| 研究課題/領域番号 |
20K05576
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| 研究種目 |
基盤研究(C)
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| 配分区分 | 基金 |
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| 応募区分 | 一般 |
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| 審査区分 |
小区分34030:グリーンサステイナブルケミストリーおよび環境化学関連
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| 研究機関 | 東京都立大学 (2021)
北海道大学 (2020) |
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研究代表者 |
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| 研究分担者 |
Siddiki Hakim 北海道大学, 触媒科学研究所, 特任助教 (60722650)
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| 研究期間 (年度) |
2020-04-01 – 2022-03-31
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| 研究課題ステータス |
中途終了 (2021年度)
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| 配分額 *注記 |
4,290千円 (直接経費: 3,300千円、間接経費: 990千円)
2022年度: 780千円 (直接経費: 600千円、間接経費: 180千円)
2021年度: 1,170千円 (直接経費: 900千円、間接経費: 270千円)
2020年度: 2,340千円 (直接経費: 1,800千円、間接経費: 540千円)
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| キーワード | Heterogeneous catalysis / Step-efficient Synthesis / Oncology drug / Heterogeneous Catalysis / API Intermediates / Green Synthesis / Acceptorless / Metal nanoparticles |
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| 研究開始時の研究の概要 |
This research focuses on the step efficient green heterogeneous catalysis of supported metal nanoparticles and Lewis acid-base incorporated catalysis of metal oxides for the synthesis of life-saving nib group oncology drug intermediates. It is identified that acceptorless dehydrogenative coupling, hydrogen transfer type coupling, and acid-base promoted condensation type reaction methods are the most vital issues for this green synthesis. In this study, I will develop new catalytic methods for selective and efficient synthesis of oncology APIs.
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| 研究実績の概要 |
To develop the heterogeneous catalytic methods for the proposed plan, the reactions (1) Dehydrogenative selective methylation and reductive amination of 2-aminobenzamide derivative to quinazolin-4-amine derivative, (2) Dehydrogenative heterocyclization reaction of 1,2-diamino benzene derivative in reaction with methanol produced benzimidazole derivatives, and (3) Hydrolysis of triglycerides to fatty acids are being demonstrated by employing sustainable and environmentally benign green synthesis methods.
For the reactions 1-3 we identified effective catalysts. Further optimization, demonstration, kinetics and mechanistic studies are underway for reactions 1 and 2. For the reaction 3 we have already submitted the paper and it is under review.
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