| 研究課題/領域番号 |
21K04758
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| 研究種目 |
基盤研究(C)
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| 配分区分 | 基金 |
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| 応募区分 | 一般 |
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| 審査区分 |
小区分27010:移動現象および単位操作関連
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| 研究機関 | 福岡大学 |
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研究代表者 |
シャーミン タンジナ 福岡大学, 工学部, 助教 (00794182)
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| 研究分担者 |
相田 卓 福岡大学, 工学部, 助教 (00466541)
三島 健司 福岡大学, 工学部, 教授 (40190623)
佐藤 朝光 福岡大学, 薬学部, 教授 (90369025)
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| 研究期間 (年度) |
2021-04-01 – 2024-03-31
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| 研究課題ステータス |
交付 (2022年度)
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| 配分額 *注記 |
4,030千円 (直接経費: 3,100千円、間接経費: 930千円)
2023年度: 650千円 (直接経費: 500千円、間接経費: 150千円)
2022年度: 1,690千円 (直接経費: 1,300千円、間接経費: 390千円)
2021年度: 1,690千円 (直接経費: 1,300千円、間接経費: 390千円)
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| キーワード | supercritical CO2 / JHA / Pyriproxyfen / microencapsulation / control release / carbon dioxide / Protein microparticles / supercritical fluids / hormone analogues / microparticles / mosquito-borne diseases |
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| 研究開始時の研究の概要 |
In this study we introduce highly advance technology of supercritical carbon dioxide (ScCO2) to manufacture Juvenile hormone analogues (JHAs) microcapsules which will be very light to float and enable releasing effective doses just at the place of need. Parameters like pressure (8~14MPa) and temperature (313~343K), polymer ratio, and antisolvent to solvent ratio will be varied to adjust the output. To ensure their controlled release for a longer time, JHAs will be encapsulated with a biodegradable polymer. Evaluation of the encapsulated JHAs particles in Aedes vectors will be carried out.
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| 研究実績の概要 |
We have examined the Development of several supercritical carbon dioxide-mediated microparticles of proteins and JHA hormones using the PGSS process and the liquid-liquid two-phase separation. Our experimental data on Microencapsulation of insect growth regulator in poly-(ε-caprolactones) by PGSS process were presented in the 化学工学会 第53回秋季大会 (2022, 9) and the 7th International Conference on the Characterization and Control of Interfaces for High-Quality Advanced Materials ICCCI 2022 (2022,11) was highly evaluated. An article on “Microencapsulation of pyriproxyfen using the particles from gas-saturated solutions process as a controlled-release system” is submitted in the Journal: Powder Technology (Ref: POWTEC-D-23-00573) is under review process. An article on ‘Recognition of liquid-liquid two-phase separation by digital image processing’ was successfully published in July 2022 in the Journal of the Institute of Industrial Applications Engineers.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
This fund provided enough financial support to purchase all equipment's and chemical required for the research making the smooth execution of this research project.
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| 今後の研究の推進方策 |
The bioassay on larval mortality (laboratory scale) assay has been successfully carried out in the Faculty of Pharmaceutical Sciences, Fukuoka University using 4th instar larvae of Aedes albopictus. By this time we have achieved enough data to publish the result of this investigation. In parallels, we will try to develop a PEG-PCL diblock copolymer microencapsulation system composed of poly(ethylene glycol) (PEG) and poly(ε-caprolactone, PCL) using the PGSS process to minimize the hydrophobicity of the polymer PCL. The effect of process conditions, i.e., pre-expansion temperature and pressure, and pyriproxyfen/polymer mass ratio, on the morphology of particles and the efficiency of encapsulation will be analyzed.
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