放射線異感受性腫瘍に対する重粒子マイクロビーム照射・抗癌剤併用に関する基礎研究

• 研究課題/領域番号: 20591504
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 放射線科学
• 研究機関: 群馬大学
• 研究代表者: 高橋 健夫 群馬大学, 医学部, 教授 (70241883)
• 研究期間 (年度): 2008 – 2010
• 研究課題ステータス: 完了 (2010年度)
• 配分額: 3,770千円 (直接経費: 2,900千円、間接経費: 870千円); 2010年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円); 2009年度: 1,170千円 (直接経費: 900千円、間接経費: 270千円); 2008年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円)
• キーワード: 重粒子線 / バイスタンダー効果 / p53 / 抗癌剤 / DNA修復 / 抗がん剤 / マイクロビーム / 増感効果 / Ku70

研究概要

重粒子線(炭素線)は物理学的線量分布に加え、生物学的効果比が高く、放射線抵抗性腫瘍に特に有用である。重粒子線治療が今後、一般的に普及するためには局所進行癌に対する集学的治療の中での有効性を、科学的に明らかにする必要がある。In vitroの検討で重粒子線はp53変異株で放射線抵抗性腫瘍に対し効果が高く、照射効果はp53に非依存的である。抗癌剤の増感効果はトポイソメラーゼII阻害剤でみられ、アポトーシスとKu70蛋白の発現抑制が関与していた。バイスタンダー効果が重粒子線照射後見られるが、薬剤増感効果は未確認である。

研究成果

• [雑誌論文] Intracavitary Combined with CT-guided Interstitial Brachytherapyfor Locally Advanced Uterine Cervical Cancer : Introductionof the Technique and a Case Presentation. (2011)
  • 著者名/発表者名: Wakatsuki M, Ohno T, Yoshida D, Noda S, Saitoh J, Shibuya K, Katoh H, Suzuki Y, Takahashi T, Nakano T
  • 雑誌名: J.Radiat.Res 52 ページ: 54-58
  • 査読あり
• [雑誌論文] In Vitro Interaction of High-LET Heavy-ion Irradiation and Chemotherapeutic Agent in Two Cell Iines with Different Radiosensitivities and Different p53 Status. (2010)
  • 著者名/発表者名: Takahashi T, Fukawa T, Hirayama R, Yoshida Y, Musha A, Furusawa Y, Ando K, Nakano T
  • 雑誌名: Anticancer Research 30 ページ: 1961-1968
  • 査読あり
• [雑誌論文] Signal Transduction and Heavy Ion Radiation Therapy : Biological Mechanisms, Biological Quality Assurance, and New Multimodality Approach. (2010)
  • 著者名/発表者名: Takahashi T, Yoshida Y, Ando K, Kawamura H, Okamoto M, Saitoh J, Ishikawa H, Ebara T, Suzuki Y, Ohno T, Nakano T
  • 雑誌名: Current Signal Transduction therapy 5 ページ: 237-243
  • 査読あり
• [雑誌論文] Effectiveness of carbon-ion Beams for Apoptosis Induction in Rat Primary Immature Hippocampal Neurons. (2010)
  • 著者名/発表者名: Kaminuma T, Suzuki Y, Shirai K, Mizui T, Noda SE, Yoshida Y, Funayama T, Takahashi T, Kobayashi Y, Shirao T, Nakano T
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  • NAID: 10026963838
  • 査読あり
• [雑誌論文] Protective effect of urinary trypsin inhibitor on the development of radiation-induced lung fibrosis in mice. (2010)
  • 著者名/発表者名: Katoh H, Ishikawa H, Hasegawa M, Yoshida Y, Suzuki Y, Ohno T, Takahashi T, Nakano T
  • 雑誌名: J Radiate Res. 51 ページ: 325-32
  • NAID: 10026471232
  • 査読あり
• [雑誌論文] Current Advancement in Radiaion Therapy for Uterine Cervical Cancer. (2010)
  • 著者名/発表者名: Nakano T, Ohno T, Ishikawa H, Suzuki Y, Takahashi T
  • 雑誌名: J.Radiat Res 51 ページ: 1-8
  • 査読あり
• [雑誌論文] Usefulness of intraluminal brachytherapy combined with external beam radiation therapy for submucosal esophageal cancer : long-term follow-up results. (2010)
  • 著者名/発表者名: Ishikawa H, Nonaka T, Sakurai H, Tamaki Y, Kitamoto Y, Ebara T, Shioya M, Noda SE, Shirai K, Suzuki Y, Takahashi T, Nakano T
  • 雑誌名: Int J Radiat Oncol Biol Phys. 76 ページ: 452-9
  • 査読あり
• [雑誌論文] High-dose-rate intracavity brachytherapy combined with external beam radiotherapy for stage III B adenocarcinoma of the uterine cervix in japan : A multi-institutional study of Japanene society of therapeutic radiorogy and oncology 2006-2007. (2010)
  • 著者名/発表者名: Niibe Y, Kenjo M, Onishi H, Ogawa Y, Kazumoto T, Ogino I, Tsujino K, Harima Y, Takahashi T, Anbai A, Tsuchiba E, Toita T, Takemoto M, Yamashita H, Hayakawa K
  • 雑誌名: Jpn J Clini Oncol 8 ページ: 795-799
  • 査読あり
• [雑誌論文] The Benefit of Small Bowel and Pelvic Bone Sparing in Excluding Common Ilic Lymph Node Region from Conventional Radiation Fields in Patients with Uterine Cervical Cancer : A Dosimetric Study. (2010)
  • 著者名/発表者名: Oike T, Ohno T, Wakatsuki M, Node SE, Saitoh JI, MIzukami T, Yoshimoto Y, Okonogi N, Katoh H, Shibuya K, Suzuki Y, Ishikawa H, Ebara T, Takahashi T, Nakano T
  • 雑誌名: Journal of Radiation Research 51 ページ: 715-721
  • 査読あり
• [雑誌論文] Influence of histological subtype on survival after combined therapy of surgery and radiation in WHO grade 3 glioma. (2010)
  • 著者名/発表者名: Shirai K, Suzuki Y, Okamoto M, Wakatsuki M, Noda SE, Takahashi T, Ishiuchi S.Hasegawa M, Nakazato Y, Nakano T
  • 雑誌名: J Radiat Res 51 ページ: 589-94
  • NAID: 10026644482
  • 査読あり
• [雑誌論文] L-type Amino-Acid Transporter 1 Expression Predicts the Response to Preoperative Hyperthermo-Chemoradiotherapy for Advanced Rectal Cancer. (2010)
  • 著者名/発表者名: Ebara T, Kaira K, Saitoh J, Shioya M, Asao T, Takahashi T, Sakurai H, Kanai Y, Kuwano H, Nakano T
  • 雑誌名: Anticancer Research 30 ページ: 4223-4228
  • 査読あり
• [雑誌論文] In Vitro Interaction of High-LET Heavy-ion Irradiation and Chemotherapeutic Agent in Two Cell lines with Different Radiosensitivities and Different p53 Status (2010)
  • 著者名/発表者名: Takahashi T.Fukawa T, Hirayama R, Yoshida Y, Musha A, Furusawa Y, Ando K, Nakano T
  • 雑誌名: Anticancer Research 巻: 30 ページ: 1961-1968
  • 査読あり
• [雑誌論文] Signal Transduction and Heavy Ion Radiation Therapy : Biological Mechanisms, Biological Quality Assurance, and New Multimodality Approach (2010)
  • 著者名/発表者名: Takahashi T, Yoshida Y, Ando K, Kawamura H, Okamoto M, Saitoh J, Ishikawa H, Ebara T, Suzuki Y, Ohno T, Nakano T
  • 雑誌名: Current Signal Transduction therapy 巻: 5 ページ: 237-243
  • 査読あり
• [雑誌論文] Protective effect of urinary trypsin inhibitor on the development of radiation-induced lung fibrosis in mice (2010)
  • 著者名/発表者名: Katoh H, Ishikawa H, Hasegawa M, Yoshida Y, Suzuki Y, Ohno T, Takahashi T, Nakano T
  • 雑誌名: J Radiate Res 巻: 51 ページ: 325-332
  • NAID: 10026471232
  • 査読あり
• [雑誌論文] Interaction of high-LET heavy ion irradiation and chemotherapeutic agents on two cell lines with different radiosensitivities and different p53 status in vitro (2010)
  • 著者名/発表者名: Takahashi T, Fukawa T, Hirayama R, Yoshida Y, Musha A, Furusawa Y, Ando K, Nakano T
  • 雑誌名: Anticancer Research (In press)
  • 査読あり
• [雑誌論文] Signal transtluction and heavy ion radiation therapy : biological mechanisms, biological quality assurance, and new multimodality approach (2010)
  • 著者名/発表者名: Takahashi T, Yoshida Y, Ando K, Kawamura H, Okamoto M, Saito J, Ishikawa H, Ebara T, Suzuki Y, Ohno T, Nakano T
  • 雑誌名: Current Signal Transduction Therapy (In press)
  • 査読あり
• [雑誌論文] mechanism of enhancement effect of carbon-beam irradiation and topoisomerase ll inhibitor on two cell lines with different radiosensitivities and different p53 status in vitro. (2009)
  • 著者名/発表者名: Takahashi T, Yoshida Y, Musya A, Kawamura H, Ando K, Nakano T
  • 雑誌名: 37th Annual Meeting of the European Radiation research Society (Praque August 26-29) ページ: 83-85
• [雑誌論文] Metastatic angiosarcoma of the lung with alveolar hemorrhage. (2009)
  • 著者名/発表者名: Saitoh J, Sakurai H, Suzuki Y, Katoh H, Takahashi T, Nakano T
  • 雑誌名: Jpn J Radiol 27 ページ: 381-384
  • NAID: 50007373615
  • 査読あり
• [雑誌論文] Metastatic angiosarcoma of the lung with alveolar hemorrhage (2009)
  • 著者名/発表者名: Saitoh J, Sakurai H, Suzuki Y, Katoh, H, Takahashi T, Nakano T
  • 雑誌名: Jpn J Radiol 27 ページ: 381-384
  • NAID: 50007373615
  • 査読あり
• [雑誌論文] Evaluation of quality of life and psychological response in cancer patients treated with radiotherapy. (2008)
  • 著者名/発表者名: Takahashi T, Hondo M, Nishimura K, Kitani A, Yamano T, Yanagita H, Osada H, Shinbo M, Honda N
  • 雑誌名: Radiation Medicine 26 ページ: 396-401
  • NAID: 10021943642
  • 査読あり
• [雑誌論文] Multidetector computed tomography diagnosis of primary and secondary epiploic appendagitis. (2008)
  • 著者名/発表者名: Osada H, Ohno H, Watanabe W, Nakada K, Okada T, Yanagita H, Nishimura K, Hondo M, Takahashi T, Honda N
  • 雑誌名: Radiation Medicine 26 ページ: 582-586
  • NAID: 50007069386
• [雑誌論文] Usefulness of Intraluminal Brachytherapy combined with External Beam Radiation Therapy for Submucosal Esophageal Cancer: Long-term Follow-up Results
  • 著者名/発表者名: Ishikawa H, Nonaka T, Sakurai H, Tamaki Y, Kitamoto Y, Ebara T, Shioya M, Noda S, Shirai K, Suzuki Y, Takahashi T. Nakano T
  • 雑誌名: International Journal of Radiation Oncology Biology Physics (In press)
• [学会発表] High-dose-rate brachytherapy combined with hypofractioneted external beam radiotherapy for locally advanced prostate cancer. (2010)
  • 著者名/発表者名: Ishikawa H
  • 学会等名: ASTRO.
  • 発表場所: San Diego
• [学会発表] Mechanism of sensitizing effect of high-LET carbon ion irradiation and anticancer drug on two cell lines with different radiosensitivities and p53 status in vitro. (2010)
  • 著者名/発表者名: Takahashi T
  • 学会等名: ESTRO 29
  • 発表場所: Barcelona
• [学会発表] Mechanism of enhancement effect of carbon-beam irradiation combined with chemotherapeutic agents on two cell lines with different radiosensitivities and different p53 status in vitro. (2010)
  • 著者名/発表者名: Takahashi T
  • 学会等名: PTCOG 49.
  • 発表場所: Maebashi
• [学会発表] Biological quality assurance (QA) of carbon beam irradiation at spread-out Bragg peak beams. (2010)
  • 著者名/発表者名: Takahashi T
  • 学会等名: PTCOG 49.
  • 発表場所: Maebashi
• [学会発表] Preclinical biological assessment for treatment planning of carbon-ion therapy. (2010)
  • 著者名/発表者名: Yoshida Y
  • 学会等名: PTCOG 49.
  • 発表場所: Maebashi
• [学会発表] Analysis of esophageal mobility during normal respiration in 4DCT planning. (2010)
  • 著者名/発表者名: Murata K
  • 学会等名: PTCOG 49.
  • 発表場所: Maebashi
• [学会発表] Assessment of interfractional set-up accuracy in lung cancer for highly precise radiotherapy, especially for particle therapy, using a body immobilization system of stereotactic radiotherapy. (2010)
  • 著者名/発表者名: Nishimura K
  • 学会等名: PTCOG 49.
  • 発表場所: Maebashi
• [学会発表] Mechanism of sensitizing effect of high-LET carbon ion irradiation and anticancer drug on two cell lines with different radiosensitivities and p53 status in vitro (2010)
  • 著者名/発表者名: Takahashi T
  • 学会等名: ESTRO 29
  • 発表場所: Barcelona, Spain
• [学会発表] Enhancement effect of high-LET carbon-ion beam and anticancer drugs on two cell lines with different radiosensitivities and p53 status in vitro. (2009)
  • 著者名/発表者名: Takahashi T
  • 学会等名: ASTRO Annual Meeting.
  • 発表場所: Chicago
• [学会発表] Enhancement effect of hight-LET carhon-ion beam and anticancer drugs on two cell lines with different radiosensitivities and p53 status in vitro (2009)
  • 著者名/発表者名: Takahashi T, Fukawa T, Hirayama R, Furusawa Y, Ando K, Yoshida Y, Suzuki Y, Nakano T
  • 学会等名: ASTRO Annual Meeting
  • 発表場所: Chicago, U.S.A.
• [学会発表] Gross tumor volume definition in treatment planning of stereotactic radiotherapy for brain metastases : dose comparison study with gadoteridol. (2008)
  • 著者名/発表者名: Takahashi T
  • 学会等名: ESTRO 27.
  • 発表場所: Gotengerg
  • 年月日: 2008-09-14
• [学会発表] Gross tumor volume definition in treatment planning of stereotactic radiotherapy for brain metastases: dose comparison study with gadoteridol (2008)
  • 著者名/発表者名: Takahashi T, Shinbo M, Hondo M, Nishimura K, Yamano T, Yanagita H, Ohno H, Okada T, Osada H, Honda N
  • 学会等名: ESTRO 27
  • 発表場所: Gotengerg
  • 年月日: 2008-09-14
• [図書] がん・放射線療法2010、転移性腫瘍における放射線療法「骨転移」(大西洋, 唐澤克之, 唐澤久美子,監修) (2010)
  • 著者名/発表者名: 高橋健夫
  • 総ページ数: 1187
  • 出版者: 篠原出版新社
• [図書] がん・放射線療法2010.大西洋, 唐澤克之, 唐澤久美子, 監修;転移性腫瘍における放射線療法「骨転移」 (2010)
  • 著者名/発表者名: 高橋健夫
  • 総ページ数: 19
  • 出版者: 篠原出版新社