心筋代謝調節におけるmicroRNAの役割とその制御機構の解明

• 研究課題/領域番号: 20590864
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 循環器内科学
• 研究機関: 京都大学
• 研究代表者: 尾野 亘 京都大学, 医学研究科, 講師 (00359275)
• 研究期間 (年度): 2008 – 2010
• 研究課題ステータス: 完了 (2010年度)
• 配分額: 4,680千円 (直接経費: 3,600千円、間接経費: 1,080千円); 2010年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円); 2009年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円); 2008年度: 1,820千円 (直接経費: 1,400千円、間接経費: 420千円)
• キーワード: マイクロRNA / 心肥大 / 心不全 / 動脈硬化 / microRNA / コレステロール / SREBP2 / ABCA1 / ATP / ミトコンドリア / 心筋 / 糖代謝

研究概要

microRNA (miRNA ; miR)はヒトにおいて約1000種類が報告され、遺伝子の50%以上を制御しているとの報告がある。今回の検討において、心肥大、心不全、および代謝調節におけるmiRNAの役割が判明し、治療の標的となりうることが明らかとなってきた。また、流血中のmiRNA-1、133aが心筋障害のバイオマーカーとなりうること、他の臓器に作用しうることも示した。

研究成果

• [雑誌論文] Increased microRNA-1 and microRNA-133a Levels in Serum of Patients with Cardiovascular Disease Indicate the Existence of Myocardial Damage. (2011)
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  • 雑誌名: Circulation : Cardiovascular Genetics. in press
  • 査読あり
• [雑誌論文] MicroRNA links obesity and impaired glucose metabolism. (2011)
  • 著者名/発表者名: Ono K.
  • 雑誌名: Cell Res. in press
  • NAID: 120004225541
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• [雑誌論文] MicroRNAs and Cardiovascular Diseases. (2011)
  • 著者名/発表者名: Ono K, Kuwabara Y, Han J.
  • 雑誌名: FEBS J. 278 ページ: 1619-33
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• [雑誌論文] MicroRNA-27a regulates beta cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor beta 1 in neonatal rat ventricular myocytes. (2011)
  • 著者名/発表者名: Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara Y, Watanabe S, Takaya T, Tamaki Y, Takanabe-Mori R, Wada H, Hasegawa K, Iwanaga Y, Kawamura T, Kita T, Kimura T.
  • 雑誌名: Mol Cell Biol. 31 ページ: 744-55
  • NAID: 120002871162
  • 査読あり
• [雑誌論文] MicroRNA-33 encoded by an intron of Srebp2 regulates HDL in vivo Proc Natl (2010)
  • 著者名/発表者名: Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, Kinoshita M, Kuwabara Y, Marusawa H, Iwanaga Y, Hasegawa K, Yokode M, Kimura T, Kita T.
  • 雑誌名: Acad Sci USA. 107 ページ: 17321-6
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• [雑誌論文] Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5. (2010)
  • 著者名/発表者名: Kinoshita M, Ono K, Horie T, Nagao K, Nishi H, Kuwabara Y, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T.
  • 雑誌名: Molecular Endoclinology. 24 ページ: 1978-87
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• [雑誌論文] Acute Doxorubicin Cardiotoxicity Is Associated with miR-146a-induced Inhibition of the Neuregulin-ErbB (2010)
  • 著者名/発表者名: Horie T, Ono K, Nishi H, Nagao K, Kinoshita M, Watanabe S, Kuwabara Y, Nakashima Y, Takanabe-Mori R, Nishi E, Hasegawa K, Kita T, Kimura T.
  • 雑誌名: Pathway Cardiovascular Res. 87 ページ: 656-664
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• [雑誌論文] MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via ARL2 in neonatal rat cardiac myocytes. (2010)
  • 著者名/発表者名: Nishi H, Ono K, Iwanaga Y, Horie T, Nagao K, Takemura G, Kinoshita M, Kuwabara Y, Takanabe Mori R, Hasegawa K, Kita T, Kimura T.
  • 雑誌名: J Biol Chem. 285 ページ: 4920-30
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• [雑誌論文] Neural cell adhesion molecule is a cardioprotective factor up-regulated by metabolic stress. (2010)
  • 著者名/発表者名: Nagao K, Ono K, Iwanaga Y, Tamaki Y, Kojima Y, Horie T, Nishi H, Kinoshita M, Kuwabara Y, Hasegawa K, Kita T, Kimura T.
  • 雑誌名: Journal of Molecular and Cellular Cardiology. 48 ページ: 1157-68
  • NAID: 120002381089
  • 査読あり
• [雑誌論文] MicroRNA-33 encoded by an intron of Srebp2 regulates HDL in vivo (2010)
  • 著者名/発表者名: Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, Kinoshita M, Kuwabara Y, Marusawa H, Iwanaga Y, Hasegawa K, Yokode M, Kimura T, Kita T.
  • 雑誌名: Proc Natl Acad Sci U S A. 巻: 107 ページ: 17321-6
  • 査読あり
• [雑誌論文] Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5. (2010)
  • 著者名/発表者名: Kinoshita M, Ono K, Horie T, Nagao K, Nishi H, Kuwabara Y, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T.
  • 雑誌名: Molecular Endoclinology. 巻: 24 ページ: 1978-87
  • 査読あり
• [雑誌論文] Acute Doxorubicin Cardiotoxicity Is Associated with miR-146a-induced Inhibition of the Neuregulin-ErbB Pathway (2010)
  • 著者名/発表者名: Horie T, Ono K, Nishi H, Nagao K, Kinoshita M, Watanabe S, Kuwabara Y, Nakashima Y, Takanabe-Mori R, Nishi E, Hasegawa K, Kita T, Kimura T.
  • 雑誌名: Cardiovascular Res 巻: 87 ページ: 656-664
  • 査読あり
• [雑誌論文] MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via ARL2 in neonatal rat cardiac myocytes. (2010)
  • 著者名/発表者名: Nishi H, Ono K, Iwanaga Y, Horie T, Nagao K, Takemura G, Kinoshita M, Kuwabara Y, Takanabe Mori R, Hasegawa K, Kita T, Kimura T.
  • 雑誌名: J Biol Chem. 巻: 285 ページ: 4920-30
  • 査読あり
• [雑誌論文] Neural cell adhesion molecule is a cardioprotective factor up-regulated by metabolic stress. (2010)
  • 著者名/発表者名: Nagao K, Ono K, Iwanaga Y, Tamaki Y, Kojima Y, Horie T, Nishi H, Kinoshita M, Kuwabara Y, Hasegawa K, Kita T, Kimura T
  • 雑誌名: Journal of Molecular and Cellular Cardiology. 巻: 48 ページ: 1157-68
  • NAID: 120002381089
  • 査読あり
• [雑誌論文] Metaxin deficiency alters mitochondrial membrane permeability and leads to resistance to TNF-induced cell killing. (2010)
  • 著者名/発表者名: Ono K, Wang X, Kim SO, Armstrong LC, Bornstein P, Han J.
  • 雑誌名: Protein Cell ページ: 161-173
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• [雑誌論文] Insulin-like growth factor axis (insulin-like growth factor-I/insulin-like growth factor-binding protein-3) as a prognostic predictor of heart failure : association with adiponectin. (2010)
  • 著者名/発表者名: Watanabe S, Tamura T, Ono K, Horiuchi H, Kimura T, Kita T, Furukawa Y.
  • 雑誌名: Eur J Heart Failure 巻: 12 ページ: 1214-22
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• [雑誌論文] LOX-1 is required for the adipose tissue expression of proinflammatory cytokines in high-fat diet-induced obese mice. (2010)
  • 著者名/発表者名: Takanabe-Mori R, Ono K, Sowa N, Takaya T, Horie T, Satoh-Asahara N, Shimatsu A, Fujita M, Sawamura T, Hasegawa K.
  • 雑誌名: Biochem Biophys Res Commun 巻: 398 ページ: 576-80
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• [雑誌論文] Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice. (2010)
  • 著者名/発表者名: Kaichi S, Hasegawa K, Takaya T, Yokoo N, Mima T, Kawamura T, Morimoto T, Ono K, Baba S, Doi H, Yamanaka S, Nakahata T, Heike T.
  • 雑誌名: Cardiovasc Res. 巻: 88 ページ: 314-3
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• [雑誌論文] Transmitral E/A ratio decreases in association with abdominal fat accumulation in patients with impaired glucose tolerance or mild diabetes without left ventricular hypertrophy. (2010)
  • 著者名/発表者名: Wada H, Shinjo D, Kameda S, Ono K, Satoh N, Morimoto T, Osakada, G, Nakano T, Fujita M, Shimatsu A, Hasegawa K.
  • 雑誌名: Heart Vessels. 巻: 25 ページ: 45-50
  • 査読あり
• [雑誌論文] Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance. (2010)
  • 著者名/発表者名: Wada H, Satoh N, Kitaoka S, Ono K, Morimoto T, Kawamura T, Nakano T, Fujita M, Kita T, Shimatsu A, Hasegawa K.
  • 雑誌名: Atherosclerosis 巻: 208 ページ: 512-517
  • 査読あり
• [雑誌論文] A case with sudden onset of position-dependent hypoxemia caused by reopening of foramen ovale. (2010)
  • 著者名/発表者名: Tada T, Fujita M, Goto T, Tamura T, Ono K, Kita T, Takahashi K, Nagata H, Sakata R, Kimura T
  • 雑誌名: Journal of Cardiology Cases 巻: 1
  • 査読あり
• [雑誌論文] Neural cell adhesion molecule is a cardioprotective factor up-regulated by metabolic stress. (2010)
  • 著者名/発表者名: Nagao K, Ono K, Iwanaga Y, Tamaki Y, Kojima Y, Horie T, Nishi H, Kinoshita M, Kuwabara Y, Hasegawa K, Kita T, Kimura T.
  • 雑誌名: Journal of Molecular and Cellular Cardiology.
  • NAID: 120002381089
  • 査読あり
• [雑誌論文] Transmitral E/A ratio decreases in association with abdominal fat accumulation in patients with impaired glucose tolerance or mild diabetes without left ventricular hypertrophy. (2010)
  • 著者名/発表者名: Wada H, Shinjo D, Kameda S, Ono K, Satoh N, Morimoto T, Osakada G, Nakano T, Fujita M, Shimatsu A, Hasegawa K.
  • 雑誌名: Heart Vessels. 25 ページ: 45-50
  • 査読あり
• [雑誌論文] Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance. (2010)
  • 著者名/発表者名: Wada H, Satoh N, Kitaoka S, Ono K, Morimoto T, Kawamura T, Nakano T, Fujita M, Kita T, Shimatsu A, Hasegawa K.
  • 雑誌名: Atherosclerosis 208 ページ: 512-517
  • 査読あり
• [雑誌論文] MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes. (2009)
  • 著者名/発表者名: Horie T, Ono K, Nishi H, Iwanaga Y, Nagao K, Kinoshita M, Kuwabara Y, Takanabe R, Hasegawa K, Kita T, Kimura T.
  • 雑誌名: Biochem Biophys Res Commun. 389 ページ: 315-20
  • 査読あり
• [雑誌論文] MicroRNA-1 and MicroRNA-133 in Spontaneous Myocardial Differentiation of Mouse Embryonic Stem Cells. (2009)
  • 著者名/発表者名: Takaya T, Ono K, Kawamura T, Takanabe R, Kaichi S, Morimoto T, Wada H, Kita T, Shimatsu A, Hasegawa K.
  • 雑誌名: Circulation J. 73 ページ: 1492-7
  • 査読あり
• [雑誌論文] The search for Nkx2-5-regulated genes using purified embryonic stem cell-derived cardiomyocytes with Nkx2-5gene targeting. (2009)
  • 著者名/発表者名: Nakashima Y, Ono K, Yoshida Y, Kojima Y, Kita T, Tanaka M, Kimura T.
  • 雑誌名: Biochem Biophys Res Commun. 390 ページ: 821-826
  • 査読あり
• [雑誌論文] MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes. (2009)
  • 著者名/発表者名: Horie T, Ono K, Nishi H, Iwanaga Y, Nagao K, Kinoshita M, Kuwabara Y, Takanabe R, Hasegawa K, Kita T, Kimura T
  • 雑誌名: Biochem Biophys Res Commun. 389 ページ: 315-320
  • 査読あり
• [雑誌論文] Impact of CYP2C19 Polymorphisms on the Antiplatelet Effect of Clopidogrel in an Actual ClinicalSetting in Japan. (2009)
  • 著者名/発表者名: Jinnai T, Horiuchi H, Makiyama T, Tazaki J, Tada T, Akao M, Ono K, Hoshino K, Naruse Y, Takahashi K, Watanabe H, Kita T, Kimura T.
  • 雑誌名: Circ J. 73 ページ: 498-503
  • 査読あり
• [雑誌論文] MicroRNA-1 and MicroRNA-133 in Spontaneous Myocardial Differentiation of Mouse Embryonic Stem Cells. (2009)
  • 著者名/発表者名: Takaya T, Ono K, Kawamura T, Takanabe R, Kaichi S, Morimoto T Wada H, Kita T, Shimatsu A, Hasegawa K.
  • 雑誌名: Circ J. 73 ページ: 1492-1497
  • 査読あり
• [雑誌論文] Progranulin Expression in Advanced Human Atherosclerotic Plaque (2009)
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  • 雑誌名: Atherosclerosis. 206 ページ: 102-108
  • 査読あり
• [雑誌論文] Progranulin Expression in Advanced Human Atherosclerotic Plaque (2009)
  • 著者名/発表者名: Sugimoto M, Arai H, Tamura Y, Murayama T, Khaengkhan P, Nishio T, Ono K, Ariyasu H, Akamizu T, Ueda Y, Kita T, Harada S, Kamei K, Yokode M.
  • 雑誌名: Atherosclerosis. 204 ページ: 388-394
  • 査読あり
• [雑誌論文] Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet. (2008)
  • 著者名/発表者名: Takanabe R, Ono K, Abe Y, Takaya T, Horie T, Wada H, Kita T, Satoh N, Shimatsu A, Hasegawa K.
  • 雑誌名: Biochem Biophys Res Commun. 376 ページ: 728-32
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• [雑誌論文] TG-interacting factor is reauired for the differentiation of preadipocytes. (2008)
  • 著者名/発表者名: Horie-T, Ono-K, Kinoshita-M, Nishi-H, Nagao-K, Kawamura-T, Abe-Y, Wada-H, Shimatsu-A, Kita-T, Hasegawa-K.
  • 雑誌名: J Lipid Res. 49 ページ: 1224-34
  • 査読あり
• [雑誌論文] Oxidative stress induces GLUT4 translocation by activation of PI3-K/Akt and dual AMPK kinase in cardiac myocytes. (2008)
  • 著者名/発表者名: Horie-T, Ono-K, Nagao-K, Nishi-H, Kinoshita-M, Kawamura-T, Wada-H, Shimatsu-A, Kita-T, Hasegawa-K.
  • 雑誌名: J Cell Physiol. 215 ページ: 733-42
  • 査読あり
• [雑誌論文] Up-regulated expression of miicroRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet. (2008)
  • 著者名/発表者名: Takanabe R, Ono K, Abe Y, Takaya T, Horie T, Wada H, Kita T, Satoh N, Shimatsu A, Hasegawa K.
  • 雑誌名: Biochem Biophys Res Commun. 376 ページ: 728-32
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• [雑誌論文] Inhibition of CCN1 suppressed neointimal hyperplasia in a rat balloon injury model. (2008)
  • 著者名/発表者名: Matsumae-H, Yoshida-Y, Ono-K, Togi-K, Inoue-K, Furukawa-Y, Nakashima-Y, Koima-Y, Nobuyoshi-M, Kita-T, Tanak-M.
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• [雑誌論文] Small dense LDL-cholesterol relative to LDL-cholesterol is a strong independent determinant of hypoadiponectinemia in metabolic syndrome. (2008)
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• [雑誌論文] Statins activate GATA-6 and induce differentiated vascular smooth muscle cells. (2008)
  • 著者名/発表者名: Waa H, Abe M, Ono K, Morimoto T, Kawamura T, Takaya T, Satoh N, Fujita M, Kita T, Shimatsu A, Hasegawa K.
  • 雑誌名: Circulation J 374 ページ: 731-6
  • 査読あり
• [雑誌論文] Morphological and biochemical characterization of basal and starvation-induced autophagy in isolated adult rat cardiomyocytes. (2008)
  • 著者名/発表者名: Maruyama R, Goto K, Takemra G, Ono K, Nagao K, Horie T, Tsujimoto A, Kanamori H, Miyata S, Ushikoshi H, Nagashima K, Minatoguchi S, Fuj iwara T, Fuj iwara H.
  • 雑誌名: Am J Physiol Heart Circ Physiol. 295
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• [雑誌論文] Identification of p300-targeted acetylated residues in GATA-4 during hypertrophic responses in cardiac myocytes. (2008)
  • 著者名/発表者名: Takaya T, Kawaiura T, Moriffloto T, Ono K, Kita T, Shimatsu A, Hasegawa K.
  • 雑誌名: J Biol Chem. 283 ページ: 9828-35
  • 査読あり
• [雑誌論文] Mulberry leaf ameliorates the expression profile of adipocytokines by inhibiting oxidative stress in white adipose tissue in db/db mice. (2008)
  • 著者名/発表者名: Sugimoto M, Arai H, Taraura Y, Murayama T, Khaengkhan P, Nishio T, Ono K, Ariyasu H, Akamizu T, Ueda Y, Kita T, Harada S, Kamei K, Yokode M.
  • 雑誌名: Atherosclerosis. (Epub ahead of print)
  • 査読あり
• [雑誌論文] Inhibition of CCR2 Ameliorates Insulin Resistance and Hepatic Steatosis in db/db Mice. (2008)
  • 著者名/発表者名: Taiura Y, Sugimoto M, Murayama T, Ueda Y, Kanamori H, Ono K, Ariyasu H, Akamizu T, Kita T, Yokode M, Arai H.
  • 雑誌名: Arterioscler Thromb Vase Biol. 28 ページ: 2195-201
  • 査読あり
• [学会発表] Plenary session. (2011)
  • 著者名/発表者名: Ono K.
  • 学会等名: MicroRNA-33 Encoded by an Intron of Srebp2 Cooperates to Control HDL in Vivo.
  • 発表場所: 横浜市
• [学会発表] Young Investigator's Award Finalists Lectures-2 (2011)
  • 著者名/発表者名: Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, Kinoshita M, Kuwabara Y, Marusawa H, Iwanaga Y, Hasegawa K, Yokode M, Kimura T, Kita T.
  • 学会等名: MicroRNA-33 Encoded by an Intron of Srebp2 Regulates HDL in vivo.
  • 発表場所: 横浜市
• [学会発表] MiR-146a-induced Inhibition of Neuregulinl- (2011)
  • 著者名/発表者名: Horie T, Ono K, Nishi H, Kinoshita M, Watanabe S, Kuwabara Y, Baba O, Mori R, Nagao K, Iwanaga Y, Nishi E, Hasegawa K, Kita T, Kimura T.
  • 学会等名: ErbB4 Pathway may be Involved in Deterioration of Cardiotoxicity under Concurrent Chemotherapy with Doxorubicin and Trastuzumab.
  • 発表場所: 横浜市
• [学会発表] Elevated MicroRNA-1 and MicroRNA- (2011)
  • 著者名/発表者名: Kuwabara Y, Ono K, Horie T, Nishi H, Kinoshita M, Watanabe S, Baba O, Kita T, Kimura T.
  • 学会等名: 133a Levels in Serum of Patients with Acute Cronary Syndrome Indicate the Myocardial Damage.
  • 発表場所: 横浜市
• [学会発表] SREBP2のイントロンにコードされるマイクロRNA-33は生体においてHDLの形成を制御する (2010)
  • 著者名/発表者名: 堀江貴裕、尾野亘、西仁勇、長央和也、木下美菜子、桑原康秀、森利依子、長谷川浩二、北徹、木村剛
  • 学会等名: 第2回 京阪神心不全研究会
  • 発表場所: 大阪
  • 年月日: 2010-12-04
• [学会発表] Progranulin is expressed in the human atherosclerotic plaque and reduces IL-8 secretion from smooth muscle cells, endothelial cells, and macrophages. (2010)
  • 著者名/発表者名: Kojima Y, Ono K, Inoue K, Yoshida Y, Nakashima Y, Nobuyoshi M, Kita T, Kimura T, Tanaka M.
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
  • 年月日: 2010-03-07
• [学会発表] Ca2+/Calmodulin-dependent kinase kinase beta (CaMKKbeta) contributes to energy supply in adaptive phase of pressure-overload-induced heart failure. (2010)
  • 著者名/発表者名: Watanabe S, Ono K, Horie T, Nagao K, Nishi H, Kinoshita M, Kuwabara Y, Kimura T.
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
  • 年月日: 2010-03-07
• [学会発表] Midterm outcome of Inoue stent graft for the treatment of thoracic aortic aneurysm and dissections. (2010)
  • 著者名/発表者名: Tazaki J, Tohma M, Higashitani N, Tamura T, Ono K, Marui A, Sakata R, Inoue K, Kimura T.
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
  • 年月日: 2010-03-07
• [学会発表] Impact of microRNAs on cardiomyocyte metabolism. (2010)
  • 著者名/発表者名: Ono K, Nishi H, Iwanaga Y, Horie T, Nagao K, Takemura G, Kinoshita M, Kuwabara Y, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
  • 年月日: 2010-03-06
• [学会発表] MiR-146-mediated reduction of ErbB4 is an early event in doxorubicin-induced cardiomyocyte cell death. (2010)
  • 著者名/発表者名: Horie T, Ono K, Iwanaga Y, Nishi H, Nagao K, Kinoshita M, Mori R, Kuwabara Y, Hasegawa K, Kita T
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
  • 年月日: 2010-03-06
• [学会発表] MicroRNA-27a regulates beta cardiac myosin heavy chaingene expression by targeting thyroid hormone receptor beta-1. (2010)
  • 著者名/発表者名: Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara Y, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T.
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
  • 年月日: 2010-03-06
• [学会発表] Soluble VEGF receptor-2 is a possible novel indicator of impaired angiogenesis in metabolic syndrome. (2010)
  • 著者名/発表者名: Wada H, Satoh N, Kitaoka S, Ono K, Morimoto T, Kawamura T, Nakano T, Fujita M, Kita T, Shimatsu A, Hasegawa K.
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
  • 年月日: 2010-03-06
• [学会発表] Long-term clinical outcomes of unprotected left main stenting with sirolimus eluting stents : Correlation between the SYNTAX score and clinical outcomes. (2010)
  • 著者名/発表者名: Shiomi H, Tamura T, Katoh Y, Tada T, Tazaki J, Jinnai T, Ono K, Kimura T
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
  • 年月日: 2010-03-06
• [学会発表] Implantation of sirolimus-eluting stents for coronary artery ostial stenosis in Takayasu artetitis. (2010)
  • 著者名/発表者名: Shiomi H, Tamura T, Katoh Y, Tada T, Tazaki J, Jinnai T, Ono K, Kimura T
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
  • 年月日: 2010-03-06
• [学会発表] MicroRNA-378, which exists intronic lesion of PGC-1beta, deteriorate cardiomyocyte survival under oxidative stress. (2010)
  • 著者名/発表者名: Kuwabara Y, Ono K, Horie T, Nishi H, Nagao K, Watanabe S, Kinoshita M, Kojima Y, Kita T, Kimura T
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
  • 年月日: 2010-03-05
• [学会発表] LOX-1 is required for overexpression fo MCP-1 in mesenteric fat tissue of obese mice. (2010)
  • 著者名/発表者名: Takanabe-Mori R, Ono K, Sowa N, Wada H, Takaya T, Satoh N, Shimatsu A, Fujita M, Sawamura T, Hasegawa K
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
  • 年月日: 2010-03-05
• [学会発表] Roles of lectin-like oxidized low-density lipoprotein receptor-1 for glucose tolerance in normal and obese mice. (2010)
  • 著者名/発表者名: Takanabe-Mori R, Ono K, Sowa N, Wada H, Takaya T, Satoh N, Shimatsu A, Fujita M, Sawamura T, Hasegawa K
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
  • 年月日: 2010-03-05
• [学会発表] MicroRNA 26b family encoded by the introns of small CTD Phosphatases (SCPs) 1 to 3 suppresses phenylephrine-induced cardiomyocyte hypertrophy by targeting TRPC3/6 and GATA4 (2010)
  • 著者名/発表者名: Ono K, Sowa N, Horie T, Hasegawa K, Kita T, Kimura T
  • 学会等名: American Heart Association Annual Scientific Sessions
  • 発表場所: Chicago, Illinois
• [学会発表] MiR-146a-induced inhibition of the neuregulin-ErbB4 pathway may be involved in deterioration of cardiotoxicity under concurrent chemotherapy with doxorubicin and Trastuzumab. (2010)
  • 著者名/発表者名: Horie T, Ono K, Iwanaga Y, Nishi H, Nagao K, Kinoshita M, Watanabe S, Kuwabara Y, Nakashima Y, Takanabe-Mori R, Nishi E, Hasegawa K, Kita T, Kimura T
  • 学会等名: American Heart Association Annual Scientific Sessions
  • 発表場所: Chicago, Illinois
• [学会発表] MicroRNA-27a regulates beta-myocin heavy chain gene expression by targeting thyroid hormone receptor beta 1 in neonatal rat ventricular myocytes. (2010)
  • 著者名/発表者名: Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara Y, Baba O, Nakashima Y, Nagao K, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T
  • 学会等名: American Heart Association Annual Scientific Sessions
  • 発表場所: Chicago, Illinois
• [学会発表] MicroRNA-1 and microRNA-133a are useful as early diagnostic biomarkers in patients with acute coronary syndrome. (2010)
  • 著者名/発表者名: Kuwabara Y, Ono K, Horie T, Nishi H, Kinoshita M, Watanabe S, Nakashima Y, Nagao K, Kojima Y, Kita T, Kimura T
  • 学会等名: American Heart Association Annual Scientific Sessions
  • 発表場所: Chicago, Illinois
• [学会発表] MicroRNA-448 regulates adipocyte differentiation by targeting KLF5. (2010)
  • 著者名/発表者名: Kinoshita M, Ono K, Kuwabara Y, Nishi H, Nagao K, Horie T, Mori R, Hasegawa K, Kita T, Kimura T
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
• [学会発表] Impact of microRNAs on cardiomyocyte metabolism. Topic 12 (2010)
  • 著者名/発表者名: Ono K, Nishi H, Iwanaga Y, Horie T, Nagao K, Takemura G, Kinoshita M, Kuwabara Y, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
• [学会発表] MicroRNA-27a regulates beta cardiac myosin heavy chain gene expressions by targeting thyroid hormone receptor beta 1. (2010)
  • 著者名/発表者名: Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara Y, Mori-Takanabe R, Hasegawa K, Kita T, Kimura T
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
• [学会発表] MicroRNA-378, which exists intronic lesion of PGC-lbeta, deteriorates cardiomyocyte survival under oxidative stress. (2010)
  • 著者名/発表者名: Kuwabara Y, Ono K, Horie T, Nishi H, Nagao K, Watanabe S, Kinoshita M, Kojima Y, Kita T, Kimura T
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
• [学会発表] microRNA-146-mediated reduction of ErbB4 is an early event in Doxorubicin-induced cardiomyocyte cell death. (2010)
  • 著者名/発表者名: Horie T, Ono K, Nishi H, Nagao K, Kinoshita M, Kuwabara Y, takanabe R, Watanabe S, Kojima Y, Nakashima Y, Iwanaga Y, Hasegawa K, Kita T, Kimura T
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
• [学会発表] Neural cell adhesion molecule is a cardioprotective factor upregulated by metabolic stress. (2010)
  • 著者名/発表者名: Nagao K, Ono K, Horie T, Kinoshita M, Nishi H, Tamaki Y, Kuwabara Y, Iwanaga Y, Kita T, Kimura T
  • 学会等名: 第74回日本循環器学会
  • 発表場所: 京都
• [学会発表] MicroRNA 26b family encoded by the introns of small CTD Phosphatases (SCPs) 1 to 3 suppresses phenylephrine-induced cardiomyocyte hypertrophy by targeting TRPC3/6 and GATA4 (2010)
  • 著者名/発表者名: Ono K, Sowa N, Horie T, Hasegawa K, Kita T, Kimura T
  • 学会等名: American Heart Association Annual Scientific Sessions 2010
  • 発表場所: Chicago, Illinois, USA
• [学会発表] MiR-146a-induced inhibition of the neuregulin-ErbB4 pathway may be involved in deterioration of cardiotoxicity under concurrent chemotherapy with doxorubicin and Trastuzumab. (2010)
  • 著者名/発表者名: Horie T, Ono K, Iwanaga Y, Nishi H, Nagao K, Kinoshita M, Watanabe S, Kuwabara Y, Nakashima Y, Takanabe-Mori R, Nishi E, Hasegawa K, Kita T, Kimura T
  • 学会等名: American Heart Association Annual Scientific Sessions 2010
  • 発表場所: Chicago, Illinois, USA
• [学会発表] Ca2+/Calumodulin-dependent kinase kinase beta contributes to energy supply in adaptive phase of pressure-overload-induced heart failure. (2010)
  • 著者名/発表者名: Watanabe S, Ono K, Horie T, Nishi H, Kinoshita M, Kuwabara Y, Baba O, Kimura T
  • 学会等名: American Heart Association Annual Scientific Sessions 2010
  • 発表場所: Chicago, Illinois, USA
• [学会発表] MicroRNA-27a regulates beta-myocin heavy chain gene expression by targeting thyroid hormone receptor beta 1 in neonatal rat ventricular myocytes. (2010)
  • 著者名/発表者名: Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara Y, Baba O, Nakashima Y, Nagao K, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T
  • 学会等名: American Heart Association Annual Scientific Sessions 2010
  • 発表場所: Chicago, Illinois, USA
• [学会発表] MicroRNA-1 and microRNA-133a are useful as early diagnostic biomarkers in patients with acute coronary syndrome. (2010)
  • 著者名/発表者名: Kuwabara Y, Ono K, Horie T, Nishi H, Kinoshita M, Watanabe S, Nakashima Y, Nagao K, Kojima Y, Kita T, Kimura T
  • 学会等名: American Heart Association Annual Scientific Sessions 2010
  • 発表場所: Chicago, Illinois, USA
• [学会発表] Serum adiponectin levels are increased by pathophysiologically induced left ventricular hypertrophy. (2010)
  • 著者名/発表者名: Wada H, Akao M, Masunaga N, Takaya T, Takanabe-Mori R, Abe M, Funatsu J, Nakajima Y, Kanasaki M, Osakabe G, Nakano T, Ono K, Satoh-Asahara N, Shimatsu A, Hasegawa K
  • 学会等名: American Heart Association Annual Scientific Sessions 2010
  • 発表場所: Chicago, Illinois, USA
• [学会発表] Lox-1 is required for the adiposal expression of proinflammatory cytokines in high-fat diet-induced obese mice. (2010)
  • 著者名/発表者名: Takanabe-Mori R, Ono K, Sowa N, Wada H, Takaya T, Satoh-Asahara N, Shimatsu A, Fujita M, Sawamura T, Hasegawa K
  • 学会等名: American Heart Association Annual Scientific Sessions 2010
  • 発表場所: Chicago, Illinois, USA
• [学会発表] Metastasis-associated protein S100A4 contributes to cardiac fibrosis through the modulation of PTEN. (2010)
  • 著者名/発表者名: Tamaki Y, Okuda J, Niizuma S, Kawashima T, Kato T, Inuzuka Y, Shioi T, Ono K, Koshimizu T, Miyazaki S, Kita T, Kimura T
  • 学会等名: American Heart Association Annual Scientific Sessions 2010
  • 発表場所: Chicago, Illinois, USA
• [学会発表] Ca2+/calmodulin-dependent kinase kinase beta contributes to energy supply in adaptive phase of pressure-overload-induced heart failure. (2010)
  • 著者名/発表者名: Watanabe S, Ono K, Horie T, Nishi H, Kuwabara Y, Kimura T
  • 学会等名: European Society of Cardiology Congress 2010
  • 発表場所: Stockholm, Sweden
• [学会発表] ドキソルビシンによる心筋障害にはmiR-146aによるneuregulin/ErbBシグナルの抑制が関わる (2010)
  • 著者名/発表者名: 堀江貴裕、尾野亘、西仁勇、長央和也、木下美菜子、桑原康秀、森利依子、長谷川浩二、北徹、木村剛
  • 学会等名: 第47回日本臨床分子医学会学術集会
  • 発表場所: 東京
• [学会発表] MicroRNA-448は脂肪細胞分化を抑制する (2010)
  • 著者名/発表者名: 木下美菜子、尾野亘、桑原康秀、西仁勇、長央和也、堀江貴裕、森利依子、長谷川浩二、北徹、木村剛
  • 学会等名: 第47回日本臨床分子医学会学術集会
  • 発表場所: 東京
• [学会発表] MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via Ar12 in neonatal rat cardiac myocytes. (2010)
  • 著者名/発表者名: Ono K, Nishi H, Iwanaga Y, Horie T, Nagao K, Takemura G, Kinoshita M, Kuwabara Y, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T
  • 学会等名: ISHR World Congress 2010 Kyoto
  • 発表場所: Kyoto
• [学会発表] Ca2+/calmodulin-dependent kinase kinase β(CaMKKβ)contributes to energy supply in adaptive phase of pressure-overload-induced heart failure (2010)
  • 著者名/発表者名: Watanabe S, Ono K, Kimura T
  • 学会等名: 第33回心筋代謝研究会
  • 発表場所: 東京
• [学会発表] MicroRNA-15b, -16, 195, and -424, which have the same seed sequence, regulate ADP-rybosylation factor-like 2 and cellular ATP levels in neonatal rat cardiomyocytes (2009)
  • 著者名/発表者名: Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara-Y, Takanabe-Mori R, Hasegawa K, Takemura G, Iwanaga Y, Kita T, Kimura T
  • 学会等名: American Heart Association Annual Scientific Sessions 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-17
• [学会発表] MicroRNA-378, which exists intronic lesion of PGC-1beta, deteriorate cardiomyocyte survival under oxidative stress. (2009)
  • 著者名/発表者名: Kuwabara Y, Ono K, Horie T, Nishi H, Nagao K, Watanabe S, Kojima Y, Kinoshita M, Mori R, Kita T, Kimura T
  • 学会等名: American Heart Association Annual Scientific Sessions 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-17
• [学会発表] Aortic stenosis and acquired Type 2a von Willebrand syndrome : correlation between severity of aortic stenosis and gastrointestinal angiodysplasia (Heyde's syndrome) (2009)
  • 著者名/発表者名: Sowa-N, Ono K, Horie T, Iwanaga Y, Nishi H, Nagao K, Kinoshita M, Takanabe-Mori R, Kita T, Kimura T, Hasegawa K
  • 学会等名: American Heart Association Annual Scientific Sessions 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-17
• [学会発表] Let-7/miR-98 family regulates the expression fo GLUT4 by targeting Mef-2C in metabolic control of cardiomyocytes. (2009)
  • 著者名/発表者名: Tamura T, Tada T, Ono K, Horiuchi H, Kimura T
  • 学会等名: American Heart Association Annual Scientific Sessions 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-17
• [学会発表] Roles of lectin-like oxidized low-density lipoprotein (LDL) receptor-1 for maintenance of normal glucose tolerance in normal and obese states. (2009)
  • 著者名/発表者名: Takanabe-Mori R, Ono K, Sowa N, Wada H, Takaya T, Satoh N, Shimatsu A, Fujita M, Sawamura T, Hasegawa K
  • 学会等名: American Heart Association Annual Scientific Sessions 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-17
• [学会発表] The identification of the NKX2-5-regulated genes using purified ES cell-derived cardiomyocytes (2009)
  • 著者名/発表者名: Nakashima Y, Ono K, Yoshida Y, Kojima Y, Kita T, Kimura T
  • 学会等名: American Heart Association Annual Scientific Sessions 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-16
• [学会発表] Acute doxorubicin cardiomyopathy is associated with miR-146a-induced inhibition of the neuregulin-ErbB4 pathway. (2009)
  • 著者名/発表者名: Horie T, Ono K, Iwanaga Y, Nishi H, Nagao K, Kinoshita M, Kuwabara Y, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T
  • 学会等名: American Heart Association Annual Scientific Sessions 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-16
• [学会発表] Neural cell adhesion molecule is a cardioprotective factor upregulated by metabolic stress. (2009)
  • 著者名/発表者名: Nagao K, Ono K, Horie T, Nishi H, Kinoshita M, Kojima Y, Tamaki Y, Kuwabara Y, Iwanaga Y, Kita T, Kimura T
  • 学会等名: American Heart Association Annual Scientific Sessions 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-16
• [学会発表] Inhibition of histone deacetylation markedly induces myocardial differentiation of induced pluripotent stem cells in mice. (2009)
  • 著者名/発表者名: Kaichi-S, Hasegawa K, Takaya T, Morimoto T, Kawamura T, Ono K, Yokoo N, Mima T, Baba S, Doi H, Yamanaka S, Nakahata T, Heike T
  • 学会等名: American Heart Association Annual Scientific Sessions 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-16
• [学会発表] Expression of LOX-1 (OLR1) is markedly increased in the adipose tissue of high-fat diet-induced obese mice in close association with MCP-1. (2009)
  • 著者名/発表者名: Takanabe-Mori R, Ono K, Abe Y, Wada H, Takaya T, Satoh N, Shimatsu A, Fujito M, Sawamura T, Hasegawa K
  • 学会等名: American Heart Association Annual Scientific Sessions 2009
  • 発表場所: Orlando, Florida, USA
  • 年月日: 2009-11-16
• [学会発表] MicroRNA-15b, -16, 195, and -424, which have the same seed sequence, regulate ADP-rybosylation factor-like 2 and cellular ATP levels in neonatal rat cardiomyocytes (2009)
  • 著者名/発表者名: Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara-Y, Takanabe-Mori R, Hasegawa K, Takemura G, Iwanaga Y, Kita T, Kimura T
  • 学会等名: 第13回日本心不全学会
  • 発表場所: 福岡
  • 年月日: 2009-11-01
• [学会発表] Neural cell adhesion molecule is a cardioprotective factor upregulated by metabolic stress. (2009)
  • 著者名/発表者名: Nagao K, Ono K, Horie T, Nishi H, Kinoshita M, Kuwabara Y, Tamaki Y, Kojima Y, Iwanaga Y, Kita T
  • 学会等名: European Society of Cardiology ongress 2009
  • 発表場所: Barcelona, Spein
  • 年月日: 2009-09-01
• [学会発表] MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes (2009)
  • 著者名/発表者名: Horie T, Ono K, Horie T, Nishi H, Iwanaga Y, Nagao K, Kinoshita M, Kuwabara Y, Abe Y, Takanabe R, Wada H, Hasegawa K, Kita T
  • 学会等名: 第32回心筋代謝研究会
  • 発表場所: 大阪
  • 年月日: 2009-07-05
• [学会発表] Let-7/miR-98 family regulates the expression of GLUT4 by targeting Mef-2C in metabolic control of cardiomyocytes. (2009)
  • 著者名/発表者名: Sowa-N, Ono K, Horie T, Iwanaga Y, Nishi H, Nagao K, Kinoshita M, Takanabe-Mori R, Kita T, Kimura T, Hasegawa K
  • 学会等名: 第52回日本糖尿病学会年次学術集会
  • 発表場所: 京都
  • 年月日: 2009-05-23
• [学会発表] Acute doxorubicin cardiomyopathy is associated with miR-146a-induced inhibition of the neuregulin-ErbB4 pathway. (2009)
  • 著者名/発表者名: Horie T, Ono K, lwanaga Y, Nishi H, Nagao K, Kinoshita M, Kuwabara Y, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T
  • 学会等名: American Heart Association Annual Scientific Sessions
  • 発表場所: Orlando, Florida
• [学会発表] Neural cell adhesion molecule is a cardioprotective factor upregulated by metabolic stress. (2009)
  • 著者名/発表者名: Nagao K, Ono K, Horie T, Nishi H, Kinoshita M, Kojima Y, Tamaki Y, Kuwabara Y, Iwanaga Y, Kita T, Kimura T
  • 学会等名: American Heart Association Annual Scientific Sessions
  • 発表場所: Orlando, Florida
• [学会発表] MicroRNA-15b, -16, 195, and-424, which have the same seed sequence, regulate ADP-rybosylation factor-like 2 and cellular ATP levels in neonatal rat cardiomyocytes (2009)
  • 著者名/発表者名: Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara-Y, Takanabe-Mori R, Hasegawa K, Takemura G, Iwanaga Y, Kita T, Kimura T
  • 学会等名: American Heart Association Annual Scientific Sessions
  • 発表場所: Orlando, Florida
• [学会発表] MicroRNA-378, which exists intronic lesion of PGC-lbeta, deteriorate cardiomyocyte survival under oxidative stress. (2009)
  • 著者名/発表者名: Kuwabara Y, Ono K, Horie T, Nishi H, Nagao K, Watanabe S, Kojima Y, Kinoshita M, Mori R, Kita T, Kimura T
  • 学会等名: American Heart Association Annual Scientific Sessions
  • 発表場所: Orlando, Florida
• [学会発表] Let-7/miR-98 family regulates the expression of GLUT4 by targeting Mef-2C in metabolic control of cardiomyocytes. (2009)
  • 著者名/発表者名: Sowa N, Ono K, Horie T, Iwanaga Y, Nishi H, Nagao K, Kinoshita M, Takanabe-Mori R, Kita T, Kimura T, Hasegawa K
  • 学会等名: American Heart Association Annual Scientific Sessions
  • 発表場所: Orlando, Florida
• [学会発表] NF-kB-dependent induction of microRNA-146 downregulates ErbB4 and may be involved in the development of cardiomyocyte survival. (2009)
  • 著者名/発表者名: Horie T, Ono K, Iwanaga Y, Nishi H, Nagao K, Kinoshita M, Mori R, Kuwabara Y, Hasegawa K, Kita T
  • 学会等名: 第73回日本循環器学会
  • 発表場所: 大阪
• [学会発表] Neural cell adhesion molecule is upregulated by metabolic stress and enhances the cardiomyocyte survival. (2009)
  • 著者名/発表者名: Nagao K, Ono K, Horie T, Kinoshita M, Nishi H, Tamaki Y, Kuwabara Y, Iwanaga Y, Kita T.
  • 学会等名: 第73回日本循環器学会
  • 発表場所: 大阪
• [学会発表] microRNAをターゲットとした肥満に伴う心血管系疾患治療法の開発 (2008)
  • 著者名/発表者名: 尾野亘, 堀江貴裕, 西仁勇, 長央和也, 木下美菜子, 北徹
  • 学会等名: 第4回メタボリックシンドローム研究会
  • 発表場所: 東京
  • 年月日: 2008-01-19
• [学会発表] Neural cell adhesion molecule isupregulated by metabolic stress and enhances the cardiomyocyte survival rate through neurite-cardiomyocyte communication. (2008)
  • 著者名/発表者名: Nagao K, Ono K, Horie T, Kojima Y, Nishi H, Kinoshita M, Kita T
  • 学会等名: American Heart Association Annual Scientific Sessions
  • 発表場所: New Orleans, Louisiana
• [学会発表] NF-kB-dependent induction of microRNA-146 downregulates ErbB4 and may be involved in the deterioration of cardiomyocyte survival. (2008)
  • 著者名/発表者名: Horie T, Ono K, Iwanaga Y, Nishi H, Nagao K, Kinoshita M, Mori R, Hasegawa K, Kita T
  • 学会等名: American Heart Association Annual Scientific Sessions
  • 発表場所: New Orleans, Louisiana
• [学会発表] Upregulation of microRNA-27a, which downregulates retionoid X receptor a, controls cardiac myosin heavy chain gene expression in neonatal rat cardioyocyte. (2008)
  • 著者名/発表者名: Nishi H, Ono K, Kinoshita M, Nagao K, Horie T, Takanabe R, Hasegawa K, Iwanaga Y, Kita T
  • 学会等名: American Heart Association Annual Scientific Sessions
  • 発表場所: New Orleans, Louisiana
• [学会発表] Up-regulated expression of microRNA-143 in association with obesity in the adipose tissue of mice fed with high fat diet. (2008)
  • 著者名/発表者名: Takanabe R, Ono K, Takaya T, Horie T, Wada H, Kita T, Shimatsu A, Hasegawa K
  • 学会等名: American Heart Association Annual Scientific Sessions
  • 発表場所: New Orleans, Louisiana
• [学会発表] Neural cell adhesion molecule is upregulated by metabolic stress and enhances the cardiomyocyte survival rate through neurite-cardiomyocyte communication (2008)
  • 著者名/発表者名: Nagao K, Ono K, Horie T, Koj ima Y, Nishi H, Kinoshita M, Kita T
  • 学会等名: American Heart Association Annual Scientific Sessions
  • 発表場所: New Orleans, Louisiana
• [学会発表] NF-kB-dependent induction of microRNA-146 downregulates ErbB4 and may be involved in the deterioration of cardiomyocyte survival (2008)
  • 著者名/発表者名: Horie T, Ono K, Iwanaga Y, NishiH, Nagao K, Kinoshita M, Mori R, Hasegawa K, Kita T
  • 学会等名: American Heart Association Ammual Scientific Sessions
  • 発表場所: New Orleans, Louisiana
• [学会発表] Upregulation of microRNA-27a, which downregulates retionoid X receptor a, controls cardiac myosin heavy chain gene expression in neonatal rat cardioyocyte (2008)
  • 著者名/発表者名: Nishi H, Ono K, Kinoshita M, Nagao K, Horie T, Takanabe R, Hasegawa K, Iwanaga Y, Kita T
  • 学会等名: American Heart Association Annual Scientific Sessions
  • 発表場所: New Orleans, Louisiana
• [学会発表] Up-regulatex expression of microaRNA-143 in association with obesity in the adipose tissue of mice fed with high fat diet (2008)
  • 著者名/発表者名: Takanabe R, Ono K, Takaya T, Horie T, Wada H, Kita T, Shimatsu A, Hasegawa K
  • 学会等名: American Heart Association Annual Scientific Sessions
  • 発表場所: New Orleans, Louisiana
• [学会発表] IGF axis and adiponectin as prognostic markers of patients with congestive heart failure (2008)
  • 著者名/発表者名: Watanabe S, Tamura T, Ono K, Kita T, Kimura T, Furukawa Y
  • 学会等名: European Society of Cardiology Congres
  • 発表場所: Munich, Germany
• [学会発表] Upregulation of microRNA targeting retionoid X receptor a contributes to development of cardiachypertrophy (2008)
  • 著者名/発表者名: Nishi H, Ono K, Horie T. Kinoshita M. Nagao K, Iwanaga Y, Hasegawa K, Kita T
  • 学会等名: 第72回日本循環器学会
  • 発表場所: 福岡
• [学会発表] MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control incardiac myocytes (2008)
  • 著者名/発表者名: Horie T, Ono K, Kinoshita M, Nishi H, Nagao K, Mori R, Iwanaga Y, Hasegawa K, Kita T
  • 学会等名: 第72回日本循環器学会
  • 発表場所: 福岡
• [学会発表] Overexpression of microRNA-1 in mouse embryonic stem cells represses myocardial differentiation (2008)
  • 著者名/発表者名: Takaya-T, Kawamura T, Ono K, Takanabe R, Kaichi S, Kita T, Wada H, Morimoto T, Shimatsu A, Hasegawa K
  • 学会等名: 第72回日本循環器学会
  • 発表場所: 福岡
• [学会発表] A soluble VEGF receptor-2 is possible novel biomarker of cardiovascular risk in the metabolic syndrome. (2008)
  • 著者名/発表者名: Wada H, Satoh N, Ono K, Shinjo D, Morimoto T, Nakano T, Shimatsu A, Fujita M, Hasegawa K
  • 学会等名: 第72回日本循環器学会
  • 発表場所: 福岡
• [学会発表] Cyclin-dependent kinase-9 is required for the differentiation of mouse ES cells into cardiac myocytes. (2008)
  • 著者名/発表者名: Kaichi S, Takaya T, Sunagawa Y, Kawamura T, Ono K, Moriraoto T, Kita T, Baba S, Hidaka K, Morisaki T, Heike T, Nakahata T, Shimatsu A, Hasegawa K
  • 学会等名: 第72回日本循環器学会
  • 発表場所: 福岡
• [学会発表] miR-133は心筋細胞における代謝調節においてKLF15をターゲットとしてGLUT4の発現を制御している. (2008)
  • 著者名/発表者名: 堀江貴裕, 尾野亘, 西仁勇, 長央和也, 木下美菜子, 森利依子, 岩永善高, 長谷川浩二, 北徹
  • 学会等名: 第45回日本臨床分子医学会学術集会
  • 発表場所: 神戸
• [学会発表] miR-27aはラット心筋細胞においてミオシン重鎖の発現を制御する (2008)
  • 著者名/発表者名: 西仁勇, 尾野亘, 木下美菜子, 長央和也, 堀江貴裕, 岩永善高, 森利依子, 長谷川浩二, 北徹
  • 学会等名: 第45回本臨床分子医学会学術集会
  • 発表場所: 神戸
• [学会発表] microRNA-1の過剰発現はマウスES細胞の心筋分化を抑制する (2008)
  • 著者名/発表者名: 高谷智英, 川村晃久, 尾野亘, 高鍋利依子, 鶏内伸二, 馬場志郎, 平家俊男, 中畑龍俊, 森本達也, 北徹, 島津章, 長谷川浩二
  • 学会等名: 第45回日本臨床分子医学会学術集会
  • 発表場所: 神戸
• [学会発表] Trapping genes that encode secreted and transmembrane proteins in H9C2 cardiomyoblasts. (2008)
  • 著者名/発表者名: Nagao K, Ono K, Horie T, Nishi H, Kinoshita M, Hasegawa K, Kita T
  • 学会等名: 第31回心筋代謝研究会
  • 発表場所: 東京
• [図書] Micro RNA-33を介したHDL-コレステロール調節のあらたなメカニズム.医学のあゆみ(237) (2011)
  • 著者名/発表者名: 尾野亘、木村剛
• [図書] miRNA-33は生体内でHDLコレステロールを制御する 実験医学(29(4)) (2011)
  • 著者名/発表者名: 尾野亘、堀江貴裕、木村剛、北徹
• [図書] SREBP2のイントロンにコードされるマイクロRNA-33は生体においてHDL形成を制御するTherapeutic Research(32(6)) (2011)
  • 著者名/発表者名: 尾野亘
• [図書] 「心筋梗塞モデル(小動物)」循環器疾患-疾患モデルの作成と利用 (2010)
  • 著者名/発表者名: 尾野亘
  • 出版者: Life Science Information center.
• [図書] Biology topics. MicroRNAと心疾患. Bio Clinica.(25(6)) (2010)
  • 著者名/発表者名: 尾野亘、木村剛
• [図書] Biology topics.MicroRNAと心疾患 (2010)
  • 著者名/発表者名: 尾野亘、木村剛
  • 総ページ数: 4
  • 出版者: Bio Clinica
• [図書] 「心筋梗塞モデル(小動物)」循環器疾患-疾患モデルの作成と利用 (2010)
  • 著者名/発表者名: 尾野亘
  • 総ページ数: 5
  • 出版者: Life Science Information center
• [図書] 分子心血管病「メタボリックシンドロームと冠動脈イベントのリスク」 (2009)
  • 著者名/発表者名: 尾野亘、木村剛
  • 総ページ数: 9
  • 出版者: 先端医学社
• [備考] ホームページ等
  • URL: http://kyoto-u-cardio.jp/kisokenkyu/metabolic/
• [備考]
  • URL: http://kyoto-u-cardio.jp/kisokenkyu/metabolic/
• [備考]
  • URL: http://kyoto-u-cardio.ip/kisokenkyu/metabolic/