi K
  • 学会等名: Sonoporation research meeting.
  • 発表場所: Fukuoka University
  • 年月日: 2011-03-05
• [学会発表] Inhibition of melanoma growth when subcultured with melanocytes sonotransfected with interferon-beta gene. (2011)
  • 著者名/発表者名: Feril LB Jr., Yamaguchi K, Tachibana K
  • 学会等名: Sonoporation research meeting
  • 発表場所: Fukuoka, Japan
  • 年月日: 2011-03-05
• [学会発表] Biological effects of ultrasound : Potential therapeutic applications and their implications on the safety of diagnostic ultrasound. (2011)
  • 著者名/発表者名: Feril LB Jr, Tachibana K.
  • 学会等名: 6^<th> Asian-Pacific Organization for Cell Biology (APOCB) Congress.
  • 発表場所: EDSA Shangri-La, Manila, Philippines
  • 年月日: 2011-02-28
• [学会発表] Biological effects of ultrasound : Potential therapeutic applications and their implications on the safety of diagnostic ultrasound. (2011)
  • 著者名/発表者名: Feril LB Jr, Tachibana K.
  • 学会等名: 6^<th> Asian-Pacific Organization for Cell Biology(APOCB) Congress.
  • 発表場所: Manila, Philippines
  • 年月日: 2011-02-28
• [学会発表] Low intensity ultrasound inhibits melanoma cell growth in vitro and tumor growth in vivo. (2010)
  • 著者名/発表者名: Feril LB Jr., Tachibana K, Yamaguchi K, Ikeda-Dantsuji Y, Kondo T, Tabuchi Y, Furusawa Takasaki I.
  • 学会等名: 10^<th> International Symposium on Therapeutic Ultrasound
  • 発表場所: Tokyo, Japan
  • 年月日: 2010-06-11
• [学会発表] HIFU : Updates on Therapeutic Ultrasound (2010)
  • 著者名/発表者名: Feril LB Jr.U, Tachibana K.
  • 学会等名: 8^<th> Annual Convention of the Philippine Society of Ultrasound in Clinical Medicine, Inc. (PSUCMI).
  • 発表場所: Diamond Hotel, Manila, Philippines
  • 年月日: 2010-03-19
• [学会発表] Medical education and public health in the Philippines. (2010)
  • 著者名/発表者名: Feril LB Jr.
  • 学会等名: Fukuoka Philippine Friendship Association
  • 発表場所: Fukuoka City, Japan
  • 年月日: 2010-01-11
• [学会発表] Medical education and public health in the Philippines (2010)
  • 著者名/発表者名: Feril, LB Jr.
  • 学会等名: Fukuoka Philippine Friendship Association
  • 発表場所: Fukuoka City, Japan
  • 年月日: 2010-01-11
• [学会発表] HIFU : Updates on Therapeutic Ultrasound (2010)
  • 著者名/発表者名: Feril, LB Jr.
  • 学会等名: 8^<th> Annual Convention of the Philippine Society of Ultrasound in Clinical Medicine, Inc.(PSUCMI)
  • 発表場所: Manila, Philippines
• [学会発表] Echo-contrast agent, Sonazoid, enhances inhibition of cancer cell growth by ultrasound in vitro, but not in vivo. (2009)
  • 著者名/発表者名: Feril LB Jr, Tachibana K, Yamaguchi K, Ikeda-Dantsuji Y, Kondo T, Tabuchi Y, Furusawa Y, Takasaki I, Matsuo M.
  • 学会等名: 11^<th> International Symposium on Ultrasound Contrast Imaging ; and 1^<st> ASIAN Conference on Ultrasound Contrast Imaging
  • 発表場所: Kunming, China
  • 年月日: 2009-12-19
• [学会発表] Hypotonia-induced cell swelling enhances ultrasound-induced mechanical damage on cancer cells. (2009)
  • 著者名/発表者名: Feril LB Jr, Tachibana K, Kondo T, Ogawa R, Zhao QL, Yamaguchi Ogawa K, Endo H, Irie Y, Harada Y.
  • 学会等名: 12^<th> Congress of the World Federation for Ultrasound in Medicine and Biology.
  • 発表場所: Sydney, Australia
  • 年月日: 2009-09-01
• [学会発表] Updates on Therapeutic Ultrasound (2009)
  • 著者名/発表者名: Feril LB Jr, Tachibana K
  • 学会等名: 7^<th> Annual Convention of the Philippine Society of Ultrasound in Clinical Medicine, Inc. (PSUCMI).
  • 発表場所: Quezon City Sports Club, Philippines
  • 年月日: 2009-03-21
• [学会発表] Dreaming the Impossible Dreams (2009)
  • 著者名/発表者名: Feril LB Jr.
  • 学会等名: Saint Theresa College
  • 発表場所: Tandag, Surigao del Sur.
  • 年月日: 2009-03-15
• [学会発表] Hypotonia-induced cell swelling enhances ultrasound-induced mechanical damage on cancer cells (2009)
  • 著者名/発表者名: Feril, LB Jr.
  • 学会等名: 12^<th> Congress of the World Federation for Ultrasound in Medicine and Biology
  • 発表場所: Sydney, Australia
• [学会発表] Echo-contrast agent, Sonazoid, enhances inhibition of cancer cell growth by ultrasound in vitro, but not in vivo (2009)
  • 著者名/発表者名: Feril, LB Jr.
  • 学会等名: 11^<th> International Symposium on Ultrasound Contrast Imaging ; and 1^<st> ASIAN Conference on Ultrasound Contrast Imaging
  • 発表場所: Kunming, China
• [学会発表] Updates on Therapeutic Ultrasound (2009)
  • 著者名/発表者名: Feril LB Jr
  • 学会等名: 7^<th> Annual Convention of the Philippine Society of Ultrasound in Clinical Medicine, Inc. (PSUCMI)
  • 発表場所: Quezon City Sports Club, Philippines
• [学会発表] Effects of Ultrasound : Its Therapeutic Potential (2008)
  • 著者名/発表者名: Feril LB Jr., Tachibana K.
  • 学会等名: Institute of Biology, College of Science
  • 発表場所: University of the Philippines, Diliman, Quezon City, Philippines
  • 年月日: 2008-11-24
• [学会発表] Effects of Ultrasound : Its Therapeutic Potential (2008)
  • 著者名/発表者名: Feril LB Jr
  • 学会等名: Institute of Biology, College of Science, University of the Philippines special meeting
  • 発表場所: Diliman, Quezon City, Philippines
  • 年月日: 2008-11-24
• [学会発表] Low-intensity ultrasound inhibits cancer cell growth in vitro and tumor growth in vivo. (2008)
  • 著者名/発表者名: Feril LB Jr., Tachibana K, Yamaguchi K, Ikeda-Dantsuji Y, Kondo T, Tabuchi Y, Furusawa Takasaki I.
  • 学会等名: 8^<th> International Symposium on Therapeutic Ultrasound.
  • 発表場所: Minneapolis, MN, USA
  • 年月日: 2008-09-12
• [学会発表] Basics of Diagnostic and Therapeutic Ultrasound (2008)
  • 著者名/発表者名: Feril LB Jr., Tachibana K.
  • 学会等名: College of Sciences, De La Salle University-Manila, Philippines
  • 年月日: 2008-06-18
• [学会発表] Basics of Diagnostic and Therapeutic Ultrasound (2008)
  • 著者名/発表者名: Feril LB Jr
  • 学会等名: Physics Department, College of Sciences, De La Salle University special meeting
  • 発表場所: Manila, Philippines
  • 年月日: 2008-06-18
• [学会発表] Low-intensity ultrasound inhibits melanoma growth in vitro and in vivo. (2008)
  • 著者名/発表者名: Feril LB Jr, Tachibana K, Yamaguchi K
  • 学会等名: 20^<th> International Pigment Cell Conference and 5^<th> International Melanoma Research Congress.
  • 発表場所: Sapporo, Japan
  • 年月日: 2008-05-11
• [図書] Sonodynamic therapy.(Therapeutic ultrasound : mechanisms to applications.) (2011)
  • 著者名/発表者名: Feril LB Jr, Tachibana K, Kondo T, Campbell PA.
  • 出版者: Nova Publishing, Hauppauge NY, USA.
• [図書] Nova Publishing, Hauppauge NY, USA(Sonodynamic therapy.Chapter 12, Therapeutic ultrasound : mechanisms toapplications.) (2011)
  • 著者名/発表者名: Feril LB Jr, Tachibana K, Kondo T, Campbell PA.
• [図書] Gene Therapy of Cancer [Methods in Molecular Biology 2nd Edition, 2009] Ultrasound-mediated gene transfection
  • 著者名/発表者名: Feril LB Jr.
  • 出版者: eril Humana Press, Hatfield, Hertfordshire, AL10 9AB, UK.
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  • URL: http://www.fukuoka-u.ac.jp/research/data/researcher.html
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  • URL: http://resweb2.jhk.adm.fukuoka-u.ac.jp/FukuokaUnivHtml/info/4237/R110E.html