| 研究課題/領域番号 |
21F20712
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| 研究種目 |
特別研究員奨励費
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| 配分区分 | 補助金 |
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| 応募区分 | 外国 |
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| 審査区分 |
小区分46030:神経機能学関連
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| 研究機関 | 沖縄科学技術大学院大学 |
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研究代表者 |
Kuhn Bernd 沖縄科学技術大学院大学, 光学ニューロイメージングユニット, 教授 (90599557)
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| 研究分担者 |
LI MELODY 沖縄科学技術大学院大学, 光学ニューロイメージングユニット, 外国人特別研究員
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| 研究期間 (年度) |
2021-09-28 – 2023-03-31
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| 研究課題ステータス |
完了 (2022年度)
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| 配分額 *注記 |
1,200千円 (直接経費: 1,200千円)
2022年度: 400千円 (直接経費: 400千円)
2021年度: 800千円 (直接経費: 800千円)
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| キーワード | Scn2a/Nav1.2 / neurological disorders / In vivo calcium imaging |
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| 研究開始時の研究の概要 |
Dr. Melody Li will establish a method to label neurons with the voltage-sensitive dye ANNINE-6plus. This technique will allow her to image voltage changes in the dendrites of pyramidal neurons with two-photon microscopy. After establishing this technique, Melody with study a specific type of autism spectrum disorder which is caused by a genetic mutations in the SCN2A gene. So far it is unknown how this SCN2A mutations alters brain function. We hope that this research will elucidate the mechanism of this disorder and open the door for finding a cure.
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| 研究実績の概要 |
Established a novel mouse model to study disease mechanisms underlying Scn2a neurodevelopmental disorders. For the first time, in vivo two-photo calcium imaging was performed in a Scn2a mouse model. We found that single neuron activities, as well as population co-activities were reduced in Scn2a insufficient mice during wakefulness. This may be one of the pathological mechanisms driving Scn2a neurodevelopmental disorders. Results was presented in the Japan neuroscience Society Annual Meeting and in the Okinawa Institute of Science and Technology (OIST) Internal Seminar.
A manuscript is in preparation and will be submitted to a peer reviewed journal.
Established collaboration opportunities between OIST and Florey Institute of Neuroscience and Mental Health, Australia.
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| 現在までの達成度 (段落) |
令和4年度が最終年度であるため、記入しない。
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| 今後の研究の推進方策 |
令和4年度が最終年度であるため、記入しない。
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