歯周病の環境要因と遺伝要因の交互作用解明に関する疫学研究

• 研究課題/領域番号: 20791654
• 研究種目: 若手研究(B)
• 配分区分: 補助金
• 研究分野: 社会系歯学
• 研究機関: 福岡大学
• 研究代表者: 田中 景子 福岡大学, 医学部, 助教 (40341432)
• 研究期間 (年度): 2008 – 2009
• 研究課題ステータス: 完了 (2009年度)
• 配分額: 4,290千円 (直接経費: 3,300千円、間接経費: 990千円); 2009年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円); 2008年度: 2,990千円 (直接経費: 2,300千円、間接経費: 690千円)
• キーワード: 歯周病 / 横断研究 / 疫学 / 若年女性 / 社会医学 / 歯学 / 齲蝕 / 予防要因 / 若年成人女性

研究概要

前向きコホート研究である「九州・沖縄母子保健研究」の4ヶ月時追跡調査を実施した。4ヶ月時調査では、歯科衛生士が個別に訪問して口腔内を観察し、齲蝕の有無、歯周ポケットの測定、歯肉出血の有無、歯石の有無のチェックを行った。1180名が歯科疾患調査に参加した。3mmを超える歯周ポケットを持つ者は11.4%であり、アルコールの摂取と有意な正の関連を認めた。

研究成果

• [雑誌論文] the Fukuoka Kinki Parkinson's Disease Study Group. Dietary intake of folate, vitamin B-6, vitamin B-12, and riboflavin and risk of Parkinson's disease: a case-control study in Japan. (2010)
  • 著者名/発表者名: Murakami K, Miyake Y, Sasaki S, Tanaka K, Fukushima W, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M
  • 雑誌名: Br J Nutr. 26 ページ: 1-8
  • 査読あり
• [雑誌論文] Residential proximity to main roads during pregnancy and the risk of allergic disorders in Japanese infants:The Osaka Maternal and Child Health Study. (2010)
  • 著者名/発表者名: Miyake Y, Tanaka K, Fujiwara H, Mitani Y, Ikemi H, Sasaki S, Ohya Y, Hirota Y
  • 雑誌名: Pediatr Allergy Immunol 21 ページ: 22-28
  • 査読あり
• [雑誌論文] Parkinson's Disease Study Group. Dietary fat intake and risk of Parkinson's disease:a case-control study in Japan. (2010)
  • 著者名/発表者名: Miyake Y, Sasaki S, Tanaka K, Fukushima W, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, Fukuoka Kinki
  • 雑誌名: J Neurol Sci. 288 ページ: 117-122
  • 査読あり
• [雑誌論文] Association between breastfeeding and allergic disorders in Japanese children. (2010)
  • 著者名/発表者名: Tanaka K, Miyake Y, Sasaki S.
  • 雑誌名: Int J Tuberc Lung Dis 14 ページ: 513-518
  • 査読あり
• [雑誌論文] for the Fukuoka Kinki Parkinson, s Disease Study Group. Dietary glycemic index is inversely associated with the risk of Parkinson, sdisease:A case-control study in Japan. (2010)
  • 著者名/発表者名: Murakami K, Miyake Y, Sasaki S, Tanaka K, Fukushima W, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M
  • 雑誌名: Nutrition 26 ページ: 515-521
  • 査読あり
• [雑誌論文] Maternal meat and fat consumption during pregnancy and suspected atopic eczema in Japanese infants aged 3-4 months:The Osaka Maternal and Child Health Study. (2010)
  • 著者名/発表者名: Saito K, Ybkoyama T, Miyake Y, Sasaki S, Tanaka K, Ohya Y, Hirota Y.
  • 雑誌名: Pediatr Allergy Immunol 21 ページ: 35-46
  • 査読あり
• [雑誌論文] Association between breastfeeding and allergic disorders in Japanese children (2010)
  • 著者名/発表者名: Tanaka K et al.
  • 雑誌名: Int J Tuberc Lung Dis 14 ページ: 513-518
  • 査読あり
• [雑誌論文] Residential proximity to main roads during pregnancy and the risk of allergic disorders in Japanese infants : The Osaka Maternal and Child Health Study (2010)
  • 著者名/発表者名: Miyake Y, Tanaka K et al
  • 雑誌名: Pediatr Allergy Immunol 21 ページ: 22-28
  • 査読あり
• [雑誌論文] Maternal meat and fat consumption during pregnancy and suspected atopic eczema in Japanese infants aged 3-4 months : The Osaka Maternal and Child Health Study (2010)
  • 著者名/発表者名: Saito K, Yokoyama T, Miyake Y, Sasaki S, Tanaka K et al.
  • 雑誌名: Pediatr Allergy Immunol 21 ページ: 38-46
  • 査読あり
• [雑誌論文] the Osaka Maternal and Child Health Study Group. Monetary diet cost is associated with not only favorable but also unfavorable aspects of diet in pregnant Japanese women:the Osaka Maternal and Child Health Study. (2009)
  • 著者名/発表者名: Murakami K, Miyake Y, Sasaki S, Tanaka K, Ohya Y, Hirota Y
  • 雑誌名: Environmental Health Insights 2 ページ: 27-35
  • 査読あり
• [雑誌論文] The effect of maternal smoking during pregnancy and postnatal household smoking on dental caries in young children. (2009)
  • 著者名/発表者名: Tanaka K, Miyake Y, Sasaki S.
  • 雑誌名: J Pediatr. 155 ページ: 410-5
  • 査読あり
• [雑誌論文] Sibship size and prevalence of allergic disorders in Japan (2009)
  • 著者名/発表者名: Ohfuji S, Miyake Y, Arakawa M, Tanaka K, Sasaki S.
  • 雑誌名: The Ryukyus Child Health Study Pediatr Allergy Immunol 20 ページ: 377-84
  • 査読あり
• [雑誌論文] Maternal fat consumption during pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months The Osaka Maternal and Child Health Study. (2009)
  • 著者名/発表者名: Miyake Y, Sasaki S, Tanaka K, Ohfuji S, Hirota Y.
  • 雑誌名: Thorax 641 ページ: 815-21
  • 査読あり
• [雑誌論文] Osaka Maternal and Child Health Study Group. Breastfeeding and atopic eczema in Japanese infants (2009)
  • 著者名/発表者名: Miyake Y, Tanaka K, Sasaki S, Kiyohara C, Ohya Y, Fukushima W, Yokoyama T, Hirota Y
  • 雑誌名: The Osaka Maternal and Child Health Study. Pediatr Allergy Immunol 20 ページ: 234-41
  • 査読あり
• [雑誌論文] Osaka Maternal and Child Health Study Group. Education, but not occupation or household income, is positively related to favorable dietary intake patterns in pregnant Japanese women: the Osaka Maternal and Child Health Study. (2009)
  • 著者名/発表者名: Murakami K, Miyake Y, Sasaki S, Tanaka K, Ohya Y, Hirota Y
  • 雑誌名: Nutr Res. 29 ページ: 164-72
  • 査読あり
• [雑誌論文] PhDADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children. (2009)
  • 著者名/発表者名: Matsusue A, Kiyohara C, Tanaka K, Sasaki S, Miyake Y.
  • 雑誌名: Clinical Biochemistry 42 ページ: 477-483
  • 査読あり
• [雑誌論文] The effect of maternal smoking during pregnancy and postnatal household smoking on dental caries in young children (2009)
  • 著者名/発表者名: Tanaka K et al.
  • 雑誌名: J Pediatr 155 ページ: 410-415
  • 査読あり
• [雑誌論文] Education, but not occupation or household income, is positively related to favorable dietary intake patterns in pregnant Japanese women : the Osaka Maternal and Child Health Study (2009)
  • 著者名/発表者名: Murakami K, Miyake Y, Sasaki S, Tanaka K al.
  • 雑誌名: Nutr Res 29 ページ: 164-172
  • 査読あり
• [雑誌論文] Breastfeeding and atopic eczema in Japanese infants : The Osaka Maternal and Child Health Study (2009)
  • 著者名/発表者名: Miyake, Tanaka et al.
  • 雑誌名: Pediatr Allergy Immunol 20 ページ: 234-241
  • 査読あり
• [雑誌論文] Sibship size and prevalence of allergic disorders in Japan : The Ryukyus Child Health Study (2009)
  • 著者名/発表者名: Ohfuji S, Miyake Y, Arakawa M, Tanaka K et al.
  • 雑誌名: Pediatr Allergy Immunol 20 ページ: 377-384
  • 査読あり
• [雑誌論文] ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children (2009)
  • 著者名/発表者名: Matsusue A, Kiyohara C, Tanaka K et al.
  • 雑誌名: Clin Biochem 42 ページ: 477-483
  • 査読あり
• [雑誌論文] Monetary diet cost is associated with not only favorable but also unfavorable aspects of diet in pregnant Japanese women : the Osaka Maternal and Child Health Study (2009)
  • 著者名/発表者名: Murakami K, Miyake Y, Sasaki S, Tanaka K al.
  • 雑誌名: Environmental Health Insights 2 ページ: 27-35
  • 査読あり
• [雑誌論文] Maternal fat consumption during pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months : The Osaka Maternal and Child Health Study (2009)
  • 著者名/発表者名: Miyake Y, Sasaki S, Tanaka K et al.
  • 雑誌名: Thorax 64 ページ: 815-821
  • 査読あり
• [雑誌論文] ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children (2009)
  • 著者名/発表者名: Matsusue A
  • 雑誌名: Clinical Biochemistry 42 ページ: 477-483
  • 査読あり
• [雑誌論文] Relationship between dietary fat and fish intake and the prevalence of atopic eczema in pregnant Japanese females: baseline data from the Osaka Maternal and Child Health Study. (2008)
  • 著者名/発表者名: Miyake Y, Sasaki S, Tanaka K, Ohya Y, Matsunaga I, Yoshida T, Hirota Y, Oda H.
  • 雑誌名: Asia Pac J Clin Nutr. 17(4) ページ: 612-9
  • 査読あり
• [雑誌論文] for the Osaka Maternal and Child Health Study Group. Breastfeeding and the risk of wheeze and asthma in Japanese infants: The Osaka Maternal and Child Health Study. (2008)
  • 著者名/発表者名: Miyake Y, Tanaka K, Sasaki S, Kiyohara C, Ohya Y, Fukushima W, Yokoyama T, Hirota Y
  • 雑誌名: Pediatr Allergy Immunol 19 ページ: 490-496
  • 査読あり
• [雑誌論文] Osaka Maternal and Child Health Study Group. Ambient formaldehyde levels and allergic disorders among Japanese pregnant women: baseline data from the Osaka maternal and child health study. (2008)
  • 著者名/発表者名: Matsunaga I, Miyake Y, Yoshida T, Miyamoto S, Ohya Y, Sasaki S, Tanaka K, Oda H, Ishiko O, Hirota Y
  • 雑誌名: Ann Epidemiol 18 ページ: 78-84
  • 査読あり
• [雑誌論文] The Osaka Maternal and Child Health Study Group. Dietary glycemic index and load and the risk of postpartum depression in Japan: The Osaka Maternal and Child Health Study. (2008)
  • 著者名/発表者名: Murakami K, Miyake Y, Sasaki S, Tanaka K, Yokoyama T, Ohya Y, Fukushima W, Kiyohara C, Hirota Y
  • 雑誌名: J Affect Disord 110 ページ: 174-179
  • 査読あり
• [雑誌論文] The Osaka Maternal and Child Health Study Group. Maternal Smoking and Environmental Tobacco Smoke Exposure and the Risk of Allergic Diseases in Japanese Infants: the Osaka Maternal and Child Health Study. (2008)
  • 著者名/発表者名: Tanaka K, Miyake Y, Sasaki S, Ohya Y, Hirota Y.
  • 雑誌名: J Asthma 45 ページ: 833-8
  • 査読あり
• [雑誌論文] Fatty acid intake and asthma symptoms in Japanese children: The Ryukyus Child Health Study. (2008)
  • 著者名/発表者名: Miyake Y, Sasaki S, Arakawa M, Tanaka K, Murakami K, Ohya Y.
  • 雑誌名: Clin Exp Allergy 38 ページ: 1644-1650
  • 査読あり
• [雑誌論文] Dental Caries and Allergic Disorders in Japanese Children: the Ryukyus Child Health Study. (2008)
  • 著者名/発表者名: Tanaka K, Miyake Y, Arakawa M, Sasaki S, Ohya Y.
  • 雑誌名: J Asthma 45 ページ: 795-9
  • 査読あり
• [雑誌論文] the Osaka Maternal and Child Health Study Group. Beverage Consumption and the Prevalence of Tooth Loss in Pregnant Japanese Women: the Osaka Maternal and Child Health Study. (2008)
  • 著者名/発表者名: Tanaka K, Miyake Y, Sasaki S, Ohya Y, Matsunaga I, Yoshida T, Hirota Y, Oda H
  • 雑誌名: Fukuoka Igaku Zasshi 99 ページ: 80-89
  • 査読あり
• [雑誌論文] Relationship between soy and isoflavone intake and periodontal disease: the Freshmen in Dietetic Courses Study II. (2008)
  • 著者名/発表者名: Tanaka K, Sasaki S, Murakami K, Okubo H, Takahashi Y, Miyake Y.
  • 雑誌名: BMC Public Health 8 ページ: 39-39
  • 査読あり
• [雑誌論文] Dental caries in 3-year-old children and smoking status of parents. (2008)
  • 著者名/発表者名: Hanioka T, Nakamura E, Ojima M, Tanaka K, Aoyama H.
  • 雑誌名: Paediatr Perinat Epidemiol 22 ページ: 546-50
  • 査読あり
• [雑誌論文] Maternal smoking and environmental tobacco smoke exposure and the risk of allergic diseases in Japanese infants : the Osaka Maternal and Child Health Study (2008)
  • 著者名/発表者名: Tanaka K
  • 雑誌名: J Asthma 45 ページ: 833-838
  • 査読あり
• [雑誌論文] Dental caries and allergic disorders in Japanese children : the Ryukyus Child Health Study (2008)
  • 著者名/発表者名: Tanaka K
  • 雑誌名: J Asthma 45 ページ: 795-799
  • 査読あり
• [雑誌論文] Beverage consumption and the prevalence of tooth loss in pregnant Japanese women : the Osaka Maternal and Child Health Study (2008)
  • 著者名/発表者名: Tanaka K
  • 雑誌名: Fukuoka Igaku Zasshi 99 ページ: 80-89
  • NAID: 120000980424
  • 査読あり
• [雑誌論文] Breastfeeding and the risk of wheeze and asthma in Japanese infants : The Osaka Maternal and Child Health Study (2008)
  • 著者名/発表者名: Miyake Y
  • 雑誌名: Pediatr Allergy Immunol 19 ページ: 490-496
  • 査読あり
• [雑誌論文] Ambient formaldehyde levels and allergic disorders among Japanese pregnant women : baseline data from the Osaka maternal and child health study (2008)
  • 著者名/発表者名: Matsunaga I
  • 雑誌名: Ann Epidemiol 18 ページ: 78-84
  • 査読あり
• [雑誌論文] Dietary glycemic index and load and the risk of postpartum depression in Japan : The Osaka Maternal and Child Health Study (2008)
  • 著者名/発表者名: Murakami K
  • 雑誌名: J Affect Disord 110 ページ: 174-179
  • 査読あり
• [雑誌論文] Fatty acid intake and asthma symptoms in Japanese children : The Ryukyus Child Health Study (2008)
  • 著者名/発表者名: Miyake Y
  • 雑誌名: Clin Exp Allergy 38 ページ: 1644-1650
  • 査読あり
• [雑誌論文] Intake of dairy products and the prevalence of dental caries in young children.
  • 著者名/発表者名: Tanaka K, Miyake Y, Sasaki S.
  • 雑誌名: J Dent. (in press)
  • 査読あり
• [雑誌論文] Parkinson's Disease Study Group. Dietary intake of antioxidant vitamins and risk of Parkinson's disease: a case-control study in Japan.
  • 著者名/発表者名: Miyake Y, Fukushima W, Tanaka K, Sasaki S, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, Fukuoka Kinki
  • 雑誌名: Eur J Neurol. (in press)
  • 査読あり
• [雑誌論文] Parkinson's Disease Study Group. GST polymorphisms, interaction with smoking and pesticide use, and risk for Parkinson's disease in a Japanese population.
  • 著者名/発表者名: Kiyohara C, Miyake Y, Koyanagi M, Fujimoto T, Shirasawa S, Tanaka K, Fukushima W, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, Fukuoka Kinki
  • 雑誌名: Parkinsonism Relat Disord. (in press)
  • 査読あり
• [雑誌論文] Parkinson's Disease Study Group. Case-control study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan.
  • 著者名/発表者名: Miyake Y, Tanaka K, Fukushima W, Sasaki S, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, Fukuoka Kinki
  • 雑誌名: J Neurol Sci. (in press)
  • 査読あり
• [雑誌論文] Consumption of vegetables, fruit, and antioxidants during pregnancy and wheeze and eczema in infants.
  • 著者名/発表者名: Miyake Y, Sasaki S, Tanaka K, Hirota Y.
  • 雑誌名: Allergy (in press)
  • 査読あり
• [雑誌論文] Parkinson's Disease Study Group. Active and passive smoking and risk of Parkinson's disease.
  • 著者名/発表者名: Tanaka K, Miyake Y, Fukushima W, Sasaki S, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, Fukuoka Kinki
  • 雑誌名: Acta Neurol Scand (in press)
  • 査読あり
• [雑誌論文] Dairy fbod, calcium, and vitamin D intake in pregnancy and wheeze and eczema in infants.
  • 著者名/発表者名: Miyake Y, Sasaki S, Tanaka K, Hirota Y
  • 雑誌名: Eur Respir J. (in press)
  • 査読あり
• [雑誌論文] The effect of maternal smoking during pregnancy and postnatal household smoking on dental caries in young children
  • 著者名/発表者名: Tanaka K
  • 雑誌名: J Pediatr (印刷中)
  • 査読あり
• [雑誌論文] Sibship size and prevalence of allergic disorders in Japan : The Ryukyus Child Health Study
  • 著者名/発表者名: Ohfuji S
  • 雑誌名: Pediatr Allergy Immunol (印刷中)
  • 査読あり
• [学会発表] 乳製品摂取と乳歯鶴蝕との関連 (2009)
  • 著者名/発表者名: 田中景子、三宅吉博、佐々木敏
  • 学会等名: 第58回日本口腔衛生学会総会
  • 発表場所: 岐阜
  • 年月日: 2009-10-10
• [学会発表] 乳製品摂取と乳歯齲蝕との関連 (2009)
  • 著者名/発表者名: 田中景子, 他
  • 学会等名: 第58回日本口腔衛生学会総会
  • 発表場所: 長良川国際会議場(岐阜)
  • 年月日: 2009-10-10
• [学会発表] 母乳摂取と幼児アレルギー性疾患との関連 (2009)
  • 著者名/発表者名: 田中景子、三宅吉博、清原千香子、佐々木敏
  • 学会等名: 第21回日本アレルギー学会春期臨床大会
  • 発表場所: 岐阜
  • 年月日: 2009-06-05
• [学会発表] 母乳摂取と幼児アレルギー性疾患との関連 (2009)
  • 著者名/発表者名: 田中景子, 他
  • 学会等名: 第21回日本アレルギー学会春期臨床大会
  • 発表場所: 長良川国際会議場(岐阜)
  • 年月日: 2009-06-05
• [学会発表] 福岡・近畿パーキンソン研究グループ、喫煙習慣とパーキンソン病:症例対照研究 (2009)
  • 著者名/発表者名: 田中景子、三宅吉博、福島若葉、佐々木敏、清原千香子、廣田良夫、永井正規
  • 学会等名: 第19回日本疫学会
  • 発表場所: 金沢
  • 年月日: 2009-01-23
• [学会発表] 喫煙習慣とパーキンソン病 : 症例対照研究 (2009)
  • 著者名/発表者名: 田中景子
  • 学会等名: 第19回日本疫学会
  • 発表場所: 金沢
  • 年月日: 2009-01-23
• [学会発表] 母親の妊娠中の喫煙および家庭内喫煙と乳歯齲蝕との関連 (2008)
  • 著者名/発表者名: 田中景子、三宅吉博、佐々木敏
  • 学会等名: 第57回日本口腔衛生学会総会
  • 発表場所: 埼玉
  • 年月日: 2008-10-04