| 研究課題/領域番号 |
20K20209
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| 研究種目 |
若手研究
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| 配分区分 | 基金 |
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| 審査区分 |
小区分90120:生体材料学関連
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| 研究機関 | 九州大学 (2022)
公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター) (2020-2021) |
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研究代表者 |
LI JUNJIE 九州大学, 先導物質化学研究所, 准教授 (80869892)
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| 研究期間 (年度) |
2020-04-01 – 2023-03-31
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| 研究課題ステータス |
完了 (2022年度)
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| 配分額 *注記 |
3,900千円 (直接経費: 3,000千円、間接経費: 900千円)
2022年度: 780千円 (直接経費: 600千円、間接経費: 180千円)
2021年度: 1,690千円 (直接経費: 1,300千円、間接経費: 390千円)
2020年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
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| キーワード | Immunotherapy / Nanoreactors / Pyroptosis / Self-assembly / Vesicles / Tumor metabolism / immunotherapy / nanoreactors / pyroptosis / self-assembly / vesicles / tumor metabolism / vesicle / nanoreactor / drug delivery |
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| 研究開始時の研究の概要 |
The applicant will exploit the nanoreactor in the tumor-specific activation to simultaneously suppress breast tumor growth and metastasis. The glucose and lactate will be simultaneously consumed by oxidase-loaded nanoreactor with accompanying ROS production, which will aggravate metabolic stress.
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| 研究成果の概要 |
1. A generic method has been developed to construct smart enzyme-loaded nanoreactors for targeting tumor metabolism.
2. As a accident discovery, nanoreactors could induce an immunostimulatory form of cell death by pyroptosis, which has the great potential to prime anti-tumor immune responses.
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| 研究成果の学術的意義や社会的意義 |
1. Scientific significance: a generic method has been developed to construct smart oxidase-loaded nanoreactor for specifically targeting tumor metabolism.
2. Social significance: Our nanoreactors can increase the potential of immunotherapy to bring more benefits to cancer patients.
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