IL-33とマスト細胞による新しいネガティブフィードバック機構

• 研究課題/領域番号: 21390303
• 研究種目: 基盤研究(B)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 膠原病・アレルギー内科学
• 研究機関: 独立行政法人国立成育医療研究センター
• 研究代表者: 斎藤 博久 独立行政法人国立成育医療研究センター, 研究所, 副所長 (40130166)
• 研究分担者: 大保木 啓介 独立行政法人国立成育医療研究センター, 研究所免疫アレルギー研究部, 上級研究員 (80415108) ; 中江 進 東京大学, 医科学研究所, 特任准教授 (60450409)
• 研究期間 (年度): 2009 – 2011
• 研究課題ステータス: 完了 (2011年度)
• 配分額: 18,200千円 (直接経費: 14,000千円、間接経費: 4,200千円); 2011年度: 3,380千円 (直接経費: 2,600千円、間接経費: 780千円); 2010年度: 5,200千円 (直接経費: 4,000千円、間接経費: 1,200千円); 2009年度: 9,620千円 (直接経費: 7,400千円、間接経費: 2,220千円)
• キーワード: マスト細胞 / IL-33 / アレルギー・ぜんそく / 制御性T細胞

研究概要

サイトカインの一つであるIL-33は喘息病態に重要な因子として理解されている。我々はIL-33による気道炎症の制御の仕組みについてのメカニズムを新規に作成したIL-33欠損マウスを用いて明らかにした。

研究成果

• [雑誌論文] Omalizumab inhibits acceleration of FcεRI-mediated responsiveness of immature human mast cells by immunoglobulin E. (2012)
  • 著者名/発表者名: Okayama Y Kashiwakura J, Sasaki-Sakamoto T, Matsumoto K, Hashimoto N, Ohmori K, Kawakami T, Saito H, Ra C.
  • 雑誌名: Ann Allergy Asthma Immunol. 巻: 108(3) 号: 3 ページ: 188-94
  • DOI: 10.1016/j.anai.2012.01.009
  • 査読あり
• [雑誌論文] ST2 Requires Th2-, but Not Th17-, Type Airway Inflammation in Epicutaneously Antigen-Sensitized Mice (2012)
  • 著者名/発表者名: Morita H, Arae K, Ohno T, Kajiwara N, Oboki, K, Matsuda A, Suto H, Okumura K, Sudo K, Takahashi T, Matsumoto K, Nakae, S
  • 雑誌名: Allergology International 巻: 61 号: 2 ページ: 265-273
  • DOI: 10.2332/allergolint.11-OA-0379
  • NAID: 130004477129
  • ISSN: 1323-8930, 1440-1592
  • 査読あり
• [雑誌論文] The alarmin interleukin-33 drives protective antiviral CD8 + T cell responses (2012)
  • 著者名/発表者名: Bonilla WV, Fröhlich A, Senn K, Kallert S, Fernandez M, Johnson S, Kreutzfeldt M, Hegazy AN, Schrick C, Fallon PG, Klemenz R, Nakae S, Adler H, Merkler D, Löhning M, Pinschewer DD
  • 雑誌名: Science 巻: 335(6071) 号: 6071 ページ: 984-989
  • DOI: 10.1126/science.1215418
  • 査読あり
• [雑誌論文] Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness (2012)
  • 著者名/発表者名: Sawaguchi, M.
  • 雑誌名: J.Immunol. 巻: 188 号: 4 ページ: 1809-1818
  • DOI: 10.4049/jimmunol.1101746
  • 査読あり
• [雑誌論文] Interleukin-16 deficiency suppresses the development of chronic rejection in murine cardiac transplantation model (2011)
  • 著者名/発表者名: Itoh S, Kimura N, Nakae S, Axtell RC, Velotta JB, Bos EJ, Merk DR, Gong Y, Okamura H, Nagamine CM, Adachi H, Kornfeld H, Robbins RC, Fischbein MP.
  • 雑誌名: J Heart Lung Transplant 巻: 30(12) 号: 12 ページ: 1409-17
  • DOI: 10.1016/j.healun.2011.08.017
  • 査読あり
• [雑誌論文] Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity (2011)
  • 著者名/発表者名: 大塚篤司、中島沙恵子, 他
  • 雑誌名: Plos One 巻: 6 号: 9 ページ: 229-233
  • DOI: 10.1371/journal.pone.0025538
  • 査読あり
• [雑誌論文] Interleukin-17A is involved in enhancement of tumor progression in murine intestine (2011)
  • 著者名/発表者名: K.Oshiro
  • 雑誌名: Immunobiology 巻: 217 号: 1 ページ: 54-60
  • DOI: 10.1016/j.imbio.2011.08.002
  • 査読あり
• [雑誌論文] Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion (2011)
  • 著者名/発表者名: S.Itoh
  • 雑誌名: Circulation 巻: 124 号: 11_suppl_1
  • DOI: 10.1161/circulationaha.110.014852
  • 査読あり
• [雑誌論文] Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations (2011)
  • 著者名/発表者名: Noguchi E, Sakamoto H, Hirota T, Ochiai K, Imoto Y, Sakashita M, Kurosaka F, Akasawa A, Yoshihara S, Kanno N, Yamada Y, Shimojo N, Kohno Y, Suzuki Y, Kang MJ, Kwon JW, Hong SJ, Inoue K, Goto Y, Yamashita F, Asada T, Hirose H, Saito I, Fujieda S, Hizawa N, Sakamoto T, Masuko H, Nakamura Y, Nomura I, Tamari M, Arinami T, Yoshida T, Saito H, Matsumoto K
  • 雑誌名: PLoS Genet 巻: 7(7) 号: 7 ページ: 1002170-1002170
  • DOI: 10.1371/journal.pgen.1002170
  • 査読あり
• [雑誌論文] cetylglucosaminyltransferase V-deficiency increases susceptibility to murine mala (2011)
  • 著者名/発表者名: Akiko Shibui
  • 雑誌名: Experimental Parasitology 巻: 129(3) 号: 3 ページ: 318-321
  • DOI: 10.1016/j.exppara.2011.07.003
  • 査読あり
• [雑誌論文] Human eosinophils produce and release a novel chemokine, CCL23, in vitro (2011)
  • 著者名/発表者名: Matsumoto K, Fukuda S, Hashimoto N, Saito, H
  • 雑誌名: Int Arch Allergy Immunol 巻: 155 号: Suppl. 1 ページ: 34-9
  • DOI: 10.1159/000327263
• [雑誌論文] Peripheral blood mononuclear cells from patients with bronchial asthma show impaired innate immune responses to rhinovirus in vitro (2011)
  • 著者名/発表者名: Iikura K, Katsunuma T, Saika S, Saito S, Ichinohe S, Ida H, Saito H, Matsumoto K
  • 雑誌名: Int Arch Allergy Immunol 巻: 155 号: Suppl. 1 ページ: 27-33
  • DOI: 10.1159/000327262
  • 査読あり
• [雑誌論文] Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology (2011)
  • 著者名/発表者名: M.Kamanaka
  • 雑誌名: J Exp Med 巻: 208 号: 5 ページ: 1027-1040
  • DOI: 10.1084/jem.20102149
  • 査読あり
• [雑誌論文] Cimetidine Enhances Antigen-Specific IgE and Th2 Cytokine Production (2011)
  • 著者名/発表者名: Arae K, Oboki, K, Ohno T, Hirata M, Nakae, S, Taguchi H, Saito, H, Nakajima T
  • 雑誌名: Allergology International 巻: 60 号: 3 ページ: 339-344
  • DOI: 10.2332/allergolint.10-OA-0255
  • NAID: 130004723046
  • ISSN: 1323-8930, 1440-1592
  • 査読あり
• [雑誌論文] Alteration of Immune Responses by N-acetylglucosaminyltransferase V during Allergic Airway Inflammation (2011)
  • 著者名/発表者名: Akiko Shibui
  • 雑誌名: Allergology International 巻: 60 号: 3 ページ: 345-354
  • DOI: 10.2332/allergolint.10-OA-0283
  • NAID: 130004723047
  • ISSN: 1323-8930, 1440-1592
  • 査読あり
• [雑誌論文] Okumura K., Kamradt T., Saito H., Nakae S. Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage (2011)
  • 著者名/発表者名: Ohno T., Oboki K., Kajiwara N., Tanaka S., Ikeda M., Iikura M., Akiyama T., Inoue J., Matsumoto K., Sudo K., Azuma M.,
  • 雑誌名: Plos One 巻: 6 号: 4 ページ: 18404-18404
  • DOI: 10.1371/journal.pone.0018404
  • 査読あり
• [雑誌論文] Increased production of vascular endothe-lial growth factor-d and lymphangio-genesis in acute Kawasaki disease (2011)
  • 著者名/発表者名: Ebata R, Saito, H,(7番目) Kohno Y., et al
  • 雑誌名: Circ J 巻: 75(6) ページ: 1455-62
• [雑誌論文] IL-33 and Airway Inflammation (2011)
  • 著者名/発表者名: Oboki, K, Nakae, S, Matsumoto K, Saito, H
  • 雑誌名: Allergy Asthma Immunol Res 巻: 3(2) 号: 2 ページ: 81-8
  • DOI: 10.4168/aair.2011.3.2.81
  • 査読あり
• [雑誌論文] Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils (2011)
  • 著者名/発表者名: Suzukawa M, Nakae S,(8番目) Ohta K., et al
  • 雑誌名: J Immunol 巻: 186 号: 9 ページ: 5254
  • DOI: 10.4049/jimmunol.1004054
• [雑誌論文] Four distinct subtypes of non-IgE-mediated gastrointestinal food allergies in neonates and infants, distinguished by their initial symptoms (2011)
  • 著者名/発表者名: Nomura I, Morita H, Ohtsuka Y, et al
  • 雑誌名: J Allergy Clin Immunol 巻: 127 号: 3 ページ: 685-688.e8
  • DOI: 10.1016/j.jaci.2011.01.019
  • 査読あり
• [雑誌論文] Functional specialization of interleukin-17 family members (2011)
  • 著者名/発表者名: Iwakura, Y.
  • 雑誌名: Immunity 巻: 34 号: 2 ページ: 149-62
  • DOI: 10.1016/j.immuni.2011.02.012
  • 査読あり
• [雑誌論文] Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines (2011)
  • 著者名/発表者名: Aung Gyi
  • 雑誌名: IMMUNOLOGY 巻: 132 号: 4 ページ: 527-539
  • DOI: 10.1111/j.1365-2567.2010.03395.x
  • 査読あり
• [雑誌論文] Effect of Th1/Th2 cytokine pretreatment on RSV-induced gene expression in airway epithet-lial cells (2011)
  • 著者名/発表者名: Yamada Y, Saito, H.(last), et al
  • 雑誌名: Int Arch Allergy Immunol 巻: 154(3) 号: 3 ページ: 185-94
  • DOI: 10.1159/000321105
• [雑誌論文] Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma (2011)
  • 著者名/発表者名: Harada M, Hirota T, Jodo Al, et al
  • 雑誌名: Am J Respir Cell Mol Biol 巻: 44 号: 6 ページ: 787-793
  • DOI: 10.1165/rcmb.2009-0418oc
  • 査読あり
• [雑誌論文] Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion (2011)
  • 著者名/発表者名: Itoh S, Kimura N, Axtell RC, Velotta JB, Gong Y, Wang X, Kajiwara N, Nambu A, Shimura E, Adachi H, Iwakura Y, Saito H, Okumura K, Sudo K, Steinman L, Robbins RC, Nakae S, Fischbein MP
  • 雑誌名: Circulation 巻: 124
  • 査読あり
• [雑誌論文] Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations (2011)
  • 著者名/発表者名: Noguchi E, 他33名
  • 雑誌名: PLoS Genet 巻: 7 号: 7 ページ: e1002171-e1002171
  • DOI: 10.1371/journal.pgen.1002171
  • 査読あり
• [雑誌論文] Increased production of vascular endothelial growth factor-d and lymphangiogenesis in acute Kawasaki disease (2011)
  • 著者名/発表者名: Ebata R, Abe J, Yasukawa K, Hamada H, Higashi K, Suwazono Y, Saito H, Terai M, Kohno Y
  • 雑誌名: Circ J 巻: 75 ページ: 1455-62
  • NAID: 10028149134
  • 査読あり
• [雑誌論文] Four distinct subtypes of non-IgE-mediated gastrointestinal food allergies in neonates and infants, distinguished by their initial symptoms. (2011)
  • 著者名/発表者名: Nomura I, Morita H, Hosokawa S, Hoshina H, Fukuie T, Watanabe M, Ohtsuka Y, Shoda T, Terada A, Takamasu T, Arai K, Ito Y, Ohya Y, Saito H, Matsumoto K.
  • 雑誌名: J Allergy Clin Immunol. 巻: 127(3)
  • 査読あり
• [雑誌論文] Effect of Th1/Th2 cytokine pretreatment on RSV-induced gene expression in airway epithelial cells. (2011)
  • 著者名/発表者名: Yamada Y, Matsumoto K, Hashimoto N, Saikusa M, Homma T, Yoshihara S, Saito H.
  • 雑誌名: Int Arch Allergy Immunol 巻: 154 ページ: 184-194
  • 査読あり
• [雑誌論文] Identification of a polyI : C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation (2010)
  • 著者名/発表者名: Ebihara T, Azuma M, Oshiumi H, Kasamatsu J, Iwabuchi K, Matsumoto K, Saito, H, Taniguchi T, Matsumoto M, Seya T
  • 雑誌名: J Exp Med 巻: 207(12) 号: 12 ページ: 2675-87
  • DOI: 10.1084/jem.20091573
  • 査読あり / オープンアクセス
• [雑誌論文] Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits (2010)
  • 著者名/発表者名: Miyamoto T, Muneta T, Tabuchi T, Matsumoto K, Saito, H, Tsuji K, Sekiya I
  • 雑誌名: Arthritis Res Ther 巻: 12(6) 号: 6 ページ: 206-206
  • DOI: 10.1186/ar3182
• [雑誌論文] Phosphodiesterase 4B is essential for Th2-cell function and development of airway hyperresponsiveness in allergic asthma (2010)
  • 著者名/発表者名: Jin SL, Nakae, S,(3番目) Conti M., et al
  • 雑誌名: J Allergy Clin Immunol 巻: 126(6) 号: 6 ページ: 1252-1259.e12
  • DOI: 10.1016/j.jaci.2010.08.014
• [雑誌論文] IL-33 is a crucial amplifier of innate rather than acquired immunity. (2010)
  • 著者名/発表者名: Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, KiyonariH, Matsumoto K, Sudo K, Okumura K, SaitoH, Nakae S.
  • 雑誌名: Proc Natl Acad Sci U S A. 巻: 107(43) 号: 43 ページ: 18581-6
  • DOI: 10.1073/pnas.1003059107
• [雑誌論文] IL-33 mediates inflammatory responses in human lung tissue cells (2010)
  • 著者名/発表者名: Yagami A, Saito, H,(7番目) Matsuda A., et al
  • 雑誌名: J Immunol 巻: 185(10) 号: 10 ページ: 5743-50
  • DOI: 10.4049/jimmunol.0903818
• [雑誌論文] Development of IL-17-mediated Delayed-Type Hypersensitivity Is Not Affected by Down-Regulation of IL-25 Expression (2010)
  • 著者名/発表者名: Ishii A, Oboki K, Nambu A, Morita H, OhnoT, Kajiwara N, Arae K, Sudo H, Okumura K, Saito H, Nakae S.
  • 雑誌名: Allergology International 巻: 59 号: 4 ページ: 399-408
  • DOI: 10.2332/allergolint.10-OA-0218
  • NAID: 10029671236
  • ISSN: 1323-8930, 1440-1592
• [雑誌論文] Overexpression of LEDGF/DFS70 induces IL-6 via p38 activation in HaCaT cells, similar to that seen in the psoriatic condition (2010)
  • 著者名/発表者名: Takeichi T, Saito, H,(10番目) Tomita Y., et al
  • 雑誌名: J Invest Dermatol 巻: 130(12) 号: 12 ページ: 2760-7
  • DOI: 10.1038/jid.2010.203
• [雑誌論文] TNF, but Not IL-6 and IL-17, Is Crucial for the Development of T Cell-Independent Psoriasis-Like Dermatitis in Il1rn-/-Mice (2010)
  • 著者名/発表者名: Nakajima A, Matsuki T, Komine M, Asahina A, Horai R, Nakae S, Ishigame H, Kakuta S, Saijo S, and Iwakura Y
  • 雑誌名: J Immunol 巻: 185 号: 3 ページ: 1887-1893
  • DOI: 10.4049/jimmunol.1001227
  • 査読あり
• [雑誌論文] Altered effector CD4+ T cell functio n in IL-21R-/- CD4+ T cell-mediated g raft-versus-host disease (2010)
  • 著者名/発表者名: Oh I, Ozaki K 他12名
  • 雑誌名: J Immunol 巻: 185巻 号: 3 ページ: 1441-1444
  • DOI: 10.4049/jimmunol.0902217
  • 査読あり
• [雑誌論文] Amphiregulin is Not Essential for Induction of Contact Hypersensitivity (2010)
  • 著者名/発表者名: Yagami A, Oboki, K,(3番目) Saito, H,(9番目) Nakae, S.(last), et al
  • 雑誌名: Allergology International 巻: 59 号: 3 ページ: 277-284
  • DOI: 10.2332/allergolint.09-OA-0149
  • NAID: 10029670767
  • ISSN: 1323-8930, 1440-1592
• [雑誌論文] Analysis of signal transduction pathways involved in anti-CD30 mAb-induced human eosinophil apoptosis (2010)
  • 著者名/発表者名: Matsumoto K, Terakawa M, Fukuda S, Saito, H
  • 雑誌名: Int Arch Allergy Immunol 巻: 152 号: Suppl. 1 ページ: 2-8
  • DOI: 10.1159/000312119
• [雑誌論文] Amphiregulin Is Not Essential for Ovalbumin-Induced Acute Airway Inflammation in Mice (2010)
  • 著者名/発表者名: Kajiwara N, Oboki, K, Ohno T, Ishii A, Sunnarborg SW, Okumura K, Saito, H, Nakae, S
  • 雑誌名: Allergology International 巻: 59 号: 2 ページ: 207-211
  • DOI: 10.2332/allergolint.09-OA-0144
  • NAID: 130004477087
  • ISSN: 1323-8930, 1440-1592
• [雑誌論文] IL-33 and IL-33 Receptors in Host Defense and Diseases (2010)
  • 著者名/発表者名: Oboki, K, Ohno T, Kajiwara N, Saito, H, Nakae, S
  • 雑誌名: Allergology International 巻: 59 号: 2 ページ: 143-160
  • DOI: 10.2332/allergolint.10-RAI-0186
  • NAID: 130004477080
  • ISSN: 1323-8930, 1440-1592
• [雑誌論文] IL-1 and Allergy (2010)
  • 著者名/発表者名: Nambu A, Nakae, S
  • 雑誌名: Allergology International 巻: 59 号: 2 ページ: 125-135
  • DOI: 10.2332/allergolint.10-RAI-0190
  • NAID: 130004477078
  • ISSN: 1323-8930, 1440-1592
• [雑誌論文] Activation of human mast cells through the platelet-activating factor receptor (2010)
  • 著者名/発表者名: Kajiwara N, Saito, H,(7番目), Okayama Y
  • 雑誌名: J Allergy Clin Immunol 巻: 125(5) 号: 5 ページ: 1137-1145
  • DOI: 10.1016/j.jaci.2010.01.056
• [雑誌論文] Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung (2010)
  • 著者名/発表者名: Okamoto Yoshida Y, Nakae, S,(10番目), Matsuzaki G., et al
  • 雑誌名: J Immunol 巻: 184(8) ページ: 4414-22
• [雑誌論文] Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells (2010)
  • 著者名/発表者名: Niyonsaba F, Saito, H,(8番目) Okumura K., et al
  • 雑誌名: J Immunol 巻: 184(7) 号: 7 ページ: 3526-34
  • DOI: 10.4049/jimmunol.0900712
• [雑誌論文] Cells of extraembryonic mesodermal origin confer human dystro-phin in the mdx model of Duchenne muscular dystrophy (2010)
  • 著者名/発表者名: Kawamichi Y, Saito, H,(8番目) Umezawa A., et al
  • 雑誌名: J Cell Physiol 巻: 223(3) 号: 3 ページ: 695-702
  • DOI: 10.1002/jcp.22076
• [雑誌論文] The role of recipient mast cells in acute and chronic cardiac allograft rejection in C57BL/6-KitW-sh/W-sh mice (2010)
  • 著者名/発表者名: Itoh S, Nakae, S,(2番目) Fischbein MP., et al
  • 雑誌名: J Heart Lung Transplant 巻: 29(4) 号: 4 ページ: 401-9
  • DOI: 10.1016/j.healun.2009.08.019
• [雑誌論文] Identification of a poly I : C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation. (2010)
  • 著者名/発表者名: Ebihara T, Azuma M, Oshiumi H, Kasamatsu J, Iwabuchi K, Matsumoto K, Saito H, Taniguchi T, Matsumoto M, Seya T.
  • 雑誌名: J Exp Med. 巻: 207 ページ: 2675-2687
  • 査読あり
• [雑誌論文] IL-33 is a crucial amplifier of innate rather than acquired immunity. (2010)
  • 著者名/発表者名: Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, Kiyonari H, Matsumoto K, Sudo K, Okumura K, Saito H, Nakae S.
  • 雑誌名: Proc Natl Acad Sci USA. 巻: 107 ページ: 18581-18586
  • 査読あり
• [雑誌論文] IL-33 mediates inflammatory responses in human lung tissue cells. (2010)
  • 著者名/発表者名: Yagami A, Orihara K, Morita H, Futamura K, Hashimoto N, Matsumoto K, Saito H, Matsuda A.
  • 雑誌名: J Immunol. 巻: 185 ページ: 5743-5750
  • 査読あり
• [雑誌論文] Overexpression of LEDGF/DFS70 Induces IL-6 via p38 Activation in HaCaT Cells, Similar to that, Seen in the Psoriatic Condition. (2010)
  • 著者名/発表者名: Takeichi T, Sugiura K, Muro Y, Matsumoto K, Ogawa Y, Futamura K, Kaminuma O, Hashimoto N, Shimoyama Y, Saito H, Tomita Y.
  • 雑誌名: J Invest Dermatol. 巻: 130 ページ: 2760-2767
  • 査読あり
• [雑誌論文] Defining cell identity by comprehensive gene expression profiling. (2010)
  • 著者名/発表者名: Toyoda M, Hamatani T, Okada H, Matsumoto K, Saito H, Umezawa A.
  • 雑誌名: Curr Med Chem 巻: 17 ページ: 3245-3252
  • 査読あり
• [雑誌論文] Proactive treatment appears to decrease serum IgE levels in patients with severe atopie dermatitis. (2010)
  • 著者名/発表者名: Fukuie T, Nomura I, Horimukai K, Futamura M, Narita M, Ohzeki T, Matsumoto K, Saito H, Ohya Y.
  • 雑誌名: Br J Dermatol. 巻: 163 ページ: 1127-1129
  • 査読あり
• [雑誌論文] Analysis of signal transduction pathways involved in anti-CD30 mAb-induced human eosinophil apoptosis. (2010)
  • 著者名/発表者名: Matsumoto K, Terakawa M, Fukuda S, Saito H.
  • 雑誌名: Int Arch Allergy Immunol 巻: 152 Suppl 1:2-8
  • 査読あり
• [雑誌論文] Activation of human mast cells through the platelet-activating factor receptor. (2010)
  • 著者名/発表者名: Kajiwara N, Sasaki T, Bradding P, Cruse G, Sagara H, Ohmori K, Saito H, Ra C, Okayama Y.
  • 雑誌名: J Allergy Clin Immunol 巻: 125
  • 査読あり
• [雑誌論文] Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells. (2010)
  • 著者名/発表者名: Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K.
  • 雑誌名: J Immunol. 巻: 184 ページ: 3526-3534
  • 査読あり
• [雑誌論文] Cells of extraembryonic mesodermal origin confer human dystrophin in the mdx model of Duchenne muscular dystrophy. (2010)
  • 著者名/発表者名: Kawamichi Y, Cui CH, Toyoda M, Makino H, Horie A, Takahashi Y, Matsumoto K, Saito H, Ohta H, Saito K, Umezawa A.
  • 雑誌名: J Cell Physiol. 巻: 223 ページ: 695-702
  • 査読あり
• [雑誌論文] Phosphodiesterase 4B is essential for T(h)2-cell function and development of airway hyperresponsiveness in allergic asthma. (2010)
  • 著者名/発表者名: Jin SL, Goya S, Nakae S, Wang D.Bruss M, Hou C, Umetsu D, Conti M.
  • 雑誌名: J Allergy Clin Immunol. 巻: 126
  • 査読あり
• [雑誌論文] Altered effector CD4+ T cell function in IL-21R-/-CD4+ T cell-mediated graft-versus-host disease. (2010)
  • 著者名/発表者名: Oh I, Ozaki K, Meguro A, Hatanaka K, Kadowaki M, Matsu H, Tatara R, Sato K, Iwakura Y, Nakae S, Sudo K, Teshima T, Leonard WJ, Ozawa K.
  • 雑誌名: J Immunol 巻: 185 ページ: 1920-1926
  • 査読あり
• [雑誌論文] Amphiregulin is not essential for ovalbumin-induced acute airway inflammation in mice. (2010)
  • 著者名/発表者名: Kajiwara N, Oboki K, Ohno T, Ishii A, Sunnarborg SW, Okumura K, Saito H, Nakae S.
  • 雑誌名: Allergol Int. 巻: 59 ページ: 207-211
  • NAID: 10029670457
  • 査読あり
• [雑誌論文] IL-33 and IL-33 receptors in host defense and diseases. (2010)
  • 著者名/発表者名: Oboki K, Ohno T, Kajiwara N, Saito H, Nakae S.
  • 雑誌名: Allergol Int 巻: 59 ページ: 143-160
  • NAID: 10029670102
  • 査読あり
• [雑誌論文] IL-1 and Allergy. (2010)
  • 著者名/発表者名: Nambu A, Nakae S.
  • 雑誌名: Allergol Int. 巻: 59 ページ: 125-135
  • NAID: 10029669907
  • 査読あり
• [雑誌論文] TNF, but not IL-6 and IL-17, is crucial for the development of T cell-independent psoriasis-like dermatitis in Il1rn-/-mice. (2010)
  • 著者名/発表者名: Nakajima A, Matsuki T, Komine M, Asahina A, Horai R, Nakae S, Ishigame H, Kakuta S, Saijo S, Iwakura Y.
  • 雑誌名: J Immunol. 巻: 185 ページ: 1887-1893
  • 査読あり
• [雑誌論文] The role of recipient mast cells in acute and chronic cardiac allo graft rejection in C57BL/6-KitW-sh/W-sh mice. (2010)
  • 著者名/発表者名: Itoh S, Nakae S, Velotta JB, Kosuge H, Connolly A, Tsai M, Adachi H, Galli SJ, Robbins RC, Fischbein MP.
  • 雑誌名: J Heart Lung Transplant 巻: 29 ページ: 401-409
  • 査読あり
• [雑誌論文] Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung. (2010)
  • 著者名/発表者名: Okamoto Yoshida Y, Umemura M, Yahagi A, O'Brien RL, Ikuta K, Kishihara K, Hara H, Nakae S, Iwakura Y, Matsuzaki G.
  • 雑誌名: J Immunol. 巻: 184 ページ: 4414-4422
  • 査読あり
• [雑誌論文] IL-17 contributes to the development of chronic rejection in a murine heart transplant model (2010)
  • 著者名/発表者名: Itoh S, Nakae S, Axtell RC, Velotta JB, Kimura N, Kajiwara N, Iwakura Y, Saito H, Adachi H, Steinman L, Robbins RC, Fischbein MP.
  • 雑誌名: J Clin Immunol. 巻: 30 ページ: 235-240
  • 査読あり
• [雑誌論文] Development of IL-17-mediated Delayed-Type Hypersensitivity Is Not Affected by Down-Regulation of IL-25 Expression. (2010)
  • 著者名/発表者名: Ishii A, Oboki K, Nambu A, Morita H, Ohno T, Kajiwara N, Arae K, Sudo H, Okumura K, Saito H, Nakae S.
  • 雑誌名: Allergol Int. 巻: 59 ページ: 1-20
  • NAID: 10029671236
  • 査読あり
• [雑誌論文] beta(2)-Adrenoceptor Agonists Enhance Cytokine-Induced Release of Thymic Stromal Lymphopoietin by Lung Tissue Cells (2010)
  • 著者名/発表者名: Futamura K, Orihara K, Hashimoto N, Morita H, Fukuda S, Sagara H, Matsumoto K, Tomita Y, Saito H, Matsuda A.
  • 雑誌名: Int Arch Allergy Immunol. 152 ページ: 353-61
  • 査読あり
• [雑誌論文] IL-17 contributes to the development of chronic rejection in a murine heart transplant model (2010)
  • 著者名/発表者名: Itoh S, Nakae S, Axtell RC, Velotta JB, Kimura N, Kajiwara N, Iwakura Y, Saito H, Adachi H, Steinman L, Robbins RC, Fischbein MP.
  • 雑誌名: J Clin Immunol. 30 ページ: 235-40
  • 査読あり
• [雑誌論文] IQGAP1 and vimentin are key regulator genes in naturally occurring hepatotumorigenesis induced by oxidative stress (2010)
  • 著者名/発表者名: Tsubota A, Matsumoto K, Mogushi K, Nariai K, Namiki Y, Hoshina S, Hano H, Tanaka H, Saito H, Tada N.
  • 雑誌名: Carcinogenesis 31 ページ: 504-11
  • 査読あり
• [雑誌論文] Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages (2009)
  • 著者名/発表者名: Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA, Okumura K, Saito H, Nakae S.
  • 雑誌名: J Immunol. 183 ページ: 7890-7
  • 査読あり
• [雑誌論文] Tissue remodeling induced by hypersecreted epidermal growth factor and amphiregulin in the airway after an acute asthma attack (2009)
  • 著者名/発表者名: Enomoto Y, Orihara K, Takamasu T, Matsuda A, Gon Y, Saito H, Ra C, Okayama Y.
  • 雑誌名: J Allergy Clin Immunol. 124 ページ: 913-20
  • 査読あり
• [雑誌論文] Corneal and conjunctival fibroblasts are major sources of eosinophil-recruiting chemokines (2009)
  • 著者名/発表者名: Fukagawa K, Okada N, Fujishima H, Nakajima T, Takano Y, Tanaka M, Dogru M, Satake Y, Tsubota K, Saito H.
  • 雑誌名: Allergol Int. 58 ページ: 499-508
  • NAID: 10027165444
  • 査読あり
• [雑誌論文] Shortening of human cell life span by induction of p16ink4a through the platelet-derived growth factor receptor beta (2009)
  • 著者名/発表者名: Takahashi H, Toyoda M, Birumachi J, Horie A, Uyama T, Miyado K, Matsumoto K, Saito H, Umezawa A.
  • 雑誌名: J Cell Physiol. 221 ページ: 335-42
  • 査読あり
• [雑誌論文] Mesenchymal to embryonic incomplete transition of human cells by chimeric OCT4/3(POU5F1)with physiological co-activator EWS (2009)
  • 著者名/発表者名: Makino H, Toyoda M, Matsumoto K, Saito H, Nishino K, Fukawatase Y, Machida M, Akutsu H, Uyama T, Miyagawa Y, Okita H, Kiyokawa N, Fujino T, Ishikawa Y, Nakamura T, Umezawa A.
  • 雑誌名: Exp Cell Res. 315 ページ: 2727-40
  • 査読あり
• [雑誌論文] Essentials for starting a pediatric clinical study(2): Role of environment and immunity in the development of childhood allergic and immunologic disorders (2009)
  • 著者名/発表者名: Saito H.
  • 雑誌名: J Toxicol Sci. 34
  • 査読あり
• [雑誌論文] Polyclonal IgE induces mast cell survival and cytokine production (2009)
  • 著者名/発表者名: Kashiwakura J, Kawakami Y, Yuki K, Zajonc DM, Hasegawa S, Tomimori Y, Caplan B, Saito H, Furue M, Oettgen HC, Okayama Y, Kawakami T.
  • 雑誌名: Allergol Int. 58 ページ: 411-9
  • NAID: 10025867594
  • 査読あり
• [雑誌論文] TH2 cytokines potently induce an appetite-stimulating peptide, melanin-concentrating hormone, in human vascular endothelial cells (2009)
  • 著者名/発表者名: Orihara K, Morita H, Yagami A, Kajiwara N, Nakae S, Matsumoto K, Nagasaki H, Saito Y, Saito H, Matsuda A.
  • 雑誌名: J Allergy Clin Immunol. 124
  • 査読あり
• [雑誌論文] Amphiregulin production by human eosinophils (2009)
  • 著者名/発表者名: Matsumoto K, Fukuda S, Nakamura Y, Saito H.
  • 雑誌名: Int Arch Allergy Immunol. 149 Suppl 1 ページ: 39-44
  • 査読あり
• [雑誌論文] Hev B 6.02 is the most important allergen in health care workers sensitized occupationally by natural rubber latex gloves (2009)
  • 著者名/発表者名: Yagami A, Suzuki K, Saito H, Matsunaga K.
  • 雑誌名: Allergol Int. 58 ページ: 347-55
  • NAID: 10025867350
  • 査読あり
• [雑誌論文] Dexamethasone and FK506 inhibit expression of distinct subsets of the mokines in human mast cells (2009)
  • 著者名/発表者名: Kato A, Chustz RT, Ogasawara T, Kulka M, Saito H, Schleimer RP, Matsumoto K.
  • 雑誌名: J Immunol. 182 ページ: 7233-43
  • 査読あり
• [雑誌論文] Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reaction (2009)
  • 著者名/発表者名: Nishida K, Hasegawa A, Nakae S, Oboki K, Saito H, Yamasaki S, Hirano T.
  • 雑誌名: J Exp Med. 206 ページ: 1351-64
  • 査読あり
• [雑誌論文] Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients (2009)
  • 著者名/発表者名: Takahashi N, Matsumoto K, Saito H, Nanki T, Miyasaka N, Kobata T, Azuma M, Lee SK, Mizutani S, Morio T.
  • 雑誌名: J Immunol. 182 ページ: 5515-27
  • 査読あり
• [雑誌論文] Intra-articular Injected synovial stem cells differentiate into meniscal cells directly and promote meniscal regeneration without mobilization to distant organs in rat massive meniscal defect (2009)
  • 著者名/発表者名: Horie M, Sekiya I, Muneta T, Ichinose S, Matsumoto K, Saito H, Murakami T, Kobayashi E.
  • 雑誌名: Stem Cells. 27 ページ: 878-87
  • 査読あり
• [学会発表] IL-33 in airway inflammation (2011)
  • 著者名/発表者名: 大保木啓介
  • 学会等名: APAPARI 2010 & 第48回JASPACI(第16回アジア太平洋小児アレルギー呼吸器免疫学会、第48回日本小児アレルギー学会合同大会)
  • 発表場所: 福岡
  • 年月日: 2011-10-29
• [図書] 粘膜における自然免疫:マスト細胞・好酸球・好塩基球,臨床粘膜免疫 (2010)
  • 著者名/発表者名: 斎藤博久,大保木啓介,中江進,烏山一
  • 出版者: シナジー、東京