神経芽腫の増殖・分化・細胞死を抑制する新規NLRR受容体ファミリーの解析と応用

• 研究課題/領域番号: 21390317
• 研究種目: 基盤研究(B)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 小児科学
• 研究機関: 千葉県がんセンター(研究所)
• 研究代表者: 中川原 章 千葉県がんセンター(研究所), 研究局, センター長 (50117181)
• 研究分担者: 高取 敦志 千葉県がんセンター(研究所), 研究局, 研究員 (40455390)
• 連携研究者: 中村 洋子 千葉県がんセンター(研究所), 研究局, 主席研究員 (60260254)
• 研究期間 (年度): 2009 – 2011
• 研究課題ステータス: 完了 (2011年度)
• 配分額: 17,810千円 (直接経費: 13,700千円、間接経費: 4,110千円); 2011年度: 5,200千円 (直接経費: 4,000千円、間接経費: 1,200千円); 2010年度: 5,980千円 (直接経費: 4,600千円、間接経費: 1,380千円); 2009年度: 6,630千円 (直接経費: 5,100千円、間接経費: 1,530千円)
• キーワード: NLLRR1 / NLRR2 / NLRR3 / Neuroblastoma / 細胞増殖 / NLRR1

研究概要

神経芽腫cDNAプロジェクトから同定した新規遺伝子NLRRfamilyの機能解析を行った。その結果、NLRR1は細胞増殖を促進してがんの進展に寄与することが明らかになり、作製したノックアウトマウスの解析によりlipidraftを介した細胞増殖シグナルを増強することが明らかになった。また、NLRR1を標的にした治療用単クローン抗体を作製に成功した。一方、NLRR2はERストレスを誘導し、細胞の生存シグナルを負に制御した。NLRR3は逆に細胞の分化を誘導し、MYCNにより負に転写制御されていた。以上の結果から、NLRRfamilyは神経芽腫における増殖、分化、細胞死の制御をファミリー間で役割分担していることが明らかになった。

研究成果

• [雑誌論文] Inhibitory role of E2F-1 in the regulation of tumor suppressor p53 during DNA damage response (2012)
  • 著者名/発表者名: Yoshihara Y, Wu D, Kubo N, Sang M, Nakagawara A, Ozaki T
  • 雑誌名: Biochem Biophys Res Commun
  • URL: http://dx.doi.org/10.1016/j.bbrc.2012.03.108
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• [雑誌論文] ALK fusion gene positive lung cancer and 3 cases treated with an inhibitor for ALK kinase activity (2012)
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  • 査読あり
• [雑誌論文] Inhibitory role of E2F-1 in the regulation of tumor suppressor p53 during DNA damage response (2012)
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  • DOI: 10.1016/j.bbrc.2012.03.108
  • 査読あり
• [雑誌論文] Molecular and genetic bases of neuroblastoma (2012)
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  • 著者名/発表者名: Shih YY, Nakagawara A, Lee H, Juan HF, Jeng YM, Lin DT, Yang YL, Tsay YG, Huang MC, Pan CY, Hsu WM, Liao YF
  • 雑誌名: J Mol Neurosci 巻: 47 号: 3 ページ: 571-581
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  • 査読あり
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  • 著者名/発表者名: Akter J, Takatori A, Hossain S, Ozaki T, Nakazawa A, Ohira M, Suenaga Y, Nakagawara A
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  • DOI: 10.1158/1078-0432.ccr-11-0313
  • 査読あり
• [雑誌論文] A novel role of RUNX3 in the regulation of p53-mediated apoptosis in response to DNA damage (2011)
  • 著者名/発表者名: Ozaki T, Yamada C, Nakagawara A
  • 雑誌名: Seikagaku 巻: 83 ページ: 751-754
  • NAID: 10029575150
  • 査読あり
• [雑誌論文] Prognostic Value of the Stage 4S Metastatic Pattern and Tumor Biology in Patients With Metastatic Neuroblastoma Diagnosed Between Birth and 18 Months of Age (2011)
  • 著者名/発表者名: Taggart DR, De Bernardi B, Ambros PF, Pearson AD, Cohn SL, Matthay KK London WB, Schmidt ML, Dubois SG, Monclair TF, Nakagawara A
  • 雑誌名: J. Clin. Oncol 巻: 29 号: 33 ページ: 4358-4364
  • DOI: 10.1200/jco.2011.35.9570
  • 査読あり
• [雑誌論文] Nuclear GRP75 Binds Retinoic Acid Receptors to Promote Neuronal Differentiation of Neuroblastoma (2011)
  • 著者名/発表者名: Shih YY, Lee H, Nakagawara A, Juan HF, Jeng YM, Tsay YG, Lin DT, Hsieh FJ, Pan CY, Hsu WM, Liao YF
  • 雑誌名: PLoS One 巻: 6(10) 号: 10 ページ: e26236-e26236
  • DOI: 10.1371/journal.pone.0026236
  • 査読あり
• [雑誌論文] The 7th Asia Cancer Forum: from the perspective of human security, how can we collaborate as Asians in order to place cancer on the global health agenda? How can we fill in the gaps that exist among us? (2011)
  • 著者名/発表者名: Kawahara N, Roh JK, Akaza H, Inoue H, Shibuya K, Iwasaki M, Tsuji T, Nishiyama M, Nakagawara A, Watanabe K, Nozaki S, Inoue M, Sugimura H, Miyake J, Li F
  • 雑誌名: Jpn. J. Clin. Oncol 巻: 41 号: 6 ページ: 825
  • DOI: 10.1093/jjco/hyr052
  • 査読あり
• [雑誌論文] Multi-gene mutation analysis of metastatic lymph nodes in non-small cell lung cancer diagnosed by EBUS-TBNA (2011)
  • 著者名/発表者名: Nakajima T, Yasufuku K, Nakagawara A, Kimura H, Yoshino I
  • 雑誌名: Chest 巻: 140 号: 5 ページ: 1319-1324
  • DOI: 10.1378/chest.10-3186
  • 査読あり
• [雑誌論文] Clinical and Biologic Features Predictive of Survival After Relapse of Neuroblastoma : A Report From the International Neuroblastoma Risk Group Project (2011)
  • 著者名/発表者名: London WB, Castel V, Monclair T, Ambros PF, Pearson AD, Cohn SL, Berthold F, Nakagawara A, Ladenstein RL, Iehara T, Matthay KK
  • 雑誌名: J. Clin. Oncol 巻: 29 号: 24 ページ: 3286-3292
  • DOI: 10.1200/jco.2010.34.3392
  • 査読あり
• [雑誌論文] Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1 (2011)
  • 著者名/発表者名: Isogai E, Ohira M, Ozaki T, Oba S, Nakamura Y, Nakagawara A
  • 雑誌名: PLoS ONE 巻: 6(5) 号: 5 ページ: e19297-e19297
  • DOI: 10.1371/journal.pone.0019297
  • 査読あり
• [雑誌論文] A novel potent tumour promoter aberrantly overexpressed in most human cancers (2011)
  • 著者名/発表者名: Takahashi A, Tokita H, Takahashi K, Takeoka T, Murayama K, Tomotsune D, Ohira M, Iwamatsu A, Ohara K, Yazaki K, Koda T, Nakagawara A, Tani K
  • 雑誌名: Scientific Reports 巻: 1(15) 号: 1 ページ: 6-6
  • DOI: 10.1038/srep00015
  • 査読あり
• [雑誌論文] Role of p53 in cell death and human cancers (2011)
  • 著者名/発表者名: Ozaki T, Nakagawara A
  • 雑誌名: Cancers 巻: 3 ページ: 994-1013
  • 査読あり
• [雑誌論文] The 6th Asia Cancer Forum : What Should We Do to Place Cancer on the Global Health Agenda? Sharing Information Leads to Human Security (2011)
  • 著者名/発表者名: Kawahara N, Sugimura H, Nakagawara A, Masui T, Miyake J, Akiyama M, Wahid IA, Hao X, Akaza H
  • 雑誌名: Jpn. J. Clin. Oncol 巻: 1 号: 5 ページ: 723-729
  • DOI: 10.1093/jjco/hyr036
  • 査読あり
• [雑誌論文] Bmi1 regulates cell fate via tumor suppressor WWOX repression in small cell lung cancer cells (2011)
  • 著者名/発表者名: Kimura M, Takenobu H, Akita N, Nakazawa A, Ochiai H, Shimozato O, Fujimura YI, Koseki H, Yoshino I, Kimura H, Nakagawara A, Kamijo T
  • 雑誌名: Cancer Sci 巻: 102 号: 5 ページ: 983-990
  • DOI: 10.1111/j.1349-7006.2011.01891.x
  • NAID: 10029293384
  • 査読あり
• [雑誌論文] CREB represses p53-dependent transactivation of MDM2 through the complex formation with p53 and contributes to p53-mediated apoptosis in response to glucose deprivation (2011)
  • 著者名/発表者名: Okoshi R, Kubo N, Nakashima K, Shimozato O, Nakagawara A, Ozaki T
  • 雑誌名: Biochem Biophys Res Commun 巻: 406 ページ: 79-84
  • URL: http://dx.doi.org/10.1016/j.bbrc.2011.01.114
  • 査読あり
• [雑誌論文] p53 : the attractive tumor suppressor in the cancer research field (2011)
  • 著者名/発表者名: Ozaki T, Nakagawara A
  • 雑誌名: J. Biomed. Biotechnol 巻: 2011 号: 1 ページ: 603925-603925
  • DOI: 10.1155/2011/603925
  • 査読あり
• [雑誌論文] The benchmark analysis of gastric, colorectal and rectal cancer pathways : toward establishing standardized clinical pathway in the cancer care (2011)
  • 著者名/発表者名: Ryu M, Hamano M, Nakagawara A, Shinoda M, Shimizu H, Miura T, Yoshida I, Nemoto A, Yoshikawa A
  • 雑誌名: Jpn. J. Clin. Oncol 巻: 41 号: 1 ページ: 2-9
  • DOI: 10.1093/jjco/hyq211
  • 査読あり
• [雑誌論文] Cancer-related PRUNE2 protein is associated with nucleotides and is highly expressed in mature nerve tissues (2011)
  • 著者名/発表者名: Iwama E, Tsuchimoto D, Iyama T, Sakumi K, Nakagawara A, Takayama K, Nakanishi Y, Nakabeppu Y
  • 雑誌名: J. Mol. Neurosci 巻: 44 号: 2 ページ: 103-114
  • DOI: 10.1007/s12031-010-9490-2
  • 査読あり
• [雑誌論文] Muscle atrophy and motor neuron degeneration in human NEDL1 transgenic mice (2011)
  • 著者名/発表者名: Zhang L, Haraguchi S, Koda T, Hashimoto K, Nakagawara A
  • 雑誌名: J Biomed. Biotechnol 巻: 2011 号: 1 ページ: 831092-831092
  • DOI: 10.1155/2011/831092
  • 査読あり
• [雑誌論文] CD133 suppresses neuroblastoma cell differentiation via signal pathway modification (2011)
  • 著者名/発表者名: Takenobu H, Shimozato O, Nakamura T, Ochiai H, Yamaguchi Y, Ohira M, Nakagawara A, Kamijo T
  • 雑誌名: Oncogene 巻: 30 号: 1 ページ: 97-105
  • DOI: 10.1038/onc.2010.383
  • 査読あり
• [雑誌論文] CREB represses p53-dependent transactivation of MDM2 through the complex formation with p53 and contributes to p53-mediated apoptosis in response to glucose deprivation (2011)
  • 著者名/発表者名: Okoshi R, Nakagawara A, et.al.
  • 雑誌名: Biochem.Biophys.Res.Commun. 巻: 406 号: 1 ページ: 79-84
  • DOI: 10.1016/j.bbrc.2011.01.114
  • 査読あり
• [雑誌論文] CD133 suppresses neuroblastoma cell differentiation via signal pathway modification. (2011)
  • 著者名/発表者名: Takenobu H, Nakagawara A, et al.
  • 雑誌名: Oncogene. 巻: 30 ページ: 97-105
  • 査読あり
• [雑誌論文] The benchmark analysis of gastric, colorectal and rectal cancer pathways : toward establishing standardized clinical pathway in the cancer care. (2011)
  • 著者名/発表者名: Ryu M, Nakagawara A, et al.
  • 雑誌名: Jpn.J.Clin.Oncol. 巻: 41 ページ: 2-9
  • 査読あり
• [雑誌論文] CREB represses p53-dependent transactivation of MDM2 through the complex formation with p53 and contributes to p53-mediated apoptosis in response to glucose deprivation. (2011)
  • 著者名/発表者名: Okoshi R, Nakagawara A, et al.
  • 雑誌名: Biochem.Biophys.Res.Commun. 巻: 406 ページ: 79-84
  • 査読あり
• [雑誌論文] Muscle atrophy and motor neuron degeneration in human NEDLl transgenic mice. (2011)
  • 著者名/発表者名: Zhang L, Nakagawara A, et al.
  • 雑誌名: J.Biomed.Biotechnol. 巻: (Accepted)
  • 査読あり
• [雑誌論文] p53 : The attractive tumor suppressor in the cancer research field. (2011)
  • 著者名/発表者名: Ozaki T, Nakagawara A.
  • 雑誌名: J.Biomed.Biotechnol. 巻: (Accepted)
  • 査読あり
• [雑誌論文] Cancer-related PRUNE2 protein is associated with nucleotides and is highly expressed in mature nerve tissues. (2011)
  • 著者名/発表者名: Iwama E, Nakagawara A, et al.
  • 雑誌名: J.Mol.Neurosci. 巻: (Accepted)
  • 査読あり
• [雑誌論文] Bmil regulates cell fate via tumor suppressor WWOX repression in small cell lung cancer cells. (2011)
  • 著者名/発表者名: Kimura M, Nakagawara A, et al.
  • 雑誌名: Cancer Sci. 巻: (Accepted)
  • 査読あり
• [雑誌論文] The 6th Asia Cancer Forum : What Should We Do to Place Cancer on the Global Health Agenda? Sharing Information Leads to Human Security. (2011)
  • 著者名/発表者名: Kawahara N, Nakagawara A, et al.
  • 雑誌名: Jpn J Clin Oncol. 巻: (Accepted)
  • 査読あり
• [雑誌論文] A novel potent tumour promoter aberrantly overexpressed in most human cancers (2011)
  • 著者名/発表者名: Takahashi A, Nakagawara A, et al.
  • 雑誌名: Scientific Reports 巻: (Accepted)
  • 査読あり
• [雑誌論文] Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growththrough transactivation of Mashl (2011)
  • 著者名/発表者名: Isogai E, Nakagawara A, et al.
  • 雑誌名: PLoS ONE 巻: (Accepted)
  • 査読あり
• [雑誌論文] p73-binding partners and their functional significance (2010)
  • 著者名/発表者名: Ozaki T, Kubo N, Nakagawara A
  • 雑誌名: Int. J. Proteomics 巻: 2010 ページ: 1-12
  • DOI: 10.1155/2010/283863
  • 査読あり
• [雑誌論文] A novel molecular mechanism behind p53-dependent apoptosis in response to energetic stress (2010)
  • 著者名/発表者名: Rintaro O, Kubo N, Kizaki H, Nakagawara A, Ozaki T
  • 雑誌名: Seikagaku 巻: 82 ページ: 1117-1120
  • NAID: 10027880199
  • 査読あり
• [雑誌論文] Concordance for neuroblastoma in monozygotic twins : Case report and review of the literature (2010)
  • 著者名/発表者名: Tajiri T, Souzaki R, Kinoshita Y, Tanaka S, Koga Y, Suminoe A, Hara T, Kohashi K, Oda Y, Masumoto K, Ohira M, Nakagawara A, Taguchi T
  • 雑誌名: J. Pediatr, Surg 巻: 45 ページ: 2312-2316
  • URL: http://dx.doi.org/10.1016/j.jpedsurg.2010.08.025
  • 査読あり
• [雑誌論文] Reevaluation of trkA expression as a biological marker of neuroblastoma by high-sensitivity expression analysis-a study of 106 primary neuroblastomas treated in a single institute (2010)
  • 著者名/発表者名: Hishiki T, Saito T, Terui K, Sato Y, Takenouchi A, Yahata E, Ono S, Nakagawara A, Kamijo T, Nakamura Y, Matsunaga T, Yoshida H
  • 雑誌名: JP ediatr Surg 巻: 45 ページ: 2293-2298
  • URL: http://dx.doi.org/10.1016/j.jpedsurg.2010.08.021
  • 査読あり
• [雑誌論文] MDM2 promotes the proteasomal degradation of p73 through the interaction with Itch in HeLa cells (2010)
  • 著者名/発表者名: Kubo N, Okoshi R, Nakashima K, Shimozato O, Nakagawara A, Ozaki T
  • 雑誌名: Biochem. Biophys. Res. Commun 巻: 403 ページ: 405-411
  • URL: http://dx.doi.org/10.1016/j.bbrc.2010.11.043
  • 査読あり
• [雑誌論文] Global genomic and RNA profiles for novel risk stratification of neuroblastoma (2010)
  • 著者名/発表者名: Ohira M, Nakagawara A
  • 雑誌名: Cancer Sci 巻: 101 号: 11 ページ: 2295-2301
  • DOI: 10.1111/j.1349-7006.2010.01681.x
  • NAID: 10027832987
  • 査読あり
• [雑誌論文] Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification (2010)
  • 著者名/発表者名: De Brouwer S, De Preter K, Kumps C, Zabrocki P, Porcu M, Westerhout EM, Lakeman A, Vandesompele J, Hoebeeck J, Van Maerken T, De Paepe A, Laureys G, Schulte JH, Schramm A, Van Den Broecke C, Vermeulen J, Van Roy N, Beiske K, Renard M, Noguera R, Delattre O, Janoueix-Lerosey I, Kogner P, Martinsson T, Nakagawara A, Ohira M, Caron H, Eggert A, Cools J, Versteeg R, Speleman F
  • 雑誌名: Clin. Cancer Res 巻: 16 ページ: 4353-4362
  • 査読あり
• [雑誌論文] HDM2 impairs Noxa transcription and affects apoptotic cell death in a p53/p73-dependent manner in neuroblastoma (2010)
  • 著者名/発表者名: Shi Y, Takenobu H, Kurata K, Yamaguchi Y, Yanagisawa R, Ohira M, Koike K, Nakagawara A, Jiang LL, Kamijo T
  • 雑誌名: Eur. J. Cancer 巻: 46 ページ: 2324-2334
  • URL: http://dx.doi.org/10.1016/j.ejca.2010.05.026
  • 査読あり
• [雑誌論文] Polycomb group molecule PHC3 regulates polycomb complex composition and prognosis of osteosarcoma (2010)
  • 著者名/発表者名: Iwata S, Takenobu H, Kageyama H, Koseki H, Ishii T, Nakazawa A, Tatezaki S, Nakagawara A, Kamijo T
  • 雑誌名: Cancer Sci 巻: 101 ページ: 1646-1652
  • NAID: 10026594687
  • 査読あり
• [雑誌論文] NFBD1/MDC1 participates in the regulation of G2/M transition in mammalian cells (2010)
  • 著者名/発表者名: Bu Y, Suenaga Y, Okoshi R, Sang M, Kubo N, Song F, Nakagawara A, Ozaki T
  • 雑誌名: Biochem. Biophys. Res. Commun 巻: 397 ページ: 157-162
  • URL: http://dx.doi.org/10.1016/j.bbrc.2010.05.063
  • 査読あり
• [雑誌論文] Genome-wide analysis of allelic imbalances reveals 4q deletions as a poor prognostic factor and MDM4 amplification at 1q32.1 in hepatoblastoma (2010)
  • 著者名/発表者名: Arai Y, Honda S, Haruta M, Kasai F, Fujiwara Y, Ohshima J, Sasaki F, Nakagawara A, Horie H, Yamaoka H, Hiyama E, Kaneko Y
  • 雑誌名: Genes Chromosomes Cancer 巻: 49 号: 7 ページ: 596-609
  • DOI: 10.1002/gcc.20770
  • 査読あり
• [雑誌論文] LMO3 interacts with p53 and inhibits its transcriptional activity (2010)
  • 著者名/発表者名: Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A
  • 雑誌名: Biochem. Biophys. Res. Commun 巻: 392 ページ: 252-257
  • URL: http://dx.doi.org/10.1016/j.bbrc.2009.12.010
  • 査読あり
• [雑誌論文] RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a Co-activator for p53 (2010)
  • 著者名/発表者名: Yamada C, Ozaki T, Ando K, Suenaga Y, Inoue K, Ito Y, Okoshi R, Kageyama H, Kimura H, Miyazaki M, Nakagawara A
  • 雑誌名: J. Biol. Chem 巻: 285 号: 22 ページ: 16693-16703
  • DOI: 10.1074/jbc.m109.055525
  • 査読あり
• [雑誌論文] Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma (2010)
  • 著者名/発表者名: Ochiai H, Takenobu H, Nakagawa A, Yamaguchi Y, Kimura M, Ohira M, Okimoto Y, Fujimura Y, Koseki H, Kohno Y, Nakagawara A, Kamijo T
  • 雑誌名: Oncogene 巻: 29 号: 18 ページ: 2681-2690
  • DOI: 10.1038/onc.2010.22
  • 査読あり
• [雑誌論文] MCL-1V, a novel mouse antiapoptotic MCL-I variant, generated by RNA splicing at a non-canonical splicing pair (2010)
  • 著者名/発表者名: Kojima S, Hyakutake A, Koshikawa N, Nakagawara A, Takenaga K
  • 雑誌名: Biochem. Biophys. Res. Commun 巻: 391 ページ: 492-497
  • URL: http://dx.doi.org/10.1016/j.bbrc.2009.11.086
  • 査読あり
• [雑誌論文] Accurate Outcome Prediction in Neuroblastoma across Independent Data Sets Using a Multigene Signature (2010)
  • 著者名/発表者名: De Katleen P, Vermeulen J, Brors B, Delattre O, Eggert A, Fischer M, Janoueix-Lerosey I, Lavarino C, Maris JM, Mora J, Nakagawara A, Oberthuer A, Ohira M, Schleiermacher G, Schramm A, Schulte JH, Wang Q, Westermann F, Speleman F, Vandesompele J
  • 雑誌名: Clin. Cancer Res 巻: 16 ページ: 1532-1541
  • 査読あり
• [雑誌論文] Accurate Outcome Prediction in Neuroblastoma across Independent Data Sets Using a Multigene Signature. (2010)
  • 著者名/発表者名: De Katleen P, Nakagawara A, et al.
  • 雑誌名: Clin.Cancer Res. 巻: 16 ページ: 1532-1541
  • 査読あり
• [雑誌論文] MCL-1V, a novel mouse antiapoptotic MCL-I variant, generated by RNA splicing at a non-canonical splicing pair. (2010)
  • 著者名/発表者名: Kojima S, Nakagawara A, et al.
  • 雑誌名: Biochem.Biophys.Res.Commun. 巻: 391 ページ: 492-497
  • 査読あり
• [雑誌論文] Bmil is a MYCN target gene that regulates tumorigenesis through repression of KIFlBbeta and TSLCl in neuroblastoma. (2010)
  • 著者名/発表者名: Ochiai H, Nakagawara A, et al.
  • 雑誌名: Oncogene 巻: 29 ページ: 2681-2690
  • 査読あり
• [雑誌論文] RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a Co-activator for p53. (2010)
  • 著者名/発表者名: Yamada C, Nakaeawara A, et al.
  • 雑誌名: J.Biol.Chem. 巻: 285 ページ: 16693-16703
  • 査読あり
• [雑誌論文] LMO3 interacts with p53 and inhibits its transcriptional activity. (2010)
  • 著者名/発表者名: Larsen S, Nakagawara A, et al.
  • 雑誌名: Biochem.Biophys.Res.Commun. 巻: 392 ページ: 252-257
  • 査読あり
• [雑誌論文] Genome-wide analysis of allelic imbalances reveals 4q deletions as a poor prognostic factor and MDM4 amplification at 1q32.1 in hepatoblastoma (2010)
  • 著者名/発表者名: Arai Y, Nakagawara A, et al.
  • 雑誌名: Genes Chromosomes Cancer. 巻: 49 ページ: 596-609
  • 査読あり
• [雑誌論文] NFBD1/MDC1 participates in the regulation of G2/M transition in mammalian cells. (2010)
  • 著者名/発表者名: Bu Y, Nakagawara A, et al.
  • 雑誌名: Biochem.Biophys.Res.Commun. 巻: 397 ページ: 157-162
  • 査読あり
• [雑誌論文] Polycomb group molecule PHC3 regulates polycomb complex composition and prognosis of osteosarcoma. (2010)
  • 著者名/発表者名: Iwata S, Nakagawara A, et al.
  • 雑誌名: Cancer Sci. 巻: 101 ページ: 1646-1652
  • NAID: 10026594687
  • 査読あり
• [雑誌論文] HDM2 impairs Noxa transcription and affects apoptotic cell death in a p53/p73-dependent manner in neuroblastoma. (2010)
  • 著者名/発表者名: Shi Y, Nakagawara A, et al.
  • 雑誌名: Eur.J.Cancer. 巻: 46 ページ: 2324-2334
  • 査読あり
• [雑誌論文] Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tomors with MYCN amplification. (2010)
  • 著者名/発表者名: De Brouwer S, Nakagawara A, et al.
  • 雑誌名: Clin.Cancer Res. 巻: 16 ページ: 4353-4362
  • 査読あり
• [雑誌論文] Global genomic and RNA profiles for novel risk stratification of neuroblastoma. (2010)
  • 著者名/発表者名: Ohira M, Nakagawara A.
  • 雑誌名: Cancer Sci. 巻: 101 ページ: 2295-2301
  • NAID: 10027832987
  • 査読あり
• [雑誌論文] MDM2 promotes the proteasomal degradation of p73 through the interaction with Itch in HeLa cells. (2010)
  • 著者名/発表者名: Kubo N, Nakagawara A, et al.
  • 雑誌名: Biochem.Biophys.Res.Commun. 巻: 403 ページ: 405-411
  • 査読あり
• [雑誌論文] Reevaluation of trkA expression as a biological marker of neuroblastoma by high-sensitivity expression analysis-a study of 106 primary neuroblastomas treated ina single institute. (2010)
  • 著者名/発表者名: Hishiki T, Nakagawara A, et al.
  • 雑誌名: J.Pediatr.Surg.. 巻: 45 ページ: 2293-2298
  • 査読あり
• [雑誌論文] Concordance for neuroblastoma in monozygotic twins : Case report and review of the literature. (2010)
  • 著者名/発表者名: Tajiri T, Nakagawara A, et al.
  • 雑誌名: J.Pediatr, Surg. 巻: 45 ページ: 2312-2316
  • 査読あり
• [雑誌論文] A novel molecular mechanism behind p53-dependent apoptosis in response to energetic stress. (2010)
  • 著者名/発表者名: Rintaro O, Nakagawara A, et al.
  • 雑誌名: Seikagaku 巻: 82 ページ: 1117-1120
  • NAID: 10027880199
  • 査読あり
• [雑誌論文] p73-binding partners and their functional significance. (2010)
  • 著者名/発表者名: Ozaki T, Nakagawara A, et al.
  • 雑誌名: Int.J.Proteomics 巻: (Accepted)
  • 査読あり
• [雑誌論文] MCL-IV, a novel mouse antiapoptotic MCL-I variant, generated by RNA splicing at a non-canonical splicing pair (2010)
  • 著者名/発表者名: Kojima S., Nakagawara A., et al.
  • 雑誌名: Biochem.Biophys.Res.Commun. 391 ページ: 492-497
  • 査読あり
• [雑誌論文] LMO3 interacts with p53 and inhibits its transcriptional activity (2010)
  • 著者名/発表者名: Larsen S., Nakagawara A., et al.
  • 雑誌名: Biochem.Biophys.Res.Commun. 392 ページ: 252-257
  • 査読あり
• [雑誌論文] Accurate Outcome Prediction in Neuroblastoma across Independent Data Sets Using a Multigene Signature (2010)
  • 著者名/発表者名: De Katleen P., Nakagawara A., et al.
  • 雑誌名: Clin.Cancer Res. 16 ページ: 1532-1541
  • 査読あり
• [雑誌論文] Meta-analysis of neuroblastomas reveals a skewed ALK mutations spectrum in tumors with MYCN amplification (2010)
  • 著者名/発表者名: De Brouwer S., Nakagawara A., et al.
  • 雑誌名: J.Clin.Oncol. (in press)
  • 査読あり
• [雑誌論文] Bmil is a MYCN target gene and regulates tumorigenesis via repression of KIF1Bβ and TSLC1 in neuroblastoma (2010)
  • 著者名/発表者名: Ochiai H., Nakagawara A., et al.
  • 雑誌名: Oncogene (in press)
  • 査読あり
• [雑誌論文] RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a Co-actiyator for p53 (2010)
  • 著者名/発表者名: Yamada C., Nakagawara A., et al.
  • 雑誌名: J.Biol.Chem. (in press)
  • 査読あり
• [雑誌論文] TLP Is Engaged in Etoposide-induced Apoptosis through Transcriptional Activation of Human TAp63 Gene (2009)
  • 著者名/発表者名: Yusuke Suenaga, Toshifumi Ozaki, Yuji Tanaka, Youquan Bu, Takehiko Kamijo, Takeshi Tokuhisa, Akira Nakagawara Taka-aki Tamura
  • 雑誌名: J. Biol. Chem 巻: 284 号: 51 ページ: 35433-35440
  • DOI: 10.1074/jbc.m109.050047
  • 査読あり
• [雑誌論文] Transcriptional regulation of tumor suppressor p53 by cAMP-responsive element-binding protein/AMP-activated protein kinase complex in response to glucose deprivation (2009)
  • 著者名/発表者名: Okoshi R, Ando K, Suenaga Y, Sang M, Kubo N, Kizaki H, Nakagawara A, Ozaki T
  • 雑誌名: Genes Cells 巻: 14 ページ: 1429-1440
  • 査読あり
• [雑誌論文] Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1agene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway (2009)
  • 著者名/発表者名: Koshikawa N, Hayashi J-I, Nakagawara A, Takenaga K
  • 雑誌名: J. Biol. Chem 巻: 284 号: 48 ページ: 33185-33194
  • DOI: 10.1074/jbc.m109.054221
  • 査読あり
• [雑誌論文] Dysregulation of platelet-derived growth factorβ-receptor expression byΔNp73 in neuroblastoma (2009)
  • 著者名/発表者名: Wetterskog D, Moshiri A, Ozaki T, Uramoto H, Nakagawara A, Funa K
  • 雑誌名: Mol. Cancer Res 巻: 7 号: 12 ページ: 2031-2039
  • DOI: 10.1158/1541-7786.mcr-08-0501
  • 査読あり
• [雑誌論文] Positive auto-regulation of MYCN in human neuroblastoma (2009)
  • 著者名/発表者名: Suenaga Y, Kaneko Y, Matsumoto D, Hossain MS, Ozaki T, Nakagawara A
  • 雑誌名: Biochem. Biophys. Res. Commun 巻: 390 ページ: 21-26
  • URL: http://dx.doi.org/10.1016/j.bbrc.2009.09.044
  • 査読あり
• [雑誌論文] A simple PCR method for rapid genotype analysis of the TH-MYCN transgenic mouse (2009)
  • 著者名/発表者名: Haraguchi S, Nakagawara A
  • 雑誌名: PLoSONE 巻: 4 号: 9 ページ: e6902-e6902
  • DOI: 10.1371/journal.pone.0006902
  • 査読あり
• [雑誌論文] Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation (2009)
  • 著者名/発表者名: Sang M, Ando K, Okoshi R, Koida N, Li Y, Zhu Y, Shimozato O, Geng C, Shan B, Nakagawara A, Ozaki T
  • 雑誌名: Genes Cells 巻: 14 号: 7 ページ: 775-788
  • DOI: 10.1111/j.1365-2443.2009.01309.x
  • 査読あり
• [雑誌論文] Deregulated expression of E2F1 promotes proteolytic degradation of tumor suppressor p73 and inhibits its transcriptional activity (2009)
  • 著者名/発表者名: Ozaki T, Okoshi R, Ono S, Kubo N, Nakagawara A
  • 雑誌名: Biochem. Biophys. Res. Commun 巻: 387 ページ: 143-148
  • URL: http://dx.doi.org/10.1016/j.bbrc.2009.06.141
  • 査読あり
• [雑誌論文] Acetylation status of E2F-1 has an important role in the regulation of E2F-1-mediated transactivation of tumor suppressor p73 (2009)
  • 著者名/発表者名: Ozaki T, Okoshi R, Sang M, Kubo N, Nakagawara A
  • 雑誌名: Biochem. Biophys. Res. Commun 巻: 386 ページ: 207-211
  • URL: http://dx.doi.org/10.1016/j.bbrc.2009.06.035
  • 査読あり
• [雑誌論文] Plk1 regulates liver tumor cell death by phosphorylation of TAp63 (2009)
  • 著者名/発表者名: Komatsu S, Takenobu H, Ozaki T, Ando K, Koida N, Suenaga Y, Ichikawa T, Hishiki T, Chiba T, Iwama A, Yoshida H, Ohnuma N, Nakagawara A, Kamijo T
  • 雑誌名: Oncogene 巻: 28 号: 41 ページ: 3631-3641
  • DOI: 10.1038/onc.2009.216
  • 査読あり
• [雑誌論文] Netrin-1 acts as a survival factor for aggressive neuroblastoma (2009)
  • 著者名/発表者名: Delloye-Bourgeois C, Fitamant J, Paradisi A, Cappellen D, Douc-Rasy S, Raquin MA, Stupack D, Nakagawara A, Rousseau R, Combaret V, Puisieux A, Valteau-Couanet D, Benard J, Bernet A, Mehlen P
  • 雑誌名: J. Exp. Med 巻: 206 号: 4 ページ: 833-847
  • DOI: 10.1084/jem.20082299
  • 査読あり
• [雑誌論文] International consensus for neuroblastoma molecular diagnostics : Report from the international neuroblastoma risk group(INRG) biology committee (2009)
  • 著者名/発表者名: Ambros PF, Ambros IM, Brodeur GM, Haber M, Khan J, Nakagawara A, Schleiermacher G, Speleman F, Spitz R, London WB, Cohn SL, Pearson ADJ, Maris JM
  • 雑誌名: Br. J. Cancer 巻: 100 号: 9 ページ: 1471-1482
  • DOI: 10.1038/sj.bjc.6605014
  • 査読あり
• [雑誌論文] Distinct role of ShcC docking protein in the differentiation of neuroblastoma (2009)
  • 著者名/発表者名: Miyake I, Ohira M, Nakagawara A, Sakai R
  • 雑誌名: Oncogene 巻: 28 号: 5 ページ: 662-673
  • DOI: 10.1038/onc.2008.413
  • 査読あり
• [雑誌論文] High expression of ncRAN, a novel non-coding RNA mapped to chromosome 17q25.1, is associated with poor prognosis in neuroblastoma (2009)
  • 著者名/発表者名: Yu M, Ohira M, Li Y, Niizuma H, Oo ML, Zhu Y, Ozaki T, Isogai E, Nakamura Y, Koda T, Oba S, Yu B, Nakagawara A
  • 雑誌名: Int. J. Oncol 巻: 34 号: 4 ページ: 931-938
  • DOI: 10.3892/ijo_00000219
  • 査読あり
• [雑誌論文] Clinicopathological relevance of UbcH10 in breast cancer (2009)
  • 著者名/発表者名: Fujita T, Ikeda H, Kawasaki K, Taira N, Ogasawara Y, Nakagawara A, Doihara H
  • 雑誌名: Cancer Sci 巻: 100 ページ: 238-248
  • NAID: 10025142238
• [雑誌論文] Clinicopathological relevance of UbcH10 in breast cancer (2009)
  • 著者名/発表者名: Fujita T, Ikeda H, Kawasaki K, Taira N, Ogasawara Y, Nakagawara A, Doihara H.
  • 雑誌名: Cancer Sci. 100 ページ: 238-248
  • NAID: 10025142238
  • 査読あり
• [雑誌論文] High expression of ncRAN, a novel non-coding RNA mapped to chromosome 17q25.1, is associated with poor prognosis in neuroblastoma (2009)
  • 著者名/発表者名: Yu M., Nakagawara A., et al.
  • 雑誌名: Int.J.Oncol. 34 ページ: 931-938
  • 査読あり
• [雑誌論文] Distinct role of ShcC docking protein in the differentiation of neuroblastoma (2009)
  • 著者名/発表者名: Miyake I., Nakagawara, A., et al.
  • 雑誌名: Oncogene 28 ページ: 662-673
  • 査読あり
• [雑誌論文] International consensus for neuroblastoma molecular diagnostics : Report from the international neuroblastoma risk group(INRG)biology committee (2009)
  • 著者名/発表者名: Ambros PF., Nakagawara A., et al.
  • 雑誌名: Br.J.Cancer 100 ページ: 1471-1482
  • 査読あり
• [雑誌論文] Netrin-1 acts as a survival factor for aggressive neuroblastoma (2009)
  • 著者名/発表者名: Delloye-Bourgeois C., Nakagawara A., et al.
  • 雑誌名: J.Exp.Med. 206 ページ: 833-847
  • 査読あり
• [雑誌論文] Plk1 regulates liver tumor cell death by phosphorylation of TAp63 (2009)
  • 著者名/発表者名: Komatsu S., Nakagawara A., et al.
  • 雑誌名: Oncogene 28 ページ: 3631-3641
  • 査読あり
• [雑誌論文] Acetylation status of E2F-1 has an important role in the regulation of E2F-1-mediated transactivation of tumor suppressor p73 (2009)
  • 著者名/発表者名: Ozaki T., Nakagawara A., et al.
  • 雑誌名: Biochem.Biophys.Res.Commun 386 ページ: 207-211
  • 査読あり
• [雑誌論文] Deregulated expression of E2F1 promotes proteolytic degradation of tumor suppressor p73 and inhibits its transcriptional activity (2009)
  • 著者名/発表者名: Ozaki T., Nakagawara A., et al.
  • 雑誌名: Biochem.Biophys.Res.Commun. 387 ページ: 143-148
  • 査読あり
• [雑誌論文] Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosp horylation (2009)
  • 著者名/発表者名: Sang M., Nakagawara A., et al.
  • 雑誌名: Genes Cells 14 ページ: 775-788
  • 査読あり
• [雑誌論文] A simple PCR method for rapid genotype analysis of the TH-MYCN transgenic mouse (2009)
  • 著者名/発表者名: Haraguchi S., Nakagawara A., et al.
  • 雑誌名: PLoSONE 4
  • 査読あり
• [雑誌論文] Positive auto-regulation of MYCN in human neuroblastoma (2009)
  • 著者名/発表者名: Suenaga Y., Nakagawara A., et al.
  • 雑誌名: Biochem.Biophys.Res.Common. 390 ページ: 21-26
  • 査読あり
• [雑誌論文] Dysregulation of platelet-derived growth factor β-receptor expression by ΔNp73 in neuroblastoma (2009)
  • 著者名/発表者名: Wetterskog D., Nakagawara A., et al.
  • 雑誌名: Mol.Cancer Res. 7 ページ: 2031-2039
  • 査読あり
• [雑誌論文] Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1αgene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway (2009)
  • 著者名/発表者名: Koshikawa N., Nakagawara A*., et al.
  • 雑誌名: J.Biol.Chem. 284 ページ: 33185-33194
  • 査読あり
• [雑誌論文] Transcriptional regulation of tumor suppressor p53 by cAMP-responsive element-binding protein/AMP-activated protein kinase complex in response to glucose deprivation (2009)
  • 著者名/発表者名: Okoshi R., Nakagawara A., et al.
  • 雑誌名: Genes Cells. 14 ページ: 1429-1440
  • 査読あり
• [雑誌論文] TATA-binding protein(TBP)-like protein is engaged in etoposide-induced apoptosis through transcriptional activation of human TAp63 gene (2009)
  • 著者名/発表者名: Suenaga Y., Nakagawara A*., et al.
  • 雑誌名: J.Biol.Chem. 284 ページ: 35433-35440
  • 査読あり