| 研究課題/領域番号 |
20K20237
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| 研究種目 |
若手研究
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| 配分区分 | 基金 |
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| 審査区分 |
小区分90130:医用システム関連
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| 研究機関 | 沖縄科学技術大学院大学 |
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研究代表者 |
Funari Riccardo 沖縄科学技術大学院大学, マイクロ・バイオ・ナノ流体ユニット, 研究員 (20866058)
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| 研究期間 (年度) |
2020-04-01 – 2021-03-31
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| 研究課題ステータス |
完了 (2020年度)
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| 配分額 *注記 |
4,030千円 (直接経費: 3,100千円、間接経費: 930千円)
2021年度: 780千円 (直接経費: 600千円、間接経費: 180千円)
2020年度: 3,250千円 (直接経費: 2,500千円、間接経費: 750千円)
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| キーワード | Biosensor / Prostate cancer / SARS-CoV-2 / Cancer biomarkers / dual-mode sensing / Antibody |
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| 研究開始時の研究の概要 |
The outline of the research consists of three key points:
1) Optimization of the gold nanostructures on the QCM sensor surface to perform both optical and microgravimetric sensing.
2) Quantification of prostate cancer biomarkers by antibody-based biosensors.
3) Capturing the presence of the target molecules in real biological samples.
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| 研究実績の概要 |
I was able to develop an opto-microfluidic sensing platform to detect specific biomarkers in human plasma. The ongoing global pandemic of SARS-CoV-2 motivated us to use this device to detect first COVID-19 related proteins such as anti-SARS-CoV-2 S antibodies (DOI: 10.1016/j.bios.2020.112578).
This device has been further developed to achieve the detection of multiple biomarkers in the same sample using a single integrated device, and is the subject of a recently submitted pubblication about COVID-19 reasarch and of a next paper on prostate cancer biomarkers detection in human plasma. Specifically, this biosensor allows to detect prostate specific antigen, matrix metalloproteinase-2 and anti-alpha-methylacyl-CoA in real sample with high sensitivity (LOD < 0.5 ng/mL) in less than 30 min.
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