| 研究課題/領域番号 |
21K05044
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| 研究種目 |
基盤研究(C)
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| 配分区分 | 基金 |
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| 応募区分 | 一般 |
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| 審査区分 |
小区分33010:構造有機化学および物理有機化学関連
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| 研究機関 | 芝浦工業大学 |
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研究代表者 |
RICHARDS GARY 芝浦工業大学, 工学部, 准教授 (00708620)
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| 研究分担者 |
堀 顕子 芝浦工業大学, 工学部, 教授 (90433713)
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| 研究期間 (年度) |
2021-04-01 – 2024-03-31
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| 研究課題ステータス |
交付 (2022年度)
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| 配分額 *注記 |
4,030千円 (直接経費: 3,100千円、間接経費: 930千円)
2023年度: 780千円 (直接経費: 600千円、間接経費: 180千円)
2022年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円)
2021年度: 1,690千円 (直接経費: 1,300千円、間接経費: 390千円)
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| キーワード | Pyrazinacenes / Azaacenes / Near Infrared Emitters / Fluorescence / REDOX / Near infrared absorption |
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| 研究開始時の研究の概要 |
Chromophore-based bioimaging techniques rely on the availability of dyes that are emissive in regions of the electromagnetic spectrum not obscured by absorptive processes of biomolecules or water. Thus, dyes emitting in the near-infrared transparency window region of tissues from 650 to 900 nm are useful for imaging. This project aims to develop a new class of highly efficient near infra-red emitting materials based on extended pyrazinacenes - molecules built with linearly fused pyrazine units.
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| 研究実績の概要 |
We have continued to synthesize new pyrazinacenes mainly consisting of four or five consecutively fused pyrazine rings appended with electron-donating substituents that are redox active. Oxidized species show remarkably red-shifted absorption compared to the reduced species.
We have improved the synthesis of the water-soluble tetradecaazaheptacene to give better yield. This compound has been used for cellular imaging in the near infrared region. This was possible through use of a non-cytotoxic beta-cyclodextrin delivery agent which helped to prevent chromophore aggregation in aqueous solution.
We have now developed the synthesis of pyrazinacenes consisting of 8 consecutively fused pyrazine rings - now the longest-known pyrazinacenes.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
1: 当初の計画以上に進展している
理由
We have already managed to prepare water-soluble extended pyrazinacene emitters that exhibit highly efficient fluorescence in the near-infrared region (peak emission = 730 nm). Although aggregation of this chromophore quenches fluorescence in aqueous solution, we have found a suitable delivery agent that prevents aggregation and allows the dye molecules to be used as emitters for cellular imaging in the near infrared region. We are now in the process of submitting a patent application related to this work.
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| 今後の研究の推進方策 |
Working with our collaborators at NIMS, we will continue to develop our work on cellular imaging applications of our water-soluble tetradecaazaheptacene - in particular, we hope to use this material for continuous live cell imaging in the near infrared region
We will continue our efforts to synthesize new materials including those consisting of 8 fused pyrazine rings (for example, water-soluble derivatives), and shorter, redox-active compounds appended with various electron donor substituents.
We will continue to investigate these compounds for application as new types of emitters for bio and cellular imaging applications as well as for application in other nascent technologies.
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