| 研究課題/領域番号 |
21K14612
|
|---|
| 研究種目 |
若手研究
|
| 配分区分 | 基金 |
|---|
| 審査区分 |
小区分33010:構造有機化学および物理有機化学関連
|
|---|
| 研究機関 | 京都大学 |
|---|
研究代表者 |
FA SHIXIN 京都大学, 工学研究科, 特定助教 (40835922)
|
|---|
| 研究期間 (年度) |
2021-04-01 – 2022-03-31
|
| 研究課題ステータス |
中途終了 (2021年度)
|
| 配分額 *注記 |
4,680千円 (直接経費: 3,600千円、間接経費: 1,080千円)
2022年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
2021年度: 3,250千円 (直接経費: 2,500千円、間接経費: 750千円)
|
|---|
| キーワード | Pillar[5]arene / Chirality / Molecular Tube / Ionic Interaction / Assembly / self-assemblies / pillararenes / artificial channels / chirality / nanotubes |
|---|
| 研究開始時の研究の概要 |
Artificial channels with selectivity for natural molecules has becoming attractive for a long time because of the significance of the related life processes. However, this subject remains a challenging field due to the sophisticated molecular design and low efficiency. Here, the applicant will use simple assembled structures, pillar[5]arene-based discrete nanotubes, as artificial channels for amino acids and monosaccarides, as pillararenes are host molecules for them. Optical and directional control of the transportation behaviors will also be studied by modifying the molecular structures.
|
| 研究実績の概要 |
Selectively transporting hydrophilic natural molecules with chirality through artificial channels is of crucial importance. However, this work is challenging due to the sophisticated molecular design and standing low efficiency. To achieve this goal, the construction of channels with chiral information is the primary task.
Taking advantage of the controllable planar-chiral properties of pillar[n]arenes, we started the project with a rim-differentiated pillar[5]arene bearing stereogenic centers on one rim and benzoic acids on the other rim. An diastereomeric excess of the pillar[5]arene was produced through the host-guest interaction with achiral linear guests. The trimeric nanotubes with specific helicity and stability were synthesized through the ionic interaction of the pre-regulated rim-differentiated pillar[5]arene with an amino pillar[5]arene.
Another strategy on construction of helical trimeric nanochannels was also practiced. An acidic rim-differentiated pillar[5]arene without stereogenic centers was isolated into two enantiomers firstly, and interacted with the amino pillar[5]arene to produce enantiomeric nanochannels. The constructed channels possessed pure left- and right-handed helicity.
These trimeric nanotubes were expected to work as artificial channels enabling enantio-selective transportation of natural small chiral molecules, because previous work has revealed the enantio-selective recognition of pillar[5]arenes.
|
