加齢黄斑変性に対するテーラーメード医療の実現

• 研究課題/領域番号: 21249084
• 研究種目: 基盤研究(A)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 眼科学
• 研究機関: 京都大学
• 研究代表者: 吉村 長久 京都大学, 医学研究科, 教授 (70211662)
• 研究分担者: 大谷 篤史 京都大学, 医学研究科, 講師 (30314222) ; 山城 健児 京都大学, 医学研究科, 助教 (80399617) ; 山田 亮 京都大学, 医学研究科, 教授 (50301106)
• 研究期間 (年度): 2009 – 2011
• 研究課題ステータス: 完了 (2011年度)
• 配分額: 44,980千円 (直接経費: 34,600千円、間接経費: 10,380千円); 2011年度: 8,970千円 (直接経費: 6,900千円、間接経費: 2,070千円); 2010年度: 15,340千円 (直接経費: 11,800千円、間接経費: 3,540千円); 2009年度: 20,670千円 (直接経費: 15,900千円、間接経費: 4,770千円)
• キーワード: 眼細胞生物学 / 加齢黄斑変性 / 個別化医療 / 遺伝子多型 / テーラーメード医療

研究概要

ARMS2遺伝子A69Sの迅速検出キットを作成した。A69S多型は滲出型加齢黄斑変性に対する光線力学療法後の視力予後に相関し、抗VEGF治療の後の視力予後には相関しなかったことから、このキットを用いることによって、個別化医療が実現できると考えられた。さらに他の候補として、VEGF遺伝子、PEDF遺伝子が治療後反応を予測し、精度の高い個別化医療の実現が可能であることが分かった。

研究成果

• [雑誌論文] Significance ofC2/CFB variants in age-related macular degeneration and polypoidal choroidalvasculopathy in a Japanese population (2012)
  • 著者名/発表者名: Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Akagi-Kurashige Y, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, TajimaK, Matsuda F, Yoshimura N.
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 53 ページ: 794-8
• [雑誌論文] Macular Choroidal Thickness and Volume in Eyes With Angioid Streaks Measured by Swept Source Optical Coherence Tomography (2012)
  • 著者名/発表者名: Ellabban AA, Tsujikawa A, Matsumoto A, Ogino K, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N.
  • 雑誌名: Am JOphthalmol
  • NAID: 120004161067
• [雑誌論文] Relationship between retinal morphological findings and visual function in age-related macular degeneration (2012)
  • 著者名/発表者名: Akagi-Kurashige Y, Tsujikawa A, Oishi A, Ooto S, Yamashiro K, Tamura H, Nakata I, Ueda-Arakawa N, Yoshimura N.
  • 雑誌名: Graefes Arch Clin Exp Ophthalmol
  • NAID: 120004873995
• [雑誌論文] Vascular endothelial growth factor gene polymorphisms and choroidalneovascularization in highly myopic eyes (2012)
  • 著者名/発表者名: Akagi-Kurashige Y, Kumagai K, Yamashiro K, Nakanishi H, Nakata I, MiyakeM, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Yamada R, Matsuda F, Yoshimura N
  • 雑誌名: Invest Ophthalmol Vis Sci
• [雑誌論文] Factors Associated With the Response of Age-Related Macular Degeneration to Intravitreal Ranibizumab Treatment (2012)
  • 著者名/発表者名: Yamashiro K, Tomita K, Tsujikawa A, Nakata I, Akagi-Kurashige Y, Miyake M, Ooto S, Tamura H, Yoshimura N
  • 雑誌名: Am J Ophthalmol 巻: (in press)
  • 査読あり
• [雑誌論文] Vascular endothelial growth factor gene polymorphisms and choroidal neovascularization in highly myopic eyes (2012)
  • 著者名/発表者名: Akagi-Kurashige Y, Kumagai K, Yamashiro K, Nakanishi H, Nakata I, Miyake M, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Yamada R, Matsuda F, Yoshimura N
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: (in press) 号: 4 ページ: 2349-53
  • DOI: 10.1167/iovs.11-9405
  • 査読あり
• [雑誌論文] Macular Choroidal Thickness and Volume in Eyes With Angioid Streaks Measured by Swept Source Optical Coherence Tomography (2012)
  • 著者名/発表者名: Ellabban AA, Tsujikawa A, Matsumoto A, Ogino K, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N
  • 雑誌名: Am J Ophthalmol 巻: (in press) 号: 6 ページ: 1133-1143.e1
  • DOI: 10.1016/j.ajo.2011.12.013
  • NAID: 120004161067
  • 査読あり
• [雑誌論文] Relationship between retinal morphological findings and visual function in age-related macular degeneration (2012)
  • 著者名/発表者名: Akagi-Kurashige Y, Tsujikawa A, Oishi A, Ooto S, Yamashiro K, Tamura H, Nakata I, Ueda-Arakawa N, Yoshimura N
  • 雑誌名: Graefes Arch Clin Exp Ophthalmol 巻: (in press) 号: 8 ページ: 68-80
  • DOI: 10.1007/s00417-012-1928-5
  • NAID: 120004873995
  • 査読あり
• [雑誌論文] Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population (2012)
  • 著者名/発表者名: Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Akagi-Kurashige Y, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 53 号: 2 ページ: 794-798
  • DOI: 10.1167/iovs.11-8468
  • 査読あり
• [雑誌論文] Association of elastin gene polymorphism to age-related macular degeneration and polypoidal choroidalvasculopathy (2011)
  • 著者名/発表者名: Yamashiro K, Mori K, Nakata I, Tsuchihashi T, Horie-Inoue K, Nakanishi H, Tsujikawa A, Saito M, Iida T, Yamada R, Matsuda F, Inoue S, Awata T, Yoneya S, Yoshimura N
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 52 ページ: 8780-4
• [雑誌論文] Development of polypoidal lesions inage-related macular degeneration (2011)
  • 著者名/発表者名: Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, Nakata I, Yoshimura N
  • 雑誌名: Eye 巻: 25 ページ: 481-8
• [雑誌論文] Association of lesion size and visual prognosis to polypoidal choroidalvasculopathy (2011)
  • 著者名/発表者名: Tsujikawa A, Ojima Y, Yamashiro K, Nakata I, Ooto S, Tamura H, Nakanishi H, Hayashi H, Otani A, Yoshimura N
  • 雑誌名: Am J Ophthalmol 巻: 151 ページ: 961-972
• [雑誌論文] Retinal micro structural abnormalities in central serous chorioretinopathy andpolypoidal choroidal vasculopathy (2011)
  • 著者名/発表者名: Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Otani A, Yoshimura N
  • 雑誌名: Retina 巻: 31 ページ: 527-34
• [雑誌論文] Association between the SERPING1 gene andage-related macular degeneration andpolypoidal choroidal vasculopathy in Japanese (2011)
  • 著者名/発表者名: Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, TsujikawaA, Otani A, Saito M, Iida T, Oishi A, MatsuoK, Tajima K, Matsuda F, Yoshimura N
  • 雑誌名: PLoS One 巻: 6 ページ: 19108-19108
• [雑誌論文] Genetic variants in pigment epithelium-derived factor influence response of polypoidal choroidalvasculopathy to photodynamic therapy (2011)
  • 著者名/発表者名: Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, TsujikawaA, Otani A, Ooto S, Tamura H, Saito M, SaitoK, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N.
  • 雑誌名: Ophthalmology 巻: 118 ページ: 1408-15
• [雑誌論文] VEGFgene polymorphism and response tointravitreal bevacizumab and triple therapy in age-related macular degeneration (2011)
  • 著者名/発表者名: Nakata I, Yamashiro K, NakanishiH, Tsujikawa A, Otani A, Yoshimura N.
  • 雑誌名: Jpn J Ophthalmol 巻: 55 ページ: 435-43
• [雑誌論文] Prognostic factors for visual outcomes 2-years afterintravitreal bevacizumab for myopicchoroidal neovascularization (2011)
  • 著者名/発表者名: Nakanishi H, Tsujikawa A, Yodoi Y, Ojima Y, Otani A, Tamura H, Yamashiro K, Ooto S, Yoshimura N.
  • 雑誌名: Eye 巻: 25 ページ: 375-81
• [雑誌論文] Macular choroidal thickness and volume in normal subjects measured by swept-source optical coherence tomography (2011)
  • 著者名/発表者名: Hirata M, Tsujikawa A, MatsumotoA, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N.
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 52 ページ: 4971-8
• [雑誌論文] Association of 15q14 and 15q25 with high myopia in Japanese (2011)
  • 著者名/発表者名: Hayashi H, Yamashiro K, NakanishiH, Nakata I, Kurashige Y, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Ozaki M, Yamada R, Matsuda F, Yoshimura N.
  • 雑誌名: Invest Ophthalmol VisSci 巻: 52 ページ: 4853-8
• [雑誌論文] Association of elastin gene polymorphism to age-related macular degeneration and polypoidal choroidal vasculopathy (2011)
  • 著者名/発表者名: Yamashiro K, Mori K, Nakata I, Tsuchihashi T, Horie-Inoue K, Nakanishi H, Tsujikawa A, Saito M, Iida T, Yamada R, Matsuda F, Inoue S, Awata T, Yoneya S, Yoshimura N
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 52 ページ: 8780-4
  • 査読あり
• [雑誌論文] Treatment of polypoidal choroidal vasculopathy with photodynamic therapy combined with intravitreal injections of ranibizumab (2011)
  • 著者名/発表者名: Tomita K, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Otani A, Nakayama Y, Yoshimura N
  • 雑誌名: Am J Ophthalmol 巻: 153 号: 1 ページ: 68-80
  • DOI: 10.1016/j.ajo.2011.07.001
  • NAID: 120003726137
  • 査読あり
• [雑誌論文] VEGF gene polymorphism and response to intravitreal bevacizumab and triple therapy in age-related macular degeneration (2011)
  • 著者名/発表者名: Nakata I, Yamashiro K, Nakanishi H, Tsujikawa A, Otani A, Yoshimura N
  • 雑誌名: Jpn J Ophthalmol 巻: 55 号: 5 ページ: 435-43
  • DOI: 10.1007/s10384-011-0061-z
  • NAID: 10029688706
  • 査読あり
• [雑誌論文] Macular choroidal thickness and volume in normal subjects measured by swept-source optical coherence tomography (2011)
  • 著者名/発表者名: Hirata M, Tsujikawa A, Matsumoto A, Hangai M, Ooto S, Yamashiro K, Akiba M, Yoshimura N
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 52 号: 8 ページ: 4971-4978
  • DOI: 10.1167/iovs.11-7729
  • 査読あり
• [雑誌論文] Association between the SERPING1 gene and age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese (2011)
  • 著者名/発表者名: Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N
  • 雑誌名: PLoS One 巻: 6 号: 4 ページ: e19108-e19108
  • DOI: 10.1371/journal.pone.0019108
  • 査読あり
• [雑誌論文] Association of lesion size and visual prognosis to polypoidal choroidal vasculopathy (2011)
  • 著者名/発表者名: Tsujikawa A, Ojima Y, Yamashiro K, Nakata I, Ooto S, Tamura H, Nakanishi H, Hayashi H, Otani A, Yoshimura N
  • 雑誌名: Am J Ophthalmol 巻: 151 号: 6 ページ: 961-972
  • DOI: 10.1016/j.ajo.2011.01.002
  • NAID: 120003184066
  • 査読あり
• [雑誌論文] Genetic variants in pigment epithelium-derived factor influence response of polypoidal choroidal vasculopathy to photodynamic therapy (2011)
  • 著者名/発表者名: Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Ooto S, Tamura H, Saito M, Saito K, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N
  • 雑誌名: Ophthalmology 巻: 118 号: 7 ページ: 1408-15
  • DOI: 10.1016/j.ophtha.2010.12.011
  • 査読あり
• [雑誌論文] Association of 15q14 and 15q25 with high myopia in Japanese (2011)
  • 著者名/発表者名: Hayashi H, Yamashiro K, Nakanishi H, Nakata I, Kurashige Y, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Ozaki M, Yamada R, Matsuda F, Yoshimura N
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 52 号: 7 ページ: 4853-4858
  • DOI: 10.1167/iovs.11-7311
  • 査読あり
• [雑誌論文] Association of Lesion Size and Visual Prognosis to Polypoidal Choroidal Vasculopathy. (2011)
  • 著者名/発表者名: Tsujikawa A, Ojima Y, Yamashiro K, Nakata I, Ooto S, Tamura H, Nakanishi H, Hayashi H, Otani A, Yoshimura N.
  • 雑誌名: Am J Ophthalmol. 巻: (in press)
  • NAID: 120003184066
  • 査読あり
• [雑誌論文] Association of 15q14 and 15q25 with High Myopia in Japanese. (2011)
  • 著者名/発表者名: Hayashi H, Yamashiro K, Nakanishi H, Nakata I, Kurashige Y, Tsujikawa A, Moriyama M, Ohno-Matsui K, Mochizuki M, Ozaki M, Yamada R, Matsuda F, Yoshimura N.
  • 雑誌名: Invest Ophthalmol Vis Sci. 巻: (in press)
  • 査読あり
• [雑誌論文] Retinal microstructural abnormalities in central serous chorioretinopathy and polypoidal choroidal vasculopathy. (2011)
  • 著者名/発表者名: Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Otani A, Yoshimura N.
  • 雑誌名: Retina. 巻: 31 ページ: 527-534
  • NAID: 120004225529
  • 査読あり
• [雑誌論文] Sterile endophthalmitis afterintravitreal injection of bevacizumabobtained from a single batch (2010)
  • 著者名/発表者名: Yamashiro K, Tsujikawa A, Miyamoto K, Oh H, Otani A, Tamuara H, Ooto S, Sasahara M, Iwama D, Yoshimura N.
  • 雑誌名: Retina 巻: 30 ページ: 485-90
  • NAID: 120002949750
• [雑誌論文] Treatment of polypoidal choroidal vasculopathy byintravitreal injection of bevacizumab (2010)
  • 著者名/発表者名: Tsujikawa A, Ooto S, Yamashiro K, Tamura H, Otani A, Yoshimura N.
  • 雑誌名: Jpn J Ophthalmol 巻: 54 ページ: 310-9
• [雑誌論文] Punctate hyper fluorescent spots associated with central serouschorioretinopathy as seen on indocyaninegreen angiography (2010)
  • 著者名/発表者名: Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, Nakagawa S, Yoshimura N.
  • 雑誌名: Retina 巻: 30 ページ: 801-9
• [雑誌論文] Intravitreal bevacizumab for type 1 idiopathic macular telangiectasia (2010)
  • 著者名/発表者名: Takayama K, Ooto S, Tamura H, Yamashiro K, Otani A, Tsujikawa A, Yoshimura N.
  • 雑誌名: Eye 巻: 24 ページ: 1492-7
• [雑誌論文] Thickness of photoreceptor layers inpolypoidal choroidal vasculopathy and central serous chorioretinopathy (2010)
  • 著者名/発表者名: Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Yoshimura N.
  • 雑誌名: Graefes Arch Clin Exp Ophthalmol 巻: 248 ページ: 1077-86
• [雑誌論文] High-resolution imaging of resolved central serous chorioretinopathy using adaptive optics scanning laserophthalmoscopy (2010)
  • 著者名/発表者名: Ooto S, Hangai M, Sakamoto A, Tsujikawa A, Yamashiro K, Ojima Y, Yamada Y, Mukai H, Oshima S, Inoue T, Yoshimura N
  • 雑誌名: Ophthalmology 巻: 117
• [雑誌論文] Restoration of outer segments of foveal photoreceptors after resolution of central serouschorioretinopathy (2010)
  • 著者名/発表者名: Ojima Y, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Yoshimura N
  • 雑誌名: Jpn J Ophthalmol. 巻: 54 ページ: 55-60
• [雑誌論文] Joint effect of cigarette smoking and CFH and LOC387715/HTRA1 polymorphisms onpolypoidal choroidal vasculopathy (2010)
  • 著者名/発表者名: Nakanishi H, Yamashiro K, Yamada R, Gotoh N, Hayashi H, Nakata I, Saito M, Iida T, Oishi A, Kurimoto Y, Matsuo K, Tajima K, Matsuda F, Yoshimura N
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 51 ページ: 6183-7
• [雑誌論文] Single-nucleotide polymorphisms in the promoter region of matrixmetalloproteinase-1,-2, and-3 in Japanese with high myopia (2010)
  • 著者名/発表者名: Nakanishi H, Hayashi H, Yamada R, Yamashiro K, Nakata I, Shimada N, Ohno-Matsui K, Mochizuki M, Ozaki M, Yoshitake S, Kuriyama S, Saito M, Iida T, Matsuo K, Matsuda F, Yoshimura N
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 51 ページ: 4432-6
• [雑誌論文] ARMS2/HTRA1 and CFH polymorphisms are not associated withchoroidal neovascularization in highly myopic eyes of the elderly Japanese population (2010)
  • 著者名/発表者名: Nakanishi H, Gotoh N, Yamada R, Yamashiro K, Otani A, Hayashi H, TsujikawaA, Shimada N, Ohno-Matsui K, Mochizuki M, Saito M, Saito K, Iida T, Matsuda F, Yoshimura N.
  • 雑誌名: Eye 巻: 24 ページ: 1078-84
• [雑誌論文] Relationship between retinal sensitivity and morphologic changes in eyes with confluent soft drusen (2010)
  • 著者名/発表者名: Iwama D, Tsujikawa A, Ojima Y, Nakanishi H, Yamashiro K, Tamura H, OotoS, Yoshimura N
  • 雑誌名: Clin Experiment Ophthalmol 巻: 38 ページ: 483-8
• [雑誌論文] Macular hole formation following photodynamic therapy combined with intravitreal injection ofbevacizumab and triamcinolone acetonide (2010)
  • 著者名/発表者名: Iwama D, Ooto S, Tsujikawa A, Yamashiro K, Yoshimura N.
  • 雑誌名: Jpn J Ophthalmol 巻: 54 ページ: 364-6
• [雑誌論文] CFH and ARMS2variations in age-related macular degeneration, polypoidal choroidalvasculopathy, and retinal angiomatous proliferation (2010)
  • 著者名/発表者名: Hayashi H, Yamashiro K, Gotoh N, Nakanishi H, Nakata I, Tsujikawa A, OtaniA, Saito M, Iida T, Matsuo K, Tajima K, Yamada R, Yoshimura N.
  • 雑誌名: Invest Ophthalmol Vis Sci 巻: 51 ページ: 5914-9
• [雑誌論文] Prognostic factors of vitreous hemorrhage secondary to exudative age-related macular degeneration (2010)
  • 著者名/発表者名: Hasegawa T, Otani A, Sasahara M, Gotoh N, Ooto S, Tamura H, Yamashiro K, Tsujikawa A, Yoshimura N.
  • 雑誌名: Am J Ophthalmol 巻: 149 ページ: 322-329
  • NAID: 120001823762
• [雑誌論文] Haplotypeanalysis of the ARMS2/HTRA1 region in Japanese patients with typicalneovascular age-related macular degeneration or polypoidal choroidal vasculopathy (2010)
  • 著者名/発表者名: Gotoh N, Yamashiro K, Nakanishi H, Saito M, Iida T, Yoshimura N
  • 雑誌名: Jpn J Ophthalmol 巻: 54 ページ: 609-14
• [雑誌論文] Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration (2010)
  • 著者名/発表者名: Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, ConleyYP, Kanda A, Kopplin L, Li Y, AugustaitisKJ, Karoukis AJ, Scott WK, Agarwal A, Kovach JL, Schwartz SG, Postel
  • 雑誌名: Proc Natl Acad Sci USA. 巻: 107 ページ: 7401-6
• [雑誌論文] Genetic Variants in Pigment Epithelium-Derived Factor Influence Response of Polypoidal Choroidal Vasculopathy to Photodynamic Therapy. (2010)
  • 著者名/発表者名: Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Ooto S, Tamura H, Saito M, Saito K, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N.
  • 雑誌名: Ophthalmology. 巻: (in press)
  • 査読あり
• [雑誌論文] Haplotype analysis of the ARMS2/HTRA1 region in Japanese patients with typical neovascular age-related macular degeneration or polypoidal choroidal vasculopathy. (2010)
  • 著者名/発表者名: Gotoh N, Yamashiro K, Nakanishi H, Saito M, Iida T, Yoshimura N.
  • 雑誌名: Jpn J Ophthalmol. 巻: 54 ページ: 609-614
  • NAID: 10027666485
  • 査読あり
• [雑誌論文] Macular hole formation following photodynamic therapy combined with intravitreal injection of bevacizumab and triamcinolone acetonide. (2010)
  • 著者名/発表者名: Iwama D, Ooto S, Tsujikawa A, Yamashiro K, Yoshimura N.
  • 雑誌名: Jpn J Ophthalmol. 巻: 54 ページ: 364-366
  • NAID: 10027204735
  • 査読あり
• [雑誌論文] Treatment of polypoidal choroidal vasculopathy by intravitreal injection of bevacizumab. (2010)
  • 著者名/発表者名: Tsujikawa A, Ooto S, Yamashiro K, Tamura H, Otani A, Yoshimura N.
  • 雑誌名: Jpn J Ophthalmol. 巻: 54 ページ: 310-319
  • NAID: 10027204523
  • 査読あり
• [雑誌論文] Joint effect of cigarette smoking and CFH and LOC387715/HTRA1 polymorphisms on polypoidal choroidal vasculopathy. (2010)
  • 著者名/発表者名: Nakanishi H, Yamashiro K, Yamada R, Gotoh N, Hayashi H, Nakata I, Saito M, Iida T, Oishi A, Kurimoto Y, Matsuo K, Tajima K, Matsuda F, Yoshimura N.
  • 雑誌名: Invest Ophthalmol Vis Sci. 巻: 51 ページ: 6183-6187
  • 査読あり
• [雑誌論文] High-resolution imaging of resolved central serous chorioretinopathy using adaptive optics scanning laser ophthalmoscopy. (2010)
  • 著者名/発表者名: Ooto S, Hangai M, Sakamoto A, Tsujikawa A, Yamashiro K, Ojima Y, Yamada Y, Mukai H, Oshima S, Inoue T, Yoshimura N.
  • 雑誌名: Ophthalmology. 巻: 117 ページ: 1800-1809
  • 査読あり
• [雑誌論文] Relationship between retinal sensitivity and morphologic changes in eyes with confluent soft drusen. (2010)
  • 著者名/発表者名: Iwama D, Tsujikawa A, Ojima Y, Nakanishi H, Yamashiro K, Tamura H, Ooto S, Yoshimura N.
  • 雑誌名: Clin Experiment Ophthalmol. 巻: 38 ページ: 483-488
  • 査読あり
• [雑誌論文] CFH and ARMS2 variations in age-related macular degeneration, polypoidal choroidal vasculopathy, and retinal angiomatous proliferation. (2010)
  • 著者名/発表者名: Hayashi H, Yamashiro K, Gotoh N, Nakanishi H, Nakata I, Tsujikawa A, Otani A, Saito M, Iida T, Matsuo K, Tajima K, Yamada R, Yoshimura N.
  • 雑誌名: Invest Ophthalmol Vis Sci. 巻: 51 ページ: 5914-5919
  • 査読あり
• [雑誌論文] Single-nucleotide polymorphisms in the promoter region of matrix metal loproteinase-1, -2, and -3 in Japanese with high myopia. (2010)
  • 著者名/発表者名: Nakanishi H, Hayashi H, Yamada R, Yamashiro K, Nakata I, Shimada N, Ohno-Matsui K, Mochizuki M, Ozaki M, Yoshitake S, Kuriyama S, Saito M, Iida T, Matsuo K, Matsuda F, Yoshimura N.
  • 雑誌名: Invest Ophthalmol Vis Sci. 巻: 51 ページ: 4432-4436
  • 査読あり
• [雑誌論文] Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. (2010)
  • 著者名/発表者名: Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, Conley YP, Kanda A, Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK, Agarwal A, Kovach JL, Schwartz SG, Postel EA, Brooks M, Baratz KH, Brown WL, Complications of Age-Related Macular Degeneration Prevention Trial Research Group, Brucker AJ, Orlin A, Brown G, Ho A, Regillo C, Donoso L, Tian L, Kaderli B, Hadley D, Hagstrom SA, Peachey NS, Klein R, Klein BE, Gotoh N, Yamashiro K, Ferris Iii F, Fagerness JA, Reynolds R, Farrer LA, Kim IK, Miller JW, Corton M, Carracedo A, Sanchez-Salorio M, Pugh EW, Doheny KF, Brion M, Deangelis MM, Weeks DE, Zack DJ, Chew EY, Heckenlively JR,, Yoshimura N, Iyengar SK, Francis PJ, Katsanis N, Seddon JM, Haines JL, Gorin MB, Abecasis GR, Swaroop A.
  • 雑誌名: Proc Natl Acad Sci U S A. 巻: 107 ページ: 7401-7406
  • 査読あり
• [雑誌論文] Thickness of photoreceptor layers in polypoidal choroidal vasculopathy and central serous chorioretinopathy. (2010)
  • 著者名/発表者名: Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Yoshimura N.
  • 雑誌名: Graefes Arch Clin Exp Ophthalmol. 巻: 248 ページ: 1077-1086
  • NAID: 120002514711
  • 査読あり
• [雑誌論文] Punctate hyperfluorescent spots associated with central serous chorioretinopathy as seen on indocyanine green angiography. (2010)
  • 著者名/発表者名: Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, Nakagawa S, Yoshimura N.
  • 雑誌名: Retina 巻: 30 ページ: 801-809
  • 査読あり
• [雑誌論文] Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration (2010)
  • 著者名/発表者名: Chen W, Stambolian D, Edwards AO, et al.
  • 雑誌名: Proc Natl Acad Sci USA (in press)
  • 査読あり
• [雑誌論文] Prognostic factors of vitreous hemorrhage secondary to exudative age-rel ated macular degeneration. (2010)
  • 著者名/発表者名: Hasegawa T, Otani A, Sasahara M, et al.
  • 雑誌名: Am J Ophthalmol 149 ページ: 322-329
  • NAID: 120001823762
  • 査読あり
• [雑誌論文] ARMS2/HTRA1 and CFH polymorphisms are not associated with choroidal neovascularization in highly myopic eyes of the elderly Japanese population. (2010)
  • 著者名/発表者名: Nakanishi H, Gotoh N, Yamada R, et al.
  • 雑誌名: Eye (in press)
  • 査読あり
• [雑誌論文] A genome-wide association analysis identified a movel susceptible locus for pathological myopia at 11q24.1. (2009)
  • 著者名/発表者名: Nakanishi H, Yamada R, Gotoh N, et al.
  • 雑誌名: Plos Genet. 5 ページ: 1-7
  • 査読あり
• [雑誌論文] ARMS2 (LOC387715) variants in Japanese patients with exudative agerelated macular degeneration and polypoidal choroidal vasculopathy. (2009)
  • 著者名/発表者名: Gotoh N, Nakanishi H, Hayashi H, et al.
  • 雑誌名: Am J Ophthalmol. 147 ページ: 1037-41
  • 査読あり
• [雑誌論文] Absence of association between COL1A1 polymorphisms and high myopia in the Japanese population. (2009)
  • 著者名/発表者名: Nakanishi H, Yamada R, Gotoh N, et al.
  • 雑誌名: Invest Ophthalmol Vis Sci. 50 ページ: 544-550
  • 査読あり
• [学会発表] ARMS2遺伝子A69S多型の迅速検出キットの開発および加齢黄斑変性診療における臨床応用 (2009)
  • 著者名/発表者名: 山城健児、後藤謙元、中西秀雄, 等
  • 学会等名: 第63回日本臨床眼科学会
  • 発表場所: 福岡
  • 年月日: 2009-10-11
• [学会発表] ポリープ状脈絡膜血管症への光線力学療法の治療効果とARMS2 A69S多きちまはとの相関 (2009)
  • 著者名/発表者名: 林寿子、山城健児、中西秀雄, 等
  • 学会等名: 第63回日本臨床眼科学会
  • 発表場所: 福岡
  • 年月日: 2009-10-11
• [学会発表] 加齢黄斑変性に対するbevacizumab硝有子体内投与の治療効果とARMS2 A69S (2009)
  • 著者名/発表者名: 仲田勇夫、山城健児、中西秀雄, 等
  • 学会等名: 第63回日本臨床眼科学会
  • 発表場所: 福岡
  • 年月日: 2009-10-10
• [学会発表] 疾患感受性一塩基多型からAMDとPCVを考える (2009)
  • 著者名/発表者名: 吉村長久
  • 学会等名: 第63回日本臨床眼科学会
  • 発表場所: 福岡
  • 年月日: 2009-10-09