| 研究課題/領域番号 |
20K22752
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| 研究種目 |
研究活動スタート支援
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| 配分区分 | 基金 |
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| 審査区分 |
0802:生体の構造と機能およびその関連分野
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| 研究機関 | 国立研究開発法人国立循環器病研究センター |
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研究代表者 |
LAMRI LYNDA 国立研究開発法人国立循環器病研究センター, 研究所, リサーチフェロー (90883984)
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| 研究期間 (年度) |
2020-09-11 – 2023-03-31
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| 研究課題ステータス |
完了 (2022年度)
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| 配分額 *注記 |
2,860千円 (直接経費: 2,200千円、間接経費: 660千円)
2021年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
2020年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
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| キーワード | Troponin / Embryonic development / embryonic development |
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| 研究開始時の研究の概要 |
Components of the Troponin protein complex are involved in the regulation of muscle contraction; however, they are expressed in various cell types, and completely different mechanisms of actions have been proposed. Furthermore, much is left unknown about possible abnormalities due to their deficiency. This study aims to analyze how a Troponin complex gene is regulated during embryonic development and further elucidate its unexplored functions in embryonic development and disease.
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| 研究成果の概要 |
This study analyses how a Troponin complex gene is regulated during embryonic development and is elucidating its unexplored functions in embryonic development and disease.
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| 研究成果の学術的意義や社会的意義 |
We will study the mechanisms of abnormalities in troponin mutant embryos based on: (1)The defects of sarcomeric Troponin impair skeletal muscle contractility and result in abnormal phenotypes, and (2) The troponin elicits non-sarcomeric actions mainly in the embryonic skeletal muscle.
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