心血管細胞を用いたマイクロティッシュデバイスの開発

• 研究課題/領域番号: 21681019
• 研究種目: 若手研究(A)
• 配分区分: 補助金
• 研究分野: マイクロ・ナノデバイス
• 研究機関: 独立行政法人理化学研究所 (2011-2013); 東京大学 (2009-2010)
• 研究代表者: 田中 陽 独立行政法人理化学研究所, 生命システム研究センター, ユニットリーダー (40532271)
• 研究期間 (年度): 2009-04-01 – 2013-03-31
• 研究課題ステータス: 完了 (2013年度)
• 配分額: 24,700千円 (直接経費: 19,000千円、間接経費: 5,700千円); 2012年度: 2,600千円 (直接経費: 2,000千円、間接経費: 600千円); 2011年度: 3,770千円 (直接経費: 2,900千円、間接経費: 870千円); 2010年度: 4,940千円 (直接経費: 3,800千円、間接経費: 1,140千円); 2009年度: 13,390千円 (直接経費: 10,300千円、間接経費: 3,090千円)
• キーワード: マイクロバイオシステム / マイクロ・ナノデバイス / 細胞・組織 / 再生医学 / 生体機能利用 / 生物・生体工学 / 細胞パターニング / マイクロポンプ

研究概要

近年、分析・合成など様々な化学プロセスを集積化する研究が多く報告されているが、さらに飛躍的な高効率化のためには、ポンプなどの周辺機器を集積化する必要がある。しかし、機械的デバイスは通常電力を用いるため、現在の技術では集積度に限界がある。一方、研究代表者は生体の細胞やその組織はマイクロサイズに化学的・力学的機能が高度に集約化された素子であることから、これを利用することで飛躍的に集積度の高いマイクロデバイスを実現できると着想し、本研究ではマイクロ構造体と細胞・組織の機能を有機的に融合した新たなバイオマイクロデバイスを開発した。

研究成果

• [雑誌論文] A peristaltic pump integrated on a 100% glass microchip using computer controlled piezoelectric actuators (2014)
  • 著者名/発表者名: Yo Tanaka
  • 雑誌名: Micromachines 巻: -
  • 査読あり
• [雑誌論文] Electric actuating valves incorporated into an all glass-based microchip exploiting the flexibility of ultra thin glass (2013)
  • 著者名/発表者名: Yo Tanaka
  • 雑誌名: RSC Advances 巻: 3(26) ページ: 10213-10220
  • 査読あり
• [雑誌論文] An active valve incorporated into a microchip using a high strain electroactive polymer (2013)
  • 著者名/発表者名: Yo Tanaka, Tomohiro Fujikawa, Yutaka Kazoe, Takehiko Kitamori
  • 雑誌名: Sensors and Actuators B : Chemical 巻: 184(31) ページ: 163-169
  • 査読あり
• [雑誌論文] Totally glass-based microchips with valves and pumps using flexibility of ultra thin glass (2013)
  • 著者名/発表者名: Yo Tanaka
  • 雑誌名: Proceeding of Micro Total Analysis Systems 2013 ページ: 1475-1477
  • 査読あり
• [雑誌論文] Shallow antibody-coated microchannel based selective cell capture and analysis (2013)
  • 著者名/発表者名: Yo Tanaka, Kihoon Jang, Jun Wakabayashi, Reina Ishii, Kae Sato, Kazuma Mawatari, Mats Nilsson, Takehiko Kitamori
  • 雑誌名: Proceeding of Micro Total Analysis Systems 2013 ページ: 359-361
  • 査読あり
• [雑誌論文] An active valve incorporated into a microchip using a high strain electroactive polymer (2013)
  • 著者名/発表者名: Yo Tanaka, Tomohiro Fujikawa, Yutaka Kazoe, Takehiko Kitamori
  • 雑誌名: Sensors and Actuators B: Chemical 巻: 184(31) ページ: 163-169
  • 査読あり
• [雑誌論文] Totally glass based microchips with valves and pumps using flexibility of ultra thin glass (2013)
  • 著者名/発表者名: Yo Tanaka
  • 雑誌名: Proceeding of Micro Total Analysis Systems 2013 巻: 1 ページ: 1475-1477
  • 査読あり
• [雑誌論文] Selective cell capture and analysis using shallow antibody-coated microchannels (2012)
  • 著者名/発表者名: Kihoon Jang, Yo Tanaka, Jun Wakabayashi, Reina Ishii, Kae Sato, Kazuma Mawatari, Mats Nilsson, Takehiko Kitamori
  • 雑誌名: Biomicrofluidics 巻: 6(4) ページ: 44117-44117
  • 査読あり
• [雑誌論文] Microchip-based cellular biochemical systems for practical applications and fundamental research : from microfluidics to nanofluidics (2012)
  • 著者名/発表者名: Yan Xu, Kihoon Jang, Tadahiro Yamashita, Yo Tanaka, Kazuma Mawatari, Takehiko Kitamori
  • 雑誌名: Analytical and Bioanalytical Chemistry 巻: 402(1) ページ: 99-107
  • 査読あり
• [雑誌論文] All glass-based actuator for valves and pumps using ultra thin glass membrane and piezo actuators (2012)
  • 著者名/発表者名: Yo Tanaka
  • 雑誌名: Proceeding of Micro Total Analysis Systems 2012 ページ: 1273-1275
  • 査読あり
• [雑誌論文] Creation of a cell-based separation microdevice using human renal proximal tubule epithelial cells (2012)
  • 著者名/発表者名: Xiaofang Gao, Kazuma Mawatari, Yutaka Kazoe, Yo Tanaka, Takehiko Kitamori
  • 雑誌名: Proceeding of Micro Total Analysis Systems 2012 ページ: 602-604
  • 査読あり
• [雑誌論文] Smooth muscle cell culture in microchannel toward construction of multilayered vascular tissue in micro-scale (2012)
  • 著者名/発表者名: Tadahiro Yamashita, Kazuma Mawatari, Yo Tanaka, Takehiko Kitamori
  • 雑誌名: Proceeding of Micro Total Analysis Systems 2012 ページ: 1708-1710
  • 査読あり
• [雑誌論文] Microchip-based cellular biochemical systems for practical applications and fundamental research : from microfluidics to nanofluidics (2012)
  • 著者名/発表者名: Y.Xu
  • 雑誌名: Analytical and Bioanalytical Chemistry 巻: 402 ページ: 99-107
  • 査読あり
• [雑誌論文] Fluid actuation for a bio-micropump powered by previously frozen cardiomyocytes directly seeded on a diagonally stretched thin membrane (2011)
  • 著者名/発表者名: Yo Tanaka, Yuka Yanagisawa, Takehiko Kitamori
  • 雑誌名: Sensors and Actuators B, Chemical 巻: 156(1) ページ: 494-498
  • 査読あり
• [雑誌論文] Establishment of a confluent cardiomyocyte culture in a cylindrical microchannel (2011)
  • 著者名/発表者名: Yo Tanaka, Hiroto Akaike, Yasuhiko Sugii, Takehiko Kitamori
  • 雑誌名: Analytical Sciences 巻: 27(9) ページ: 957-960
  • NAID: 10029761268
  • 査読あり
• [雑誌論文] Basic structure and cell culture condition of a bioartificial renal tubule on chip towards cell-based separation microdevice (2011)
  • 著者名/発表者名: Xiaofang Gao, Yo Tanaka, Yasuhiko Sugii, Kazuma Mawatari, Takehiko Kitamori
  • 雑誌名: Analytical Sciences 巻: 27(9) ページ: 907-911
  • NAID: 10029761042
  • 査読あり
• [雑誌論文] Development of microfluidic platform for single-cell analysis using a direct photoactive cell-attaching method (2011)
  • 著者名/発表者名: Kihoon Jang, Hong Trang Thi Ngo, Yo Tanaka, Yan Xu, Kazuma Mawatari, Takehiko Kitamori
  • 雑誌名: Analytical Sciences 巻: 27(10) ページ: 973-978
  • 査読あり
• [雑誌論文] Multistep mixing, reaction and detection system in an extended-nano fluidic network (2011)
  • 著者名/発表者名: Yo Tanaka, Hong Trang Ngo, Yutaka Kazoe, Hisashi Shimizu, Kazuma Mawatari, Takehiko Kitamori
  • 雑誌名: Proceeding of Micro Total Analysis Systems 2011 ページ: 380-382
  • 査読あり
• [雑誌論文] Integration of single cell manipulation, lysis, injection at sub-picoliter scale utlizing extended-nano space for single cell analysis (2011)
  • 著者名/発表者名: Kentaro Shirai, Yasuhiko Sugii, Yo Tanaka, Kazuma Mawatari, Takehiko Kitamori
  • 雑誌名: Proceeding of Micro Total Analysis Systems 2011 ページ: 1032-1034
  • 査読あり
• [雑誌論文] Cell sheet free actuator for a bio-micropump using previously frozen cardiomyocytes (2011)
  • 著者名/発表者名: Yo Tanaka, Yuka Yanagisawa, Takehiko Kitamori
  • 雑誌名: Proceeding of Micro Total Analysis Systems 2011 ページ: 1846-1848
  • 査読あり
• [雑誌論文] Cultivation and recovery of vascular endothelial cells in microchannels of a separable micro-chemical chip (2011)
  • 著者名/発表者名: Tadahiro Yamashita, Yo Tanaka, Naokazu Idota, Kae Sato, Kazuma Mawatari, Takehiko Kitamori
  • 雑誌名: Biomaterials 巻: 32(10) ページ: 2459-2465
  • 査読あり
• [雑誌論文] Fluid actuation for a bio-micropump powered by previously frozen cardiomyocytes directly seeded on a diagonally stretched thin membrane (2011)
  • 著者名/発表者名: Y.Tanaka
  • 雑誌名: Sensors and Actuators B, Chemical 巻: 156 ページ: 494-498
  • 査読あり
• [雑誌論文] Establishment of a confluent cardiomyocyte culture in a cylindrical microchannel (2011)
  • 著者名/発表者名: Y.Tanaka
  • 雑誌名: Analytical Sciences 巻: 27 ページ: 957-960
  • NAID: 10029761268
  • 査読あり
• [雑誌論文] Basic structure and cell culture condition of a bioartificial renal tubule on chip towards cell-based separation microdevice (2011)
  • 著者名/発表者名: X.Gao
  • 雑誌名: Analytical Sciences 巻: 27 ページ: 907-911
  • 査読あり
• [雑誌論文] Development of microfluidic platform for single-cell analysis using a direct photoactive cell-attaching method (2011)
  • 著者名/発表者名: K.Jang
  • 雑誌名: Analytical Sciences 巻: 27 ページ: 907-911
  • 査読あり
• [雑誌論文] Multistep mixing, reaction and detection system in an extended-nano fluidic network (2011)
  • 著者名/発表者名: Y.Tanaka
  • 雑誌名: Proc.Micro Total Analysis Systems 2011 ページ: 380-382
  • 査読あり
• [雑誌論文] Integration of single cell manipulation, lysis, injection at sub-picoliter scale utlizing extended-nano space for single cell analysis (2011)
  • 著者名/発表者名: K.Shirai
  • 雑誌名: Proc.Micro Total Analysis Systems 2011 ページ: 1032-1034
  • 査読あり
• [雑誌論文] Cell sheet free actuator for a bio-micropump using previously frozen cardiomyocytes (2011)
  • 著者名/発表者名: Y.Tanaka
  • 雑誌名: Proc.Micro Total Analysis Systems 2011 ページ: 1846-1848
  • 査読あり
• [雑誌論文] Cultivation and recovery of vascular endothelial cells in microchannels of a separable micro-chemical chip (2011)
  • 著者名/発表者名: T.Yamashita
  • 雑誌名: Biomaterials 巻: 32 ページ: 2459-2465
  • 査読あり
• [雑誌論文] Fluid actuation for a bio-micropump powered by previously frozen cardiomyocytes directly seeded on a diagonally stretched thin membrane (2011)
  • 著者名/発表者名: Y.Tanaka
  • 雑誌名: Sensors and Actuators B : Chemical 巻: (印刷中(掲載確定))
  • 査読あり
• [雑誌論文] An efficient surface modification by 2-methacryloyloxyethyl phosphorylcholine for selective control of cell attachment using photochemical reaction in microchannel (2010)
  • 著者名/発表者名: Kihoon Jang, Kae Sato, Yo Tanaka, Yan Xu, Kazuma Mawatari, Moritoshi Sato, Takahiro Nakajima, Tomohiro Konno, Kazuhiko Ishihara, Takehiko Kitamori
  • 雑誌名: Lab on a Chip 巻: 10(15) ページ: 1937-1945
  • 査読あり
• [雑誌論文] Single-cell attachment and culture method using a photochemical reaction in a closed microfluidic system (2010)
  • 著者名/発表者名: Kihoon Jang, Yan Xu, Yo Tanaka, Kae Sato, Kazuma Mawatari, Tomohiro Konno, Kazuhiko Ishihara, Takehiko Kitamori
  • 雑誌名: Biomicrofluidics 巻: 4(3) ページ: 32208-32208
  • 査読あり
• [雑誌論文] Development of insulin delivery devices composed of Langerhans islets and cardiomyocytes (2010)
  • 著者名/発表者名: Hiroto Akaike, Yo Tanaka, Yasuhiko Sugii, Takahiko Kitamori
  • 雑誌名: Proceeding of Micro Total Analysis Systems 2010 ページ: 2017-2019
  • 査読あり
• [雑誌論文] Construction of vascular-mimetic tissue in a separable microchip (2010)
  • 著者名/発表者名: Tadahiro Yamashita, Yo Tanaka, Yasuhiko Sugii, Kazuma Mawatari, Takehiko Kitamori
  • 雑誌名: Proceeding of Micro Total Analysis Systems 2010 ページ: 1316-1318
  • 査読あり
• [雑誌論文] An efficient surface modification using 2-methacryloyloxyethyl phosphorylcholine to control cell attachment via photochemical reaction in a microchannel (2010)
  • 著者名/発表者名: K.Jang
  • 雑誌名: Lab on a Chip 巻: 10 ページ: 1937-1945
  • 査読あり
• [雑誌論文] Single-cell attachment and culture method using a photochemical reaction in a closed microfluidic system (2010)
  • 著者名/発表者名: K.Jang
  • 雑誌名: Biomicrofluidics 巻: 4 ページ: 32208-32208
  • 査読あり
• [雑誌論文] Development of insulin delivery devices composed of Langerhans islets and cardiomyocytes (2010)
  • 著者名/発表者名: H.Akaike
  • 雑誌名: Proc.Micro Total Analysis Systems 2010 ページ: 2017-2019
  • 査読あり
• [雑誌論文] Construction of vascular-mimetic tissue in a separable microchip (2010)
  • 著者名/発表者名: T.Yamashita
  • 雑誌名: Proc.Micro Total Analysis Systems 2010 ページ: 2017-2019
  • 査読あり
• [雑誌論文] An efficient surface modification by 2-methacryloyloxyethyl phosphorylcholine for selective control of cell attachment using photochemical reaction in microchannel (2010)
  • 著者名/発表者名: K.Jang, K.Sato, Y.Tanaka, Y.Xu, K.Mawatari, M.Sato, T.Nakajima, T.Konno, K.Ishihara, T.Kitamori
  • 雑誌名: Lab on a Chip (印刷中(掲載確定))
  • 査読あり
• [雑誌論文] Assembly and simple demonstration of a micropump installing PDMS-based thin membranes as flexible micro check valves (2009)
  • 著者名/発表者名: Yo Tanaka, Kae Sato, Takehiko Kitamori
  • 雑誌名: Journal of Biomedical Nanotechnology 巻: 5(5) ページ: 516-520
  • 査読あり
• [雑誌論文] Recovery and manipulation system of vascular tissue cultured in a separable microchip (2009)
  • 著者名/発表者名: Tadahiro Yamashita, Yo Tanaka, Kae Sato, Takehiko Kitamori
  • 雑誌名: Proceeding of Micro Total Analysis Systems 2010 ページ: 1832-1834
  • 査読あり
• [雑誌論文] Cell-based microfluidic co-culture system for indication of nitric oxide secrete from endothelial cells (2009)
  • 著者名/発表者名: Kihoon Jang, Kae Sato, Yo Tanaka, Takahiro Nakajima, Moritoshi Sato, Takehiko Kitamori
  • 雑誌名: Proceeding of Micro Total Analysis Systems 2010 ページ: 1907-1909
  • 査読あり
• [雑誌論文] Assembly and simple demonstration of a micropump installing PDMS-based thin membranes (2009)
  • 著者名/発表者名: Y.Tanaka, K.Sato, T.Kitamori
  • 雑誌名: Journal of Boimedical Nanotechnology 5 ページ: 516-520
  • 査読あり
• [雑誌論文] Recovery and manipulation system of vascular tissue cultured in a separable microchip (2009)
  • 著者名/発表者名: T.Yamashita, Y.Tanaka, K.Sato, T.Kitamori
  • 雑誌名: Proceedings of Micro Total Analysis Systems 2009 2 ページ: 1832-1834
  • 査読あり
• [雑誌論文] Cell-based microfluidic co-culture system for indication of nitric oxide secrete from endothelial cells (2009)
  • 著者名/発表者名: K.Jang, K.Sato, Y.Tanaka, T.Nakazima, M.Sato, T.Kitamori
  • 雑誌名: Proceedings of Micro Total Analysis Systems 2009 2 ページ: 1907-1909
  • 査読あり
• [雑誌論文] A peristaltic pump integrated on a 100% glass microchip using computer controlled piezoelectric actuators
  • 著者名/発表者名: Yo Tanaka
  • 雑誌名: Micromachines 巻: (in press)
  • 査読あり
• [学会発表] Microfluidic devices in totally glass microchips using flexible ultra thin glass (2014)
  • 著者名/発表者名: Yo Tanaka
  • 学会等名: 2014 EMN Summer meeting (Energy Material Nanotechnology)
  • 発表場所: The Westin Resort & Spa, Cancun, Mexico
  • 年月日: 2014-06-09
• [学会発表] An active valve incorporated into a microchip using a high strain electroactive polymer (2014)
  • 著者名/発表者名: Yo Tanaka
  • 学会等名: BIT's 3rd Annual Conference and EXPO of AnalytiX 2014
  • 発表場所: Dalian World Expo Center, China
  • 年月日: 2014-04-27
• [学会発表] An active valve incorporated into a microchip using a high strain electroactive plymer (2014)
  • 著者名/発表者名: Yo Tanaka
  • 学会等名: BIT's 3rd Annual Conference and EXPO of AnalytiX 2014
  • 発表場所: Dalian World Expo Center, China
  • 招待講演
• [学会発表] Totally glass-based microchips with valves and pumps using flexibility of ultra thin glass (2013)
  • 著者名/発表者名: Yo Tanaka
  • 学会等名: 17th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
  • 発表場所: Freiburg, Germany
  • 年月日: 2013-10-29
• [学会発表] Shallow antibody-coated microchannel based selective cell capture and analysis (2013)
  • 著者名/発表者名: Yo Tanaka, Kihoon Jang, Jun Wakabayashi, Reina Ishii, Kae Sato, Kazuma Mawatari, Mats Nilsson, Takehiko Kitamori
  • 学会等名: 17th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
  • 発表場所: Freiburg, Germany
  • 年月日: 2013-10-28
• [学会発表] All glass-based actuator for valves and pumps using ultra thin glass membrane and piezo actuators (2012)
  • 著者名/発表者名: Yo Tanaka
  • 学会等名: 16th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
  • 発表場所: Okinawa, Japan
  • 年月日: 2012-10-30
• [学会発表] Creation of a cell-based separation microdevice using human renal proximal tubule epithelial cells (2012)
  • 著者名/発表者名: Xiaofang Gao, Kazuma Mawatari, Yutaka Kazoe, Yo Tanaka, Takehiko Kitamori
  • 学会等名: 16th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
  • 発表場所: Okinawa, Japan
  • 年月日: 2012-10-29
• [学会発表] Multistep mixing, reaction and detection system in an extended-nano fluidic network (2011)
  • 著者名/発表者名: Y.Tanaka
  • 学会等名: 15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
  • 発表場所: Seattle, WA, USA
  • 年月日: 2011-11-04
• [学会発表] Integration of single cell manipulation, lysis, injection at sub-picoliter scale utlizing extended-nano space for single cell analysis (2011)
  • 著者名/発表者名: K.Shirai
  • 学会等名: 15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
  • 発表場所: Seattle, WA, USA
  • 年月日: 2011-11-04
• [学会発表] Cell sheet free actuator for a bio-micropump using previously frozen cardiomyocytes (2011)
  • 著者名/発表者名: Y.Tanaka
  • 学会等名: 15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
  • 発表場所: Seattle, WA, USA
  • 年月日: 2011-11-04
• [学会発表] Cell sheet free actuator for a bio-micropump using previously frozen cardiomyocytes (2011)
  • 著者名/発表者名: Yo Tanaka, Yuka Yanagisawa, Takehiko Kitamori
  • 学会等名: 15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
  • 発表場所: Seattle, USA
  • 年月日: 2011-10-05
• [学会発表] Integration of single cell manipulation, lysis, injection at sub-picoliter scale utlizing extended-nano space for single cell analysis (2011)
  • 著者名/発表者名: Kentaro Shirai, Yasuhiko Sugii, Yo Tanaka, Kazuma Mawatari, Takehiko Kitamori
  • 学会等名: 15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
  • 発表場所: Seattle, USA
  • 年月日: 2011-10-04
• [学会発表] Multistep mixing, reaction and detection system in an extended-nano fluidic network (2011)
  • 著者名/発表者名: Yo Tanaka, Hong Trang Ngo, Yutaka Kazoe, Hisashi Shimizu, Kazuma Mawatari, Takehiko Kitamori
  • 学会等名: 15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
  • 発表場所: Seattle, USA
  • 年月日: 2011-10-03
• [学会発表] Construction of a cell-based separation microdevice using renal tubule cells cultured on chip (2011)
  • 著者名/発表者名: 高小放, 田中陽, 杉井康彦, 馬渡和真, 北森武彦
  • 学会等名: 日本分析化学会第60年会
  • 発表場所: 名古屋
  • 年月日: 2011-09-15
• [学会発表] Construction of a cell-based separation microdevice using renal tubule cells cultured on chip (2011)
  • 著者名/発表者名: X.Gao
  • 学会等名: 日本分析化学会第60年会
  • 発表場所: 名古屋大学東山キャンパス
  • 年月日: 2011-09-15
• [学会発表] Structure and cell culture condition for miniaturization of a bioartificial renal tubule on chip (2011)
  • 著者名/発表者名: 高小放, 田中陽, 杉井康彦, 馬渡和真, 北森武彦
  • 学会等名: 第23回化学とマイクロ・ナノシステム研究会
  • 発表場所: 千葉
  • 年月日: 2011-06-10
• [学会発表] Structure and cell culture condition for miniaturization of a bioartificial renal tubule on chip (2011)
  • 著者名/発表者名: X.Gao
  • 学会等名: 第23回化学とマイクロ・ナノシステム研究会(CHEMINAS)
  • 発表場所: 千葉大学西千葉キャンパス
  • 年月日: 2011-06-10
• [学会発表] Development of interface between micro and extended-nano spaces for femtoliter scale analysis of single cells (2011)
  • 著者名/発表者名: Kentaro Shirai, Yasuhiko Sugii, Yo Tanaka, Kazuma Mawatari, Takehiko Kitamori
  • 学会等名: International Symposium on Microchemistry and Microsystems 2011 (ISMM)
  • 発表場所: Seoul, Korea
  • 年月日: 2011-06-03
• [学会発表] Development of interface between micro and extended-nano spaces for femtoliter scale analysis of single cells (2011)
  • 著者名/発表者名: K.Shirai
  • 学会等名: International Symposium on Microchemistry and Microsystems 2011 (ISMM 2011)
  • 発表場所: Seoul, Korea
  • 年月日: 2011-06-03
• [学会発表] Design and initial test of a bioartificial renal tuble on chip (2011)
  • 著者名/発表者名: Xiaofang Gao, Yo Tanaka, Yasuhiko Sugii, Takehiko Kitamori
  • 学会等名: IUPAC International Congress on Analytical Sciences 2011 (ICAS)
  • 発表場所: Kyoto, Japan
  • 年月日: 2011-05-23
• [学会発表] Design and initial test of a bioartificial renal tuble on chip (2011)
  • 著者名/発表者名: X.Gao
  • 学会等名: IUPAC International Congress on Analytical Sciences 2011 (ICAS 2011)
  • 発表場所: Kyoto, Japan
  • 年月日: 2011-05-23
• [学会発表] Single cell analysis at femtoliter scale utilizing extended-nano space (2011)
  • 著者名/発表者名: Kentaro Shirai, Yasuhiko Sugii, Yo Tanaka, Kazuma Mawatari, Takehiko Kitamori
  • 学会等名: 2nd Annual Single Cell Analysis Congress
  • 発表場所: London, UK
  • 年月日: 2011-05-18
• [学会発表] Single cell analysis at femtoliter scale utilizing extended-nano space (2011)
  • 著者名/発表者名: K.Shirai
  • 学会等名: 2nd annual Single Cell Analysis Congress
  • 発表場所: London, UK
  • 年月日: 2011-05-18
• [学会発表] Study on the culturing condition and recovery of smoth muscle cels in a separable microchip (2010)
  • 著者名/発表者名: Tadahiro Yamashita, Yo Tanaka, Yasuhiko Sugii, Kazuma Mawatari, Takehiko Kitamori
  • 学会等名: 6th International Chemical Congress of Pacific Basin Societies Sponsors (PACIFICHEM)
  • 発表場所: Honolulu, USA
  • 年月日: 2010-12-18
• [学会発表] Development of a self-perfusion micro insulin pump powered by cardiomyocytes (2010)
  • 著者名/発表者名: Hiroto Akaike, Yo Tanaka, Yasuhiko Sugii, Takehiko Kitamori
  • 学会等名: 6th International Chemical Congress of Pacific Basin Societies Sponsors (PACIFICHEM)
  • 発表場所: Honolulu, USA
  • 年月日: 2010-12-18
• [学会発表] Study on the culturing condition and recovery of smooth muscle cells in a separable microchip (2010)
  • 著者名/発表者名: T.Yamashita
  • 学会等名: International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
  • 発表場所: Honolulu, Hawaii, USA
  • 年月日: 2010-12-18
• [学会発表] Development of a self-perfusion micro insulin pump powered by cardiomyocytes (2010)
  • 著者名/発表者名: H.Akaike
  • 学会等名: International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
  • 発表場所: Honolulu, USA
  • 年月日: 2010-12-18
• [学会発表] Creation of cell-based separation microdevices : design and initial test of a bioartificial kidney on chip (2010)
  • 著者名/発表者名: X.Gao
  • 学会等名: 10th Asian-Pacific International Symposium on Microscale Separations and Analysis (APCE 2010)
  • 発表場所: Hong Kong, China
  • 年月日: 2010-12-18
• [学会発表] Creation of cell-based separation microdevices : Design and initial test of a bioartificial kidney on chip (2010)
  • 著者名/発表者名: Xiaofang Gao, Yo Tanaka, Yasuhiko Sugii, Takehiko Kitamori
  • 学会等名: 10th Asian-Pacific International Symposium on Microscale Separations and Analysis (APCE)
  • 発表場所: Hong Kong, China
  • 年月日: 2010-12-11
• [学会発表] Creation of cell-based separation microdevices : design and initial test of a bioartificial kidney (BAK) microchip (2010)
  • 著者名/発表者名: 高小放, 田中陽, 杉井康彦, 北森武彦
  • 学会等名: 第22回化学とマイクロ・ナノシステム研究会
  • 発表場所: 名古屋
  • 年月日: 2010-11-17
• [学会発表] Creation of cell-based separation microdevices : design and initial test of abioartificial kidney (BAK) microchip (2010)
  • 著者名/発表者名: X.Gao
  • 学会等名: 第22回化学とマイクロ・ナノシステム研究会(CHEMINAS)
  • 発表場所: 名古屋大学医学部附属病院
  • 年月日: 2010-11-17
• [学会発表] Development of insulin delivery devices composed of Langerhans islets and cardiomyocytes (2010)
  • 著者名/発表者名: Hiroto Akaike, Yo Tanaka, Yasuhiko Sugii, Takahiko Kitamori
  • 学会等名: 15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
  • 発表場所: Groningen, Netherland
  • 年月日: 2010-10-06
• [学会発表] Construction of vascular-mimetic tissue in a separable microchip (2010)
  • 著者名/発表者名: Tadahiro Yamashita, Yo Tanaka, Yasuhiko Sugii, Kazuma Mawatari, Takehiko Kitamori
  • 学会等名: 15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
  • 発表場所: Groningen, Netherland
  • 年月日: 2010-10-06
• [学会発表] Development of insulin delivery devices composed of Langerhansislets and cardiomyocytes (2010)
  • 著者名/発表者名: H.Akaike
  • 学会等名: 14th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
  • 発表場所: Groningen, Netherland
  • 年月日: 2010-10-06
• [学会発表] Construction of vascular-mimetic tissue in a separable microchip (2010)
  • 著者名/発表者名: T.Yamashita
  • 学会等名: 14th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
  • 発表場所: Groningen, Netherland
  • 年月日: 2010-10-06
• [学会発表] Multi-patterning of biological samples on glass substrate and inside the fused microchannel by using photochemical reaction (2010)
  • 著者名/発表者名: Kihoon Jang, Yan Xu, Yo Tanaka, Takehiko Kitamori
  • 学会等名: 17th International Symposium on Capillary Electroseparation Techniques (ITP)
  • 発表場所: Baltimore, Maryland
  • 年月日: 2010-08-30
• [学会発表] Multi-patterning of biological samples on glass substrate and inside the fused microchannel by using photochemical reaction (2010)
  • 著者名/発表者名: K.Jang
  • 学会等名: 17th International Symposium on Electro- and Liquid Phase-separation Techniques (ITP 2010)
  • 発表場所: Baltimore, USA
  • 年月日: 2010-08-30
• [学会発表] 心筋細胞を用いた自己灌流マイクロインスリンポンプの開発 (2010)
  • 著者名/発表者名: 高小放, 田中陽, 杉井康彦, 北森武彦
  • 学会等名: 第21回化学とマイクロ・ナノシステム研究会
  • 発表場所: 東京
  • 年月日: 2010-06-10
• [学会発表] 分離型マイクロ化学チップ内での血管平滑筋細胞の培養条件の検討 (2010)
  • 著者名/発表者名: 山下忠紘, 田中陽, 杉井康彦, 馬渡和真, 北森武彦
  • 学会等名: 第21回化学とマイクロ・ナノシステム研究会
  • 発表場所: 東京
  • 年月日: 2010-06-10
• [学会発表] 心筋細胞を用いた自己灌流マイクロインスリンポンプの開発 (2010)
  • 著者名/発表者名: 赤池寛人
  • 学会等名: 第21回化学とマイクロ・ナノシステム研究会(CHEMINAS)
  • 発表場所: 東京大学本郷キャンパス
  • 年月日: 2010-06-10
• [学会発表] 分離型マイクロ化学チップ内での血管平滑筋細胞の培養条件の検討 (2010)
  • 著者名/発表者名: 山下忠紘
  • 学会等名: 第21回化学とマイクロ・ナノシステム研究会(CHEMINAS)
  • 発表場所: 東京大学本郷キャンパス
  • 年月日: 2010-06-10
• [学会発表] Culture and recovery of smooth muscle cells in a separable microchip for the construction of micro-scale vascular tissue (2010)
  • 著者名/発表者名: Tadahiro Yamashita, Yo Tanaka, Takehiko Kitamori
  • 学会等名: International Symposium on Microchemistry and Microsystems (ISMM) 2010
  • 発表場所: Hong Kong, China
  • 年月日: 2010-05-29
• [学会発表] A method for single cell patterning by using photochemical reaction in fused microchannel (2010)
  • 著者名/発表者名: Kihoon Jang, Yan Xu, Yo Tanaka, Takehiko Kitamori
  • 学会等名: International Symposium on Microchemistry and Microsystems (ISMM) 2010
  • 発表場所: Hong Kong, China
  • 年月日: 2010-05-29
• [学会発表] Culture and recovery of smooth muscle cells in a separable microchip for the construction of micro-scale vascular tissue (2010)
  • 著者名/発表者名: T.Yamashita
  • 学会等名: International Symposium on Microchemistry and Microsystems 2010 (ISMM 2010)
  • 発表場所: Hong Kong, China
  • 年月日: 2010-05-29
• [学会発表] A method for single cell patterning by using photochemical reaction infused micrcoahnnel (2010)
  • 著者名/発表者名: K.Jang
  • 学会等名: International Symposium on Microchemistry and Microsystems 2010 (ISMM 2010)
  • 発表場所: Hong Kong, China
  • 年月日: 2010-05-29
• [学会発表] Single cell patterning in semi-closed microchannel using photoactivation (2010)
  • 著者名/発表者名: Kihoon Jang, Yan Xu, Yo Tanaka, Takehiko Kitamori
  • 学会等名: 25th International Symposium on Microscale Bioseapartions (MSB)
  • 発表場所: Prague, Czech Republic
  • 年月日: 2010-03-23
• [学会発表] Single cell patterning in semi-closed microchannel using photoactivation (2010)
  • 著者名/発表者名: K.Jang, Y.Xu, Y.Tanaka, T.Kitamori
  • 学会等名: 25th International Symposium on MicroScale Bioseparations and Methods for Systems Biology(MSB)
  • 発表場所: Prague, Czech Republic
  • 年月日: 2010-03-23
• [学会発表] Recovery and manipulation system of vascular tissue cultured in a separable microchip (2009)
  • 著者名/発表者名: Tadahiro Yamashita, Yo Tanaka, Kae Sato, Takehiko Kitamori
  • 学会等名: 15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
  • 発表場所: Jeju, Korea
  • 年月日: 2009-11-04
• [学会発表] Cell-based microfluidic co-culture system for indication of nitric oxide secrete from endothelial cells (2009)
  • 著者名/発表者名: Kihoon Jang, Kae Sato, Yo Tanaka, Takahiro Nakajima, Moritoshi Sato, Takehiko Kitamori
  • 学会等名: 15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (μTAS)
  • 発表場所: Jeju, Korea
  • 年月日: 2009-11-04
• [学会発表] Recovery and manipulation system of vascular tissue cultured in a separable microchip (2009)
  • 著者名/発表者名: 山下忠紘、田中陽、佐藤香枝、北森武彦
  • 学会等名: 12th International Conference on Miniaturized Chemical and Biochemical Analysis Systems(μTAS)
  • 発表場所: Jeju, Korea
  • 年月日: 2009-11-04
• [学会発表] Cell-based microfluidic co-culture system for indication of nitric oxide secrete from endothelial cells (2009)
  • 著者名/発表者名: K.Jang, K.Sato, Y.Tanaka, T.Nakazima, M.Sato, T.Kitamori
  • 学会等名: 12th International Conference on Miniaturized Chemical and Biochemical Analysis Systems(μTAS)
  • 発表場所: Jeju, Korea
  • 年月日: 2009-11-04
• [学会発表] Endothelial cell-piccell co-culture microfluidic system for indication of nitric oxide (2009)
  • 著者名/発表者名: Kihoon Jang, Kae Sato, Yo Tanaka, Takahiro Nakazima, Moritoshi Sato, Takehiko Kitamori
  • 学会等名: 24th International Symposium on MicroScale Bioseparations and Methods for Systems Biology (MSB)
  • 発表場所: Dalian, China
  • 年月日: 2009-10-19
• [学会発表] Endothelial cell-piccell co-culture microfluidic system for indication of nitric oxide (2009)
  • 著者名/発表者名: K.Jang, K.Sato, Y.Tanaka, T.Nakazima, M.Sato, T.Kitamori
  • 学会等名: 24th International Symposium on MicroScale Bioseparations and Methods for Systems Biology(MSB)
  • 発表場所: Dalian, China
  • 年月日: 2009-10-19
• [学会発表] 分離型マイクロ化学チップによる血管組織の構築と回収 (2009)
  • 著者名/発表者名: 山下忠紘, 田中陽, 佐藤香枝, 北森武彦
  • 学会等名: 第19回化学とマイクロ・ナノシステム研究会
  • 発表場所: 広島
  • 年月日: 2009-05-29
• [学会発表] Nitric oxide indicator based on microfluidic co-culture system (2009)
  • 著者名/発表者名: 張氣薫, 佐藤香枝, 田中陽, 中嶋隆浩, 佐藤守俊, 北森武彦
  • 学会等名: 第19回化学とマイクロ・ナノシステム研究会
  • 発表場所: 広島
  • 年月日: 2009-05-29
• [備考] 研究代表者(PI)研究室ホームページ
  • URL: http://www.qbic.riken.jp/ibd/jpn/
• [備考] 集積バイオデバイス研究ユニットホームページ
  • URL: http://www.qbic.riken.jp/ibd/jpn/
• [産業財産権] Fluid-controlling device for microchip and use thereof (2013)
  • 発明者名: Yo Tanaka, Hiroki R. Ueda
  • 権利者名: RIKEN
  • 産業財産権種類: 特許
  • 出願年月日: 2013-07-02
  • 外国
• [産業財産権] Fluid-controlling device for microchip and use thereof (2013)
  • 発明者名: Yo Tanaka, Hiroki R. Ueda
  • 権利者名: 理化学研究所
  • 産業財産権種類: 特許
  • 出願年月日: 2013-07-02
  • 外国