| 研究課題/領域番号 |
21K16962
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| 研究種目 |
若手研究
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| 配分区分 | 基金 |
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| 審査区分 |
小区分57030:保存治療系歯学関連
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| 研究機関 | 東北大学 |
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研究代表者 |
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| 研究期間 (年度) |
2021-04-01 – 2024-03-31
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| 研究課題ステータス |
中途終了 (2023年度)
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| 配分額 *注記 |
4,550千円 (直接経費: 3,500千円、間接経費: 1,050千円)
2024年度: 260千円 (直接経費: 200千円、間接経費: 60千円)
2023年度: 520千円 (直接経費: 400千円、間接経費: 120千円)
2022年度: 2,340千円 (直接経費: 1,800千円、間接経費: 540千円)
2021年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
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| キーワード | Regenerated Bone / Nanoindentation / Implant Therapy / Functional Bone / Micro-CT analysis / Calvaria osteoblasts / Polylactic acid scaffold / Critical bone defect / Bone tissue engineering / Bone product |
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| 研究開始時の研究の概要 |
In the proposed study, we will establish a method to develop bone regeneration product that will enhance healing of various bone defects.
Our main goal is to develop a method to prepare a regulatory science-based quality-controlled bone regeneration product with enhanced bone regeneration ability which can used for horizontal bone loss caused of severe periodontitis.
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| 研究実績の概要 |
After quantitatively assessed new bone in mice jaw bone defects, we investigated mechanical and functional properties of regenerated bone. The Nanoindentation tests showed cytrans group exhibit higher tissue hardness and elastic modulus, followed by 3DPL4, MCOB-3DPL4, and empty groups. To assess functional properties, mini-implants placed in defect area. CT analysis showed lack of complete osseointegration of the implants across all groups. HE staining showed good osseointegration in the MCOB-3DPL4 and cytrans groups, partial osseointegration in the 3DPL4 and empty defect groups
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