生物学的製剤に対する薬剤反応性遺伝子の同定

• 研究課題/領域番号: 20591791
• 研究種目: 基盤研究(C)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 整形外科学
• 研究機関: 東京女子医科大学
• 研究代表者: 桃原 茂樹 東京女子医科大学, 医学部, 教授 (00190984)
• 研究分担者: 猪狩 勝則 東京女子医科大学, 医学部, 講師 (80343557) ; 塚原 聡 東京女子医科大学, 医学部, 助教 (90433995)
• 連携研究者: 猪狩 勝則 東京女子医科大学, 医学部, 講師 (80343557)
• 研究期間 (年度): 2008 – 2010
• 研究課題ステータス: 完了 (2010年度)
• 配分額: 4,810千円 (直接経費: 3,700千円、間接経費: 1,110千円); 2010年度: 650千円 (直接経費: 500千円、間接経費: 150千円); 2009年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円); 2008年度: 2,860千円 (直接経費: 2,200千円、間接経費: 660千円)
• キーワード: リウマチ病学 / 関節リウマチ / 生物学的製剤

研究概要

既知の疾患感受性遺伝子を候補遺伝子として、疾患関連多型について生物学的製剤反応遺伝子の検索を行った結果、PTPRC上のrs10919563で有意な関連を認めた(P<0.05)。rs10919563は欧米での検討でも生物学的反応性と有意な関連を認めており、結果の信頼性は高いと言える。本研究により、投与前のスクリーニングでこの多型解析を行うことで、生物学的製剤不応例となるリスクを軽減できる可能を示すことが出来た。

研究成果

• [雑誌論文] Interleukin-18 promoter polymorphisms in Japanese patients with rheumatoid arthritis: protective effect of the T allele and T/T genotype at rs360722. (2011)
  • 著者名/発表者名: Sugiura T, Kawaguchi Y, Ikari K, Ichida H, Kawamoto M, Momohara S, Hara M, Yamanaka H
  • 雑誌名: Mod Rheumatol.
  • NAID: 10029512800
  • 査読あり
• [雑誌論文] Studies of the efficacy and safety of methotrexate at dosages over 8 mg/week using the IORRA cohort database. (2011)
  • 著者名/発表者名: Seto Y, Tanaka E, Inoue E, Nakajima A, Taniguchi A, Momohara S, Yamanaka H
  • 雑誌名: Mod Rheumatol.
  • NAID: 10030205975
  • 査読あり
• [雑誌論文] Recent trends in orthopedic surgery performed in Japan for rheumatoid arthritis. (2011)
  • 著者名/発表者名: Momohara S, Tanaka S, Nakamura H, Mibe J, Iwamoto T, Ikari K, Nishino J, Kadono Y, Yasui T, Takahashi K, Takenouchi K, Hashizume K, Nakahara R, Kubota A, Nakamura T, Nishida K, Suguro T
  • 雑誌名: Mod Rheumatol.
  • NAID: 10029512726
  • 査読あり
• [雑誌論文] Reparative radiological changes of a large joint after adalimumab for rheumatoid arthritis. (2011)
  • 著者名/発表者名: Momohara S, Tanaka E, Iwamoto T, Ikari K, Yamanaka H
  • 雑誌名: Clin Rheumatol. 30(4) ページ: 591-2
  • 査読あり
• [雑誌論文] 0Prosthetic joint infection after total hip or knee arthroplasty in rheumatoid arthritis patients treated with nonbiologic and biologic disease-modifying antirheumatic drugs. (2011)
  • 著者名/発表者名: Momohara S, Kawakami K, Iwamoto T, Yano K, Sakuma Y, Hiroshima R, Imamura H, Masuda I, Tokita A, Ikari K
  • 雑誌名: Mod Rheumatol.
  • 査読あり
• [雑誌論文] Efficacy of total joint arthroplasty in patients with established rheumatoid arthritis: improved longitudinal effects on disease activity but not on health-related quality of life. (2011)
  • 著者名/発表者名: Momohara S, Inoue E, Ikari K, Yano K, Tokita A, Suzuki T, Sakuma Y, Hiroshima R, Kawakami K, Masuda I, Iwamoto T, Taniguchi A, Yamanaka H
  • 雑誌名: Mod Rheumatol.
  • NAID: 10030205622
  • 査読あり
• [雑誌論文] Interleukin-18 promoter polymorphisms in Japanese patients with rheumatoid arthritis : protective effect of the T allele and T/T genotype at rs360722 (2011)
  • 著者名/発表者名: Sugiura T, et al.
  • 雑誌名: Mod Rheumatol 巻: (e-pub)
  • 査読あり
• [雑誌論文] Association of EMCN with susceptibility to rheumatoid arthritis in a Japanese population (2011)
  • 著者名/発表者名: Nishimoto K, et al
  • 雑誌名: J Rheumatol 巻: 38 ページ: 221-8
  • 査読あり
• [雑誌論文] Effect of total knee arthroplasty on disease activity in patients with established rheumatoid arthritis : 3-year follow-up results of combined medical therapy and surgical intervention. (2010)
  • 著者名/発表者名: Yano K, Ikari K, Inoue E, Tokita A, Sakuma Y, Hiroshima R, Iwamoto T, Kawakami K, Taniguchi A, Yamanaka H, Momohara S
  • 雑誌名: Mod Rheumatol. 20(5) ページ: 452-7
  • NAID: 10027646979
  • 査読あり
• [雑誌論文] Efficacy and tolerability of tocilizumab in rheumatoid arthritis patients seen in daily clinical practice in Japan : results from a retrospective study (REACTION study). (2010)
  • 著者名/発表者名: Yamanaka H, Tanaka Y, Inoue E, Hoshi D, Momohara S, Hanami K, Yunoue N, Saito K, Amano K, Kameda H, Takeuchi T
  • 雑誌名: Mod Rheumatol. 21(2) ページ: 122-33
  • NAID: 10029361627
  • 査読あり
• [雑誌論文] A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR. (2010)
  • 著者名/発表者名: Yamamoto YH, Kimura T, Momohara S, Takeuchi M, Tani T, Kimata Y, Kadokura H, Kohno K
  • 雑誌名: Cell Struct Funct. 35(2) ページ: 107-16
  • 査読あり
• [雑誌論文] Incidence of falls and fear of falling in Japanese patients with rheumatoid arthritis. (2010)
  • 著者名/発表者名: Yamagiwa K, Iijima S, Furuya T, Ikai T, Inoue E, Taniguchi A, Momohara S, Yamanaka H
  • 雑誌名: Mod Rheumatol. 21(1) ページ: 51-6
  • NAID: 10029361259
  • 査読あり
• [雑誌論文] Incidence of malignancy in Japanese patients with rheumatoid arthritis. (2010)
  • 著者名/発表者名: Yamada T, Nakajima A, Inoue E, Tanaka E, Taniguchi A, Momohara S, Yamanaka H
  • 雑誌名: Rheumatol Int.
  • 査読あり
• [雑誌論文] Effects of long-term corticosteroid usage on functional disability in patients with early rheumatoid arthritis, regardless of controlled disease activity. (2010)
  • 著者名/発表者名: Tanaka E, Mannalithara A, Inoue E, Iikuni N, Taniguchi A, Momohara S, Singh G, Yamanaka H
  • 雑誌名: Rheumatol Int.
  • 査読あり
• [雑誌論文] The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population. (2010)
  • 著者名/発表者名: Shimane K, Kochi Y, Horita T, Ikari K, Amano H, Hirakata M, Okamoto A, Yamada R, Myouzen K, Suzuki A, Kubo M, Atsumi T, Koike T, Takasaki Y, Momohara S, Yamanaka H, Nakamura Y, Yamamoto K
  • 雑誌名: Arthritis Rheum. 62(2) ページ: 574-9
  • 査読あり
• [雑誌論文] Comparison of the second and third generation anti-cyclic citrullinated peptide antibody assays in the diagnosis of Japanese patients with rheumatoid arthritis. (2010)
  • 著者名/発表者名: Shidara K, Inoue E, Tanaka E, Hoshi D, Seto Y, Nakajima A, Momohara S, Taniguchi A, Yamanaka H
  • 雑誌名: Rheumatol Int. 31(5) ページ: 617-22
  • 査読あり
• [雑誌論文] Anti-cyclic citrullinated peptide antibody predicts functional disability in patients with rheumatoid arthritis in a large prospective observational cohort in Japan. (2010)
  • 著者名/発表者名: Shidara K, Inoue E, Hoshi D, Sato E, Nakajima A, Momohara S, Taniguchi A, Yamanaka H.
  • 雑誌名: Rheumatol Int.
  • 査読あり
• [雑誌論文] Incidence of and risk factors for interstitial pneumonia in patients with rheumatoid arthritis in a large Japanese observational cohort, IORRA. (2010)
  • 著者名/発表者名: Shidara K, Hoshi D, Inoue E, Yamada T, Nakajima A, Taniguchi A, Hara M, Momohara S, Kamatani N,Yamanaka H
  • 雑誌名: Mod Rheumatol. 20(3) ページ: 280-6
  • NAID: 10027169405
  • 査読あり
• [雑誌論文] Reparative radiological changes of the hip joint in rheumatoid arthritis : do these findings indicate the true repair of the joint? (2010)
  • 著者名/発表者名: Sakuma Y, Ikari K, Iwamoto T, Tokita A, Momohara S.
  • 雑誌名: Joint Bone Spine. 77(3) ページ: 278-9
  • 査読あり
• [雑誌論文] Single nucleotide polymorphisms of CD244 gene predispose to renal and neuropsychiatric manifestations with systemic lupus erythematosus. (2010)
  • 著者名/発表者名: Ota Y, Kawaguchi Y, Takagi K, Tochimoto A, Kawamoto M, Katsumata Y, Gono T, Masuda I, Ikari K, Momohara S, Yamanaka H.
  • 雑誌名: Mod Rheumatol. 20(5) ページ: 427-31
  • NAID: 10027646881
  • 査読あり
• [雑誌論文] Association of EMCN with susceptibility to rheumatoid arthritis in a Japanese population. (2010)
  • 著者名/発表者名: Nishimoto K, Ikari K, Kaneko H, Tsukahara S, Kochi Y, Yamamoto K, Nakamura Y, Toyama Y, Taniguchi A, Yamanaka H, Momohara S
  • 雑誌名: J Rheumatol. 38(2) ページ: 221-8
  • 査読あり
• [雑誌論文] Rheumatoid arthritis: a risk factor for deep venous thrombosis after total knee arthroplasty? Comparative study with osteoarthritis. (2010)
  • 著者名/発表者名: Niki Y, Matsumoto H, Hakozaki A, Mochizuki T, Momohara S
  • 雑誌名: J Orthop Sci. 15(1) ページ: 57-63
  • NAID: 10027402972
  • 査読あり
• [雑誌論文] Mortality and cause of death in Japanese patients with rheumatoid arthritis based on a large observational cohort, IORRA. (2010)
  • 著者名/発表者名: Nakajima A, Inoue E, Tanaka E, Singh G, Sato E, Hoshi D, Shidara K, Hara M, Momohara S, Taniguchi A, Kamatani N, Yamanaka H
  • 雑誌名: Scand J Rheumatol. 39(5) ページ: 360-7
  • 査読あり
• [雑誌論文] Neglected spontaneous rupture of the Achilles tendon in elderly patients with rheumatoid arthritis. (2010)
  • 著者名/発表者名: Mikashima Y, Kawamura K, Miyawaki M, Murakoshi K, Usami N, Momohara S
  • 雑誌名: J Clin Rheumatol. 16(5) ページ: 221-4
  • 査読あり
• [雑誌論文] A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. (2010)
  • 著者名/発表者名: Kochi Y, Okada Y, Suzuki A, Ikari K, Terao C, Takahashi A, Yamazaki K, Hosono N, Myouzen K, Tsunoda T, Kamatani N, Furuichi T, Ikegawa S, Ohmura K, Mimori T, Matsuda F, Iwamoto T, Momohara S, Yamanaka H, Yamada R, Kubo M, Nakamura Y, Yamamoto K
  • 雑誌名: Nat Genet. 42(6) ページ: 515-9
  • 査読あり
• [雑誌論文] Efficacy and safety of tacrolimus in 101 consecutive patients with rheumatoid arthritis. (2010)
  • 著者名/発表者名: Kitahama M, Okamoto H, Koseki Y, Inoue E, Kaneko H, Taniguchi A, Momohara S, Yamanaka H
  • 雑誌名: Mod Rheumatol. 20(5) ページ: 478-85
  • NAID: 10027647055
  • 査読あり
• [雑誌論文] Clinical images : Solitary extranodal malignant lymphoma of the forearm in rheumatoid arthritis. (2010)
  • 著者名/発表者名: Iwamoto T, Seto Y, Ikari K, Yamanaka H, Momohara S
  • 雑誌名: Arthritis Rheum. 63(1) ページ: 304-304
  • 査読あり
• [雑誌論文] Analysis of C-reactive protein levels and febrile tendency after joint surgery in rheumatoid arthritis patients treated with a perioperative 4-week interruption of tocilizumab. (2010)
  • 著者名/発表者名: Hiroshima R, Kawakami K, Iwamoto T, Tokita A, Yano K, Sakuma Y, Ikari K, Momohara S
  • 雑誌名: Mod Rheumatol. 21(1) ページ: 109-11
  • NAID: 10029361543
  • 査読あり
• [雑誌論文] A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility (2010)
  • 著者名/発表者名: Kochi Y, et al.
  • 雑誌名: Nat Genet 巻: 42 ページ: 515-9
  • 査読あり
• [雑誌論文] Association study of TRAFI-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese (2010)
  • 著者名/発表者名: Nishimoto K., et al.
  • 雑誌名: Ann Rheum Dis. 69(2):368-73. 69 ページ: 368-73
  • 査読あり
• [雑誌論文] The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population. (2010)
  • 著者名/発表者名: Shimane S., et el.
  • 雑誌名: Arthritis Rheum 62 ページ: 574-9
  • 査読あり
• [雑誌論文] Associations between methotrexate treatment and methylenetetrahydrofolate reductase gene polymorphisms with incident fractures in Japanese female rheumatoid arthritis patients (2009)
  • 著者名/発表者名: Urano W, Furuya T, Inoue E, Taniguchi A, Urano T, Kotake S, Sekita C, Inoue S, Hara M, Momohara S, Kamatani N, Yamanaka H
  • 雑誌名: J Bone Miner Metab. 27(5) ページ: 574-83
  • NAID: 10027205660
  • 査読あり
• [雑誌論文] Medical care costs of patients with rheumatoid arthritis during the prebiologics period in Japan : a large prospective observational cohort study (2009)
  • 著者名/発表者名: Tanaka E, Inoue E, Mannalithara A, Bennett M, Kamitsuji S, Taniguchi A, Momohara S, Hara M, Singh G, Yamanaka H
  • 雑誌名: Mod Rheumatol. 20(1) ページ: 46-53
  • NAID: 10027168356
  • 査読あり
• [雑誌論文] The intra-articular efficacy of hyaluronate injections in the treatment of rheumatoid arthritis. (2009)
  • 著者名/発表者名: Saito S, Momohara S, Taniguchi A, Yamanaka H
  • 雑誌名: Mod Rheumatol. 19(6) ページ: 643-51
  • NAID: 10027167863
  • 査読あり
• [雑誌論文] Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese. (2009)
  • 著者名/発表者名: Nishimoto K, Kochi Y, Ikari K, Yamamoto K, Suzuki A, Shimane K, Nakamura Y, Yano K, Iikuni N, Tsukahara S, Kamatani N, Okamoto H, Kaneko H, Kawaguchi Y, Hara M, Toyama Y, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Yamanaka H, Momohara S
  • 雑誌名: Ann Rheum Dis. 69(2) ページ: 368-73
• [雑誌論文] Is minimally invasive surgery in total knee arthroplasty really minimally invasive surgery? (2009)
  • 著者名/発表者名: Niki Y, Mochizuki T, Momohara S, Saito S, Toyama Y, Matsumoto H.
  • 雑誌名: J Arthroplasty. 24(4) ページ: 499-504
  • 査読あり
• [雑誌論文] Decrease in orthopaedic operations, including total joint replacements, in patients with rheumatoid arthritis between 2001 and 2007 : data from Japanese outpatients in a single institute-based large observational cohort (IORRA). (2009)
  • 著者名/発表者名: Momohara S, Inoue E, Ikari K, Kawamura K, Tsukahara S, Iwamoto T, Hara M, Taniguchi A, Yamanaka H
  • 雑誌名: Ann Rheum Dis. 69(1) ページ: 312-3
  • 査読あり
• [雑誌論文] Declining use of synovectomy surgery for patients with rheumatoid arthritis in Japan. (2009)
  • 著者名/発表者名: Momohara S, Ikari K, Mochizuki T, Kawamura K, Tsukahara S, Toki H, Hara M, Kamatani N, Yamanaka H, Tomatsu T.
  • 雑誌名: Ann Rheum Dis. 68(2) ページ: 291-2
  • 査読あり
• [雑誌論文] In vivo deep-flexion kinematics in patients with posterior-cruciate retaining and anterior-cruciate substituting total knee arthroplasty. (2009)
  • 著者名/発表者名: Mikashima Y, Tomatsu T, Horikoshi M, Nakatani T, Saito S, Momohara S, Banks SA
  • 雑誌名: Clin Biomech (Bristol, Avon). 25(1) ページ: 83-7
  • 査読あり
• [雑誌論文] T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis. (2009)
  • 著者名/発表者名: Kotake S, Nanke Y, Kawamoto M, Yago T, Udagawa N, Ichikawa N, Kobashigawa T, Saito S, Momohara S, Kamatani N, Yamanaka H
  • 雑誌名: Bone. 45(4) ページ: 627-39
  • 査読あり
• [雑誌論文] A case of isolated gouty tophus in a patient without a previous history of gouty arthritis. (2009)
  • 著者名/発表者名: Kobayashi S, Taniguchi A, Okamoto H, Momohara S, Tomatsu T.
  • 雑誌名: J Clin Rheumatol. 15(7) ページ: 373-373
  • 査読あり
• [雑誌論文] Multiple rheumatoid bursal cysts with invasion into the calcaneus. (2009)
  • 著者名/発表者名: Kawamura K, Momohara S.
  • 雑誌名: J Clin Rheumatol. 15(8) ページ: 430-430
  • 査読あり
• [雑誌論文] Clinical image : adductor muscle strain in an elderly patient with suspected femoral neck fracture. (2009)
  • 著者名/発表者名: Kawakami K, Ikari K, Yano K, Momohara S
  • 雑誌名: Arthritis Rheum. 60(11) ページ: 3446-3446
  • 査読あり
• [雑誌論文] Complications and features after joint surgery in rheumatoid arthritis patients treated with tumour necrosis factor-alpha blockers : perioperative interruption of tumour necrosis factor-alpha blockers decreases complications? (2009)
  • 著者名/発表者名: Kawakami K, Ikari K, Kawamura K, Tsukahara S, Iwamoto T, Yano K, Sakuma Y, Tokita A, Momohara S
  • 雑誌名: Rheumatology (Oxford). 49(2) ページ: 341-7
  • 査読あり
• [雑誌論文] Multiple extensor tendon ruptures caused by tophaceous gout. (2009)
  • 著者名/発表者名: Iwamoto T, Toki H, Ikari K, Yamanaka H, Momohara S
  • 雑誌名: Mod Rheumatol. 20(2) ページ: 210-2
  • NAID: 10027169126
  • 査読あり
• [雑誌論文] Associated factors for falls and fear of falling in Japanese patients with rheumatoid arthritis. (2009)
  • 著者名/発表者名: Furuya T, Yamagiwa K, Ikai T, Inoue E, Taniguchi A, Momohara S, Yamanaka H
  • 雑誌名: Clin Rheumatol. 28(11) ページ: 1325-30
  • 査読あり
• [雑誌論文] A1330V polymorphism of low-density lipoprotein receptor-related protein 5 gene and self-reported incident fractures in Japanese female patients with rheumatoid arthritis. (2009)
  • 著者名/発表者名: Furuya T, Urano T, Ikari K, Kotake S, Inoue S, Hara M, Momohara S, Kamatani N, Yamanaka H.
  • 雑誌名: Mod Rheumatol. 19(2) ページ: 140-6
  • NAID: 10025112411
  • 査読あり
• [雑誌論文] A polymorphism in the gene encoding the Fcgamma IIIA receptor is a possible genetic marker to predict the primary response to infliximab in Japanese patients with rheumatoid arthritis. (2009)
  • 著者名/発表者名: S. Tsukahara, et al.
  • 雑誌名: Annals of the Rheumatic Diseases 67 ページ: 1791-1792
  • 査読あり
• [雑誌論文] Effect of matrix metalloproteinase-3 functional SNP on serum matrix metalloproteinase-3 level and outcome measures in Japanese RA patients. (2008)
  • 著者名/発表者名: Tsukahara S, Shinozaki M, Ikari K, Mochizuki T, Inoue E, Tomatsu T, Hara M, Yamanaka H, Kamatani N, Momohara S
  • 雑誌名: Rheumatology (Oxford). 47(1) ページ: 41-4
  • 査読あり
• [雑誌論文] CTLA-4 CT60 polymorphism is not an independent genetic risk marker of rheumatoid arthritis in a Japanese population (2008)
  • 著者名/発表者名: Tsukahara S, Iwamoto T, Ikari K, Inoue E, Tomatsu T, Hara M, Yamanaka H, Kamatani N, Momohara S
  • 雑誌名: Ann Rheum Dis. 67(3) ページ: 428-9
  • 査読あり
• [雑誌論文] A polymorphism in the gene encoding the Fcgamma IIIA receptor is a possible genetic marker to predict the primary response to infliximab in Japanese patients with rheumatoid arthritis. (2008)
  • 著者名/発表者名: Tsukahara S, Ikari K, Sato E, Yamanaka H, Hara M, Tomatsu T, Momohara S, Kamatani N
  • 雑誌名: Ann Rheum Dis. 67(12) ページ: 1791-2
  • 査読あり
• [雑誌論文] Iliopsoas bursitis-associated femoral neuropathy exacerbated after internal fixation of an intertrochanteric hip fracture in rheumatoid arthritis : a case report. (2008)
  • 著者名/発表者名: Tokita A, Ikari K, Tsukahara S, Toki H, Miyawaki M, Mochizuki T, Kawamura K, Tomatsu T, Momohara S
  • 雑誌名: Mod Rheumatol. 18(4) ページ: 394-8
  • NAID: 10021947039
  • 査読あり
• [雑誌論文] Infusion reaction to infliximab in a patient with rheumatoid arthritis after discontinuation over 1 year and readministration. (2008)
  • 著者名/発表者名: Toki H, Momohara S, Tsukahara S, Ikari K
  • 雑誌名: J Rheumatol. 35(9) ページ: 1896-7
  • 査読あり
• [雑誌論文] Return of infliximab efficacy after total knee arthroplasty in a patient with rheumatoid arthritis. (2008)
  • 著者名/発表者名: Toki H, Momohara S, Ikari K, Kawamura K, Tsukahara S, Mochizuki T, Sato E, Yamanaka H
  • 雑誌名: Clin Rheumatol. 27(4) ページ: 549-50
  • 査読あり
• [雑誌論文] Serum amyloid A activates nuclear factor-kappaB in rheumatoid synovial fibroblasts through binding to receptor of advanced glycation end-products. (2008)
  • 著者名/発表者名: Okamoto H, Katagiri Y, Kiire A, Momohara S, Kamatani N
  • 雑誌名: J Rheumatol. 35(5) ページ: 752-6
  • 査読あり
• [雑誌論文] Lack of association between PADI4 and functional severity in Japanese rheumatoid arthritis patients. (2008)
  • 著者名/発表者名: Nishimoto K, Ikari K, Mochizuki T, Tomatsu T, Toyama Y, Hara M, Yamanaka H, Kamatani N, Momohara S
  • 雑誌名: Ann Rheum Dis. 67(3) ページ: 431-2
  • 査読あり
• [雑誌論文] Factors affecting anteroposterior instability following cruciate-retaining total knee arthroplasty in patients with rheumatoid arthritis. (2008)
  • 著者名/発表者名: Niki Y, Mochizuki T, Momohara S, Saito S, Matsumoto H, Tomatsu T
  • 雑誌名: Knee. 15(1) ページ: 26-30
  • 査読あり
• [雑誌論文] Chondrocyte of rheumatoid arthritis serve as a source of intra-articular acute-phase serum amyloid A protein. (2008)
  • 著者名/発表者名: Momohara S, Okamoto H, Yamanaka H
  • 雑誌名: Clin Chim Acta. 398(1-2) ページ: 155-6
• [雑誌論文] Risk factors for wrist surgery in rheumatoid arthritis. (2008)
  • 著者名/発表者名: Momohara S, Inoue E, Ikari K, Tsukahara S, Kawamura K, Toki H, Hara M, Kamatani N, Yamanaka H, Tomatsu T.
  • 雑誌名: Clin Rheumatol. 27(11) ページ: 1387-91
  • 査読あり
• [雑誌論文] A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis. (2008)
  • 著者名/発表者名: Kobayashi S, Okamoto H, Iwamoto T, Toyama Y, Tomatsu T, Yamanaka H, Momohara S
  • 雑誌名: Rheumatology (Oxford). 47(9) ページ: 1317-22
  • 査読あり
• [雑誌論文] Molecular aspects of rheumatoid arthritis : role of environmental factors. (2008)
  • 著者名/発表者名: Kobayashi S, Momohara S, Kamatani N, Okamoto H
  • 雑誌名: FEBS J. 275(18) ページ: 4456-62
  • 査読あり
• [雑誌論文] Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population. (2008)
  • 著者名/発表者名: Kobayashi S, Ikari K, Kaneko H, Kochi Y, Yamamoto K, Shimane K, Nakamura Y, Toyama Y, Mochizuki T, Tsukahara S, Kawaguchi Y, Terai C, Hara M, Tomatsu T, Yamanaka H, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Okamoto H, Kamatani N, Momohara S.
  • 雑誌名: Arthritis Rheum. 58(7) ページ: 1940-6
  • 査読あり
• [雑誌論文] Molecular aspects of rheumatoid arthritis : chemokines in the joints of patients. (2008)
  • 著者名/発表者名: Iwamoto T, Okamoto H, Toyama Y, Momohara S
  • 雑誌名: FEBS J. 275(18) ページ: 4448-55
  • 査読あり
• [学会発表] Biochemical Characterization of the Catalytic Domain of Human Matrix Metalloproteinase 28 (2009)
  • 著者名/発表者名: K. Nishimoto, et al.
  • 学会等名: Annual Meeting of the Orthopaedic Research Society
  • 発表場所: ラスベガス、アメリカ
  • 年月日: 2009-02-22
• [学会発表] IMPACT OF HLA-DRB1 AND NON-HLA GENETIC FACTORS ON DISEASE SUSCEPTIBILITY AND RADIOGRAPHIC JOINT DAMAGE IN JAPANESE RHEUMATOID ARTHRITIS PATIENTS (2009)
  • 著者名/発表者名: Ikari K., et al.
  • 学会等名: 欧州リウマチ会議(EULAR)
  • 発表場所: デンマーク
• [学会発表] CD40 IS ASSOCIATED WITH RA IN JAPANESE (2009)
  • 著者名/発表者名: Tokita A., et al.
  • 学会等名: 欧州リウマチ会議(EULAR)
  • 発表場所: デンマーク
• [学会発表] Interleukin 2 receptor-alpha is associated with radiographic joint damage in a Japanese RA population. (2009)
  • 著者名/発表者名: Suzuki T., et al.
  • 学会等名: 米国リウマチ学会(ACR)
  • 発表場所: フィラデルフィア、米国
• [学会発表] Failure to confirm association of three polymorphisms of rheumatoid arthritis susceptibility identified by the Wellcome Trust Case Control Consortium in a Japanese population (2009)
  • 著者名/発表者名: Suzuki T., et al.
  • 学会等名: 米国人類遺伝学会(ASHG)
  • 発表場所: ホノルル、米国
• [備考] ホームページ等
  • URL: http://www.twmu.ac.jp/IOR/JointSurgery/
• [備考]
  • URL: http://www.twmu.ac.jp/IOR/JointSurgery/achievement.html
• [備考]
  • URL: http://www.twmu.ac.jp/IOR/JointSurgery/