父親に特異的に由来する染色体構造異常発生メカニズム

• 研究課題/領域番号: 21390101
• 研究種目: 基盤研究(B)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 人類遺伝学
• 研究機関: 藤田保健衛生大学
• 研究代表者: 倉橋 浩樹 藤田保健衛生大学, 総合医科学研究所, 教授 (30243215)
• 研究期間 (年度): 2009 – 2011
• 研究課題ステータス: 完了 (2011年度)
• 配分額: 18,460千円 (直接経費: 14,200千円、間接経費: 4,260千円); 2011年度: 5,330千円 (直接経費: 4,100千円、間接経費: 1,230千円); 2010年度: 6,240千円 (直接経費: 4,800千円、間接経費: 1,440千円); 2009年度: 6,890千円 (直接経費: 5,300千円、間接経費: 1,590千円)
• キーワード: 染色体転座 / 切断点 / 回文配列 / パリンドローム / 十字架型DNA / 非B型DNA / 染色体再構成 / 染色体構造異常

研究概要

t(11 ; 22)転座は、頻度の高い反復性生殖細胞系列染色体転座である。転座保因者は無症状だが、無精子症、反復性流産、子の染色体不均衡による先天異常など、産科的問題が生じる。研究代表者たちは、2つの転座切断点をそれぞれベクターに組み込み、細胞株に導入すると転座反応が起きる、という転座のモデル系を確立した。この実験系を利用して、転座反応が、2段階のDNA切断反応を介して進行すること、すなわち、(1)十字架型DNAの根本をホリデイ構造切断酵素であるGEN1が対角線の向きに切断し、(2)その結果としてできたヘアピン末端をARTEMISが開裂すること、そして両断端が非相同末端結合によって修復されることが、繰り返し起こる染色体転座の原因であることを証明した。

研究成果

• [雑誌論文] Molecular basis of maternal age-related increase in oocyte aneuploidy (2012)
  • 著者名/発表者名: Kurahashi H, Tsutsumi M, Nishiyama S, Kogo H, Inagaki H, Ohye T
  • 雑誌名: Congenit Anom (Kyoto) 巻: 52 号: 1 ページ: 8-15
  • DOI: 10.1111/j.1741-4520.2011.00350.x
  • 査読あり
• [雑誌論文] Mechanism of complex gross chromosomal rearrangements : A commentary on Concomitant microduplications of MECP2 and ATRX in male patients with severe mental retardation (2012)
  • 著者名/発表者名: Kurahashi H, Ohye T, Inagaki H, Kogo H, Tsutsumi M
  • 雑誌名: J Hum Genet 巻: 57 号: 2 ページ: 81-83
  • DOI: 10.1038/jhg.2011.143
  • NAID: 10030711395
  • 査読あり
• [雑誌論文] DNA secondary structure is influenced by genetic variation and alters susceptibility to de novo translocation (2011)
  • 著者名/発表者名: Kato T, Inagaki H, Tong M, Kogo H, Ohye T, Yamada K, Tsutsumi M, Emanuel BS, Kurahashi H
  • 雑誌名: Mol Cytoenet 巻: 4 ページ: 18-18
  • 査読あり
• [雑誌論文] Characterization of a novel mouse gene encoding an SYCP3-like protein that re-localizes from the XY body to the nucleolus during prophase of male meiosis I (2011)
  • 著者名/発表者名: Tsutsumi M, Kogo H, Kowa-Sugiyama H, Inagaki H, Ohye T, Kurahashi H
  • 雑誌名: Biol Reprod 巻: 85 号: 1 ページ: 165-171
  • DOI: 10.1095/biolreprod.110.087270
  • 査読あり
• [雑誌論文] Pathogenic exon-trapping by SVA retrotransposon and rescue in Fukuyama muscular dystrophy (2011)
  • 著者名/発表者名: Taniguchi-Ikeda M, Kobayashi K, Kanagawa M, Yu CC, Mori K, Oda T, Kuga A, Kurahashi H, Akman HO, DiMauro S, Kaji R, Yokota T, Takeda S, Toda T
  • 雑誌名: Nature 巻: 478 号: 7367 ページ: 127-131
  • DOI: 10.1038/nature10456
  • 査読あり
• [雑誌論文] A rare synaptonemal complex protein 3 gene variant in unexplained female infertility (2011)
  • 著者名/発表者名: Nishiyama S, Kishi T, Kato T, Suzuki M, Bolor H, Udagawa Y, Kurahashi H
  • 雑誌名: Mol Hum Reprod 巻: 17 号: 4 ページ: 266-271
  • DOI: 10.1093/molehr/gaq098
  • 査読あり
• [雑誌論文] Polymorphism in annexin A5 gene promoter in Japanese women with recurrent pregnancy loss (2011)
  • 著者名/発表者名: Miyamura H, Nishizawa H, Ota S, Suzuki M, Inagaki A, Egusa H, Nishiyama S, Kato T, Pryor-Koishi K, Nakanishi I, Fujita T, Imayoshi Y, Markoff A, Yanagihara I, Udagawa Y, Kurahashi H
  • 雑誌名: Mol Hum Reprod 巻: 17 号: 7 ページ: 447-452
  • DOI: 10.1093/molehr/gar008
  • 査読あり
• [雑誌論文] DNA secondary structure is influenced by genetic variation and alters susceptibility to de novo translocation (2011)
  • 著者名/発表者名: Kato T, Inagaki H, Tong M, Kogo H, Ohye T, Yamada K, Tsutsumi M, Emanuel BS, Kurahashi H
  • 雑誌名: Mol Cytogenet 巻: 4 号: 1 ページ: 18-18
  • DOI: 10.1186/1755-8166-4-18
  • 査読あり
• [雑誌論文] Comparative gene expression profiling of placentas from patients with severe pre-eclampsia and unexplained fetal growth restriction (2011)
  • 著者名/発表者名: Nishizawa H, Ota S, Suzuki M, Kato T, Sekiya T, Kurahashi H, Udagawa Y
  • 雑誌名: Reprod Biol Endocrinol 巻: 9 号: 1 ページ: 107-107
  • DOI: 10.1186/1477-7827-9-107
  • 査読あり
• [雑誌論文] Impact of indoleamine 2,3-dioxygenase on the antioxidant system in the placentas of severely pre-eclamptic patients (2011)
  • 著者名/発表者名: Nishizawa H, Suzuki M, Pryor-Koishi K, Sekiya T, Tada S, Kurahashi H, Udagawa Y
  • 雑誌名: Syst Biol Reprod Med 巻: 57 号: 4 ページ: 174-178
  • DOI: 10.3109/19396368.2011.587590
  • 査読あり
• [雑誌論文] Global gene expression profiling in early-stage polycystic kidney disease in the Han : SPRD Cy rat identifies a role for RXR signaling (2011)
  • 著者名/発表者名: Kugita M, Nishii K, Morita M, Yoshihara D, Kowa-Sugiyama H, Yamada K, Yamaguchi T, Wallace DP, Calvet JP, Kurahashi H, Nagao S
  • 雑誌名: Am J Physiol Renal Physiol 巻: 300 号: 1 ページ: F177-F188
  • DOI: 10.1152/ajprenal.00470.2010
  • 査読あり
• [雑誌論文] PPAR-{gamma} agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease (2011)
  • 著者名/発表者名: Yoshihara D, Kurahashi H, Morita M, Kugita M, Hiki Y, Aukema HM, Yamaguchi T, Calvet JP, Wallace DP, Nagao S
  • 雑誌名: Am J Physiol Renal Physiol 巻: 300 号: 2 ページ: F465-F474
  • DOI: 10.1152/ajprenal.00460.2010
  • 査読あり
• [雑誌論文] Lack of Association between Orexin Receptor Genes Polymorphisms and Obstructive Sleep Apnea Syndrome in Japanese (2011)
  • 著者名/発表者名: Ahmed WA, Mori T, Nishimura Y, Kitanaka T, Kato T, Bhardwaj KA, Kurahashi H, Suzuki K
  • 雑誌名: Sleep Biol Rhythms 巻: 9 ページ: 73-77
  • 査読あり
• [雑誌論文] Polymorphism in annexin A5 gene promoter in Japanese women with recurrent pregnancy loss. (2011)
  • 著者名/発表者名: Miyamura H, Nishizawa H, Ota S, Suzuki M, Inagaki A, Egusa H, Nishiyama S, Kato T, Pryor-Koishi K, Nakanishi I, Fujita T, Imayoshi Y, Markoff A, Yanagihara I, Udagawa Y, Kurahashi H.
  • 雑誌名: Mol Hum Reprod 巻: (In press)
  • 査読あり
• [雑誌論文] A rare synaptonemal complex protein 3 gene variant is associated with unexplained female infertility. (2011)
  • 著者名/発表者名: Nishiyama S, Kishi T, Kato T, Suzuki M, Bolor H, Udagawa Y, Kurahashi H.
  • 雑誌名: Mol Hum Reprod 巻: (In press)
  • 査読あり
• [雑誌論文] Global gene expression profiling in early-stage polycystic kidney disease in the Han : SPRD Cy rat identifies a role for RXR signaling. (2011)
  • 著者名/発表者名: Kugita M, Nishii K, Morita M, Yoshihara D, Kowa-Sugiyama H, Yamada K, Yamaguchi T, Wallace DP, Calvet JP, Kurahashi H, Nagao S.
  • 雑誌名: Am J Physiol Renal Physiol 巻: (In press)
  • 査読あり
• [雑誌論文] PPAR-{gamma} agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease. (2011)
  • 著者名/発表者名: Yoshihara D, Kurahashi H, Morita M, Kugita M, Hiki Y, Aukema HM, Yamaguchi T, Calvet JP, Wallace DP, Nagao S.
  • 雑誌名: Am J Physiol Renal Physiol 巻: (In press)
  • 査読あり
• [雑誌論文] Paternal origin of the de novo constitutional t(11 ; 22)(q23 ; q11) (2010)
  • 著者名/発表者名: Ohye T, Inagaki H, Kogo H, Tsutsumi M, Kato T, Tong M, Macville M, Medne L, Zackai EH, Emanuel BS, Kurahashi H
  • 雑誌名: Eur J Hum Genet 巻: 18(7) ページ: 783-7
  • 査読あり
• [雑誌論文] Polymorphisms of the 22q11.2 breakpoint region influence the frequency of de novo constitutional t(11 ; 22) s in sperm (2010)
  • 著者名/発表者名: Tong M, Kato T, Yamada K, Inagaki H, Kogo H, Ohye T, Tsutsumi M, Wang J, Emanuel BS, Kurahashi H
  • 雑誌名: Hum Mol Genet 巻: 19(13) ページ: 2630-7
  • 査読あり
• [雑誌論文] A new palindrome-mediated recurrent translocation with 3 : 1 meiotic non-disjunction : the t(8 ; 22)(q24.13 ; q11.21) (2010)
  • 著者名/発表者名: Sheridan MB, Kato T, Haldeman-Englert C, Jalali GR, Milunsky JM, Zou Y, Klaes R, Gimelli S, Gemmill RM, Drabkin HA, Hacker AM, Brown J, Tomkins D, Shaikh TH, Kurahashi H, Zackai EH, Emanuel BS
  • 雑誌名: Am J Hum Genet 巻: 87(2) ページ: 209-18
  • 査読あり
• [雑誌論文] The constitutional t(11 ; 22): implications for a novel mechanism responsible for gross chromosomal rearrangement (2010)
  • 著者名/発表者名: Kurahashi H, Inagaki H, Kogo H, Ohye T, Tsutsumi M, Kato T, Tong M, Emanuel BS
  • 雑誌名: Clin Genet 巻: 78(4) ページ: 299-309
  • 査読あり
• [雑誌論文] Paternal origin of the de novo constitutional t(11;22)(q23;q11). (2010)
  • 著者名/発表者名: Ohye T, Inagaki H, Kogo H, Tsutsumi M, Kato T, Tong M, Macville M, Medne L, Zackai EH, Emanuel BS, Kurahashi H.
  • 雑誌名: Eur J Hum Genet 巻: 18 ページ: 783-7
  • 査読あり
• [雑誌論文] Polymorphisms of the 22q11.2 breakpoint region influence the frequency of de novo constitutional t(11;22)s in sperm. (2010)
  • 著者名/発表者名: Tong M, Kato T, Yamada K, Inagaki H, Kogo H, Ohye T, Tsutsumi M, Wang J, Emanuel BS, Kurahashi H.
  • 雑誌名: Hum Mol Genet 巻: 19 ページ: 2630-7
  • 査読あり
• [雑誌論文] A new palindrome -mediated recurrent translocation with 3:1 meiotic non-disjunction : the t(8;22)(q24.13 ; q11.21). (2010)
  • 著者名/発表者名: Sheridan MB, Kato T, Haldem an-Englert C, Jalali GR, Milunsky JM, Zou Y, Klaes R, Gimelli S, Gemmill RM, Drabkin HA, Hacker AM, Brown J, Tomkins D, Shaikh TH, Kurahashi H, Zackai EH, Emanuel BS.
  • 雑誌名: Am J Hum Genet 巻: 87 ページ: 209-18
  • 査読あり
• [雑誌論文] The constitutional t(11;22) : implications for a novel mechanism responsible for gross chromosomal rearrangement. (2010)
  • 著者名/発表者名: Kurahashi H, Inagaki H, Kogo H, Ohye T, Tsutsumi M, Kato T, Tong M, Emanuel BS.
  • 雑誌名: Clin Genet 巻: 78 ページ: 299-309
  • 査読あり
• [雑誌論文] Screening of genes involved in chromosome segregation during meiosis I : towards the identification of genes responsible for infertility in humans. (2010)
  • 著者名/発表者名: Kogo H, Kowa-Sugiyama H, Yamada K, Bolor H, Tsutsumi M, Ohye T, Inagaki H, Taniguchi M, Tada T, Kurahashi H.
  • 雑誌名: J Hum Genet 巻: 55 ページ: 293-9
  • NAID: 10030734983
  • 査読あり
• [雑誌論文] CD9 gene variations are not associated with female infertility in humans. (2010)
  • 著者名/発表者名: Nishiyama S, Kishi T, Kato T, Suzuki M, Nishizawa H, Pryor-Koishi K, Sawada T, Nishiyama Y, Iwata N, Udagawa Y, Kurahashi H.
  • 雑誌名: Gynecol Obstet Invest 巻: 69 ページ: 116-21
  • 査読あり
• [雑誌論文] Genetic variation in the indoleamine 2,3-dioxygenase gene in pre-eclampsia. (2010)
  • 著者名/発表者名: Nishizawa H, Kato T, Ohta S, Nishiyama S, Pryor-Koishi K, Suzuki M, Tsutsumi M, Inagaki H, Kurahashi H, Udagawa Y.
  • 雑誌名: Am J Reprod Immunol 巻: 64 ページ: 68-76
  • 査読あり
• [雑誌論文] Genetic variation in the indoleamine 2,3-dioxygenase gene in pre-eclampsia (Reply). (2010)
  • 著者名/発表者名: Nishizawa H, Kurahashi H.
  • 雑誌名: Am J Reprod Immunol 巻: 64 ページ: 317-317
  • 査読あり
• [雑誌論文] Polycystic kidney disease in Han : SPRD Cy rats is associated with elevated expression and mislocalization of SamCystin. (2010)
  • 著者名/発表者名: Nagao S, Morita M, Kugita M, Yoshihara D, Yamaguchi T, Kurahashi H, Calvet JP, Wallace DP.
  • 雑誌名: Am J Physiol Renal Physiol 巻: 299
  • 査読あり
• [雑誌論文] Urinary neutrophil gelatinase-associated lipocalin is a potential non-invasive marker for renal scarring in patients with vesicoureteral reflux. (2010)
  • 著者名/発表者名: Ichino M, Kusaka M, Kuroyanagi Y, Mori T, Morooka M, Sasaki H, Shiroki R, Shishido S, Kurahashi H, Hoshinaga K.
  • 雑誌名: J Urol 巻: 183 ページ: 2001-7
  • 査読あり
• [雑誌論文] Serum tissue inhibitor of metalloproteinases 1 (TIMP-1) predicts organ recovery from delayed graft function after kidney transplantation from donors after cardiac death. (2010)
  • 著者名/発表者名: Kusaka M, Kuroyanagi Y, Ichino M, Sasaki H, Maruyama T, Hayakawa K, Shiroki R, Sugitani A, Kurahashi H, Hoshinaga K.
  • 雑誌名: Cell Transplant 巻: 19 ページ: 723-9
  • 査読あり
• [雑誌論文] Correlation of axillary osmidrosis to a SNP in the ABCC11 gene determined by the smart-amplification process (SMAP). (2010)
  • 著者名/発表者名: Inoue Y, Mori T, Sakurai A, Mitani Y, Toyoda Y, Ishikawa T, Hayashizaki Y, Yoshimura Y, Kurahashi H, Sakai Y.
  • 雑誌名: J Plast Reconstr Aesthet Surg 巻: 63 ページ: 1369-74
  • 査読あり
• [雑誌論文] Angiotensin converting enzyme 2 gene expression increased compensatory for left ventricular remodeling in patients with end-stage heart failure. (2010)
  • 著者名/発表者名: Ohtsuki M, Morimoto S, Izawa H, Ismail TF, Ishibashi-Ueda H, Kato Y, Horii T, Isomura T, Suma H, Nomura M, Hishida H, Kurahashi H, Ozaki Y.
  • 雑誌名: Int J Cardiol 巻: 145 ページ: 333-4
  • 査読あり
• [雑誌論文] CD9 gene variations are not associated with female infertility in humans (2010)
  • 著者名/発表者名: Nishiyama S, Kishi T, Kato T, Suzuki M, Nishizawa H, Pryor-Koishi K, Sawada T, Nishiyama Y, Iwata N, Udagawa Y, Kurahashi H
  • 雑誌名: Gynecologic and Obstetric Investigation 69 ページ: 116-121
  • 査読あり
• [雑誌論文] Chromosomal instability mediated by non-B DNA : Cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans (2009)
  • 著者名/発表者名: Inagaki H, Ohye T, Kogo H, Kato T, Bolor H, Taniguchi M, Shaikh TH, Emanuel BS, Kurahashi H
  • 雑誌名: Genome Res 巻: 19(2) ページ: 191-198
  • 査読あり
• [雑誌論文] Impaired DNA replication prompts deletions within palindromic sequences, but does not induce translocations in human cells (2009)
  • 著者名/発表者名: Kurahashi H, Inagaki H, Kato T, Hosoba E, Kogo H, Ohye T, Tsutsumi M, Bolor H, Tong M, Emanuel BS
  • 雑誌名: Hum Mol Genet 巻: 18(18) ページ: 3397-3406
  • 査読あり
• [雑誌論文] Recent advance in our understanding of the molecular nature of chromosomal abnormalities (2009)
  • 著者名/発表者名: Kurahashi H, Bolor H, Kato T, Kogo H, Tsutsumi M, Inagaki H, Ohye T
  • 雑誌名: J Hum Genet 巻: 54(5) ページ: 253-260
  • NAID: 10030730167
  • 査読あり
• [雑誌論文] Mutations of the SYCP3 gene in women with recurrent pregnancy loss (2009)
  • 著者名/発表者名: Bolor H, Mori T, Nishiyama S, Ito Y, Hosoba E, Inagaki H, Kogo H, Ohye T, Makiko T, Kato T, Tong M, Nishizawa H, Pryor-Koishi K, Kitaoka E, Sawada T, Nishiyama Y, Udagawa Y, Kurahashi H
  • 雑誌名: American Journal of Human Genetics 84 ページ: 14-20
  • 査読あり
• [雑誌論文] Chromosomal instability mediated by non-B DNA : Cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans (2009)
  • 著者名/発表者名: Inagaki H, Ohye T, Kogo H, Kato T, Bolor H, Taniguchi M, Shaikh TH, Emanuel BS, Kurahashi H
  • 雑誌名: Genome Research 19 ページ: 191-198
  • 査読あり
• [雑誌論文] Impaired DNA replication prompts deletions within palindromic sequences, but does not induce translocations in human cells (2009)
  • 著者名/発表者名: Kurahashi H, Inagaki H, Kato T, Hosoba E, Kogo H, Ohye T, Tsutsumi M, Bolor H, Tong M, Emanuel BS
  • 雑誌名: Human Molecular Genetics 18 ページ: 3397-3406
  • 査読あり
• [雑誌論文] Recent advance in our understanding of the molecular nature of chromosomal abnormalities (2009)
  • 著者名/発表者名: Kurahashi H, Bolor H, Kato T, Kogo H, Tsutsumi M, Inagaki H, Ohye T
  • 雑誌名: Journal of Human Genetics 54 ページ: 253-260
  • NAID: 10030730167
  • 査読あり
• [雑誌論文] Analysis of nitric oxide metabolism as a placental or maternal factor underlying the etiology of pre-eclampsia (2009)
  • 著者名/発表者名: Nishizawa H, Pryor-Koishi K, Suzuki M, Kato T, Sekiya T, Tada S, Kurahashi H, Udagawa Y
  • 雑誌名: Gynecologic and Obstetric Investigation 68 ページ: 239-247
  • 査読あり
• [雑誌論文] Increased urinary neutrophil gelatinase-associated lipocalin levels in a rat model of upper urinary tract infection (2009)
  • 著者名/発表者名: Ichino M, Kuroyanagi Y, Kusaka M, Mori T, Ishikawa K, Shiroki R, Kurahashi H, Hoshinaga K
  • 雑誌名: Journal of Urology 181 ページ: 2326-2331
  • 査読あり
• [雑誌論文] Global expression profiles in 1-hour biopsy specimens of human kidney transplantation from donors after cardiac death (2009)
  • 著者名/発表者名: Kusaka M, Kuroyanagi Y, Mori T, Nagaoka K, Sasaki H, Maruyama T, Hayakawa K, Shiroki R, Kurahashi H, Hoshinaga K
  • 雑誌名: Cell Transplantation 18 ページ: 647-656
  • 査読あり
• [雑誌論文] Chromosomal translocations and palindromic AT-rich repeats
  • 著者名/発表者名: Kato T, Kurahashi H, Emanuel BS
  • 雑誌名: Curr Opin Genet Dev. 巻: (In press)
  • 査読あり
• [雑誌論文] HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes
  • 著者名/発表者名: Kogo H, Tsutsumi M, Ohye T, Inagaki H, Abe T, Kurahashi H
  • 雑誌名: Genes Cells 巻: (In press)
  • 査読あり
• [雑誌論文] A Functional variation in the hypocretin neuropeptide precursor gene may be associated with obstructive sleep apnea syndrome in Japan
  • 著者名/発表者名: Ahmed WA, Tsutsumi M, Nakata S, Mori T, Nishimura Y, Fujisawa T, Kato I, Nakashima M, Kurahashi H, Suzuki K
  • 雑誌名: Laryngoscope 巻: (In press)
  • 査読あり
• [雑誌論文] Serum neutrophil gelatinase-associated lipocalin during the early postoperative period predicts the recovery of graft function after kidney transplantation from donors after cardiac death
  • 著者名/発表者名: Kusaka M, Iwamatsu F, Kuroyanagi Y, Nakaya M, Ichino M, Marubashi S, Nagano H, Shiroki R, Kurahashi H, Hoshinaga K
  • 雑誌名: J Urol 巻: (In press)
  • 査読あり
• [学会発表] Mechanism of recurrent translocation t(11 ; 22) initiated by cruciform conformation of palindromic sequences (2011)
  • 著者名/発表者名: Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel BS, Kurahashi H
  • 学会等名: The 12th International Congress of Human Genetics
  • 発表場所: Montreal, Canada
• [学会発表] Identification of a novel palindrome mediated translocation associated with the t(3 ; 8) of hereditary renal cancer (2011)
  • 著者名/発表者名: Kato T, Sheridan MB, Hacker AM, Inagaki H, Glover TW, Plon SE, Drabkin HA, Gemmill RM, Kurahashi H, Emanuel BS
  • 学会等名: The 12th International Congress of Human Genetics
  • 発表場所: Montreal, Canada
• [学会発表] GEN1 resolves cruciform-forming palindromic DNA leading to a recurrent translocation in humans (2011)
  • 著者名/発表者名: Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel BS, Kurahashi H
  • 学会等名: Kyestone Symposia : Functional consequences of structural variation in the genome
  • 発表場所: Steamboat Springs, USA
• [学会発表] Polymorphisms in the annexin A5 gene promoter in Japanese women with recurrent pregnancy loss (2011)
  • 著者名/発表者名: Kurahashi H, Miyamura H, Nishizawa H, Ota S, Suzuki M, Inagaki A, Egusa H, Nishiyama S, Kato T, Pryor-Koishi K, Nakanishi I, Fujita T, Imayoshi Y, Negi R, Markoff A, Yanagihara I, Udagawa, Y
  • 学会等名: European Society of Human Genetics Conference 2011
  • 発表場所: Amsterdam, Netherlands
• [学会発表] Polymorphisms in the annexin A5 gene promoter in Japanese women with recurrent pregnancy loss (2011)
  • 著者名/発表者名: Miyamura H, Nishizawa H, Ota S, Suzuki M, Inagaki A, Egusa H, Nishiyama s, Kato T, Pryor-Koishi K, Nakanishi I, Fujita T, Imayoshi Y, Markoff A, Yanagihara I, Udagawa Y, Kurahashi H
  • 学会等名: 59th Annual Clinical Meeting, ACOG
  • 発表場所: Washington DC, USA
• [学会発表] Polymorphisms in the annexin A5 gene promoter in Japanese women with recurrent pregnancy loss (2011)
  • 著者名/発表者名: Miyamura H, Nishizawa H, Ota S, Suzuki M, Inagaki A, Egusa H, Nishiyama S, Kato T, Pryor-Koishi K, Nakanishi I, Fujita T, Imayoshi Y, Markoff A, Yanagihara I, Udagawa Y, Kurahashi H
  • 学会等名: 27th Annual Meeting of ESHRE-Stockholm 2011
  • 発表場所: Stockholm, Sweden
• [学会発表] Mechanism of recurrent translocation t(11;22) initiated by cruciform conformation of palindromic sequences (2011)
  • 著者名/発表者名: Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel BS, Kurahashi H
  • 学会等名: The 12th International Congress of Human Genetics
  • 発表場所: Montreal, Canada
• [学会発表] Identification of a recombination hotspot sequence at the breakpoint region of the 22q11 deletion using a yeast model (2011)
  • 著者名/発表者名: Ohye T, Inagaki H, Kogo H, Tsutsumi M, Emanuel BS, Kurahashi H
  • 学会等名: The 12th International Congress of Human Genetics
  • 発表場所: Montreal, Canada
• [学会発表] HORMAD1-deficiency causes azoospermia in males and pregnancy loss in females (2011)
  • 著者名/発表者名: Kogo H, Tsutsumi M, Ohye T, Inagaki H, Kurahashi H
  • 学会等名: The 12th International Congress of Human Genetics
  • 発表場所: Montreal, Canada
• [学会発表] Identification of a novel palindrome mediated translocation associated with the t(3;8) of hereditary renal cancer (2011)
  • 著者名/発表者名: Kato T, Sheridan MB, Hacker AM, Inagaki H, Glover TW, Plon SE, Drabkin HA, Gemmill RM, Kurahashi H, Emanuel BS
  • 学会等名: The 12th International Congress of Human Genetics
  • 発表場所: Montreal, Canada
• [学会発表] Mutation in the SYCP3 gene identified in a woman with recurrent pregnancy loss affect the synaptonemal complex conformation at meiotic prophase I (2011)
  • 著者名/発表者名: Tsutsumi M, Kogo H, Inagaki H, Ohye T, Kurahashi H
  • 学会等名: The 12th International Congress of Human Genetics
  • 発表場所: Montreal, Canada
• [学会発表] HORMAD1-dependent synapsis checkpoint in mammalian meiosis (2011)
  • 著者名/発表者名: Kogo H, Tsutsumi M, Ohye T, Inagaki H, Kurahashi H
  • 学会等名: 2011 FASEB Summer Research Conferences, Genetic Recombination & Genome Rearrangements
  • 発表場所: Steamboat Spring, USA
• [学会発表] PPAR-gamma agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease (2011)
  • 著者名/発表者名: Yoshihara D, Kurahashi H, Morita M, Kugita M, Hiki Y, Aukema HM, Yamaguchi T, Calvet JP, Wallace DP, Nagao S
  • 学会等名: World Congress of Nephrology 2011
  • 発表場所: Vancouver, Canada
• [学会発表] Global gene expression profiling in kidneys of PPAR-gamma agonist-treated PCK rats, an orthologous model of human ARPKD (2011)
  • 著者名/発表者名: Yoshihara D, Kugita M, Kurahashi H, Morita M, Hiki Y, Yamaguchi T, Aukema HM, Wallace DP, Calvet JP, Toyohara T, Abe T, Nagao S
  • 学会等名: American Society of Nephrology 44th Annual Meetine & Scientific Exposition
  • 発表場所: Philadelphia, PA USA
• [学会発表] GEN1 resolves cruciform-forming palindromic DNA leading to a recurrent translocation in humans. (2011)
  • 著者名/発表者名: Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel BS, Kurahashi H.
  • 学会等名: Keystone Symposia : Functional Consequences of Structural Variation in the Genome
  • 発表場所: Steamboat Springs, Colorado, USA
• [学会発表] GEN1 resolves cruciform-forming palindromic DNA leading to a recurrent translocation in humans (2010)
  • 著者名/発表者名: Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel BS, Kurahashi H
  • 学会等名: The American Society of Human Genetics 60th Annual Meeting
  • 発表場所: Washington DC, USA
• [学会発表] GEN1 resolves cruciform-forming palindromic DNA leading to a recurrent translocation in humans (2010)
  • 著者名/発表者名: Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel BS, Kurahashi H
  • 学会等名: The 7th 3R Symposium
  • 発表場所: Toyama, Japan
• [学会発表] Palindrome-mediated chromosomal translocation in humans. (2010)
  • 著者名/発表者名: Kurahashi H
  • 学会等名: FASEB Summer Research Conferences. Biological Impact of Alternatively Structured DNA
  • 発表場所: Colorado, USA
• [学会発表] Paternal origin of the de novo constitutional t(11 ; 22)(q23 ; q11) (2010)
  • 著者名/発表者名: Ohye T, Inagaki H, Kogo H, Tsutsumi M, Kato T, Tong M, Macville MVE, Medne L, Zackai EH, Emanuel BS, Kurahashi H
  • 学会等名: European Society of Human Genetics Conference 2010
  • 発表場所: Gothenburg, Sweden
• [学会発表] Palindrome-mediated chromosomal translocation in humans. (2010)
  • 著者名/発表者名: Kurahashi H.
  • 学会等名: FASEB Summer Research Conferences. Biological Impact of Alternatively Structured DNA.
  • 発表場所: Steamboat Springs, Colorado, USA(招待講演)
• [学会発表] Mutation of the SYCP3 gene in women with recurrent pregnancy loss. (2010)
  • 著者名/発表者名: Kurahashi H, Tsutsumi M, Egusa H, Nishiyama S, Suzuki M, Kogo H, Inagaki H, Ohye T.
  • 学会等名: International Symposium on Epigenome Network, Development and Reprogramming of Germ Cells.
  • 発表場所: Fukuoka, Japan
• [学会発表] Paternal origin of the de novo constitutional t(11;22) (q23;q11). (2010)
  • 著者名/発表者名: Ohye T, Inagaki H, Kogo H, Tsutsumi M, Kato T, Tong M, Macville MVE, Medne L, Zackai EH, Emanuel BS, Kurahashi H.
  • 学会等名: European Society of Human Genetics Conference 2010.
  • 発表場所: Gothenburg, Sweden
• [学会発表] GEN1 resolves cruciform-forming palindromic DNA leading to a recurrent translocation in humans. (2010)
  • 著者名/発表者名: Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel BS, Kurahashi H.
  • 学会等名: The 7th 3R Symposium
  • 発表場所: Toyama, Japan
• [学会発表] GEN1 resolves cruciform-forming palindromic DNA leading to a recurrent translocation in humans. (2010)
  • 著者名/発表者名: Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel BS, Kurahashi H.
  • 学会等名: The American Society of Human Genetics 60th Annual Meeting
  • 発表場所: Washington DC, USA
• [学会発表] Parental origin of de novo t(11 ; 22)(q23 ; q11) (2009)
  • 著者名/発表者名: Ohye T, Inagaki H, Kogo H, Tsutsumi M, Kato T, Tong M, Macville MV, Medne L, Zackai EH, Emanuel BS, Kurahashi H
  • 学会等名: 59th annual meeting of American Society of Human Genetics
  • 発表場所: Hawai, USA
• [学会発表] Two successive cleavages in palindrome-mediated translocation (2009)
  • 著者名/発表者名: Kurahashi H, Inagaki H, Kato T, Ohye T, Kogo H, Shaikh TH, Emanuel BS
  • 学会等名: Genome Instability and DNA Repair
  • 発表場所: Taos, USA
• [学会発表] Mutations of the SYCP3 gene in women with recurrent pregnancy loss (2009)
  • 著者名/発表者名: Kurahashi H, Bolor H, Mori T, Nishiyama S, Inagaki H, Kogo H, Tsutsumi M, Ohye T
  • 学会等名: European Society of Human Genetics conference 2009
  • 発表場所: Vienna, Austria
• [学会発表] Parental origin of de novo t(11;22)(q23;q11) (2009)
  • 著者名/発表者名: Kurahashi H, Inagaki H, Kato T, Ohye T, Kogo H, Shaikh TH, Emanuel BS
  • 学会等名: 59th annual meeting of American Society of Human Genetics
  • 発表場所: Honolulu, Hawai, USA
• [図書] Cruciform DNA. Encyclopedia of Genetics, 2nd Edition
  • 著者名/発表者名: Inagaki H, Kurahashi H
  • 出版者: Elsevier(in press)
• [備考] 藤田保健衛生大学・総合医科学研究所
  • URL: http://www.fujita-hu.ac.jp/ICMS/
• [備考] 分子遺伝学研究部門
  • URL: http://www.fujita-hu.ac.jp/~genome/mg/
• [備考]
  • URL: http://www.fujita-hu.ac.jp/~genome/mg/