| 研究課題/領域番号 |
21K05302
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| 研究種目 |
基盤研究(C)
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| 配分区分 | 基金 |
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| 応募区分 | 一般 |
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| 審査区分 |
小区分37020:生物分子化学関連
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| 研究機関 | 東京工業大学 (2023)
国立研究開発法人理化学研究所 (2021-2022) |
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研究代表者 |
張 宗哲 東京工業大学, 物質理工学院, 特任助教 (00774853)
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| 研究期間 (年度) |
2021-04-01 – 2024-03-31
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| 研究課題ステータス |
完了 (2023年度)
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| 配分額 *注記 |
4,160千円 (直接経費: 3,200千円、間接経費: 960千円)
2023年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円)
2022年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円)
2021年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円)
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| キーワード | Prodrug / Sialyltransferase / Acrolein / In vivo synthesis / Gold metal / Immunotherapy / Metal catalysis / Sialic acid / Glycoalbumin |
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| 研究開始時の研究の概要 |
Cancer is the second leading cause of death globally, and is responsible for about 10 million deaths per year. The research could innovate the cancer immunotherapy to achieve efficiently cancer therapy for life extension and reduce numbers and death number.
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| 研究実績の概要 |
Inhibiting sialylation is thus a potential anticancer treatment strategy. However, targeting sialic acids is difficult because of the lack of selective delivery tools. I present a prodrug strategy for selectively releasing the global inhibitor of sialylation peracetylated 3Fax-Neu5Ac (PFN) in cancer cells using the reaction between phenyl azide and endogenous acrolein, which is overproduced in most cancer cells. The method significantly suppressed tumor growth in mice as effectively as PFN without causing kidney dysfunction, which is associated with PFN.
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