研究課題/領域番号 |
20K06761
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研究種目 |
基盤研究(C)
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配分区分 | 基金 |
応募区分 | 一般 |
審査区分 |
小区分45010:遺伝学関連
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研究機関 | 国立研究開発法人理化学研究所 |
研究代表者 |
FAWCETT JEFFREY 国立研究開発法人理化学研究所, 数理創造プログラム, 上級研究員 (50727394)
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研究分担者 |
印南 秀樹 総合研究大学院大学, 先導科学研究科, 教授 (90444140)
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研究期間 (年度) |
2020-04-01 – 2024-03-31
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研究課題ステータス |
交付 (2022年度)
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配分額 *注記 |
4,290千円 (直接経費: 3,300千円、間接経費: 990千円)
2023年度: 1,170千円 (直接経費: 900千円、間接経費: 270千円)
2022年度: 1,170千円 (直接経費: 900千円、間接経費: 270千円)
2021年度: 1,170千円 (直接経費: 900千円、間接経費: 270千円)
2020年度: 780千円 (直接経費: 600千円、間接経費: 180千円)
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キーワード | Transposable Elements / gene conversion / Transposable Element / Gene conversion / evolution |
研究開始時の研究の概要 |
We will test the role of non-allelic gene conversion between Transposable Elements (TEs) in the evolution of TEs, and in the evolution of regulatory networks using computer simulation and genomic data analyses.
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研究実績の概要 |
Transposable Elements are thought to be key drivers of evolution and have most likely contributed to the rewiring of regulatory networks. In particular, we previously argued that non-allelic gene conversion between TEs likely contributes not only to the evolution of TEs, but also to the rewiring of regulatory networks via TEs. The drastic increase in whole-genome sequence data of various different species in the recent years provides the opportunity to understand the evolution of TEs, including the occurrence of non-allelic gene conversion and their contribution to genome evolution, in great detail that was not possible before. In this study, we have been exploring the evolutionary dynamics of TEs by theory, computer simulation using a previously developed framework, and genomic data analysis using genome sequences of various mammal and plant species. In particular, we have been able to show the contribution of the differential activity of different TE families to genome size evolution, genome structure, and centromere evolution in plant species.
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現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
We have been able to prepare a manuscript including our results on the contribution of TEs to genome size evolution and centromere evolution in plants which is currently under review.
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今後の研究の推進方策 |
We will summarize our findings of TE evolution based on theoretical study, simulation study, and genomic data analysis and develop a framework of TE evolution.
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