| 研究課題/領域番号 |
20K15945
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| 研究種目 |
若手研究
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| 配分区分 | 基金 |
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| 審査区分 |
小区分46030:神経機能学関連
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| 研究機関 | 国立研究開発法人理化学研究所 |
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研究代表者 |
アウティオ ヨーナス 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員 (40755485)
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| 研究期間 (年度) |
2020-04-01 – 2024-03-31
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| 研究課題ステータス |
交付 (2022年度)
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| 配分額 *注記 |
3,640千円 (直接経費: 2,800千円、間接経費: 840千円)
2023年度: 520千円 (直接経費: 400千円、間接経費: 120千円)
2022年度: 520千円 (直接経費: 400千円、間接経費: 120千円)
2021年度: 1,040千円 (直接経費: 800千円、間接経費: 240千円)
2020年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円)
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| キーワード | Evolution / Cerebellum / Human / Macaque / fMRI / cerebellum / macaque / Cerebro-cerebellar / Resting-state / System neuroscience / Functional / MRI |
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| 研究開始時の研究の概要 |
Cerebellum contain the large majority of the neurons in the brain (80% in humans) and contributes to a wide range of brain functions. However, little is known about the evolution of cerebro-cerebellar system due to the technical challenge imposed by the multi-synaptic circuitry. To corroborate the evolution of primate cerebro-cerebellar communication, here, I investigate the cerebro-cerebellar functional connectivity by capitalizing on our recent advances in the resting-state functional magnetic resonance imaging in awake behaving macaque monkeys and compare the findings with those in humans.
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| 研究実績の概要 |
In summary, our results study shows that cognition plays a major role in human cerebellum (> 40%) whereas in macaque only a small fraction is associated with cognitive functions (< 15%). Interestingly, in macaques we find cerebro-cerebral functional connectivity associated with early auditory processing which is absent in humans. Based on topological arrangement, this macaque cerebro-cerebral auditory circuit appears to have evolved into a human language network. Relevant to the grant, two first authorship publications have been completed (2x NeuroImage) and further three first authorship manuscripts are under preparation.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
3: やや遅れている
理由
Data acquisition has been successfully completed and the initial data analyses proceeded according to the plan. However, the project was delayed by two major and unfortunate set backs: 1) the data acquisition was delayed due to covid-19 and 2) initial macaque and human data analyses were lost due to the failure of data server system summer 2022. Both of the factors were independent from the principal investigator (me). Notwithstanding, data is currently being re-analyzed and figures for the publication re-generated.
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| 今後の研究の推進方策 |
All raw data has been recovered that was lost in the server failure (see above). The data analysis pipeline is almost re-established for the macaque monkey. This will be followed by manual artifact de-noising of each subject and generation of robust group-level functional connectivity maps. Then, newly acquired high-resolution structural MR images will be used for generation of cerebellum surface map in macaques. Finally, the functional cerebellum surface maps will be directly compared with those achieved in humans.
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