| 研究課題/領域番号 |
20K15269
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| 研究種目 |
若手研究
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| 配分区分 | 基金 |
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| 審査区分 |
小区分33020:有機合成化学関連
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| 研究機関 | 北海道大学 |
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研究代表者 |
REYES RONALD・LAZO 北海道大学, 化学反応創成研究拠点, 特任助教 (30845475)
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| 研究期間 (年度) |
2020-04-01 – 2023-03-31
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| 研究課題ステータス |
中途終了 (2022年度)
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| 配分額 *注記 |
4,160千円 (直接経費: 3,200千円、間接経費: 960千円)
2023年度: 650千円 (直接経費: 500千円、間接経費: 150千円)
2022年度: 780千円 (直接経費: 600千円、間接経費: 180千円)
2021年度: 1,040千円 (直接経費: 800千円、間接経費: 240千円)
2020年度: 1,690千円 (直接経費: 1,300千円、間接経費: 390千円)
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| キーワード | borylation / asymmetric synthesis / organometallic catalysis / organic synthesis / C-H activation / C-H functionalization / remote C-H bonds / noncovalent interactions |
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| 研究開始時の研究の概要 |
In this work, combined theoretical calculations (AFIR, DFT, etc.) and experimental methodologies will be utilized for the construction of efficient catalytic system that will enable the competent functionalization of remote C-H bonds from simple and readily available feedstocks.
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| 研究実績の概要 |
With our interest in the development of novel methodologies for the transformation of C-H bonds in readily available feedstock chemicals, we previously demonstrated the competent activation and subsequent asymmetric borylation of g-C(sp3)-H bonds under Ir catalysis. Our collaboration with ICReDD scientists has given us infinite opportunity to further extend the reactivity of our catalytic system. Thus, guided by calculation derived transition-state models, we recently succeeded in the asymmetric borylation of more distal C-H bonds in the aliphatic hydrocarbon chain of common and readily available chemical feedstocks including biomass resources allowing for a more sustainable and efficient organic synthesis. Thereby, the borylation of e-C-H bonds, located five carbons away from the carbonyl group of the substrate, has been achieved - a direct functionalization realized using a modularly designed supramolecular catalytic assembly.
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