| 研究課題/領域番号 |
21K09149
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| 研究種目 |
基盤研究(C)
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| 配分区分 | 基金 |
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| 応募区分 | 一般 |
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| 審査区分 |
小区分56010:脳神経外科学関連
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| 研究機関 | 名古屋大学 |
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研究代表者 |
Bagarinao E. 名古屋大学, 医学系研究科(保健), 准教授 (00443218)
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| 研究分担者 |
礒田 治夫 名古屋大学, 脳とこころの研究センター(保健), 教授 (40223060)
前澤 聡 名古屋大学, 医学系研究科, 准教授 (90566960)
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| 研究期間 (年度) |
2021-04-01 – 2024-03-31
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| 研究課題ステータス |
交付 (2022年度)
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| 配分額 *注記 |
4,160千円 (直接経費: 3,200千円、間接経費: 960千円)
2023年度: 260千円 (直接経費: 200千円、間接経費: 60千円)
2022年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
2021年度: 2,470千円 (直接経費: 1,900千円、間接経費: 570千円)
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| キーワード | precision mapping / functional connectivity / real-time fMRI / essential tremor / resting state fMRI / human connectome / neurosurgery |
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| 研究開始時の研究の概要 |
Advances in brain imaging research have significantly improved our understanding of the brain's functions and its functional organization, yet their clinical applications remain very limited. This research aims to bridge this gap by developing a system that can be used to generate individualized, highly reliable, and reproducible functional connection profile of the human brain in real-time that can be used for neurosurgical applications including preoperative planning and during online intraoperative assessment.
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| 研究実績の概要 |
For the FY2022, we have scanned 10 more healthy volunteers, completing the MRI scans of all 20 healthy controls. All participants underwent two imaging sessions, about one month apart. Acquired MRI data includes structural T1 MRI data, an hour of resting state functional MRI data, and diffusion-weighted MRI data. Additionally, we have also acquired the MRI data from patients with essential tremor. Preliminary analysis of the acquired datasets from healthy controls have shown that the reliability of the whole-brain FCOR map exhibited an initial rapid increase as more volumes are incorporated into the analysis. With more volumes added, the reliability measure later plateaus suggesting an upper limit to the reliability as well as an optimal number of volumes to achieve this limit. We have also started the analysis of the data from patients with essential tremor. This will be completed in FY2023.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
The implementation of the project in the second year was progressing smoothly as planned. With all the data acquired, we have started the full analysis, which we plan to complete in FY2023.
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| 今後の研究の推進方策 |
For the FY2023, we will complete the full analysis of the acquired MRI data. The results of the analysis will be presented in upcoming domestic and international conferences and will be organized into a manuscript to be submitted for possible publication in international journals.
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