NOTCH-FABP経路は心臓毛細血管内皮細胞の脂肪酸能動輸送を制御する

• 研究課題/領域番号: 20590877
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 循環器内科学
• 研究機関: 群馬大学
• 研究代表者: 磯 達也 群馬大学, 大学院・医学系研究科, 助教 (10400756)
• 研究分担者: 倉林 正彦 群馬大学, 大学院・医学系研究科, 教授 (00215047)
• 研究期間 (年度): 2008 – 2010
• 研究課題ステータス: 完了 (2010年度)
• 配分額: 4,680千円 (直接経費: 3,600千円、間接経費: 1,080千円); 2010年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円); 2009年度: 1,690千円 (直接経費: 1,300千円、間接経費: 390千円); 2008年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
• キーワード: 毛細血管 / 内皮細胞 / 脂肪酸代謝 / Notchシグナル / FABP4 / FABP5 / PPAR-・ / 経内皮的脂肪酸輸送 / 筋型毛細血管内皮細胞 / EABP5 / 脂肪酸 / グルコース / 毛細血管内皮細胞 / PPAR-γ / 能動輸送

研究概要

エネルギー代謝とその異常は臓器を形成する実質細胞にのみ焦点が当てられてきたが、本研究では筋型毛細血管内皮細胞に焦点を当てた。筋型毛細血管内皮細胞にはFABP4/FABP5が発現し、経内皮的脂肪酸輸送において重要な役割を担う。また、筋型毛細血管内皮細胞にはNotchシグナル構成因子やPPAR・が発現し、FABP4の発現誘導を介して経内皮的脂肪酸輸送を制御する。本研究では、経内皮的脂肪酸輸送機構の概念を提唱し、新たな治療戦略の可能性を示した。

研究成果

• [雑誌論文] Identification of Six Novel SCN5A Mutations in Japanese Patients with Brugada Syndrome. (2011)
  • 著者名/発表者名: Tadashi Nakajima
  • 雑誌名: Int Heart J 巻: 52 ページ: 27-341
  • 査読あり
• [雑誌論文] Hypoxia-inducible factor-1 {alpha} mediates TGF-{beta}-induced PAI-1 production in alveolar macrophages in pulmonary fibrosis. (2011)
  • 著者名/発表者名: Manabu Ueno
  • 雑誌名: Am J Physiol Lung Cell Mol Physiol. 巻: in press
  • 査読あり
• [雑誌論文] Post myocardial ischemia-associated torsades de pointes in a patient carrying a KCNQ1 G643S variant. (2011)
  • 著者名/発表者名: Tadashi Nakajima
  • 雑誌名: Intern Med 巻: 49 ページ: 2587-2591
  • 査読あり
• [雑誌論文] Multiple Spontaneous Coronary Artery Ruptures and Cardiac Tamponade in Vascular Ehlers-Danlos Syndrome. (2011)
  • 著者名/発表者名: Yoshiaki Ohyama
  • 雑誌名: Journal of Cardiology Cases 巻: in press
  • 査読あり
• [雑誌論文] Notch Induces Myofibroblast Differentiation of Alveolar Epithelial Cells via TGF-b/Smad3 Pathway. (2011)
  • 著者名/発表者名: Kana Aoyagi-Ikeda
  • 雑誌名: Am J Respir Cell Mol Biol. 巻: in press
  • 査読あり
• [雑誌論文] Multiple Spontaneous Coronary Artery Ruptures and Cardiac Tamponade in Vascular Ehlers-Danlos Syndrome. (2010)
  • 著者名/発表者名: Yoshiaki Ohyama, Tatsuya Iso,, Adriana Carolina Vargas Nino, Masaru Obokata, Rieko Takahashi, Wataru Okumura, Akihiko Nakano, Masao Amano, Isao Naito, Masamitsu Takatama, Masahiko Kurabayashi
  • 雑誌名: Journal of Cardiology Cases (in press)
  • 査読あり
• [雑誌論文] Post myocardial ischemia-associated torsades de pointes in a patient carrying a KCNQ1 G643S variant. (2010)
  • 著者名/発表者名: Nakajima T, Kaneko Y, Saito A, Irie T, Kato T, Iso T, Kurabayashi M
  • 雑誌名: Intern Med. 49(23)(Epub 2010 Dec 1.) ページ: 2587-91
  • NAID: 130000413404
  • 査読あり
• [雑誌論文] Notch Induces Myofibroblast Differentiation of Alveolar Epithelial Cells via TGF-ss/Smad3 Pathway. (2010)
  • 著者名/発表者名: Aoyagi-Ikeda K, Maeno T, Matsui H, Ueno M, Hara K, Aoki Y, Aoki F, Shimizu T, Doi H, Kawai-Kowase K, Iso T,, Suga T, Arai M, Kurabayashi M
  • 雑誌名: Am J Respir Cell Mol Biol. (Epub ahead)
  • 査読あり
• [雑誌論文] Aborted cardiac arrest in a patient carrying KCNE1 D85N variant during the postpartum period. (2010)
  • 著者名/発表者名: Nakajima T, Kaneko Y, Manita M, Iso T, Kurabayashi M
  • 雑誌名: Intern Med. 49(17) ページ: 1875-8
  • NAID: 130000336868
  • 査読あり
• [雑誌論文] Fibroblast Growth Factor 2 Induces Osteogenic Differentiation through a Runx2 Activation in Vascular Smooth Muscle Cells. (2010)
  • 著者名/発表者名: Nakahara T, Sato H, Shimizu T, Tanaka T, Matsui H, Kawai-Kowase K, Sato M, Iso T, Arai M, Kurabayashi M
  • 雑誌名: Biochem Biophys Res Commun. 394(2) ページ: 243-8
  • 査読あり
• [雑誌論文] Aborted cardiac arrest in a patient carrying KCNE1 D85N variant during the postpartum period. (2010)
  • 著者名/発表者名: Tadashi Nakajima
  • 雑誌名: Intern Med. 巻: 49 ページ: 1875-1878
  • 査読あり
• [雑誌論文] Fibroblast Growth Factor 2 Induces Osteogenic Differentiation through a Runx2 Activation in Vascular Smooth Muscle Cells. (2010)
  • 著者名/発表者名: Takehiro Nakahara
  • 雑誌名: Biochem Biophys Res Commun. 巻: 394 ページ: 243-248
  • 査読あり
• [雑誌論文] Marked high density lipoprotein deficiency due to apolipoprotein A-I Tomioka (codon 138 deletion). (2009)
  • 著者名/発表者名: Wada M, Iso T,, Asztalos BF, Takama N, Nakajima T, Seta Y, Kaneko K, Taniguchi Y, Kobayashi H, Nakajima K, Schaefer EJ, Kurabayashi M
  • 雑誌名: Atherosclerosis. 207(1) ページ: 157-161
  • 査読あり
• [雑誌論文] Notch signaling induces osteogenic differentiation and mineralization of vascular smooth muscle cells : role of Msx2 gene induction via Notch-RBP-Jk signaling. (2009)
  • 著者名/発表者名: Shimizu T, Tanaka T, Iso T, Doi H, Sato H, Kawai-Kowase K, Arai M, Kurabayashi M
  • 雑誌名: Arterioscler Thromb Vasc Biol. 29(7) ページ: 1104-11
  • 査読あり
• [雑誌論文] Notch signaling regulates the differentiation of bone marrow-derived cells into smooth muscle-like cells during arterial lesion formation. (2009)
  • 著者名/発表者名: Doi H, Iso T, Shiba Y, Sato H, Yamazaki M, Oyama Y, Akiyama H, Tanaka T, Tomita T, Arai M, Takahashi M, Ikeda U, Kurabayashi M
  • 雑誌名: Biochem Biophys Res Commun. 381 ページ: 654-659
  • 査読あり
• [雑誌論文] IAS1 Mediates TGF{beta}-Induced SM {alpha}-Actin Gene Expression Through Inhibition of KLF4 Function-Expression by Protein Sumoylation. (2009)
  • 著者名/発表者名: Kawai-Kowase K, Ohshima T, Matsui H, Tanaka T, Shimizu T, Iso T, Arai M, Owens GK, Kurabayashi M
  • 雑誌名: Arterioscler Thromb Vasc Biol. 29(1) ページ: 99-106
  • 査読あり
• [雑誌論文] Marked high density lipoprotein deficiency due to apolipoprotein A-I Tomioka(codon 138 deletion). (2009)
  • 著者名/発表者名: Wada M, Iso T, Asztalos BF, Takama N, Nakajima T, Seta Y, Kaneko K, Taniguchi Y, Kobayashi H, Nakajima K, Schaefer EJ, Kurabayashi M.
  • 雑誌名: Atherosclerosis 207(1) ページ: 157-161
  • 査読あり
• [雑誌論文] Notch signaling induces osteogenic differentiation and mineralization of vascular smooth muscle cells : role of Msx2 gene induction via Notch-RBP-Jk signaling. (2009)
  • 著者名/発表者名: Shimizu T, Tanaka T, Iso T, Doi H, Sato H, Kawai-Kowase K, Arai M, Kurabayashi M.
  • 雑誌名: Arterioscler Thromb Vasc Biol. 29(7) ページ: 1104-11
  • 査読あり
• [雑誌論文] Notch signaling regulates the differentiation of bone marrow-derived cells into smooth muscle-like cells during arterial lesion formation. (2009)
  • 著者名/発表者名: Doi H, Iso T, Shiba Y, Sato H, Yamazaki M, Oyama Y, Akiyama H, Tanaka T, Tomita T, Arai M, Takahashi M, Ikeda U, Kura bayashi M.
  • 雑誌名: Biochem Biophys Res Commun. 381 ページ: 654-659
  • 査読あり
• [雑誌論文] Notch signaling regulates the differentiation of bone marrow-derived cells into smooth muscle-like cells during arterial lesion for mation. (2009)
  • 著者名/発表者名: Doi H, Iso T, Shiba Y, Sato H, Yamazaki M, Oyama Y, Akiyama H, Tanaka T, Tomita T, Arai M, Takahashi M, Ikeda U, Kurabayashi M.
  • 雑誌名: Biochem Biophys Res Commun. (in press)
  • 査読あり
• [雑誌論文] PIAS1 Mediates TGF{beta}-Induced SM {alpha}-Actin Gene Expression Through Inhibition of KLF4 Function-Expression by Protein Sumoylation. (2009)
  • 著者名/発表者名: Kawai-Kowase K, Ohshima T, Matsui H, Tanaka T, Shimizu T, Iso T, Arai M, Owens GK, Kurabayashi M.
  • 雑誌名: Arterioscler Thromb Vasc Biol. 29 ページ: 99-106
  • 査読あり
• [雑誌論文] Prostaglandin F2alpha inhibits SERCA2 gene transcription through an induction of Egr-1 in cultured neonatal rat cardiac myocytes. (2008)
  • 著者名/発表者名: Hara S, Arai M, Tomaru K, Doi H, Koitabashi N, Iso T, Watanabe A, Tanaka T, Maeno T, Suga T, Yokoyama T, Kurabayashi M
  • 雑誌名: Int Heart J. 49(3) ページ: 329-42
  • NAID: 130000069021
  • 査読あり
• [雑誌論文] Effects of a stable prostacyclin analogue beraprost sodium on VEGF and PAI-1 gene expression in vascular smooth muscle cells. (2008)
  • 著者名/発表者名: Atsuta H, Uchiyama T, Kanai H, Iso T, Tanaka T, Suga T, Maeno T, Arai M, Nagai R, Kurabayashi M
  • 雑誌名: Int J Cardiol. 132(3) ページ: 411-8
  • 査読あり
• [雑誌論文] Runx2 Represses Myocardin-mediated Differentiation and Facilitates Osteogenic Conversion of Vascular Smooth Muscle Cells. (2008)
  • 著者名/発表者名: Tanaka T, Sato H, Doi H, Yoshida CA, Schimizu T, Matsui H, Yamazaki M, Akiyama H, Kawai-Kowase K, Iso T, Komori T, Arai M, Kurabayashi M
  • 雑誌名: Mol Cell Biol. 28(3) ページ: 1147-60
• [雑誌論文] PPARsと動脈硬化 (2008)
  • 著者名/発表者名: 磯達也、倉林正彦
  • 雑誌名: 炎症と免疫 16 ページ: 67-73
• [雑誌論文] 胸痛 (2008)
  • 著者名/発表者名: 磯達也
  • 雑誌名: 看護に役立つ疾患・症候辞典 ページ: 1501-1505
• [雑誌論文] Prostaglandin F2alpha inhibits SERCA2 gene transcription through an induction of Egr-1 in cultured neonatal rat cardiac myocytes. (2008)
  • 著者名/発表者名: Hara S, Arai M, Tomaru K, Doi H, Koitabashi N, Iso T, Watanabe A, Tanaka T, Ma eno T, Suga T, Yokoyama T, Kurabayashi M.
  • 雑誌名: Int Heart J. 49 ページ: 329-342
  • NAID: 130000069021
  • 査読あり
• [雑誌論文] Effects of a stable prostacyclin analogue beraprost sodium on VEGF and PAI-1 gene expression in vascular smooth muscle cells. (2008)
  • 著者名/発表者名: Atsuta H, Uchiyama T, Kanai H, Iso T, Tanaka T, Suga T, Maeno T, Arai M, Nagai R, Kurabayashi M.
  • 雑誌名: Int Heart J. 132 ページ: 411-418
  • 査読あり
• [学会発表] Elongation of long chain fatty acid member-6 protects from osteogenic differentiation and apoptosis in vascular smooth muscle cells (2011)
  • 著者名/発表者名: Hiroki Matsui
  • 学会等名: 第75回日本循環器学会
  • 発表場所: 横浜
  • 年月日: 2011-03-20
• [学会発表] Peroxisome Proliferator Activated Receptor-y Regulates Trans-endothelial Fatty Acid Transport in Capillary Endothelial Cells in Heart and Adipose Tissue (2011)
  • 著者名/発表者名: Kosaku Goto
  • 学会等名: 第75回日本循環器学会
  • 発表場所: 横浜
  • 年月日: 2011-03-20
• [学会発表] Peroxisome Proliferator Activated Receptor-Alpha regulates Trans-endothelial Fatty Acid Transport in Capillary Endothelial Cells in Heart (2011)
  • 著者名/発表者名: Yasunori Irie
  • 学会等名: 第75回日本循環器学会
  • 発表場所: 横浜
  • 年月日: 2011-03-20
• [学会発表] Blockade of trans-endothelial fatty acid transport and compensated glucose utilization in the myocardium prevent heart failure in septic mice (2011)
  • 著者名/発表者名: Anwarul Hague
  • 学会等名: 第75回日本循環器学会
  • 発表場所: 横浜
  • 年月日: 2011-03-19
• [学会発表] Physiological cardiac hypertrophy evoked by markedly increased glucose consumption in mice lacking both fatty acid binding protein 4 and-5 (2011)
  • 著者名/発表者名: Tatsuya Iso
  • 学会等名: 第75回日本循環器学会
  • 発表場所: 横浜
  • 年月日: 2011-03-18
• [学会発表] Peroxisome Proliferator Activated Receptor Gamma Regulates Trans-endothelial Fatty Acid Transport via Induction of Fatty Acid Binding Protein 4 and Fatty Acid Translocase in Capillary Endothelial Cells in Heart and Adiose Tissue. (2010)
  • 著者名/発表者名: Goto K, Tatsuya Iso T, Hanaoka H, Suga T, Matsui H, Arai M, Endo K, Frank J Gonzalez, Kurabayashi M.
  • 学会等名: Annual meeting of American Heart Association, Chicago
  • 発表場所: McCormick Place (Chicago, USA).
  • 年月日: 2010-11-17
• [学会発表] Peroxisome Proliferat or Activated Receptor Gamma Regulates Trans-endothelial Fatty Acid Transport via Induction of Fatty Acid Binding Protein 4 and Fatty Acid Translocase in Capillary Endothelial Cells in Heart and Adiose Tissue (2010)
  • 著者名/発表者名: Kosaku Goto
  • 学会等名: Annual meeting of American Heart Association
  • 発表場所: Chicago, USA
  • 年月日: 2010-11-17
• [学会発表] 筋型毛細血管内皮細胞に発現するEABP4/5は経内皮的脂肪酸輸送を制御する (2010)
  • 著者名/発表者名: 磯達也
  • 学会等名: 第31回日本肥満学会
  • 発表場所: 前橋
  • 年月日: 2010-10-01
• [学会発表] Notch signaling enhances BMP2-induced osteogenic differentiation of vascular smooth muscle cells and vascular calcification (2010)
  • 著者名/発表者名: Shimizu T, Tanaka T, Iso T, Kurabayashi M.
  • 学会等名: XX^<th> World Congress International Society for Heart Research (ISHR)
  • 発表場所: Kyoto International Conference Center.(Kyoto)
  • 年月日: 2010-05-16
• [学会発表] Elevated stearoyl-CoA desaturase-1 expression in obese and diabetic heart plays a protective role against fatty acid-induced cardiac dysfunction (2010)
  • 著者名/発表者名: Matsui H, Yokoyama T, Iijima D, Maniwa M, Iso T, Arai M, Kurabayashi M.
  • 学会等名: XX^<th> World Congress International Society for Heart Research (ISHR)
  • 発表場所: Kyoto International Conference Center (Kyoto).
  • 年月日: 2010-05-16
• [学会発表] Notch-peroxisome proliferator activated receptor-gamma2 pathway regulates transendothelial fatty acid transport in capillary endothelial cells in heart (2010)
  • 著者名/発表者名: Goto K, Iso T, Suga T, Matsui H, Arai M, Kurabayashi M.
  • 学会等名: XX^<th> World Congress International Society for Heart Research (ISHR)
  • 発表場所: Kyoto International Conference Center.(Kyoto)
  • 年月日: 2010-05-16
• [学会発表] A possible role of transendothelial glycerol transport through aquaporin 7 regulated by peroxisome proliferated activator reveptor-gamma (2010)
  • 著者名/発表者名: Haque A, Iso T, Kunimoto F, Saito S, Kurabayashi M.
  • 学会等名: XX^<th> World Congress International Society for Heart Research (ISHR)
  • 発表場所: Kyoto International Conference Center.(Kyoto)
  • 年月日: 2010-05-16
• [学会発表] Notch signaling enhances BMP2-induced osteogenic differentiation of vascular smooth muscle cells and vascular calcifications (2010)
  • 著者名/発表者名: Takehisa Shimizu
  • 学会等名: XX^<th> World Congress International Society for Heart Research (ISHR)
  • 発表場所: Kyoto
  • 年月日: 2010-05-16
• [学会発表] Elevated stearoyl-CoA desaturase-1 expression in obese and diabetic heart plays a protective role against fatty arid-induced cardiac dysfunction (2010)
  • 著者名/発表者名: Matsui Hiroki
  • 学会等名: XX^<th> World Congress International Society for Heart Research (ISHR)
  • 発表場所: Kyoto
  • 年月日: 2010-05-16
• [学会発表] Notch-peroxisome proliferator activated receptor-gamma2 pathway regulates transendothelial fatty acid transport in capillary endothelial cells in heart. (2010)
  • 著者名/発表者名: Kosaku Gotc
  • 学会等名: XX^<th> World Congress International Society for Heart Research (ISHR)
  • 発表場所: Kyoto
  • 年月日: 2010-05-16
• [学会発表] A possible role of transendothelial glycerol transport through aquaporin 7 regulated by peroxisome proliferated activator reveptor-gamma (2010)
  • 著者名/発表者名: Anwarul Hague
  • 学会等名: XX^<th> World Congress International Society for Heart Research (ISHR)
  • 発表場所: Kyoto
  • 年月日: 2010-05-16
• [学会発表] Muscle-type capillary endothelial cells actively transport fatty acids via intracellular fatty acid binding protein-4 and -5 (2010)
  • 著者名/発表者名: Iso T, Maeda K, Hanaoka H, Suga T, Matsui H, Goto K, Arai M, Endo K, Gokhan H, Kurabayashi M.
  • 学会等名: XX^<th> World Congress International Society for Heart Research (ISHR)
  • 発表場所: Kyoto International Conference Center.(Kyoto)
  • 年月日: 2010-05-14
• [学会発表] Muscle-type capillary endothelial cells actively transport fatty acids via intracellular fatty acid binding protein-4 and-5 (2010)
  • 著者名/発表者名: Tatsuya Iso
  • 学会等名: XX^<th> World Congress International Society for Heart Research (ISHR)
  • 発表場所: Kyoto
  • 年月日: 2010-05-14
• [学会発表] Runx2 suppresses atrial and B-type natriuretic peptide gene expression in rat cardiac myocytes. (2010)
  • 著者名/発表者名: Nakahara T, Shimizu T, Tanaka T, Kowase K, Iso T, Arai M, Kurabayashi M.
  • 学会等名: XX^<th> World Congress International Society for Heart Research (ISHR)
  • 発表場所: Kyoto International Conference Center.(Kyoto)
  • 年月日: 2010-05-13
• [学会発表] Steroyl-CoA desaturase-1 has a protective effect against saturated fatty acids-induced osteogenic differentiation and apoptosis in vascular smooth muscle cells (2010)
  • 著者名/発表者名: Matsui H, Yokoyama T, Gotoh Y, Iso T, Arai M, Kurabayashi M.
  • 学会等名: XX^<th> World Congress International Society for Heart Research (ISHR)
  • 発表場所: Kyoto International Conference Center(Kyoto).
  • 年月日: 2010-05-13
• [学会発表] Runx2 suppresses atrial and B-type natriuretic peptide gene expression in rat cardiac myocytes (2010)
  • 著者名/発表者名: Takehiro Nakahara
  • 学会等名: XX^<th> World Congress International Society for Heart Research (ISHR)
  • 発表場所: Kyoto
  • 年月日: 2010-05-13
• [学会発表] Osteogenic Transcription Factor Runx2 Suppresses Atrial and B-type Natriuretic Peptide Gene Expression in Rat Cardiac Myocytes. (2010)
  • 著者名/発表者名: Takehiro Nakahara, Takehisa Shimizu, Toru Tanaka, Keiko Kowase, Tatsuya Iso, Masashi Arai, Masahiko Kurabayashi
  • 学会等名: The 74th Annual Scientific Meeting of the Japanese Circulation Society
  • 発表場所: Kyoto International Conference Center (Kyoto).
  • 年月日: 2010-03-07
• [学会発表] Identification of Four Novel Mutations in SCN5A in Brugada Syndrome. (2010)
  • 著者名/発表者名: Tadashi Nakajima, Yoshiaki Kaneko, Akohiko Saitoh, Tadanobu Irie, Tatsuya Iso, Masahiko Kurabayashi
  • 学会等名: The 74th Annual Scientific Meeting of the Japanese Circulation Society
  • 発表場所: Kyoto International Conference Center(Kyoto).
  • 年月日: 2010-03-07
• [学会発表] Peroxisome Proliferator Activated Receptor-Alpha Regulates Transendothelial Fatty Acid Transport in Capillary Endothelial Cells in Heart. (2010)
  • 著者名/発表者名: Yuji Shinagawa, Tatsuya Iso, Hiroki Matsui, Tomoyuki Yokoyama, Masahiko Kurabayashi
  • 学会等名: The 74th Annual Scientific Meeting of the Japanese Circulation Society
  • 発表場所: Kyoto International Conference Center(Kyoto).
  • 年月日: 2010-03-07
• [学会発表] Osteogenic Transcription Factor Runx2 Suppresses Atrial and B-type Natriuretic Peptide Gene Expression in Rat Cardiac Myocytes (2010)
  • 著者名/発表者名: Takehiro Nakahara, Takehisa Shimizu, Toru Tanaka, Keiko Kowase, Tatsuya Iso, Masashi Arai, Masahiko Kurabayashi
  • 学会等名: 第74回 日本循環器病学会総会・学術集会
  • 発表場所: 京都国際会館
  • 年月日: 2010-03-07
• [学会発表] Runx2 inhibits TGF-induced Connective Tissue Growth Factor Gene Expression through Physical Association with Smad3 in Vascular Smooth Muscle Cells (2010)
  • 著者名/発表者名: Yoshiaki Oyama, Toru Tanaka, Takehisa Shimizu, Hiroko Sato, Norimichi Koitabashi, Hiroshi Doi, Tatsuya Iso, Masashi Arai, Masahiko Kurabayashi
  • 学会等名: 第74回 日本循環器病学会総会・学術集会
  • 発表場所: 京都国際会館
  • 年月日: 2010-03-07
• [学会発表] Bone Morphogenetic Proteins Works as Instructive Signals to Specify Smooth Muscle Cell Differentiation Induced by Notch Signaling. (2010)
  • 著者名/発表者名: Takehisa Shimizu, Toru Tanaka, Takehiro Nakahara, Tatsuya Iso, Masashi Arai, Masahiko Kurabayashi
  • 学会等名: The 74th Annual Scientific Meeting of the Japanese Circulation Society
  • 発表場所: KyotoInternational Conference Center(Kyoto).
  • 年月日: 2010-03-06
• [学会発表] Muscle-Type Capillary Endothelial Cells Actively Transport Fatty Acids via Intracellular Fatty Acid Binding Protein-4 and -5. (2010)
  • 著者名/発表者名: Tatsuya Iso, Kazuhisa Maeda, Hirofumi Hanaoka, Toshihiro Suga, Hiroki Matsui, Kosaku Goto, Masashi Arai, Keigo Endo, Gohkan Hotamisligil, Masahiko Kurabayashi
  • 学会等名: The 74th Annual Scientific Meeting of the Japanese Circulation Society
  • 発表場所: Kyoto International Conference Center(Kyoto).
  • 年月日: 2010-03-06
• [学会発表] Notch and BMP2 Signalings Cooperatively Enhance Runx2-mediated Induction of Osteoblastic Phenotype in Vascular Smooth Muscle Cells (2010)
  • 著者名/発表者名: Takehisa Shimizu, Toru Tanaka, Keiko Kowase, Tatsuya Iso, Masashi Arai, Masahiko Kurabayashi
  • 学会等名: 第74回 日本循環器病学会総会・学術集会
  • 発表場所: 京都国際会館
  • 年月日: 2010-03-06
• [学会発表] Bone Morphogenetic Proteins Works as Instructive Signals to Specify Smooth Muscle Cell Differentiation Induced by Notch Signaling (2010)
  • 著者名/発表者名: Takehisa Shimizu, Toru Tanaka, Takehiro Nakahara, Tatsuya Iso, Masashi Arai, Masahiko Kurabayashi
  • 学会等名: 第74回 日本循環器病学会総会・学術集会
  • 発表場所: 京都国際会館
  • 年月日: 2010-03-06
• [学会発表] Identification of Four Novel Mutations in SCN5A in Brugada Syndrome (2010)
  • 著者名/発表者名: Tadashi Nakajima, Yoshiaki Kaneko, Akohiko Saitoh, Tadanobu Irie, Tatsuya Iso, Masahiko Kurabayashi
  • 学会等名: 第74回 日本循環器病学会総会・学術集会
  • 発表場所: 京都国際会館
  • 年月日: 2010-03-06
• [学会発表] Peroxisome Proliferator Activated Receptor-Alpha Regulates Transendothelial Fatty Acid Transport in Capillary Endothelial Cells in Heart (2010)
  • 著者名/発表者名: Yuji Shinagawa, Tatsuya Iso, Hiroki Matsui, Tomoyuki Yokoyama, Masahiko Kurabayashi
  • 学会等名: 第74回 日本循環器病学会総会・学術集会
  • 発表場所: 京都国際会館
  • 年月日: 2010-03-06
• [学会発表] Notch and BMP2 Signalings Cooperatively Enhance Runx2-mediated Induction of Osteoblastic Phenotype in Vascular Smooth Muscle Cells. (2010)
  • 著者名/発表者名: Takehisa Shimizu, Toru Tanaka, Keiko Kowase, Tatsuya Iso, Masashi Arai, Masahiko Kurabayashi
  • 学会等名: The 74th Annual Scientific Meeting of the Japanese Circulation Society
  • 発表場所: Kyoto International Conference Center(Kyoto).
  • 年月日: 2010-03-05
• [学会発表] Muscle-Type Capillary Endothelial Cells Actively Transport Fatty Acida via Intracellular Fatty Acid Binding Protein-4 and -5 (2010)
  • 著者名/発表者名: Tatsuya Iso, Kazuhisa Maeda, Hirofumi Hanaoka, Toshihiro Suga, Hiroki Matsui, Kosaku Goto, Masashi Arai, Keigo Endo, Gohkan Hotamisligil, Masahiko Kurabayashi
  • 学会等名: 第74回 日本循環器病学会総会・学術集会
  • 発表場所: 京都国際会館
  • 年月日: 2010-03-05
• [学会発表] Runx2 Inhibits TGF・-induced Connective Tissue Growth Factor Gene Expression Through Physical Association with Smad3 in Vascular Smooth Muscle Cells (2009)
  • 著者名/発表者名: Yoshiaki Oyama, Toru Tanaka, Takehisa Shimizu, Hiroko Sato, Norimichi Koitabashi, Hiroshi Doi, Tatsuya Iso, Masashi Arai, Masahiko Kurabayashi
  • 学会等名: Annual meeting of American Heart Association
  • 発表場所: Orange County Convention Center(Orlando, USA).
  • 年月日: 2009-11-18
• [学会発表] Runx2 Inhibits TGFβ-induced Connective Tissue Growth Factor Gene Expression Through Physical Association with Smad3 in Vascular Smooth Muscle Cells (2009)
  • 著者名/発表者名: Yoshiaki Oyama, Toru Tanaka, Takehisa Shimizu, Hiroko Sato, Norimichi Koitabashi, Hiroshi Doi, Tatsuya Iso, Masashi Arai, Masahiko Kurabayashi
  • 学会等名: Annual meeting of American Heart Association
  • 発表場所: Orland, U.S.A.
  • 年月日: 2009-11-18
• [学会発表] Notch-Peroxisome Proliferator Activated Receptor Gamma2 Pathway Regulates Transendothelial Fatty Acid Transport via Induction of Fatty Acid Binding Protein 4 and Fatty Acid Translocase in Capillary Endothelial Cells in Heart. (2009)
  • 著者名/発表者名: Kosaku Goto, Tatsuya Iso, Toshihiro Suga, Hiroki Matsui, Masashi Arai, Frank J Gonzalez, Masahiko Kurabayashi
  • 学会等名: Annual meeting of American Heart Association
  • 発表場所: Orange County Convention Center(Orlando, USA).
  • 年月日: 2009-11-17
• [学会発表] Bone Morphogenetic Protein-2 (BMP-2) and BMP-7 Act as Instructive Factors to Specify Notch Signaling Controlling Smooth Muscle Cell Phenotype. (2009)
  • 著者名/発表者名: Takehisa Shimizu, Toru Tanaka, Tatsuya Iso, Keiko Kawai-Kowase, Masahiko Kurabayashi
  • 学会等名: Annual meeting of American Heart Association
  • 発表場所: Orange County Convention Center(Orlando, USA).
  • 年月日: 2009-11-17
• [学会発表] Notch-Peroxisome Proliferator Activated Receptor Gamma2 Pathway Regulates Transendothelial Fatty Acid Transport via Induction of Fatty Acid Binding Protein 4 and Fatty Acid Translocase in Capillary Endothelial Cells in Heart (2009)
  • 著者名/発表者名: Kosaku Goto, Tatsuya Iso, Toshihiro Suga, Hiroki Matsui, Masashi Arai, Frank J Gonzalez, Masahiko Kurabayashi
  • 学会等名: Annual meeting of American Heart Association
  • 発表場所: Orland, U.S.A.
  • 年月日: 2009-11-17
• [学会発表] Bone Morphogenetic Protein-2(BMP-2)and BMP-7 Act as Instructive Factors to Specify Notch Signaling Controlling Smooth Muscle Cell Phenotype (2009)
  • 著者名/発表者名: Takehisa Shimizu, Toru Tanaka, Tatsuya Iso, Keiko Kawai-Kowase, Masahiko Kurabayashi
  • 学会等名: Annual meeting of American Heart Association
  • 発表場所: Orland, U.S.A.
  • 年月日: 2009-11-17
• [学会発表] Muscle-Type Capillary Endothelial Cells Actively Transport Fatty Acids via Intracellular Fatty Acid Binding Protein-4 and-5. (2009)
  • 著者名/発表者名: Tatsuya Iso, Kazuhisa Maeda, Hirofumi Hanaoka, Toshihiro Suga, Hiroki Matsui, Kosaku Goto, Masashi Arai, Keigo Endo, Gohkan Hotamisligil, Masahiko Kurabayashi
  • 学会等名: Annual meeting of American Heart Association
  • 発表場所: Orange County Convention Center(Orlando, USA).
  • 年月日: 2009-11-16
• [学会発表] Increased Stearoyl-CoA Desaturase-1 Expression in Obese and Diabetic Heart Plays a Protective Role Against Fatty Acid-Induced Cardiac Dysfunction (2009)
  • 著者名/発表者名: Hiroki Matsui, Tomoyuki Yokoyama, Daisuke Iijima, Kenichi Sekiguchi, Tatsuya Iso, Masahi Arai, Masahiko Kurabayashi
  • 学会等名: Annual meeting of American Heart Association
  • 発表場所: Orange County Convention Center(Orlando, USA).
  • 年月日: 2009-11-16
• [学会発表] Muscle-Type Capillary Endothelial Cells Actively Transport Fatty Acida via Intracellular Fatty Acid Binding Protein-4 and -5 (2009)
  • 著者名/発表者名: Tatsuya Iso, Kazuhisa Maeda, Hirofumi Hanaoka, Toshihiro Suga, Hiroki Matsui, Kosaku Goto, Masashi Arai, Keigo Endo, Gohkan Hotamisligil, Masahiko Kurabayashi
  • 学会等名: Annual meeting of American Heart Association
  • 発表場所: Orland, U.S.A.
  • 年月日: 2009-11-16
• [学会発表] Increased Stearoyl-CoA Desaturase-1 Expression in Obese and Diabetic Heart Plays a Protective Role Against Fatty Acid-Induced Cardiac Dysfunction (2009)
  • 著者名/発表者名: Hiroki Matsui, Tomoyuki Yokoyama, Daisuke Iijima, Kenichi Sekiguchi, Tatsuya Iso, Masahi Arai, Masahiko Kurabayashi
  • 学会等名: Annual meeting of American Heart Association
  • 発表場所: Orland, U.S.A.
  • 年月日: 2009-11-16
• [学会発表] Osteogenic Transcription Factor Runx2 Suppresses Atrial and B-Type Natriuretic Peptide Gene Expression in Rat Cardiomyocytes : Possible Role of Runx2 in Cardiac Fibrosis. (2008)
  • 著者名/発表者名: Takahiro Nakahara, Takehisa Shimizu, Keiko Kawai-Kowase, Toru Tanaka, Tatsuya Iso, Masashi Arai, Masahiko Kurabayashi
  • 学会等名: Annual meeting of American Heart Association
  • 発表場所: Ernest N. Morial Convention Center.(New Orleans, USA)
  • 年月日: 2008-11-11
• [学会発表] Activation of Receptor for advanced-glycation end products (RAGE) induces Notch-Msx2-dependent osteoblastic differentiation of vascular smooth muscle cells. (2008)
  • 著者名/発表者名: Toshihiro Suga, Tatsuya Iso, Takehisa Shimizu, Toru Tanaka, Sho-ichi Yamagishi, Masashi Arai, Tsutomu Imaizumi, Masahiko Kurabayashi
  • 学会等名: Annual meeting of American Heart Association
  • 発表場所: Ernest N.Morial Convention Center.(New Orleans, USA)
  • 年月日: 2008-11-11
• [学会発表] Activation of Receptor for advanced-glycation end products (RAGE) in duces Notch-Msx2-dependent osteoblastic, differentiation of vascular smooth muscle cells. (2008)
  • 著者名/発表者名: Toshihiro Suga, Tatsuya Iso, Takehisa Shimizu, Toru Tanaka, Sho-ichi Yamagishi, Masashi Arai, Tsutomu Imaizumi, Masahiko Kurabayashi
  • 学会等名: Annual meeting of American Heart Association
  • 発表場所: New Orlens
  • 年月日: 2008-11-11
• [学会発表] Notch signaling Enhances BMP2-induced Msx2 Gene Expression and Vascular Calcification. (2008)
  • 著者名/発表者名: Takehisa Shimizu, Toru Tanaka, Tatsuya Iso, Masahiko Kurabayashi
  • 学会等名: Annual meeting of American Heart Association
  • 発表場所: Ernest N.Morial Convention Center.(New Orleans, USA)
  • 年月日: 2008-11-10
• [学会発表] Stearoyl-CoA Desaturase-1 Protects Against Saturated Fatty Acids-Induced Osteogenic Differentiation and Apoptosis of Vascular Smooth Muscle Cells. (2008)
  • 著者名/発表者名: Hiroki Matsui, Tomoyuki Yokoyama, Kenichi Sekiguchi, Yousuke Gotoh, Tatsuya Iso, Masahi Arai, Masahiko Kurabayashi
  • 学会等名: Annual meeting of American Heart Association
  • 発表場所: Ernest N. Morial Convention Center.(New Orleans, USA)
  • 年月日: 2008-11-10
• [学会発表] Notch Signaling induces Expression of Fatty Acid Binding Protein 4 via Induction of PPAR-g2 in Capillary Endothelial Cells in Heart. (2008)
  • 著者名/発表者名: Tatsuya Iso, Toshihiro Suga, Hiroki Matsui, Masashi Arai, Masahiko Kurabayashi
  • 学会等名: Annual meeting of American Heart Association
  • 発表場所: Ernest N.Morial Convention Center.(New Orleans, USA)
  • 年月日: 2008-11-10
• [学会発表] Notch Signaling induces Expression of Fatty Acid Binding Protein 4 via Induction of PPAR-g2 in Capillary Endothelial Cells in Heart. (2008)
  • 著者名/発表者名: Tatsuya Iso, Toshihiro Suga, Hiroki Matsui, Masashi Arai, Masahiko Kurabayashi
  • 学会等名: Annual meeting of American Heart Association
  • 発表場所: New Orlens
  • 年月日: 2008-11-10
• [学会発表] Notch signaling Directly Targets Msx2 : Possible Role of Notch Signaling in Osteogenic Conversion of Vascular Smooth Muscle Cells and Vascular Calcification (2008)
  • 著者名/発表者名: Takehisa Shimizu, Toru Tanaka, Tatsuya Iso, Masahiko Kurabayashi
  • 学会等名: Annual meeting of American Heart Association
  • 発表場所: Ernest N.Morial Convention Center.(New Orleans, USA)
  • 年月日: 2008-11-09
• [学会発表] Notch signaling contributes to pathogenesis of vascular diseases. (2008)
  • 著者名/発表者名: Tatsuya Iso
  • 学会等名: International Vascular Biology Meeting, Sydney
  • 発表場所: Sydney Convention Center(Sydney, Australia).(Invited)
  • 年月日: 2008-06-04
• [学会発表] Notch signaling contributes to pathogenesis of vascular diseases. (2008)
  • 著者名/発表者名: Tatsuya Iso (Invited)
  • 学会等名: International Vascular Biology Meeting
  • 発表場所: Sydney
  • 年月日: 2008-06-04
• [図書] 胸痛(看護に役立つ疾患・症候辞典) (2008)
  • 著者名/発表者名: 磯達也
  • 出版者: メヂカルフレンド社
• [図書] PPARsと動脈硬化(炎症と免疫) (2008)
  • 著者名/発表者名: 磯達也、倉林正彦
  • 出版者: 先端医学社