| 研究課題/領域番号 |
21K14169
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| 研究種目 |
若手研究
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| 配分区分 | 基金 |
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| 審査区分 |
小区分21030:計測工学関連
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| 研究機関 | 岡山大学 |
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研究代表者 |
WANG JIN 岡山大学, ヘルスシステム統合科学学域, 准教授 (10870975)
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| 研究期間 (年度) |
2021-04-01 – 2024-03-31
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| 研究課題ステータス |
完了 (2023年度)
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| 配分額 *注記 |
4,680千円 (直接経費: 3,600千円、間接経費: 1,080千円)
2023年度: 1,170千円 (直接経費: 900千円、間接経費: 270千円)
2022年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円)
2021年度: 1,950千円 (直接経費: 1,500千円、間接経費: 450千円)
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| キーワード | peptide / drug molecule / computational design / small molecules / odorant binding protein / docking / organic receptors / 計算分子設計 / ペプチド / プラズモニック / がんやCOVID-19のVOCsバイオマーカー |
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| 研究開始時の研究の概要 |
Peptide as a promising molecular recognition element has gained intense interest for developing novel sensing devices. In this study, rational design of peptide based plasmonic biosensor for small molecules (volatile organic compounds biomarkers from cancer/disease and COVID-19) will be developed.
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| 研究実績の概要 |
Small drug molecule, esculetin, are very important in adipose tissues, and regulates serum lipid profiles and shows potential anti-atherosclerosis benefits. In this stage, we use the computational design and molecular docking to simulate that the direct interaction between C/EBPβ and esculetin and conducted the research to clarify their reaction in vitro using optical sensor. These findings suggest that esculetin accelerates postprandial lipid circulation by binding to C/EBPβ and augmenting CD36-dependent phagocytosis in ATMs. The work was under review by Advanced Science. Furthermore, another novel designed peptide for TNT explosive was performed.
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