ヒト癌幹細胞に対する分子免疫病理学的基盤研究

• 研究課題/領域番号: 21249025
• 研究種目: 基盤研究(A)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 人体病理学
• 研究機関: 札幌医科大学
• 研究代表者: 佐藤 昇志 札幌医科大学, 医学部, 教授 (50158937)
• 研究分担者: 鳥越 俊彦 札幌医科大学, 医学部, 准教授 (20301400)
• 連携研究者: 一宮 慎吾 札幌医科大学, 保健医療学部, 教授 (30305221) ; 田村 保明 札幌医科大学, 医学部, 講師 (80322329) ; 廣橋 良彦 札幌医科大学, 医学部, 助教 (30516901) ; 菊地 智樹 東海大学, 医学部, 助教 (50404588)
• 研究期間 (年度): 2009 – 2011
• 研究課題ステータス: 完了 (2011年度)
• 配分額: 46,020千円 (直接経費: 35,400千円、間接経費: 10,620千円); 2011年度: 14,820千円 (直接経費: 11,400千円、間接経費: 3,420千円); 2010年度: 14,820千円 (直接経費: 11,400千円、間接経費: 3,420千円); 2009年度: 16,380千円 (直接経費: 12,600千円、間接経費: 3,780千円)
• キーワード: 分子病理 / 癌幹細胞 / 腫瘍抗原 / CTL / 癌免疫 / 分子標的 / SP法 / CSC/CIC / CSC / CIC

研究概要

ヒト癌幹細胞cancer stem cell/癌起始細胞cancer initiating cell(CSC/CIC)に発現する癌抗原の同定とCSC/CIC癌ワクチン開発を目的として、CSC/CIC癌抗原の解析を進めた。その結果、そのような抗原として数十の分子を同定した。これらのうち発現が正常幹細胞に発現を認めない、極めて腫瘍限局性のすぐれた分子として特徴づけられた3分子につきCSC特異的ヒト腫瘍抗原として詳細な解析を行うことができた。これらの成果はヒトCSC腫瘍ワクチン開発の基盤となるものであり、臨床研究、臨床試験に移行可能な段階に達することが出来た。

研究成果

• [雑誌論文] Heat shock protein 40 family, DNAJB8 is expressed in renal cancer stem-like cell, controls the tumor-initiating ability and can be a potent target of immunotherapy. (2012)
  • 著者名/発表者名: Nishizawa, S., Mori, T., Hirohashi, Y., Torigoe, T., Tamura, Y., Kamiguchi, K., Takahashi, A., Kanaseki, T., Nakazawa, E., Asanuma, H., Sokolovskaya, A., Morita, R., Yamada, R., Fujii, R., Kondo, T., Hasegawa, T., Hara, I. and Sato, N.
  • 雑誌名: Cancer Res 巻: (in press) 号: 11 ページ: 2844-54
  • DOI: 10.1158/0008-5472.can-11-3062
  • 査読あり
• [雑誌論文] Establishment of a monoclonal anti-pan HLA class I antibody suitable for immunostaining of formalin-fixed tissue : Unusually high frequency of down-regulation in breast cancer tissues (2012)
  • 著者名/発表者名: Torigoe, T., Asanuma, H., Nakazawa. E., Tamura, Y., Hirohashi, Y., Yamamoto, E., Kanaseki, T., Hasegawa, T., Sato, N.
  • 雑誌名: Pathol Int 巻: 62 号: 5 ページ: 303-8
  • DOI: 10.1111/j.1440-1827.2012.02789.x
  • NAID: 10031185205
  • 査読あり
• [雑誌論文] Sorting Nexin 5 of a New Diagnostic Marker of Papillary Thyroid Carcinoma Regulates Caspase-2 (2012)
  • 著者名/発表者名: Ara S,Kikuchi T,Matsumiya H,Kojima T,Kubo T, Ye RC, Sato A, Kon SI, Honma T,Asakura K, Hasegawa T, Himi T,Sato N, Ichimiya S.
  • 雑誌名: Cancer Science 巻: 103 号: 7 ページ: 1356-62
  • DOI: 10.1111/j.1349-7006.2012.02296.x
  • 査読あり
• [雑誌論文] ECRG4 is a negative regulator of caspase-8-mediated apoptosis in human T-leukemia cells (2012)
  • 著者名/発表者名: Matsuzaki J,Torigoe T,Hirohashi Y, Kamiguchi K,Tamura Y, Tsukahara T,Kubo T, Takahashi A, Nakazawa E,Saka E, Yasuda K,Takahashi S,Sato N.
  • 雑誌名: Carcinogenesis 巻: 33 号: 5 ページ: 996-1003
  • DOI: 10.1093/carcin/bgs118
  • 査読あり
• [雑誌論文] Novel oligomannose liposome-DNA complex DNA vaccination efficiently evokes anti-HPV E6 and E7 CTL responses (2012)
  • 著者名/発表者名: Mizuuchi M, Hirohashi Y, Torigoe T, Takafumi K, Yasuda K, Saito T, Sato N.
  • 雑誌名: Exp Mol Pathol 巻: 92 ページ: 185-190
  • URL: http://dx.doi.org/10.1016/j.yexmp.2011.10.002
  • 査読あり
• [雑誌論文] Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population (2012)
  • 著者名/発表者名: Mori T, Nishizawa S, Hirohashi Y, Torigoe T, Tamura Y, Takahashi A, Kochin V, Fujii R, Toru K, Greene MI, Hara I, Sato N.
  • 雑誌名: Exp Mol Pathol 巻: 92 ページ: 27-32
  • URL: http://dx.doi.org/10.1016/j.yexmp.2011.09.016
  • 査読あり
• [雑誌論文] SOX2 is expressed in stem-like cells of human lung adenocarcinoma and augments the tumor-initiating potential (2011)
  • 著者名/発表者名: Nakatsugawa, M., Takahashi, A., Hirohashi, Y., Torigoe, T., Inoda, S., Asanuma, H., Tamura, Y., Hasegawa, T., Takahashi, H., and Sato, N.
  • 雑誌名: Lab Invest. 巻: 91 号: 12 ページ: 1796-1804
  • DOI: 10.1038/labinvest.2011.140
  • 査読あり
• [雑誌論文] Tumor associated dendritic cells : molecular mechanisms to suppress anti-tumor immunity (2011)
  • 著者名/発表者名: Hirohashi, Y. and Sato, N.
  • 雑誌名: Immunotherapy 巻: 3 号: 8 ページ: 945-947
  • DOI: 10.2217/imt.11.94
  • 査読あり
• [雑誌論文] Tumor-Produced Secreted Form of Binding of Immunoglobulin Protein Elicits Antigen-Specific Tumor Immunity. (2011)
  • 著者名/発表者名: Tamura Y, Hirohashi Y, Kutomi G, Nakanishi K, Kamiguchi K, Torigoe T, Sato N.
  • 雑誌名: J. Immunol 巻: 186 号: 7 ページ: 4325-4330
  • DOI: 10.4049/jimmunol.1004048
  • 査読あり
• [雑誌論文] Extracellular heat shock protein 90 plays a role in translocating chaperoned antigen from endosome to proteasome for generating antigenic peptide to be cross-presented by dendritic cells. (2011)
  • 著者名/発表者名: Oura, J., Tamura, Y., Kamiguchi, K., Kutomi, G., Sahara, H., Torigoe, T., Himi, T., and Sato, N.
  • 雑誌名: Int. Immunol 巻: 23 号: 4 ページ: 223-237
  • DOI: 10.1093/intimm/dxq475
  • 査読あり
• [雑誌論文] Autologous CTL response against cancer stem-like cells/cancer-initiating cells of bone malignant fibrous histiocytoma (2011)
  • 著者名/発表者名: Kano, M., Tsukahara, T., Emori, M., Murase, M., Torigoe, T., Kawaguchi, S., Wada, T., Yamashita, T., Sato, N.
  • 雑誌名: Cancer Sci 巻: 102 号: 8 ページ: 1443-1137
  • DOI: 10.1111/j.1349-7006.2011.01962.x
  • NAID: 10030241866
  • 査読あり
• [雑誌論文] Immunogenic enhancement and clinical effect by type-I interferon of anti-apoptotic protein, survivin-derived peptide vaccine, in advanced colorectal cancer patients (2011)
  • 著者名/発表者名: Kameshima, H., Tsuruma, T., Torigoe, T., Takahashi, A., Hirohashi, Y., Tamura, Y., Tsukahara, T., Ichimiya, S., Kanaseki, T., Iwayama, Y., Sato, N., Hirata, K.
  • 雑誌名: Cancer Sci 巻: 102 号: 6 ページ: 1181-1187
  • DOI: 10.1111/j.1349-7006.2011.01918.x
  • NAID: 10029294487
  • 査読あり
• [雑誌論文] Comparison of speedy PCR-ssp method and serological typing of hla-a24 for Japanese cancer patients. (2011)
  • 著者名/発表者名: Nakatsugawa M, Hirohashi Y, Torigoe T, Inoda S, Kiriyama K, Tamura Y, Sato E, Takahashi H, Sato N.
  • 雑誌名: J Immunoassay Immunochem 巻: 32 号: 2 ページ: 93-102
  • DOI: 10.1080/15321819.2010.543219
  • 査読あり
• [雑誌論文] Cytotixic T lymphocytes efficiently recognize human colon cancer stem-like cells (2011)
  • 著者名/発表者名: Inoda, S., Hirohashi, Y., Torigoe, T., Takahashi, A., Morita, R., Nakatsugawa, M., Nishizawa, S., Tamura, Y., Tsuruma, T., Terui, T., Ishitani, K., Hirata, K. and Sato, N.
  • 雑誌名: Am. J. Pathol 巻: 178 ページ: 1805-1813
  • URL: http://dx.doi.org/10.1016/j.ajpath.2011.01.004
  • 査読あり
• [雑誌論文] Phase I clinical trial of survivin-derived peptide vaccine therapy for patients with advanced or recurrent oral cancer (2011)
  • 著者名/発表者名: Miyazaki A, Kobayashi J, Torigoe T, Hirohashi Y, Yamamoto T, Yamaguchi A, Asanuma H, Takahashi A, Michifuri Y, Nakamori K, Nagai I, Sato N, Hiratsuka H.
  • 雑誌名: Cancer Sci 巻: 102 号: 2 ページ: 324-329
  • DOI: 10.1111/j.1349-7006.2010.01789.x
  • NAID: 10029289826
  • 査読あり
• [雑誌論文] The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma (2011)
  • 著者名/発表者名: Inoda S, Morita R, Hirohashi Y, Torigoe T, Asanuma H, Nakazawa E, Nakatsugawa M, Tamura Y, Kamiguchi K, Tsuruma T, Terui T, Ishitani K, Hashino S, Wang Q, Greene MI, Hasegawa T, Hirata K, Asaka M, Sato N.
  • 雑誌名: Exp. Mol. Pathol 巻: 90 ページ: 55-60
  • URL: http://dx.doi.org/10.1016/j.yexmp.2010.10.001
  • 査読あり
• [雑誌論文] Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlong primary B cells and their cognate T cell help (2011)
  • 著者名/発表者名: Nagashima, T., Ichimiya, S., Kikuchi, T., Saito, Y., Matsumiya, H., Ara, S., Koshiba, S., Zhang, J., Hatate, S., Tonooka, A., Kubo, T., Hirose, B., Shirasaki, H., Izumi, T., Takami, T., Himi, T. and Sato, N.
  • 雑誌名: Am. J. Pathol 巻: 171 号: 1 ページ: 222-232
  • DOI: 10.1016/j.ajpath.2010.11.033
  • 査読あり
• [雑誌論文] Autoantibody against hypoxia-inducible factor prolyl hydroxylase-3 is a potential serological marker for renal cell carcinoma (2011)
  • 著者名/発表者名: Tanaka, T., Kitamura, H., Torigoe, T., Hirohashi, Y., Masumori, N., Sato, N. and Tsukamoto, T.
  • 雑誌名: J. Cancer Res. Clin. Oncol 巻: 137 号: 5 ページ: 789-794
  • DOI: 10.1007/s00432-010-0940-6
  • 査読あり
• [雑誌論文] Heat shock protein 40 family, DNAJB8 is expressed in renal cancer stem-like cell, controls the tumor-initiating ability and can be a potent target of immunotherapy (2011)
  • 著者名/発表者名: Nishizawa, S., Sato, N., et al
  • 雑誌名: Cancer Res. 巻: (in press)
  • 査読あり
• [雑誌論文] Cytotixic T lymphocytes efficiently recognize human colon cancer stem-like cells (2011)
  • 著者名/発表者名: Inoda, S., Sato, N., et al
  • 雑誌名: Am.J.Pathol. 巻: 178 ページ: 1805-1813
  • 査読あり
• [雑誌論文] Tumor-Produced Secreted Form of Binding of Immunoglobulin Protein Elicits Antigen-Specific Tumor Immunity. Selected paper in "In thia issue" of the Journal (2011)
  • 著者名/発表者名: Tamura Y., Sato, N., et al.
  • 雑誌名: J.Immunol. 巻: 186 ページ: 4325-4330
  • 査読あり
• [雑誌論文] Extracellular heat shock protein 90 plays a role in translocating chaperoned antigen from endosome to proteasome for generating antigenic peptide to be cross-presented by dendritic cells. Selected paper in "In this issue" of the Journal (2011)
  • 著者名/発表者名: Oura, J., Sato, N., et al.
  • 雑誌名: Int.Immunol. 巻: 23 ページ: 223-237
  • 査読あり
• [雑誌論文] Immunogenic enhancement and clinical effect by type-I interferon of anti-apoptotic protein, survivin-derived peptide vaccine, in advanced colorectal cancer patients. (2011)
  • 著者名/発表者名: Kameshima, H., Sato, N., et al.
  • 雑誌名: Cancer Sci. 巻: (in press)
  • NAID: 10029294487
  • 査読あり
• [雑誌論文] Comparison of speedy PCR-ssp method and serological typing of hla-a24 for Japanese cancer patients. (2011)
  • 著者名/発表者名: Nakatsugawa M, Sato, N., et al.
  • 雑誌名: J Immunoassay Immunochem. 巻: 32 ページ: 93-102
  • 査読あり
• [雑誌論文] SOX2 is expressed in stem-like cells of human lung adenocarcinoma and augments the tumor-initiating potential. (2011)
  • 著者名/発表者名: Nakatsugawa, M., Sato, N., et al.
  • 雑誌名: Lab Invest. 巻: (in press)
  • 査読あり
• [雑誌論文] DNA methyltransferase 1 is essential for maintenance of human colon cancer stem-like cells. (2011)
  • 著者名/発表者名: Morita, R., Sato, N., et al.
  • 雑誌名: Am J.Pathol. 巻: (in press)
  • 査読あり
• [雑誌論文] Cytotixic T lymphocytes efficiently recognize human colon cancer stem-like cells. (2011)
  • 著者名/発表者名: Inoda, S., Sato, N., et al.
  • 雑誌名: Am.J.Pathol. 巻: 178 ページ: 1805-1813
  • 査読あり
• [雑誌論文] Phase I clinical trial of survivin-derived peptide vaccine therapy for patients with advanced or recurrent oral cancer. (2011)
  • 著者名/発表者名: Miyazaki A, Sato, N., et al.
  • 雑誌名: Cancer Sci. 巻: 102 ページ: 324-329
  • NAID: 10029289826
  • 査読あり
• [雑誌論文] The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma. (2011)
  • 著者名/発表者名: Inoda S, Sato, N., et al.
  • 雑誌名: Exp.Mol.Pathol. 巻: 90 ページ: 55-60
  • 査読あり
• [雑誌論文] Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlong primary B cells and their cognate T cell help. (2011)
  • 著者名/発表者名: Nagashima, T., Sato, N., et al.
  • 雑誌名: Am.J.Pathol. 巻: 171 ページ: 222-232
  • 査読あり
• [雑誌論文] Spatiotemporal regulation of heat shock protein 90-chaperoned self-DNA and CpG-oligodeoxynucleotide for type I IFN induction via targeting to static early endosome (2010)
  • 著者名/発表者名: Okuya, K., Tamura, Y., Saito, K., Kutomi, G., Torigoe, T., Hirata, K., Sato, N.
  • 雑誌名: J. Immunol 巻: 184 号: 12 ページ: 7092-7099
  • DOI: 10.4049/jimmunol.1000490
  • 査読あり
• [雑誌論文] Melanoma-targeted chemo-thermo-immuno(CTI)-therapy using N-propionyl-4-S-cysteaminylphenol-m agnetite nanoparticles elicits CTL response via heat shock protein-peptide complex release (2010)
  • 著者名/発表者名: Sato A, Tamura Y, Sato N, Yamashita T, Takada T, Sato M, Osai Y, Okura M, Ono I, Ito A, Honda H, Wakamatsu K, Ito S, Jimbow K.
  • 雑誌名: Cancer Sci 巻: 101 号: 9 ページ: 1939-1946
  • DOI: 10.1111/j.1349-7006.2010.01623.x
  • NAID: 10027831209
  • 査読あり
• [雑誌論文] Immune response against tumor antigens expressed on human cancer stem-like cells/tumor-initiating cells (2010)
  • 著者名/発表者名: Hirohashi, Y., Torigoe, T., Inoda, S., Takahashi, A., Morita, R., Nishizawa, S., Tamura, Y., Suzuki, H., Yoyota, M. Sato, N.
  • 雑誌名: Immunotherapy 巻: 2 ページ: 201-211
  • 査読あり
• [雑誌論文] Inhibition of osteopontin reduces liver metastasis of human pancreatic cancer xenografts injected into the spleen in a mouse model (2010)
  • 著者名/発表者名: Ohno, K., Nishimori, H., Yasoshima, T., Kamiguchi, K., Hata, F., Fukui, R., Okuya, K., Kimura, Y., Denno, R., Kon, S., Uede, T., Sato, N. Hirata, K.
  • 雑誌名: Surg. Today 巻: 40 号: 4 ページ: 347-356
  • DOI: 10.1007/s00595-009-4082-x
  • NAID: 10027395148
  • 査読あり
• [雑誌論文] Spatiotemporal regulation of heat shock protein 90-chaperoned self-DNA and CpG-oligodeoxynucleotide for type I IFN induction via targeting to static early endosome. (2010)
  • 著者名/発表者名: Okuya, K., Sato, N., et al.
  • 雑誌名: J.Immunol. 巻: 184 ページ: 7092-7099
  • 査読あり
• [雑誌論文] Melanoma-targeted chemo-thermo-immuno(CTI)-therapy using N-propionyl-4-S-cysteaminylphenol-magnetite nanoparticles elicits CTL response via heat shock protein-peptide complex release. (2010)
  • 著者名/発表者名: Sato A, Sato, N., et al.
  • 雑誌名: Cancer Sci. 巻: 101 ページ: 1939-1946
  • NAID: 10027831209
  • 査読あり
• [雑誌論文] Immune response against tumor antigens expressed on human cancer stem-like cells/tumor-initiating cells. (2010)
  • 著者名/発表者名: Hirohashi, Y., Sato, N., et al.
  • 雑誌名: Immunotherapy 巻: 2 ページ: 201-211
  • 査読あり
• [雑誌論文] Inhibition of osteopontin reduces liver metastasis of human pancreatic cancer xenografts injected into the spleen in a mouse model. (2010)
  • 著者名/発表者名: Ohno, K., Sato, N., et al.
  • 雑誌名: Surg.Today 巻: 40 ページ: 347-356
  • NAID: 10027395148
  • 査読あり
• [雑誌論文] Immune response against tumor antigens expressed on human cancer stem-like cells/tumor-initiating cells (2010)
  • 著者名/発表者名: Hirohashi, Y., et al
  • 雑誌名: Immunotherapy 2 ページ: 201-211
  • 査読あり
• [雑誌論文] Side population cells have the characteristics of cancer stem-like cells/cancer-initiating cells in bone sarcomas (2009)
  • 著者名/発表者名: Murase, M., Kano, M., Tsukahara, T., Takahashi, A., Torigoe, T., Kawaguchi, S., Kimura, S., Wada, T., Uchihashi, Y., Kondo, T., Yamashita, T. and Sato N.
  • 雑誌名: Brit. J. Cancer 巻: 101 号: 8 ページ: 1425-1432
  • DOI: 10.1038/sj.bjc.6605330
  • 査読あり
• [雑誌論文] Targeting to static endosome is required for efficient cross-presentation of endoplasmic reticulum-resident oxygen regulated protein 150(ORP150)-peptide complexes (2009)
  • 著者名/発表者名: Kutomi, G., Tamura, Y., Okuya, K., Hirohashi, Y., Kamiguchi, K., Saito, K., Torigoe, T., Ogawa, S., Hirata, K. and Sato, N.
  • 雑誌名: J. Immunol 巻: 183 号: 9 ページ: 5861-5869
  • DOI: 10.4049/jimmunol.0803768
  • 査読あり
• [雑誌論文] Heat shock proteins and immunity : application of hyperthermia for immunomodulation (2009)
  • 著者名/発表者名: Torigoe, T., Tamura, Y., Sato, N.
  • 雑誌名: Int. J. Hyperthermia 巻: 25 号: 8 ページ: 610-616
  • DOI: 10.3109/02656730903315831
  • 査読あり
• [雑誌論文] Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer (2009)
  • 著者名/発表者名: Honma, I., Torigoe, T., Hirohashi, Y., Kitamura, H., Sato, E., Masumori, N., Tamura, Y., Tsukamoto, T., Sato, N.
  • 雑誌名: J. Transl. Med 巻: 7 号: 1 ページ: 103-110
  • DOI: 10.1186/1479-5876-7-103
  • 査読あり
• [雑誌論文] Growth inhibition of re-challenge B16 melanoma transplant by conjugates of melanogenesis substrate and magnetite nanoparticles as the basis for developing melanoma-targeted chemo-thermo-immunotherapy (2009)
  • 著者名/発表者名: Takada, T., Yamashita, T., Sato, M., Sato, A., Ono, I., Tamura, Y., Sato, N., Miyamoto, A, Ito, A., Honda, H., Wakamstu, K., Oto, S., Jimbow, K.
  • 雑誌名: J. Biomed. Biothechnol 巻: 2009 号: 1 ページ: 457936-457936
  • DOI: 10.1155/2009/457936
  • 査読あり
• [雑誌論文] Establishment of shared antigen reactive cytotixic T lymphocytes using co-stimulatory molecule introduced autologous cancer cells (2009)
  • 著者名/発表者名: Hirohashi, Y., Torigoe, T., Hirai, I., Tamura, Y., Nakatsugawa, M., Inoue, Y., Kanaseki, T., Kamiguchi, K., Ikeda, H., Sasaki, A., Yamanaka, N. and Sato, N.
  • 雑誌名: Exp. Mol. Pathol
  • URL: http://dx.doi.org/10.1016/j.yexmp.2009.09.021
  • 査読あり
• [雑誌論文] N-propionyl-cysteaminylphenol-magn etite conjugate(NPrCAP/M) is a nanoparticle for the targeted growth suppression of melanoma cells (2009)
  • 著者名/発表者名: Sato, M., Yamashita, T., Ohkura, M., Osai, Y., Sato, A., Takada, T., Matsusaka, H., Ono, I., Tamura, Y., Sato, N., Sasaki, Y., Ito, A., Honda, H., Wakamastu, K., Ito, S. and Jimbow, K.
  • 雑誌名: J. Invest. Dermatol 巻: 129 号: 9 ページ: 2233-2241
  • DOI: 10.1038/jid.2009.39
  • 査読あり
• [雑誌論文] Human leukocyte antigen class I down-regulation in muscle-invasive bladder cancer : Its association with clinical characteristics and survival after cystectomy (2009)
  • 著者名/発表者名: Homma, I., Kitamura, H., Torigoe, T., Tanaka, T., Sato, E., Hirohashi, Y., Masumori, N., Sato, N. and Tsukamoto, T.
  • 雑誌名: Cancer Sci 巻: 100 号: 12 ページ: 2331-2334
  • DOI: 10.1111/j.1349-7006.2009.01329.x
  • NAID: 10027198144
  • 査読あり
• [雑誌論文] A novel spliced form of a lens protein as a novel lung cancer antigen (2009)
  • 著者名/発表者名: Nakatsugawa, M. Hirohashi, Y., Torigoe, T., Asanuma, H., Takahashi, A., Inosa, S., Kiriyama, K., Nakazawa, E., Harada, K., Takasi, H., Tamura, Y., Kamiguchi, K., Shijubo, N., Honda, R., Nomura, N., Hasegawa, T., Takahashi, H. and Sato, N.
  • 雑誌名: Cancer Sci 巻: 100 号: 8 ページ: 1485-1493
  • DOI: 10.1111/j.1349-7006.2009.01187.x
  • 査読あり
• [雑誌論文] HLA-A 0201-restricted CTL epitope of a novel osteosarcoma antigen, papillomavirus binding factor (2009)
  • 著者名/発表者名: Tsukahara, T., Kawaguchi, S., Torigoe, T., Takahashi, A., Murase, M., Kano, M., Wada, T., Kaya, M., Nagoya, S., Yamashita, T. and Sato, N.
  • 雑誌名: J. Transl. Med 巻: 7 号: 1 ページ: 44-51
  • DOI: 10.1186/1479-5876-7-44
  • 査読あり
• [雑誌論文] Molecular pathologic approaches to human tumor immunology (2009)
  • 著者名/発表者名: Sato, N., Hirohashi, Y., Tsukahara, T., Kikuchi, T., Sahara, H., Kamiguchi, K., Ichimiya, S., Tamura, H. and Torigoe, T.
  • 雑誌名: Pathol. Int 巻: 59 号: 4 ページ: 205-217
  • DOI: 10.1111/j.1440-1827.2009.02353.x
  • NAID: 10027379604
  • 査読あり
• [雑誌論文] Polyamine compound deoxyspergualin inhibits heat shock protein-induced activation of immature dendritic cells (2009)
  • 著者名/発表者名: Sugawara, A., Torigoe, T., Tamura, Y., Kamiguchi, K., Nemoto, K., Oguro, H., Sato, N.
  • 雑誌名: Cell Stress Chaperone 巻: 14 号: 2 ページ: 133-139
  • DOI: 10.1007/s12192-008-0064-y
  • 査読あり
• [雑誌論文] The functioning antigens ; beyond just as the immunologic targets (2009)
  • 著者名/発表者名: Hirohashi, Y., Torigoe, T., Inoda, S., Kobayashi, J., Nakatsugawa, M., Mori, T., Hara, I. and Sato, N.
  • 雑誌名: Cancer Sci 巻: 100 号: 5 ページ: 798-806
  • DOI: 10.1111/j.1349-7006.2009.01137.x
  • NAID: 10025145179
  • 査読あり
• [雑誌論文] Cep55/c10orf3, a tumor antigen derived from a centrosome residing protein in breast carcinoma (2009)
  • 著者名/発表者名: Inoda, S., Hirohashi, Y., Torigoe, T., Nakatsugawa, M., Kiriyama, K., Harada, K., Takasu, H., Tamura, Y., Kamiguchi, K., Asanuma, H., Tsuruma, T., Terui, T., Ishitani, K., Ohmura, T., Hasegawa, T., Hirata, K. and Sato, N.
  • 雑誌名: J. Immunother 巻: 32 ページ: 474-485
  • 査読あり
• [雑誌論文] Phase I clinical study of anti-apoptosis protein survivin-derived peptide vaccination for patients with advanced or recurrent urothelial cancer (2009)
  • 著者名/発表者名: Honma, I., Kitamura, H., Torigoe, A. Takahashi, T., Tanaka, T., Sato, E., Hirohashi, Y., Masumori, N., Tsukamoto, T., Sato, N.
  • 雑誌名: Cancer Immunol. Immunother 巻: 58 号: 11 ページ: 1801-1807
  • DOI: 10.1007/s00262-009-0691-x
  • 査読あり
• [雑誌論文] Wild-type AIRE cooperates with p63 in HLA class II expression of medullary thymic stroma cells. (2009)
  • 著者名/発表者名: Tonooka, A., Kubo, T., Ichimiya, S., Tamura, Y., Ilmarinen, T., Ulmanen, I., Kimura, S., Yokoyama, S., Takano, Y., Kikuchi, T. and Sato, N.
  • 雑誌名: Biochem. Biophys. Res. Commun 巻: 379 ページ: 765-770
  • URL: http://dx.doi.org/10.1016/j.bbrc.2008.12.123
  • 査読あり
• [雑誌論文] Clonal diversity of cytotoxic T lymphocytes that recognize autologous oral squamous cell carcinoma (2009)
  • 著者名/発表者名: Kobayashi, J., Torigoe, T., Hirohashi, Y., Tamura, Y., Kamiguchi, K., Miyazaki, A., Yamaguchi, A., Yamamoto, T., Hariu, H., Hiratsuka, H. and Sato, N.
  • 雑誌名: Hum Immunol 巻: 70 ページ: 89-95
  • URL: http://dx.doi.org/10.1016/j.humimm.2008.11.004
  • 査読あり
• [雑誌論文] Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from surviving and that from its splice variant surviving-2B in oral cancer patients (2009)
  • 著者名/発表者名: Kobayashi, J., Torigoe, T., Hirohashi, Y., Idenoue, S., Miyazaki, A., Yamaguchi, A., Hiratsuka, H. and Sato, N.
  • 雑誌名: J. Transl. Med 巻: 7 号: 1 ページ: 1-11
  • DOI: 10.1186/1479-5876-7-1
  • 査読あり
• [雑誌論文] Diagnosis of alveolar echinococcosis using immunoblotting with pleural low molecular weight antigens (2009)
  • 著者名/発表者名: Yamano, K., Goto, A., Miyoshi, M., Furuya, K., Sawada, Y., Sato, N.
  • 雑誌名: J. Helminthol 巻: 83 ページ: 57-61
  • URL: http://dx.doi.org/10.1017/S0022149X08116510
  • 査読あり
• [雑誌論文] Immunosuppressive effect on T cell activation by interleukin-16 and interleukin 10 cDNA-double-transfected human squamous cell line (2009)
  • 著者名/発表者名: Matsumoto, Y., Fujita, T., Hirai, I., Sahara, H., Torigoe, T., Ezoe, K., Saito, Y., Cruikshank, W. W., Yotsuyanagi, T. and Sato, N.
  • 雑誌名: Burns 巻: 35 ページ: 383-389
  • URL: http://dx.doi.org/10.1016/j.burns.2008.06.017
  • 査読あり
• [雑誌論文] Side population cells have the characteristics of cancer stem-like cells/cancer-initiating cells in bone sarcomas (2009)
  • 著者名/発表者名: Murase, M., et al
  • 雑誌名: Brit.J.Cancer 101 ページ: 1425-1432
  • 査読あり
• [雑誌論文] Targeting to static endosome is required for efficient cross-presentation of endoplasmic reticulum-resident oxygen regulated protein 150(ORP150)-peptide complexes (2009)
  • 著者名/発表者名: Kutomi, G., et al
  • 雑誌名: J.Immunol. 183 ページ: 5861-5869
  • 査読あり
• [雑誌論文] Heat shock proteins and immunity : application of hyperthermia for immunomodulation (2009)
  • 著者名/発表者名: Torigoe, T., et al
  • 雑誌名: Int.J.Hyperthermia 25 ページ: 610-616
  • 査読あり
• [雑誌論文] Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer (2009)
  • 著者名/発表者名: Honma, I., et al
  • 雑誌名: J.Transl.Med. 7 ページ: 103-110
  • 査読あり
• [雑誌論文] Growth inhibition of re-challenge B16 melanoma trnsplant by conjugates of melanogenesis substrate and magnetite nanoparticles as the basis for developing melanoma-targeted chemo-thermo-immunotherapy (2009)
  • 著者名/発表者名: Takada, T., et al
  • 雑誌名: J.Biomed.Biothechnol.
  • 査読あり
• [雑誌論文] N-propionyl-cysteaminylphenol-magnetite conjugate(NPrCAP/M)is a nanoparticle for the targeted growth suppression of melanoma cells (2009)
  • 著者名/発表者名: Sato, M., et al
  • 雑誌名: J.Invest.Dermatol. 129 ページ: 2233-2241
  • 査読あり
• [雑誌論文] A novel spliced form of a lens protein as a novel lung cancer antigen, Lengsin splicing variant4 (2009)
  • 著者名/発表者名: Nakatsugawa, M., et al
  • 雑誌名: Cancer Sci. 100 ページ: 1485-1493
  • 査読あり
• [雑誌論文] HLA-A*0201-restricted CTL epitope of a novel osteosarcoma antigen, papillomavirus binding factor (2009)
  • 著者名/発表者名: Tsukahara, T., et al
  • 雑誌名: J.Transl.Med. 7 ページ: 44-51
  • 査読あり
• [雑誌論文] Molecular pathologic approaches to human tumor immunology (2009)
  • 著者名/発表者名: Sato, N., et al
  • 雑誌名: Pathol.Int. 59 ページ: 205-217
  • NAID: 10027379604
  • 査読あり
• [雑誌論文] Polyamine compound deoxyspergualin inhibits heat shock protein-induced activation of immature dendritic cells (2009)
  • 著者名/発表者名: Sugawara, A., et al
  • 雑誌名: Cell Stress Chaperone 14 ページ: 133-139
  • 査読あり
• [雑誌論文] The functioning antigens ; beyond just as the immunologic targets (2009)
  • 著者名/発表者名: Hirohashi, Y., et al
  • 雑誌名: Cancer Sci 100 ページ: 798-806
  • NAID: 10025145179
  • 査読あり
• [雑誌論文] Cep55/c10orf3, a tumor antigen derived from a centrosome residing protein in breast carcinoma (2009)
  • 著者名/発表者名: Inoda, S., et al
  • 雑誌名: J.Immunother. 32 ページ: 474-485
  • 査読あり
• [雑誌論文] Phase I clinical study of anti-apoptosis protein survivin-derived peptide vaccination for patients with advanced or recurrent urothelial cancer (2009)
  • 著者名/発表者名: Homma, I., et al
  • 雑誌名: Cancer Immunol.Immunother. 58 ページ: 1801-1807
  • 査読あり
• [雑誌論文] Wild-type AIRE cooperates with p63 in HLA class II expression of med ullary thymic stroma cells (2009)
  • 著者名/発表者名: Tonooka, A., et al
  • 雑誌名: Biochem.Biophys.Res.Commun. 379 ページ: 765-770
  • 査読あり
• [雑誌論文] Clonal diversity of cytotoxic T lymphocytes that recognize autologous or al squamous cell carcinoma (2009)
  • 著者名/発表者名: Kobayashi, J., et al
  • 雑誌名: Hum Immunol. 70 ページ: 89-95
  • 査読あり
• [雑誌論文] Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from surviving and that from its splice variant surviving-2B in oral cancer patients (2009)
  • 著者名/発表者名: Kobayashi, J., et al
  • 雑誌名: J.Transl.Med. 7 ページ: 1-11
  • 査読あり
• [雑誌論文] Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma (2009)
  • 著者名/発表者名: Tsukahara, T., et al
  • 雑誌名: Cancer Sci. 100 ページ: 47-53
  • 査読あり
• [雑誌論文] Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma (2008)
  • 著者名/発表者名: Tsukahara, T., Kimura, S., Ichimiya, S., Torigoe, T., Kawaguchi, S., Wada, T., Yamashita, T., Sato, N.
  • 雑誌名: Cancer Sci 巻: 100 号: 1 ページ: 47-53
  • DOI: 10.1111/j.1349-7006.2008.00991.x
  • NAID: 10025141244
  • 査読あり
• [雑誌論文] DNA methyltransferase 1 is essential for maintenance of human colon cancer stem-like cells
  • 著者名/発表者名: Morita, R., Hirohashi, Y., Torigoe, T., Takahashi, A., Saka, E., Asanuma, H., Suzuki, H., Tamura, H., Nakazawa, E., Ito-Inoda, S., Hashino, S., Hasegawa, T., Tokino, T., Toyota, M., Asaka, M. and Sato, N.
  • 雑誌名: Am J. Pathol. 巻: (in press)
  • 査読あり
• [雑誌論文] Heat shock protein 90 governs self-nucleic acid recognition by Toll-like receptors
  • 著者名/発表者名: Saito, K., Tamura, Y., Kukita, K., Kutomi, G., Okuya, K., Asanuma, H., Torigoe, T., Hirata, K., Sato, N.
  • 雑誌名: Nature
  • 査読あり
• [学会発表] がん幹細胞を標的とする免疫療法 (2011)
  • 著者名/発表者名: 廣橋良彦、佐藤昇志, 他
  • 学会等名: 第70回日本癌学会学術総会
  • 発表場所: 名古屋
  • 年月日: 2011-10-03
• [学会発表] Stress Response Genes Expressed in Cancer Stem Cells-potent molecular targets for cancer therapy (2011)
  • 著者名/発表者名: Toshihiko Torigoe, Hirohashi Yoshihiko, Yasuaki Tamura, Noriyuki Sato
  • 学会等名: The 5^<th> International Congress on Stress Responses in Biology and Medicine
  • 発表場所: Quebec City, Canada
• [学会発表] Stress Response Genes Expressed in Cancer Stem Cells-potent molecular targets for cancer therapy- (2011)
  • 著者名/発表者名: Toshihiko Torigoe, Noriyuki Sato, 他
  • 学会等名: The 5^<th> CSSI International Meeting
  • 発表場所: Quebec, Canada
• [学会発表] Immune responses against cancer stem cells (2010)
  • 著者名/発表者名: Toshihiko Torigoe, Yoshihiko Hirohashi, Noriyuki Sato
  • 学会等名: 第69回日本癌学会学術総会
  • 発表場所: 大阪
  • 年月日: 2010-09-22
• [学会発表] Progress of cancer immunotherapy. Immunotherapeutic clinical trial of surviving-based tumor antigens and manipulation of antigenicity enhancement by HSP90. Special Clinical Seminar. (2010)
  • 著者名/発表者名: Noriyuki Sato.
  • 学会等名: 14^<th> International Congress on Immunology
  • 発表場所: Kobe, Japan
  • 年月日: 2010-08-24
• [学会発表] Progress of cancer immunotherapy. Immunotherapeutic clinical trial of surviving-based tumor antigens and manipulation of antigenicity enhancement by HSP90. (2010)
  • 著者名/発表者名: Noriyuki Sato
  • 学会等名: Special Clinical Seminar. 14^<th> International Congress of Immunology
  • 発表場所: Kobe, Japan
• [学会発表] A novel DNAJ family protein is a cancer initiating cell antigen.-A potent molecular target for cancer immunotherapy (2010)
  • 著者名/発表者名: Toshihiko Torigoe, Yoshihiko Hirohashi, Satoshi Nishizawa, Akari Takahashi, Hiroko Asanuma, Munehide Nakatsugawa, Kenjiro Kamiguchi, Alisa A. Sokolovskaya, Noriyuki Sato
  • 学会等名: The 8th International Workshop on the Molecular Biology of Stress Responses
  • 発表場所: Seorak Mt., Korea
• [学会発表] Pathology-based development of human cancer immunotherapy (2009)
  • 著者名/発表者名: Sato, N.
  • 学会等名: 第68回日本癌学会学術総会
  • 発表場所: パシフィコ横浜(横浜)
  • 年月日: 2009-10-02
• [学会発表] Cancer, Immunology and Photonics Science. (2009)
  • 著者名/発表者名: Sato, N.
  • 学会等名: Symposium, 10^<th> Chitose International Forum Photonics Science & Technology
  • 発表場所: Chitose, Japan
• [学会発表] Apoptosis regulator protein PBF is an immunological target for patients with osteosarcoma (2009)
  • 著者名/発表者名: Tsukahara, T., Kawaguchi, S., Kano, M., Wada, T., Yamashita, T., Torigoe, T., Takahashi, A. and Sato, N.
  • 学会等名: 24^<th> Annual Meeting of International Society for Biological Therapy of Cancer
  • 発表場所: Washington DC, USA
• [学会発表] Identification of cancer stem cell antigens revealed unique characteristics of triple negative breast cancer (2009)
  • 著者名/発表者名: Torigoe, T., Hirohashi, Y., Takahashi, A., Asanuma, H., Nakatsugawa, M., Inoda, S., Sato, N.
  • 学会等名: 14th World Congress on Advances in Oncology and 12th International Symposium on Molecular Medicine
  • 発表場所: Loutraki, Greece
• [学会発表] Development of HSP90-based cancer vaccine and its mechanism (2009)
  • 著者名/発表者名: Tamura, Y., Okuya, K., Saito, K., Torigoe, T., Sato, N.
  • 学会等名: The 4th International Congress on Stress Responses in Biology and Medicine/The 4th Annual Meeting of the Biomedical Society for Stress Response
  • 発表場所: Sapporo
• [学会発表] HSP as the chief pilot of immunity and aseptic inflammation (2009)
  • 著者名/発表者名: Sato, N.
  • 学会等名: The 4th International Congress on Stress Responses in Biology and Medicine/The 4th Annual Meeting of the Biomedical Society for Stress Response
  • 発表場所: Sapporo
• [学会発表] Targeting immune-competent endosome by heat shok proteins(HSPs) for enhancing cancer immunotherapeutic potential (2009)
  • 著者名/発表者名: Tamura, Y., Sato, N.
  • 学会等名: 第68回日本癌学会学術総会、Internarional Sessions
  • 発表場所: 横浜
• [学会発表] Pathology-based development of human cancer immunotherapy (2009)
  • 著者名/発表者名: Sato, N.
  • 学会等名: 第68回日本癌学会学術総会
  • 発表場所: 横浜
• [図書] Cancer, Immunology and Photonics Science. Optical Devices and Systems, Biomedical and Green Technologies (2010)
  • 著者名/発表者名: Noriyuki Sato, Yoshihiko Hirohashi, Tomohide Tsukahara, Shingo Ichimiya, Yasuaki Tamura and Toshihiko Torigoe
• [図書] がん免疫療法の標的抗原、がん免疫療法-実用化へのチャレンジ- (2010)
  • 著者名/発表者名: 守田玲菜、鳥越俊彦, et al.
  • 出版者: シーエムシー出版
• [図書] バイオ医薬の開発技術とシーズ。第30章がんペプチド免疫治療 (2009)
  • 著者名/発表者名: 佐藤昇志, 他
  • 総ページ数: 14
  • 出版者: シーエムシー出版
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• [産業財産権] 改良された糖被覆リポソーム組成物 (2011)
  • 発明者名: 梶原敏充、沼崎麻希、佐藤昇志, 他
  • 権利者名: 梶原敏充、沼崎麻希、佐藤昇志, 他
  • 産業財産権番号: 2011-102962
  • 出願年月日: 2011-05-02
• [産業財産権] 抗原特異的T細胞誘導脳測定法 (2010)
  • 発明者名: 鳥越俊彦、廣橋良彦、水内将人、佐藤昇志、鈴木哲、清水佳隆、佐藤雄一郎
  • 権利者名: 鳥越俊彦、廣橋良彦、水内将人、佐藤昇志、鈴木哲、清水佳隆、佐藤雄一郎
  • 出願年月日: 2010-08-30
  • 外国
• [産業財産権] インターフェロンα産生阻害剤 (2010)
  • 発明者名: 田村保明、佐藤昇志、鳥越俊彦、齋藤慶太
  • 権利者名: 田村保明、佐藤昇志、鳥越俊彦、齋藤慶太
  • 産業財産権番号: 2010-219422
  • 出願年月日: 2010-09-29
• [産業財産権] サバイビン由来のHLA-A 24結合性癌抗原ペプチド (2010)
  • 発明者名: 佐藤昇志、鳥越俊彦、廣橋良彦、井手之上里美、小林淳一
  • 権利者名: 佐藤昇志、鳥越俊彦、廣橋良彦、井手之上里美、小林淳一
  • 産業財産権番号: 2004-191478
  • 出願年月日: 2010-10-08
• [産業財産権] がん幹細胞分子マーカー (2009)
  • 発明者名: 鳥越俊彦、廣橋良彦、佐藤昇志(他4名)
  • 権利者名: 鳥越俊彦、廣橋良彦、佐藤昇志(他4名)
  • 出願年月日: 2009-10-27
  • 外国
• [産業財産権] 癌ワクチン (2009)
  • 発明者名: 佐藤昇志, 鳥越俊彦, 田村保明, 佐藤雄一郎, 清水佳隆
  • 権利者名: 佐藤昇志, 鳥越俊彦, 田村保明, 佐藤雄一郎, 清水佳隆
  • 産業財産権番号: 2009-124041
  • 出願年月日: 2009-05-22