| 研究課題/領域番号 |
20K20302
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| 補助金の研究課題番号 |
17H06257 (2017-2019)
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| 研究種目 |
挑戦的研究(開拓)
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| 配分区分 | 基金 (2020)
補助金 (2017-2019) |
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| 研究分野 |
細胞レベルから個体レベルの生物学およびその関連分野
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| 研究機関 | 京都大学 |
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研究代表者 |
FUSTIN JM 京都大学, 薬学研究科, 准教授 (50711818)
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| 研究期間 (年度) |
2017-06-30 – 2021-03-31
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| 研究課題ステータス |
採択後辞退 (2020年度)
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| 配分額 *注記 |
25,740千円 (直接経費: 19,800千円、間接経費: 5,940千円)
2020年度: 2,080千円 (直接経費: 1,600千円、間接経費: 480千円)
2019年度: 3,770千円 (直接経費: 2,900千円、間接経費: 870千円)
2018年度: 3,770千円 (直接経費: 2,900千円、間接経費: 870千円)
2017年度: 16,120千円 (直接経費: 12,400千円、間接経費: 3,720千円)
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| キーワード | circadian / methylation / organ-on-a-chip / circadian clock / casein kinase / RNA methylation / ck1d / casein kinase 1 delta / Mettl3 / Casein kinase 1 delta |
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| 研究実績の概要 |
Experiments with animals genetically deficient in methylation or in which methylations have been pharmacologically inhibited have progressed well, although the high inter-individual variability between animals and poor conditions in our department's animal house has so far prevented us to obtain publication-level results with genetically deficient animals.
Nevertheless, pharmacological studies in multiple organisms, in intercontinental collaboration with many laboratories have progressed very well and a new paper titled "Methylation deficiency disrupts biological rhythms from bacteria to humans" has been published in a Nature journal on the 6th of May (Fustin et al., 2020), with two other publications this year (Doi et al., 2019; Fustin et al., 2019)
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
We are continuing the research described in the project but have experiences some delays because of the COVID-19 crisis. Moreover, I have relocated to the University of Manchester in the United Kingdom and will continue my experiments there. It will take time to set my laboratory up and start experiments with newly generated animal models. It is my hope that the high-quality of animal house at the University of Manchester compared to that at Kyoto University Pharmaceutical Science Department will allow me to study methylation deficient animals more reliably. Indeed, these animals are likely to be immunocompromised and need therefore a very clean environment.
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| 今後の研究の推進方策 |
I plan to continue the research described in the project as well as start new investigations related to methyl metabolism. However, since these experiments are going to be done in the United Kingdom I do not want to disclose my plans here.
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