| 研究課題/領域番号 |
21K15609
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| 研究種目 |
若手研究
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| 配分区分 | 基金 |
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| 審査区分 |
小区分51010:基盤脳科学関連
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| 研究機関 | 京都大学 |
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研究代表者 |
Veale Richard 京都大学, 医学研究科, 助教 (80828880)
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| 研究期間 (年度) |
2021-04-01 – 2025-03-31
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| 研究課題ステータス |
交付 (2023年度)
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| 配分額 *注記 |
4,550千円 (直接経費: 3,500千円、間接経費: 1,050千円)
2023年度: 260千円 (直接経費: 200千円、間接経費: 60千円)
2022年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
2021年度: 2,860千円 (直接経費: 2,200千円、間接経費: 660千円)
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| キーワード | Saliency map / Neuroprosthesis / Visual attention / Marmoset / Silicon Probe / Spiking simulation / Free Viewing / Superior Colliculus / Blindsight / Gaze Behavior / Saliency / Neural Prosthesis / Visual Attention |
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| 研究開始時の研究の概要 |
I will record brain activity in marmoset monkeys to understand how visual features like color or motion pull visual attention. The goal is to understand how the brain calculates which interesting thing to look at when there are many interesting things visible. This will help us build neural prosthetics that will directly stimulate the brain to repair deficits in attentional behavior caused by brain damage.
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| 研究実績の概要 |
We have collected data from silicon probe implantations in marmoset viewing free-viewing video, and prepared the complex software necessary for both statistical analysis of the gaze data, as well as estimation of parameters of models for predicting the gaze data given visual input (i.e. saliency maps). The next steps will be active stimulation and multi-probe implantations.
In addition, we have been collecting significant data from human infants and adults to confirm the application of the model beyond marmosets and to better understand the differences between species that may limit adoption of the prosthesis in humans.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
4: 遅れている
理由
Due to limitations on experiment time, technical difficulties with surgery/implantation, and difficult developing the statistical software, the project is significantly delayed. However, I hope to show significant and interesting results within this final year.
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| 今後の研究の推進方策 |
It is possible that closed-loop stimulation will not be fully achievable by the end of the project. However, full model of marmoset SC and simulated expectation and sham stimulation should be possible in at least one animal. This year we plan to (1) continue free-viewing experiments with silicon probe recording from SC (2) Fit models (spiking network stimulation) and (3) attempt closed-loop stimulation. Additionally, we have prepared an animal for V1 lesion but it is unclear if recovery from the lesion will be ready before the end of this research grant (although we will publish the results aftewards).
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