| 研究課題/領域番号 |
21K14804
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| 研究種目 |
若手研究
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| 配分区分 | 基金 |
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| 審査区分 |
小区分38050:食品科学関連
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| 研究機関 | 広島大学 |
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研究代表者 |
KUMRUNGSEE THANUTCHAPORN (カムランシー タナッチャポーン) 広島大学, 統合生命科学研究科(生), 准教授 (90781849)
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| 研究期間 (年度) |
2021-04-01 – 2024-03-31
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| 研究課題ステータス |
完了 (2023年度)
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| 配分額 *注記 |
4,680千円 (直接経費: 3,600千円、間接経費: 1,080千円)
2023年度: 1,690千円 (直接経費: 1,300千円、間接経費: 390千円)
2022年度: 1,690千円 (直接経費: 1,300千円、間接経費: 390千円)
2021年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円)
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| キーワード | Carnosine / Muscle regeneration / Skeletal muscle / Vitamin B6 / sarcopenia / dexamethasone / Satellite cells / Twist2 |
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| 研究開始時の研究の概要 |
For decades, carnosine has been believed to improve exercise performance and prevent sarcopenia, but its exact molecular mechanisms remain unknown. This study aims to clarify if carnosine has any effects on muscle satellite cells (SCs, Pax7+ cells) and recently identified muscle progenitor cells (PCs, Tw2+ cells), essential for skeletal muscle regeneration and maintaining muscle mass, respectively. Moreover, this study will determine how carnosine plays a role in muscle regeneration and muscle energy metabolism.
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| 研究実績の概要 |
In FY2023, effects of vitamin B6 on satellite cell activity and muscle atrophy have been examined. As a results, a vitamin B6 deficient diet exhibited a significant decrease in the quiescent satellite cell (SC) pool in mouse muscles, as compared to the vitamin B6 supplemented diet. By the single myofiber culture experiment, vitamin B6 deficiency suppressed the proliferation and self-renewal of SCs during myogenesis. In the dexamethasone-induce muscle atrophy model, we found that vitamin B6 deficiency aggravated muscle atrophy, while vitamin B6 supplementation attenuated muscle atrophy. Vitamin B6 supplementation significantly suppressed the up-regulation of Murf-1 and Atrogin-1 expressions in muscles, suggesting that vitamin B6 possibly attenuated muscle atrophy via preventing muscle degradation.
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