交替制勤務者の睡眠習慣・インスリン抵抗性とメタボリック症候群に関する研究

• 研究課題/領域番号: 20590616
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 衛生学
• 研究機関: 日本医科大学
• 研究代表者: 川田 智之 日本医科大学, 大学院・医学研究科, 教授 (00224791)
• 研究分担者: 稲垣 弘文 日本医科大学, 医学部, 講師 (50213111) ; 若山 葉子 日本医科大学, 医学部, 講師 (40104062) ; 李 卿 日本医科大学, 医学部, 講師 (50250048) ; 大塚 俊昭 日本医科大学, 医学部, 講師 (80339374) ; 李 英姫 日本医科大学, 医学部, 講師 (60350039) ; 勝又 聖夫 日本医科大学, 医学部, 助教 (80169482)
• 研究期間 (年度): 2008 – 2011
• 研究課題ステータス: 完了 (2011年度)
• 配分額: 5,330千円 (直接経費: 4,100千円、間接経費: 1,230千円); 2011年度: 260千円 (直接経費: 200千円、間接経費: 60千円); 2010年度: 650千円 (直接経費: 500千円、間接経費: 150千円); 2009年度: 650千円 (直接経費: 500千円、間接経費: 150千円); 2008年度: 3,770千円 (直接経費: 2,900千円、間接経費: 870千円)
• キーワード: 産業衛生 / 交替制勤務 / 生活習慣 / 睡眠 / インスリン抵抗性 / メタボリック症候群 / 自覚的睡眠感 / アメニティ / QOL

研究概要

メタボリックシンドローム(MetS)発症要因分析を行った.対象は製造業男性社員のうち,明らかな睡眠障害者,および糖尿病,高血圧,脂質異常症,心脳血管疾患,高尿酸血症のいずれかで治療中の者を除く34-64歳3, 054人である. MetS予測をロジスティック回帰分析で行ったが,血清インスリンの寄与が最大で,次に肝臓酵素,尿酸,非喫煙が選択されたが,勤務状況や睡眠時間は選択されなかった.

研究成果

• [雑誌論文] Effect of metabolic components on the incidence of cerebrovascular/cardiovascular disease among male workers in Japan : 3-year follow-up study (2012)
  • 著者名/発表者名: Kawada T.
  • 雑誌名: J Clin Hypertens 巻: 14(1) 号: 1 ページ: 67-67
  • DOI: 10.1111/j.1751-7176.2011.00561.x
  • 査読あり
• [雑誌論文] Predictors of the development of metabolic syndrome in male workers : a 3-year follow-up study (2012)
  • 著者名/発表者名: Kawada T.
  • 雑誌名: J Occup Environ Med 巻: 54(3) 号: 3 ページ: 292-295
  • DOI: 10.1097/jom.0b013e3182492070
  • 査読あり
• [雑誌論文] Relationship between several markers and presence of metabolic syndrome or components of the metabolic components in Japanese workers (2012)
  • 著者名/発表者名: Kawada T.
  • 雑誌名: J Occup Environ Med 巻: (in press) 号: 8 ページ: 984-988
  • DOI: 10.1097/jom.0b013e31825335ae
• [雑誌論文] Monitoring of the sleep patterns of shift workers in the automotive industry (2011)
  • 著者名/発表者名: Kawada T, Shimizu T, Kuratomi Y, Suto S, Kanai T, Nishime A, Nakano N.
  • 雑誌名: Work 巻: 38(2) 号: 2 ページ: 163-167
  • DOI: 10.3233/wor-2011-1118
  • 査読あり
• [雑誌論文] Optimal cut-off levels of body mass index and waist circumference to predict each component of metabolic syndrome(MetS) and the number of MetS component (2011)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Li Q, Li YJ, Katsumata M.
  • 雑誌名: Diabetes Metab Syndr 巻: 5(1) 号: 1 ページ: 25-28
  • DOI: 10.1016/j.dsx.2010.05.012
  • 査読あり
• [雑誌論文] The metabolic syndrome, smoking, inflammatory markers and obesity (2011)
  • 著者名/発表者名: Kawada T, Otsuka T, Endo T, Kon Y
  • 雑誌名: Int J Cardiol 巻: 151 号: 3 ページ: 367-368
  • DOI: 10.1016/j.ijcard.2011.06.095
  • 査読あり
• [雑誌論文] Monitoring of the sleep patterns of shift workers in the automotive industry. (2011)
  • 著者名/発表者名: Kawada T, Shimizu T, Kuratomi Y, Suto S, Kanai T, Nishime A, Nakano N.
  • 雑誌名: Work 巻: 38(2) ページ: 163-167
  • 査読あり
• [雑誌論文] Insulin resistance, as expressed by HOMA-R, is strongly determined by waist circumference or body mass index among Japanese working men (2010)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Li Q, Li YJ, Katsumata M.
  • 雑誌名: Obes Res & Clin Practice 巻: 4 号: 1 ページ: e9-e14
  • DOI: 10.1016/j.orcp.2009.07.001
  • 査読あり
• [雑誌論文] HOMA-R, an indicator of insulin resistance, is strongly related to serum insulin : practical data presentation and its mathematical basis (2010)
  • 著者名/発表者名: Kawada T.
  • 雑誌名: Metabolism 巻: 59(7) ページ: 1044-1046
  • 査読あり
• [雑誌論文] Serum insulin is significantly related to components of the metabolic syndrome in Japanese working men (2010)
  • 著者名/発表者名: Kawada T, Inagaki H, Wakayama Y, Li Q, Katsumata M.
  • 雑誌名: J Clin Hypertens 巻: 12(4) 号: 4 ページ: 309-314
  • DOI: 10.1016/j.dsx.2010.12.005
  • 査読あり
• [雑誌論文] Association of smoking status, insulin resistance, body mass index, and metabolic syndrome in workers : a one-year follow-up study (2010)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Li Q, Li YJ, Katsumata M.
  • 雑誌名: Obes Res & Clin Practice 巻: 4 号: 3 ページ: e163-e169
  • DOI: 10.1016/j.orcp.2009.12.004
  • 査読あり
• [雑誌論文] A cross-sectional study on the shift work and metabolic syndrome in Japanese male workers (2010)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Katsumata M, Li Q, Li YJ.
  • 雑誌名: The Aging Male 巻: 13(3) ページ: 174-178
  • 査読あり
• [雑誌論文] Increasing in the prevalence of metabolic syndrome among workers according to age (2010)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Li Q, Li YJ, Katsumata M.
  • 雑誌名: The aging Male 巻: 13(3) 号: 3 ページ: 184-187
  • DOI: 10.3109/13685531003586983
  • 査読あり
• [雑誌論文] Association of hematological parameters and uric acid with clustered components of metabolic syndrome among Japanese male workers (2010)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Katsumata M, Li Q, Li YJ.
  • 雑誌名: Diabetes Metab Syndr 巻: 4(3) 号: 3 ページ: 165-167
  • DOI: 10.1016/j.dsx.2010.05.016
  • 査読あり
• [雑誌論文] Framingham Hypertension Risk Score : the prevalence estimation of hypertension after one year in the population (2010)
  • 著者名/発表者名: Kawada T, Otsuka T.
  • 雑誌名: J Clin Hypertension 巻: 12(10) 号: 10 ページ: 814-815
  • DOI: 10.1111/j.1751-7176.2010.00345.x
  • 査読あり
• [雑誌論文] A cross-sectional study on lifestyles and the metabolic syndrome(MetS) components mainly targeting glucose metabolism in Japanese working men (2010)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Li Q, Li YJ, Katsumata M.
  • 雑誌名: Diabetes Metab Syndr 巻: 4(4) 号: 4 ページ: 230-233
  • DOI: 10.1016/j.dsx.2010.05.015
  • 査読あり
• [雑誌論文] Insulin resistance, as expressed by HOMA-R, is strongly determined by waist circumference or body mass index among Japanese working men. (2010)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Li Q, Li YJ, Katsumata M.
  • 雑誌名: Obes Res Clin Pract 4(1)
  • 査読あり
• [雑誌論文] Serum insulin is significantly related to components of the metabolic syndrome in Japanese working men. (2010)
  • 著者名/発表者名: Kawada T, Inagaki H, Wakayama Y, Li Q, Katsumata M.
  • 雑誌名: J Clin Hypertens 12(4) ページ: 309-314
  • 査読あり
• [雑誌論文] Preliminary report : homeostasis model assessment of insulin resistance, an indicator of insulin resistance, is strongly related to serum insulin : practical data presentation and the mathematical basis. (2010)
  • 著者名/発表者名: Kawada T.
  • 雑誌名: Metabolism 59(7) ページ: 1044-1046
  • 査読あり
• [雑誌論文] Association of smoking status, insulin resistance, body mass index, and metabolic syndrome in workers : a one-year follow-up study. (2010)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Li Q, Li YJ, Katsumata M.
  • 雑誌名: Obes Res Clin Pract 4(3)
  • 査読あり
• [雑誌論文] A cross-sectional study on the shift work and metabolic syndrome in Japanese male workers. (2010)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Katsumata M, Li Q, Li YJ.
  • 雑誌名: The Aging Male 13(3) ページ: 174-178
  • 査読あり
• [雑誌論文] Increasing in the prevalence of metabolic syndrome among workers according to age. (2010)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Li Q, Li YJ, Katsumata M.
  • 雑誌名: The Aging Male 13(3) ページ: 184-187
  • 査読あり
• [雑誌論文] Association of hematological parameters and uric acid with clustered components of metabolic syndrome among Japanese male workers. (2010)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Katsumata M, Li Q, Li YJ.
  • 雑誌名: Diabetes Metab Syndr 4(3) ページ: 165-167
  • 査読あり
• [雑誌論文] A cross-sectional study on lifestyles and the metabolic syndrome (MetS) components mainly targeting glucose metabolism in Japanese working men. (2010)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Li Q, Li YJ, Katsumata M.
  • 雑誌名: Diabetes Metab Syndr 4(4) ページ: 230-233
  • 査読あり
• [雑誌論文] Monitoring of the sleep patterns of shift workers in the automotive industry. (2010)
  • 著者名/発表者名: Kawada T, Shimizu T, Kuratomi Y, Suto S, Kanai T, Nishime A, Nakano N.
  • 雑誌名: Work 38(2) ページ: 163-167
  • 査読あり
• [雑誌論文] Insulin resistance, as expressed by HOMA-R, is strongly determined by waist circumference or body mass index among Japanese working men. (2010)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Li Q, Li YJ, Katsumata M.
  • 雑誌名: Obes Res & Clin Practice 巻: 4(1)
  • 査読あり
• [雑誌論文] Serum insulin is significantly related to components of the metabolic syndrome in Japanese working men. (2010)
  • 著者名/発表者名: Kawada T, Inagaki H, Wakayama Y, Li Q, Katsumata M.
  • 雑誌名: J Clin Hypertens 巻: 12(4) ページ: 309-314
  • 査読あり
• [雑誌論文] Preliminary report : homeostasis model assessment of insulin resistance, an indicator of insulin resistance, is strongly related to serum insulin : practical data presentation and the mathematical basis. (2010)
  • 著者名/発表者名: Kawada T.
  • 雑誌名: Metabolism 巻: 59(7) ページ: 1044-1046
  • 査読あり
• [雑誌論文] Association of smoking status, insulin resistance, body mass index, and metabolic syndrome in workers : a one-year follow-up study. (2010)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Li Q, Li YJ, Katsumata M.
  • 雑誌名: Obes Res & Clin Practice 巻: 4(3)
  • 査読あり
• [雑誌論文] A cross-sectional study on the shift work and metabolic syndrome in Japanese male workers. (2010)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Katsumata M, Li Q, Li YJ.
  • 雑誌名: The Aging Male 巻: 13(3) ページ: 174-178
  • 査読あり
• [雑誌論文] Increasing in the prevalence of metabolic syndrome among workers according to age. (2010)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Li Q, Li YJ, Katsumata M.
  • 雑誌名: The Aging Male 巻: 13(3) ページ: 184-187
  • 査読あり
• [雑誌論文] Association of hematological parameters and uric acid with clustered components of metabolic syndrome among Japanese male workers. (2010)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Katsumata M, Li Q, Li YJ.
  • 雑誌名: Diabetes Metab Syndr 巻: 4(3) ページ: 165-167
  • 査読あり
• [雑誌論文] A cross-sectional study on lifestyles and the metabolic syndrome (MetS) components mainly targeting glucose metabolism in Japanese working men. (2010)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Li Q, Li YJ, Katsumata M.
  • 雑誌名: Diabetes Metab Syndr 巻: 4(4) ページ: 230-233
  • 査読あり
• [雑誌論文] Relationship between Two Indicators of Coronary Risk Estimated by the Framingham Risk Score and the Number of Metabolic Syndrome Components in Japanese Manufacturing Male Workers (2009)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Li Q, Katsumata M.
  • 雑誌名: Met Syndr Relat Disord 巻: 7(5) ページ: 435-440
  • 査読あり
• [雑誌論文] Relationship between two indicators of coronary risk estimated by the Framingham Risk Score and the number of metabolic syndrome components in Japanese manufacturing male workers. (2009)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Li Q, Katsumata M.
  • 雑誌名: Met Syndr Relat Disord 7(5) ページ: 435-440
  • 査読あり
• [雑誌論文] Anthropometric obesity indices and metabolic syndrome in Japanese working men. (2009)
  • 著者名/発表者名: Kawada T, Kuratomi Y, KanaiT, Suto S, Nihsime A, Koizumi M, Nakano N.
  • 雑誌名: Work 34(1) ページ: 89-94
  • 査読あり
• [雑誌論文] Relationship between Two Indicators of Coronary Risk Estimated by the Framingham Risk Score and the number of Metabolic Syndrome Components in Japanese Manufacturing Male Workers. (2009)
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Li Q, Katsumata M.
  • 雑誌名: Met Syndr Relat Disord 7(5) ページ: 435-440
  • 査読あり
• [雑誌論文] Optimal cut-off levels of body mass index and waist circumference to predict each component of metabolic syndrome (MetS) and the number of MetS component.
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Li Q, Li YJ, Katsumata M.
  • 雑誌名: Diabetes Metab Syndr in press)
  • 査読あり
• [雑誌論文] Serum insulin is significantly related to components of the metabolic syndrome in Japanese working women.
  • 著者名/発表者名: Kawada T, Otsuka T, Inagaki H, Wakayama Y, Li Q, Li YJ, Katsumata M.
  • 雑誌名: Diabetes Metab Syndr in press
  • 査読あり