低酸素応答転写制御ネットワークの網羅的解析による慢性腎臓病の病態生理の解明

• 研究課題/領域番号: 21390260
• 研究種目: 基盤研究(B)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 腎臓内科学
• 研究機関: 東京大学
• 研究代表者: 南学 正臣 東京大学, 医学部附属病院, 特任講師 (90311620)
• 研究分担者: 和田 健彦 東京大学, 医学部附属病院, 助教 (90447409) ; 稲城 玲子 東京大学, 医学部附属病院, 特任研究員 (50232509) ; 田中 哲洋 東京大学, 保健健康推進本部, 助教 (90508079)
• 連携研究者: 児玉 龍彦 東京大学, 先端科学技術センター, 教授 (90170266) ; 油谷 浩幸 東京大学, 先端科学技術センター, 教授 (10202657)
• 研究期間 (年度): 2009 – 2011
• 研究課題ステータス: 完了 (2011年度)
• 配分額: 18,070千円 (直接経費: 13,900千円、間接経費: 4,170千円); 2011年度: 2,600千円 (直接経費: 2,000千円、間接経費: 600千円); 2010年度: 6,890千円 (直接経費: 5,300千円、間接経費: 1,590千円); 2009年度: 8,580千円 (直接経費: 6,600千円、間接経費: 1,980千円)
• キーワード: 腎臓学 / 虚血 / 慢性腎臓病 / 腎不全 / 低酸素

研究概要

siRNA libraryスクリーニングとChIPシークエンスおよびmicroarrayにより、hypoxia-inducible factor(HIF)の転写制御ネットワークの解析を行った。新規HIF調節分子および新規HIFターゲット遺伝子の同定に成功し、そのうちの1つであるGene Aについては、腎細胞癌の予後とよく相関し、細胞質分裂に重要な役割を果たすことを見出した。

研究成果

• [雑誌論文] Dysregulated oxygen metabolism of the kidney by uremic toxins (2012)
  • 著者名/発表者名: Chiang CK, Tanaka T, Nangaku M
  • 雑誌名: J Ren Nutr 巻: 22 ページ: 77-80
  • URL: http://www.sciencedirect.com/science/article/pii/S1051227611002184
  • 査読あり
• [雑誌論文] Glyoxalase I retards renal senescence (2011)
  • 著者名/発表者名: Ikeda Y, Inagi R, Miyata T, Nagai R, Arai M, Miyashita M, Itokawa M, Fujita T, Nangaku M.
  • 雑誌名: Am J Pathol 巻: 179 ページ: 2810-21
  • URL: http://linkinghub.elsevier.com/retrieve/pii/S0002-9440(11)00840-6
  • 査読あり
• [雑誌論文] Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in a HIF-dependent manner (2011)
  • 著者名/発表者名: Chiang CK, Tanaka T, Inagi R, Fujita T, Nangaku M
  • 雑誌名: Lab Invest 巻: 91 号: 11 ページ: 1564-71
  • DOI: 10.1038/labinvest.2011.114
  • 査読あり
• [雑誌論文] Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions (2011)
  • 著者名/発表者名: Nishi H, Inagi R, Kawada N, Yoshizato K, Mimura I, Fujita T, Nangaku M
  • 雑誌名: Am J Pathol 巻: 178 ページ: 128-39
  • URL: http://linkinghub.elsevier.com/retrieve/pii/S0002-9440(10)00057-X
  • 査読あり
• [雑誌論文] Epigenetic regulation for hypoxic response via HIF and histone demethylase (2011)
  • 著者名/発表者名: Mimura I, Tanaka T, Wada Y, Kodama T, Nangaku M.
  • 雑誌名: J Pharmacol Sci 巻: 115 ページ: 453-8
  • URL: https://www.jstage.jst.go.jp/article/jphs/advpub/0/advpub_10R19FM/_article
  • 査読あり
• [雑誌論文] Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions. (2011)
  • 著者名/発表者名: Nishi, et al.
  • 雑誌名: Am J Pathol 巻: 178 ページ: 128-139
  • 査読あり
• [雑誌論文] Cytoglobin, a novel globin, plays an anti-fibrotic role in the kidney (2010)
  • 著者名/発表者名: Mimura I, Nangaku M, Nishi H, Inagi R, Tanaka T, Fujita T
  • 雑誌名: Am J Physiol Renal Physiol 巻: 299
  • 査読あり
• [雑誌論文] Uremia induces abnormal oxygen consumption in tubules and aggravates chronic hypoxia of the kidney via oxidative stress (2010)
  • 著者名/発表者名: Palm F, Nangaku M, Fasching A, Tanaka T, Nordquist L, Hansell P, Kawakami T, Nishijima F, Fujita T
  • 雑誌名: Am J Physiol Renal Physiol 巻: 299
  • 査読あり
• [雑誌論文] Indoxyl sulfate inhibits proliferation of human proximal tubular cells via endoplasmic reticulum stress (2010)
  • 著者名/発表者名: Kawakami T, Inagi R, Wada T, Tanaka T, Fujita T, Nangaku M.
  • 雑誌名: Am J Physiol Renal Physiol 巻: 299
  • 査読あり
• [雑誌論文] Body weight control by a high-carbohydrate/low-fat diet slows the progression of diabetic kidney damage in an obese, hypertensive, type 2 diabetic rat model (2010)
  • 著者名/発表者名: Ohtomo S, Izuhara Y, Nangaku M, Dan T, Ito S, vanYpersele de Strihou C, Miyata T
  • 雑誌名: J Obesity pii ページ: 136502-136502
  • URL: http://dx.doi.org/10.1155/2010/136502
  • 査読あり
• [雑誌論文] The suffocating kidney : Tubulointerstitial hypoxia in the pathogenesis of end-stage kidney disease (2010)
  • 著者名/発表者名: Mimura I, Nangaku M
  • 雑誌名: Nat Rev Nephrol 巻: 6 ページ: 667-78
  • URL: http://www.nature.com/nrneph/journal/v6/n11/full/nrneph.2010.124.html
  • 査読あり
• [雑誌論文] The role of hypoxia, increased oxygen consumption, and hypoxia-inducible factor-1 alpha in progression of chronic kidney disease (2010)
  • 著者名/発表者名: Tanaka T, Nangaku M
  • 雑誌名: Curr Opin Nephrol Hypretens 巻: 19 ページ: 43-50
  • 査読あり
• [雑誌論文] Cytoglobin, a novel globin, plays an anti-fibrotic role in the kidney. (2010)
  • 著者名/発表者名: Mimura, et al.
  • 雑誌名: Am J Physiol Renal Physiol 巻: 299 ページ: 1120-1133
  • 査読あり
• [雑誌論文] Uremia induces abnormal oxygen consumption in tubules and aggravates chronic hypoxia of the kidney via oxidative stress (2010)
  • 著者名/発表者名: Palm, et al.
  • 雑誌名: Am J Physiol Renal Physiol 巻: 299
  • 査読あり
• [雑誌論文] Indoxyl sulfate inhibits proliferation of human proximal tubular cells via endonlasmic reticulum stress. (2010)
  • 著者名/発表者名: Kawakami, et al.
  • 雑誌名: Am J Physiol Renal Physiol 巻: 299
  • 査読あり
• [雑誌論文] Body weight control by a high-carbohydrate/low-fat diet slows the progression of diabetic kidney damage in an obese, hypertensive, type 2 diabetic rat model. (2010)
  • 著者名/発表者名: Ohtomo, et al.
  • 雑誌名: J Obesity 巻: pii ページ: 136502-136502
  • 査読あり
• [雑誌論文] The suffocating kidney : Tubulointerstitial hypoxia in the pnthogenesis of end-stage kidney disease. (2010)
  • 著者名/発表者名: Mimura, Nangaku
  • 雑誌名: Nat Rev Nephrol 巻: 6 ページ: 667-678
  • 査読あり
• [雑誌論文] The role of hypoxia, increased oxygen consumption, and hypoxia-inducible factor-1 alpha in progression of chronic kidney disease. (2010)
  • 著者名/発表者名: Tanaka, Nangaku
  • 雑誌名: Curr Op Nephrol Hypertens 巻: 19 ページ: 43-50
  • 査読あり
• [雑誌論文] Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells (2009)
  • 著者名/発表者名: Kawakami T, Inagi R, Takano H, Sato S, Ingelfinger JR, Fujita T, Nangaku M
  • 雑誌名: Nephrol Dial Transplant 巻: 24 ページ: 2665-72
  • 査読あり
• [雑誌論文] Glyoxalse I overexpression ameliorates renal ischemia-reperfusion injury in rats (2009)
  • 著者名/発表者名: Kumagai T, Nangaku M, Kojima I, Nagai R, Ingelfinger JR, Miyata T, Fujita T, Inagi R
  • 雑誌名: Am J Physiol Renal Physiol 巻: 296
  • 査読あり
• [雑誌論文] Suppression of MAP3 kinase 6 mediates anti-angiogenic and tumor-suppressive effects via VEGF repression (2009)
  • 著者名/発表者名: Eto N, Miyagishi Y, Inagi R, Fujita T, Nangaku M
  • 雑誌名: Am J Pathol 巻: 174 ページ: 1553-63
  • URL: http://linkinghub.elsevier.com/retrieve/pii/S0002-9440(10)61011-5
  • 査読あり
• [雑誌論文] Metallothionein is up-regulated by hypoxia and stabilizes HIF in the kidney (2009)
  • 著者名/発表者名: Kojima I, Tanaka T, Inagi R, Nishi H, Aburatani H, Kato H, Miyata T, Fujita T, Nangaku M
  • 雑誌名: Kidney Int 巻: 75 ページ: 268-277
  • URL: http://dx.doi.org/10.1038/ki.2008.488
  • 査読あり
• [雑誌論文] Novel therapeutic approach targeting the HIF-HRE system in the kidney (2009)
  • 著者名/発表者名: Nangaku M
  • 雑誌名: Adv Exp Biol Med 巻: 645 ページ: 81-86
  • URL: http://dx.doi.org/10.1007/978-0-387-85998-9_13
  • 査読あり
• [雑誌論文] Prolyl hydroxylase inhibitors to active HIF as a novel therapeutic approach against CKD (2009)
  • 著者名/発表者名: Tanaka T, Nangaku M
  • 雑誌名: J Pharmacol Sci 巻: 109 ページ: 24-31
  • URL: http://joi.jlc.jst.go.jp/JST.JSTAGE/jphs/08R09FM?from=PubMed
  • 査読あり
• [雑誌論文] Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells. (2009)
  • 著者名/発表者名: Kawakami T, et al.
  • 雑誌名: Nephrol Dial Transplant 24 ページ: 2665-72
  • 査読あり
• [雑誌論文] Glyoxalse I overexpression ameliorates renal ischemia-reperfusion injury in rats. (2009)
  • 著者名/発表者名: Kumagai T, et al.
  • 雑誌名: Am J Physiol Renal Physiol 296
  • 査読あり
• [雑誌論文] Suppression of MAP3 kinase 6 mediates anti-angiogenic and tumor-suppressive effects via VEGF repression. (2009)
  • 著者名/発表者名: Eto N, et al.
  • 雑誌名: Am J Pathol 174 ページ: 1553-63
  • 査読あり
• [雑誌論文] Metallothionein is up-regulated by hypoxia and stabilizes HIF in the kidney. (2009)
  • 著者名/発表者名: Kojima I, et al.
  • 雑誌名: Kidney Int 75 ページ: 268-277
  • 査読あり
• [雑誌論文] Prolyl hydroxylase inhibitors to active HIF as a novel therapeutic approachagainst CKD. (2009)
  • 著者名/発表者名: Tanaka T, Nangaku M
  • 雑誌名: J Pharmacol Sci 109 ページ: 24-31
  • 査読あり
• [雑誌論文] Novel therapeutic approach targeting the HIF-HRE system in the kidney. (2009)
  • 著者名/発表者名: Nangaku M
  • 雑誌名: Adv Exp Biol Med 645 ページ: 81-86
  • 査読あり
• [学会発表] Abnormal Oxygen Metabolism and Epigenetic changes in Diabetic Kidney Disease (2012)
  • 著者名/発表者名: Nangaku M
  • 学会等名: Keystone Symposium on Complications of Diabetes
  • 発表場所: Boston, U. S. A.
  • 年月日: 2012-03-12
• [学会発表] Abnormal Oxygen Metabolism and Epigenetic changes in Diabetic Kidney Disease (2012)
  • 著者名/発表者名: Nangaku
  • 学会等名: Keystone Symposium on Complications of Diabetes
  • 発表場所: Boston, U.S.A.(Invited)
  • 年月日: 2012-03-12
• [学会発表] Derangement of Oxygen Sensing for Erythropoietin(EPO) Production by Unfolded Protein Response(UPR) (2011)
  • 著者名/発表者名: Inagi R, Chiang CK, Tanaka T, Fujita T, Nangaku M
  • 学会等名: The 44^<th> Annual Meeting of the American Society of Nephrology
  • 発表場所: Philadelphia, U. S. A
  • 年月日: 2011-11-12
• [学会発表] Indoxyl Sulfate Induces Cbp/p300-Interacting Transactivator, with Glu/Asp-Rich Carboxy-Terminal Domain, 2, and Impairs Hypoxia Response in Proximal Tubular Cells (2011)
  • 著者名/発表者名: Tanaka T, Fujita T, Nangaku M
  • 学会等名: The 44^<th> Annual Meeting of the American Society of Nephrology
  • 発表場所: Philadelphia, U. S. A
  • 年月日: 2011-11-12
• [学会発表] Identification & Characterization of a Novel Oncogenic HIF-1 Target Involved in Renal Cell Carcinoma (2011)
  • 著者名/発表者名: Shoji K, Mimura I, Ohse T, Murayama T, Inagi R, Wada T, Tanaka T, Kume H, Goto A, Fujita T, Aburatani H, Kodama T, Nangaku M
  • 学会等名: The 44^<th> Annual Meeting of the American Society of Nephrology
  • 発表場所: Philadelphia, U. S. A
  • 年月日: 2011-11-12
• [学会発表] Derangement of Oxygen Sensing for Erythropoietin (EPO) Production by Unfolded Protein Response (UPR) (2011)
  • 著者名/発表者名: Inagi, et al.
  • 学会等名: The 44^<th> Annual Meeting of the American Society of Nephrology
  • 発表場所: Philadelphia, U.S.A.
  • 年月日: 2011-11-12
• [学会発表] Indoxyl Sulfate Induces Cbp/p300-Interacting Transactivator, with Glu/Asp-Rich Carboxy-Terminal Domain, 2, and Impairs Hypoxia Response in Proximal Tubular Cells (2011)
  • 著者名/発表者名: Tanaka, et al.
  • 学会等名: The 44^<th> Annual Meeting of the American Society of Nephrology
  • 発表場所: Philadelphia, U.S.A.
  • 年月日: 2011-11-12
• [学会発表] Identification & Characterization of a Novel Oncogenic HIF-1 Target Involved in Renal Cell Carcinoma (2011)
  • 著者名/発表者名: Shoji, et al.
  • 学会等名: The 44^<th> Annual Meeting of the American Society of Nephrology
  • 発表場所: Philadelphia, U.S.A.
  • 年月日: 2011-11-12
• [学会発表] HIF1 Modulates Chromatin Conformational Change by Recruiting KDM3A and Enhances Regulation of Glucose Transporter 3 in Endothelial Cells (2011)
  • 著者名/発表者名: Mimura I, Inoue T, Wada Y, Kanki Y, Fujita T, Aburatani H, Kodama T, Nangaku M
  • 学会等名: The 44^<th> Annual Meeting of the American Society of Nephrology
  • 発表場所: Philadelphia, U. S. A.
  • 年月日: 2011-11-11
• [学会発表] HIF1 Modulates Chromatin Conformational Change by Recruiting KDM3A and Enhances Regulation of Glucose Transporter 3 in Endothelial Cells (2011)
  • 著者名/発表者名: Mimura, et al.
  • 学会等名: The 44^<th> Annual Meeting of the American Society of Nephrology
  • 発表場所: Philadelphia, U.S.A.
  • 年月日: 2011-11-11
• [学会発表] Renal Ischemia Reperfusion Injury Promotes Mid-Term Tubular Senescence (2011)
  • 著者名/発表者名: Ikeda T, Inagi R, Fujita T, Nangaku M
  • 学会等名: The 44^<th> Annual Meeting of the American Society of Nephrology
  • 発表場所: Philadelphia, U. S. A
  • 年月日: 2011-11-10
• [学会発表] Renal Ischemia Reperfusion Injury Promotes Mid-Term Tubular Senescence (2011)
  • 著者名/発表者名: Ikeda, et al.
  • 学会等名: The 44^<th> Annual Meeting of the American Society of Nephrology
  • 発表場所: Philadelphia, U.S.A.
  • 年月日: 2011-11-10
• [学会発表] Progression of CKD following AKI : Role of hypoxia (2011)
  • 著者名/発表者名: Nangaku
  • 学会等名: The 44^<th> Annual Meeting of the American Society of Nephrology
  • 発表場所: Philadelphia, U.S.A.(Invited)
  • 年月日: 2011-11-10
• [学会発表] Mechanism of the development of renal anemia and its treatment (2011)
  • 著者名/発表者名: Nangaku M
  • 学会等名: International Forum of Chronic Kidney Disease of the Taiwan Society of Nephrology
  • 発表場所: Taipei, Taiwan
  • 年月日: 2011-07-10
• [学会発表] Mechanism of the development of renal anemia and its treatment (2011)
  • 著者名/発表者名: Nangaku
  • 学会等名: International Forum of Chronic Kidney Disease of the Taiwan Society of Nephrology
  • 発表場所: Taipei, Taiwan(Invited)
  • 年月日: 2011-07-10
• [学会発表] Dysregulated oxygen metabolism of the kidney by uremic toxins (2011)
  • 著者名/発表者名: Nangaku M
  • 学会等名: 7^<th> International Congress on Uremia Research and Toxicity
  • 発表場所: Nagoya, Japan
  • 年月日: 2011-05-12
• [学会発表] Indoxyl sulfate impairs hypoxia response in cultured proximal tubular cells (2011)
  • 著者名/発表者名: Tanaka T, Fujita T, Nangaku M
  • 学会等名: 7^<th> International Congress on Uremia Research and Toxicity
  • 発表場所: Nagoya, Japan
  • 年月日: 2011-05-12
• [学会発表] Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in HIF-dependent manner (2011)
  • 著者名/発表者名: Chiang CK, Inagi R, Tanaka T, Fujita T, Nangaku M
  • 学会等名: 7^<th> International Congress on Uremia Research and Toxicity
  • 発表場所: Nagoya, Japan
  • 年月日: 2011-05-12
• [学会発表] Cellular Defense Systems in Hypoxia : Mechanisms for Renal Protection (2011)
  • 著者名/発表者名: Nangaku M
  • 学会等名: World Congress of Nephrology
  • 発表場所: Vancouver, Canada
  • 年月日: 2011-04-11
• [学会発表] Cellular Defense Systems in Hypoxia : Mechanisms for Renal Protection (2011)
  • 著者名/発表者名: Nangaku
  • 学会等名: World Congress of Nephrology
  • 発表場所: Vancouver, Canada(Invited)
  • 年月日: 2011-04-11
• [学会発表] Progression of CKD following AKI : Role of hypoxia (2011)
  • 著者名/発表者名: Nangaku M
  • 学会等名: The 44^<th> Annual Meeting of the American Society of Nephrology
  • 発表場所: Philadelphia, U. S. A
• [学会発表] Dysregulated oxygen metabolism of the kidney by uremic toxins (2011)
  • 著者名/発表者名: Nangaku
  • 学会等名: 7^<th> International Congress on Uremia Research and Toxicity
  • 発表場所: 名古屋(Invited)
• [学会発表] Indoxyl sulfate impairs hypoxia response in cultured proximal tubular cells (2011)
  • 著者名/発表者名: Tanaka, et al.
  • 学会等名: 7^<th> International Congress on Uremia Research and Toxicity
  • 発表場所: 名古屋
• [学会発表] Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in HIF-dependent manner (2011)
  • 著者名/発表者名: Chiang, et al.
  • 学会等名: 7^<th> International Congress on Uremia Research and Toxicity
  • 発表場所: 名古屋
• [学会発表] Glyoxalase I Prevent Age-Related Aortic Medial Thickening by Reducing TGF-βand CTGF Signals Independent of Blood Pressure (2010)
  • 著者名/発表者名: Ikeda T, Inagi R, Jo A, Ohse T, Miyata T, Manabe I, Nagai R, Fujita T, Nangaku M
  • 学会等名: The 43^<rd> Annual Meeting of the American Society of Nephrology
  • 発表場所: Denver, U. S. A
  • 年月日: 2010-11-20
• [学会発表] Glyoxalase I Prevent Age-Related Aortic Medial Thickening by Reducing TGF-B and CTGF Signals Independent of Blood Pressure. (2010)
  • 著者名/発表者名: Ikeda, et al.
  • 学会等名: The 43rd Annual Meeting of the American Society of Nephrology
  • 発表場所: Denver, U.S.A.
  • 年月日: 2010-11-20
• [学会発表] Endoplasmic Reticulum Stress Disturbs Erythropoietin Gene Expression in a HIF-Dependent Manner (2010)
  • 著者名/発表者名: Chiang CK, Nangaku M, Tanaka T, Fujita T, Inagi R
  • 学会等名: The 43^<rd> Annual Meeting of the American Society of Nephrology
  • 発表場所: Denver, U. S. A
  • 年月日: 2010-11-19
• [学会発表] Elucidation of the Anti-Fibrotic Mechanism of a Novel HIF-Regulated Globin, Cytoglobin, with Molecular Genetics (2010)
  • 著者名/発表者名: Mimura I, Nishi H, Tanaka T, Inagi R, Fujita T, Nangaku M
  • 学会等名: The 43^<rd> Annual Meeting of the American Society of Nephrology
  • 発表場所: Denver, U. S. A
  • 年月日: 2010-11-19
• [学会発表] Impact of Anthracyclines on Hypoxia Response in Tubular Epithelial Cells (2010)
  • 著者名/発表者名: Tanaka T, Fujita T, Nangaku M
  • 学会等名: The 43^<rd> Annual Meeting of the American Society of Nephrology
  • 発表場所: Denver, U. S. A
  • 年月日: 2010-11-19
• [学会発表] MicroRNA Profiles of Tubular Cells under Hypoxia-Reoxygenation and Endoplasmic Reticulum Stress (2010)
  • 著者名/発表者名: Muratsu S, Nangaku M, Tanaka T, Chiang CK, Wada T, Fujita T, Inagi R
  • 学会等名: The 43^<rd> Annual Meeting of the American Society of Nephrology
  • 発表場所: Denver, U. S. A
  • 年月日: 2010-11-19
• [学会発表] Endoplasmic Reticulum Stress Disturbs Erythropoietin Gene Expression in a HIF-Dependent Manner. (2010)
  • 著者名/発表者名: Chiang, et al.
  • 学会等名: The 43rd Annual Meeting of the American Society of Nephrology
  • 発表場所: Denver, U.S.A.
  • 年月日: 2010-11-19
• [学会発表] Elucidation of the Anti-Fibrotic Mechanism of a Novel HIF-Regulated Globin, Cytoglobin, with Molecular Genetics. (2010)
  • 著者名/発表者名: Mimura, et al.
  • 学会等名: The 43rd Annual Meeting of the American Society of Nephrology
  • 発表場所: Denver, U.S.A.
  • 年月日: 2010-11-19
• [学会発表] Impact of Anthracyclines on Hypoxia Response in Tubular Epithelial Cells. (2010)
  • 著者名/発表者名: Tanaka, et al.
  • 学会等名: The 43rd Annual Meeting of the American Society of Nephrology
  • 発表場所: Denver, U.S.A.
  • 年月日: 2010-11-19
• [学会発表] MicroRNA Profiles of Tubular Cells under Hypoxia-Reoxyge nation and Endonlasmic Reticulum Stress. (2010)
  • 著者名/発表者名: Muratsu, et al.
  • 学会等名: The 43rd Annual Meeting of the American Society of Nephrology
  • 発表場所: Denver, U.S.A.
  • 年月日: 2010-11-19
• [学会発表] Role of carbonyl stress in renal senescence (2010)
  • 著者名/発表者名: Nangaku M, Ikeda Y, Fujita T, Inagi R
  • 学会等名: FASEB Summer Research Conference
  • 発表場所: Otsu, Japan
  • 年月日: 2010-10-06
• [学会発表] Role of carbonyl stress in renal senescence. (2010)
  • 著者名/発表者名: Nangaku, et al.
  • 学会等名: FASEB summer research conference
  • 発表場所: Otsu, Japan
  • 年月日: 2010-10-06
• [学会発表] Defensive mechanisms against fibrosis in the hypoxic kidney (2010)
  • 著者名/発表者名: Nangaku M
  • 学会等名: ISN-NEXUS : fibrosis and the kidney
  • 発表場所: Geneva, Switzerland
  • 年月日: 2010-07-01
• [学会発表] Defensive mechanisms against fibrosis in the hypoxic kidnev. (2010)
  • 著者名/発表者名: Nangaku (invited)
  • 学会等名: ISN-NEXUS
  • 発表場所: Geneva, Switzerland
  • 年月日: 2010-07-01
• [学会発表] Role of hypoxia in chronic kidney disease (2010)
  • 著者名/発表者名: Nangaku M
  • 学会等名: FASEB Summer Research Conference
  • 発表場所: Saxton River, U. S. A
  • 年月日: 2010-06-29
• [学会発表] Role of hypoxia in chronic kidney disease. (2010)
  • 著者名/発表者名: Nangaku (invited)
  • 学会等名: FASEB summer research conference
  • 発表場所: Saxtons River, Vermont U.S.A.
  • 年月日: 2010-06-29
• [学会発表] HIF and Renal Disease (2010)
  • 著者名/発表者名: Nangaku M
  • 学会等名: 12^<th> Asian Pacific Congress of Nephrology
  • 発表場所: Seoul, Korea
  • 年月日: 2010-06-06
• [学会発表] HIF and renal disease. (2010)
  • 著者名/発表者名: Nangaku (invited)
  • 学会等名: 12^<th> Asian Pacific Congress of Nephrology
  • 発表場所: Seoul, Korea
  • 年月日: 2010-06-06
• [学会発表] Identification of novel targets of hypoxia-responsive pathways (2010)
  • 著者名/発表者名: Nangaku M
  • 学会等名: ISN-NEXUS : the kidney and the vascular system
  • 発表場所: Kyoto, Japan
  • 年月日: 2010-04-17
• [学会発表] Impaired glomerular healing with persistent glomerular inflammation in streptozotocin-induced diabetic nephropathy (2010)
  • 著者名/発表者名: Takano H, Shimizu A, Wakamatsu K, Ishikawa A, Masuda Y, Ishizaki M, Nangaku M, Fukuda Y
  • 学会等名: ISN-NEXUS : the kidney and the vascular system
  • 発表場所: Kyoto, Japan
  • 年月日: 2010-04-17
• [学会発表] Identification of novel targets of hypoxia-responsive pathways. (2010)
  • 著者名/発表者名: Nangaku (invited)
  • 学会等名: ISN-NEXUS
  • 発表場所: Kyoto, Japan
  • 年月日: 2010-04-17
• [学会発表] Impaired glomerular healing with persistent glomerular inflammation in streptozotocin-induced diabetic nephropathy. (2010)
  • 著者名/発表者名: Takano, et al.
  • 学会等名: ISN-NEXUS
  • 発表場所: Kyoto, Japan
  • 年月日: 2010-04-17
• [学会発表] Genome-wide analysis of hypoxic inducible factor 1 binding sites in human endothelial cells under hypoxia (2010)
  • 著者名/発表者名: Mimura I, Wada Y, Tsutsumi S, Aburatani H, Kodama T, Nangaku M
  • 学会等名: ISN-NEXUS : the kidney and the vascular system
  • 発表場所: Kyoto, Japan
  • 年月日: 2010-04-16
• [学会発表] The evaluation of renal senescence and its retardation by the reduction of carbonyl stress (2010)
  • 著者名/発表者名: Ikeda Y, Nangaku M, Inagi R, Kumagai T, Miyata T, Fujita T
  • 学会等名: ISN-NEXUS : the kidney and the vascular system
  • 発表場所: Kyoto, Japan
  • 年月日: 2010-04-16
• [学会発表] Genome-wide analysis of hypoxic inducible factor 1 binding sites in human endothelial cells under hypoxia. (2010)
  • 著者名/発表者名: Mimura, et al.
  • 学会等名: ISN-NEXUS
  • 発表場所: Kyoto, Japan
  • 年月日: 2010-04-16
• [学会発表] The evaluation of renal senescence and its retardation by the reduction of carbonyl stress. (2010)
  • 著者名/発表者名: Ikeda, et al.
  • 学会等名: ISN-NEXUS
  • 発表場所: Kyoto, Japan
  • 年月日: 2010-04-16
• [学会発表] Glyoxalase I(GLO I)による老化の抑制 (2009)
  • 著者名/発表者名: 池田洋一郎
  • 学会等名: 第4回高血圧と冠動脈疾患研究会
  • 発表場所: 東京
  • 年月日: 2009-12-26
• [学会発表] 腎臓における老化の評価系確立とAGEs関与の解明 (2009)
  • 著者名/発表者名: 池田洋一郎
  • 学会等名: 第10回腎不全病態治療研究会
  • 発表場所: 東京
  • 年月日: 2009-12-12
• [学会発表] Abnormal oxygen metabolism in diabetic kidney (2009)
  • 著者名/発表者名: 南学正臣(invited)
  • 学会等名: 第21回日本糖尿病性腎症研究会
  • 発表場所: 東京
  • 年月日: 2009-12-05
• [学会発表] Cytoglobin, a novel member of the globin family, protects the kidney fibroblasts against oxidative stress under ischemic conditions (2009)
  • 著者名/発表者名: Nishi H, Inagi R, Kawada N, Yoshizato K, Mimura I, Miyata T, Fujita T, Nangaku M
  • 学会等名: The 42^<nd> Annual Meeting of the American Society of Nephrology
  • 発表場所: San Diego, U. S. A
  • 年月日: 2009-10-31
• [学会発表] Indoxyl sulfate inhibits proliferation of human proximal tubular cells via endoplasmic reticulum stress (2009)
  • 著者名/発表者名: Kawakami T, Inagi R, Fujita T, Nangaku M
  • 学会等名: The 42^<nd> Annual Meeting of the American Society of Nephrology
  • 発表場所: San Diego, U. S. A
  • 年月日: 2009-10-31
• [学会発表] Cytoglobin, a novel member of the globin family, protects the kidney fibroblasts against oxidative stress under ischemic conditions. (2009)
  • 著者名/発表者名: Nishi H
  • 学会等名: The 42nd Annual Meeting of the American Society of Nephrology
  • 発表場所: San Diego, U.S.A.
  • 年月日: 2009-10-31
• [学会発表] Indoxyl sulfate inhibits proliferation of human proximal tubular cells via endonlasmic reticulum stress. (2009)
  • 著者名/発表者名: Kawakami T
  • 学会等名: The 42nd Annual Meeting of the American Society of Nephrology
  • 発表場所: San Diego, U.S.A.
  • 年月日: 2009-10-31
• [学会発表] Genome-wide analysis of hypoxic inducible factor 1 binding sites in human endothelial cells under hypoxia (2009)
  • 著者名/発表者名: Mimura I, Nishi H, Inagi R, Fujita T, Nangaku M
  • 学会等名: The 42^<nd> Annual Meeting of the American Society of Nephrology
  • 発表場所: San Diego, U. S. A
  • 年月日: 2009-10-30
• [学会発表] Glyoxalase1 attenuates the impact of renal aging (2009)
  • 著者名/発表者名: Ikeda Y, Inagi R, Miyata T, Fujita T, Nangaku M
  • 学会等名: The 42^<nd> Annual Meeting of the American Society of Nephrology
  • 発表場所: San Diego, U. S. A.
  • 年月日: 2009-10-30
• [学会発表] Acute Administration of Indoxyl Sulfate Increases the Glomerular Filtration Rate and Reduces Kidney Oxygenation, but without Affecting Renal Blood Flow (2009)
  • 著者名/発表者名: Palm F, Gutweiler A, Welch WJ, Wilcox CS, Nangaku M
  • 学会等名: The 42^<nd> Annual Meeting of the American Society of Nephrology
  • 発表場所: Diego, U. S. A
  • 年月日: 2009-10-30
• [学会発表] Cytoglobin reduces fibrosis of the kidney via amelioration of oxidative stress. (2009)
  • 著者名/発表者名: Mimura I
  • 学会等名: The 42nd Annual Meeting of the American Society of Nephrology
  • 発表場所: San Diego, U.S.A.
  • 年月日: 2009-10-30
• [学会発表] Genome-wide analysis of hypoxic inducible factor 1 binding sites in human endothelial cells under hypoxia. (2009)
  • 著者名/発表者名: Mimura I
  • 学会等名: The 42nd Annual Meeting of the American Society of Nephrology
  • 発表場所: San Diego, U.S.A.
  • 年月日: 2009-10-30
• [学会発表] Acute administration of indoxyl sulfate increases the glomerular filtration rate and reduces kidney oxygenation, but without affecting renal blood flow. (2009)
  • 著者名/発表者名: Palm F
  • 学会等名: The 42nd Annual Meeting of the American Society of Nephrology
  • 発表場所: San Diego, U.S.A.
  • 年月日: 2009-10-30
• [学会発表] Glyoxalasel attenuates the impact of renal aging. (2009)
  • 著者名/発表者名: Ikeda Y
  • 学会等名: The 42nd Annual Meeting of the American Society of Nephrology
  • 発表場所: San Diego, U.S.A.
  • 年月日: 2009-10-30
• [学会発表] glyoxalasel(GL01)による老化の抑制 (2009)
  • 著者名/発表者名: 池田洋一郎
  • 学会等名: 第17回日本血管生物医学会
  • 発表場所: 東京
  • 年月日: 2009-10-08
• [学会発表] CKDの発症・進展に関する基礎研究 (2009)
  • 著者名/発表者名: 南学正臣(invited)
  • 学会等名: 第31回腎臓セミナー
  • 発表場所: 東京
  • 年月日: 2009-08-31
• [学会発表] Glyoxalase1 attenuates the impact of renal aging (2009)
  • 著者名/発表者名: Ikeda Y, Nangaku M, Kumagai T, Miyata T, Inagi R
  • 学会等名: 10th International Symposium on the Maillard Reaction
  • 発表場所: Cairns, Australia
  • 年月日: 2009-08-30
• [学会発表] Glyoxalasel(GLO1)attenuates the impact of renal aging (2009)
  • 著者名/発表者名: Ikeda Y
  • 学会等名: 10th International Symposium on the Maillard Reaction
  • 発表場所: Cairns, Australia
  • 年月日: 2009-08-30
• [学会発表] 尿毒症と酸素代謝異常 (2009)
  • 著者名/発表者名: 南学正臣(invited)
  • 学会等名: 第52回日本腎臓学会学術総会
  • 発表場所: 横浜
  • 年月日: 2009-06-05
• [学会発表] インドキシル硫酸は小胞体ストレスを介して近位尿細管細胞の増殖を抑制する (2009)
  • 著者名/発表者名: 川上貴久
  • 学会等名: 第52回日本腎臓学会学術総会
  • 発表場所: 横浜
  • 年月日: 2009-06-05
• [学会発表] 新規グロビン分子であるサイトグロビン生体内高発現は腎低酸素環境において抗酸化作用を示す (2009)
  • 著者名/発表者名: 西裕志
  • 学会等名: 第52回日本腎臓学会学術総会
  • 発表場所: 横浜
  • 年月日: 2009-06-04
• [学会発表] 尿毒素による尿細管細胞の酸素代謝異常 (2009)
  • 著者名/発表者名: 南学正臣
  • 学会等名: 第52回日本腎臓学会学術総会
  • 発表場所: 横浜
  • 年月日: 2009-06-03
• [学会発表] Hypoxia-induced endoplasmic reticulum stress is ameliorated by glyoxalase I via reduction of intraWorld Congress of Nephrologycellular oxidative stress (2009)
  • 著者名/発表者名: Inagi R, Nishi H, Tanaka T, Miyata T, Fujita T, Nangaku M
  • 学会等名: World Congress of Nephrology
  • 発表場所: Milan, Italy
  • 年月日: 2009-05-25
• [学会発表] Transgenic overexpression of cytoglobin, a novel globin protein, improves tubulointerstitial injury via amelioration of oxidative stress in the hypoxic kidney (2009)
  • 著者名/発表者名: Nishi H, Inagi R, Kawada N, Yoshizato K, Miyata T, Mimura I, Fujita T, Nangaku M
  • 学会等名: World Congress of Nephrology
  • 発表場所: Milan, Italy
  • 年月日: 2009-05-25
• [学会発表] Transgenic overexpression of cytoglobin, a novel globin protein, improves the tubulo-interstitial iniury via amelioration of oxidative stress in the hypoxic kidney. (2009)
  • 著者名/発表者名: Nishi H
  • 学会等名: World Congress of Nephrology
  • 発表場所: Milan, Italy
  • 年月日: 2009-05-25
• [学会発表] Hypoxia-induced endoplasmic reticulum stress is ameliorated by glyoxalase I via reduction of intracellular oxidative stress. (2009)
  • 著者名/発表者名: Inagi R
  • 学会等名: World Congress of Nephrology
  • 発表場所: Milan, Italy
  • 年月日: 2009-05-25
• [学会発表] The renin-angiotensin system as a cause of renal hypoxia (2009)
  • 著者名/発表者名: Nangaku M
  • 学会等名: World Congress of Nephrology
  • 発表場所: Milan, Italy
  • 年月日: 2009-05-24
• [学会発表] Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats (2009)
  • 著者名/発表者名: Kumagai T, Nangaku M, Kojima I, Nishi H, Tanaka T, Miyata T, Fujita T, Inagi R
  • 学会等名: World Congress of Nephrology
  • 発表場所: Milan, Italy
  • 年月日: 2009-05-24
• [学会発表] Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells (2009)
  • 著者名/発表者名: Kawakami T, Inagi R, Takano H, Sato S, Ingelfinger J, Miyata T, Fujita T, Nangaku M
  • 学会等名: World Congress of Nephrology
  • 発表場所: Milan, Italy
  • 年月日: 2009-05-23
• [学会発表] Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells. (2009)
  • 著者名/発表者名: Kawakami T
  • 学会等名: World Congress of Nephrology
  • 発表場所: Milan, Italy
  • 年月日: 2009-05-23
• [図書] Oxidative Stress in Applied Basic Research and Clinical Practice : Studies on Renal Disorders. (2011)
  • 著者名/発表者名: Miyata, Eckardt, Nangaku
  • 出版者: Humana Press
• [図書] Oxidative Stress in Applied Basic Research and Clinical Practice : Studies on Renal Disorders (2010)
  • 著者名/発表者名: Miyata T, Eckardt KU, Nangaku M
  • 総ページ数: 783
  • 出版者: Humana Press