| 研究開始時の研究の概要 |
This research aims at ribosomal synthesis of a potential drug template, disulfide-rich cyclic peptides, with desired conformation, by in vitro incorporation of chemically protected amino acids and stepwise formation of disulfide bonds.
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| 研究実績の概要 |
This research aims at discovery of de novo disulfide-rich peptides (DRPs) with desired conformations and biological activities using in vitro selection. In this year of my JSPS fellowship, I first finished the paper publication of the research that identified an ultrapotent cyclotide-based FXIIa inhibitor. This work was published on J. Am. Chem. Soc. 2021, 143, 18481-18489. In this year, I also continued the research of controlling disulfide connectivity in DRPs taking advantage of protected cysteines. In brief, I constructed bicyclic or tricyclic DRP libraries with controllable disulfide conformations and conducted in vitro selection to yield several potent target-binding peptides with designed structures. The following work is being performed and will be summarized into publications.
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