| 研究課題/領域番号 |
21F21082
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| 研究種目 |
特別研究員奨励費
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| 配分区分 | 補助金 |
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| 応募区分 | 外国 |
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| 審査区分 |
小区分46010:神経科学一般関連
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| 研究機関 | 国立研究開発法人理化学研究所 |
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研究代表者 |
McHugh Thomas 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (50553731)
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| 研究分担者 |
ZHOU YIJUN 国立研究開発法人理化学研究所, 脳神経科学研究センター, 外国人特別研究員
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| 研究期間 (年度) |
2021-04-28 – 2023-03-31
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| 研究課題ステータス |
完了 (2022年度)
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| 配分額 *注記 |
2,300千円 (直接経費: 2,300千円)
2022年度: 1,100千円 (直接経費: 1,100千円)
2021年度: 1,200千円 (直接経費: 1,200千円)
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| キーワード | hippocampus / hypothalmus / feeding / learning / context / hunger / memory |
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| 研究開始時の研究の概要 |
The last 20 years has seen a significant increase in the prevalence of obesity and diabetes, especially in children. Homeostatic control of energy balance is vital for the survival of all animals and neurons in the brain which control food intake and energy balance by integrating relevant sensory and hormonal signal have been identified. It has been reported that dysfunction in the hippocampus can alter feeding behavior, here we aim to identify the circuits and mechanisms in the central nervous system responsible for memory guided modulation of feeding behavior.
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| 研究実績の概要 |
Over the last fiscal year, we have made significant progress in our understanding of the neural circuit from subiculum in hippocampus to arcuate nucleus in hypothalamus. Using a virus combination of CRE recombinase and FLP recombinase, we observed the labelling cells in the subiculum. We have also employed viral-based manipulation methods to investigate the role of this circuit in both feeding and learning components. Meanwhile, the behavior paradigm also confirmed that the internal state of animals (hunger or satiety) could be a context for adaptive behaviors. These findings have important implications for our understanding of neural circuits involved in feeding and learning and may pave the way for targeted therapies for related disorders.
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| 現在までの達成度 (段落) |
令和4年度が最終年度であるため、記入しない。
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| 今後の研究の推進方策 |
令和4年度が最終年度であるため、記入しない。
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