世界最高レベルの瞬発系選手の全ゲノム解析による運動能力関連多型の解明

• 研究課題/領域番号: 22240072
• 研究種目: 基盤研究(A)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: スポーツ科学
• 研究機関: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所)
• 研究代表者: 田中 雅嗣 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (60155166)
• 研究分担者: 福 典之 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 研究員 (40392526)
• 研究期間 (年度): 2010-04-01 – 2013-03-31
• 研究課題ステータス: 完了 (2013年度)
• 配分額: 41,470千円 (直接経費: 31,900千円、間接経費: 9,570千円); 2012年度: 12,870千円 (直接経費: 9,900千円、間接経費: 2,970千円); 2011年度: 13,130千円 (直接経費: 10,100千円、間接経費: 3,030千円); 2010年度: 15,470千円 (直接経費: 11,900千円、間接経費: 3,570千円)
• キーワード: エネルギー代謝 / ゲノム全領域関連解析 / エクソン全領域関連解析 / ミトコンドリアゲノム多型 / 一塩基多型 / 全エクソン塩基配列解析 / 核ゲノム多型 / 瞬発系運動能力 / 陸上短距離走 / ジャマイカ人

研究概要

核 DNA 多型について、特に優秀な成績をあげている短距離走選手(世界記録保持 者やオリンピック・世界陸上選手権の優勝者など)257 名とコントロール群 617 名の計 874名を選択 し、1000 人ゲノムプロジェクトのデータおよび国際ハップマッププロジェクトのデータに基づいて選定した tag SNP を分析ターゲットとする全ゲノム遺伝子多型高密度解析法を用いた。瞬発系スポーツにおいて“究極”の競技力を有する世界のトップアスリートを対象にした解析により、筋・骨 格系や循環器系・代謝系などの能力などに関連した遺伝子がどの染色体領域に局在するかを特定することができた。

研究成果

• [雑誌論文] Efficacy of pyruvate therapy in patients with mitochondrial disease: A semi-quantitative clinical evaluation study (2014)
  • 著者名/発表者名: Tatsuya Fujii, Fumihito Nozaki, Keiko Saito, Anri Hayashi, Yutaka Nishigaki, Kei Murayama, Masashi Tanaka, Yasutoshi Koga, Ikuko Hiejima, Tomohiro Kumada
  • 雑誌名: Molecular genetics and metabolism 巻: 112: 2 ページ: 133-138
• [雑誌論文] New MT-ND6 and NDUFA1 mutations in mitochondria respiratory chain disorders (2014)
  • 著者名/発表者名: Natsumi Uehara, Masato Mori, Yoshimi Tokuzawa, Yosuke Mizuno, Shunsuke Tamaru, Masakazu Kohda, Yohsuke Moriyama, Yutaka Nakachi, Nana Matoba, Tetsuro Sakai, Taro Yamazaki, Hiroko Harashima, Kei Murayama, Keisuke Hattori, Jun-Ichi Hayashi, Takanori Yamagata, Yasunori Fujita, Masafumi Ito, Masashi Tanaka, Ken-ichi Nibu, Akira Ohtake, Yasushi Okazaki
  • 雑誌名: Annals of Clinical and Translational Neurology 巻: 1:5 ページ: 361-369
• [雑誌論文] Evolution of mitochondrial power in vertebrate metazoans (2014)
  • 著者名/発表者名: Yasuhiro Kitazoe, Masashi Tanaka
  • 雑誌名: PloS One 巻: 9: 6 ページ: 6-6
• [雑誌論文] High cardiorespiratory fitness can reduce glycated hemoglobin levels regardless of polygenic risk for type 2 diabetes mellitus in non-diabetic Japanese men (2014)
  • 著者名/発表者名: Kumpei Tanisawa, Tomoko Ito, Xiaomin Sun, Ryuken Ise, Satomi Oshima, Zhen-Bo Cao, Shizuo Sakamoto, Masashi Tanaka, Mitsuru Higuchi
  • 雑誌名: Physiological genomics
• [雑誌論文] Polygenic risk for hypertriglyceridemia is attenuated in Japanese men with high fitness levels (2014)
  • 著者名/発表者名: Kumpei Tanisawa, Tomoko Ito, Xiaomin Sun, Zhen-Bo Cao, Shizuo Sakamoto, Masashi Tanaka, Mitsuru Higuchi
  • 雑誌名: Physiological genomics 巻: 46: 6 ページ: 207-215
• [雑誌論文] ACTN3 R577X genotype is associated with sprinting in elite Japanese athletes (2014)
  • 著者名/発表者名: E Mikami, N Fuku, H Murakami, H Tsuchie, H Takahashi, N Ohiwa, H Tanaka, Y P Pitsiladis, M Higuchi, M Miyachi, T Kawahara, M Tanaka
  • 雑誌名: International journal of sports medicine 巻: 35: 2 ページ: 172-177
• [雑誌論文] Association Analysis of ACE and ACTN3 in Elite Caucasian and East Asian Swimmers (2013)
  • 著者名/発表者名: Guan Wang, Eri Mikami, Li-Ling Chiu, Alessandra DE Perini, Michael Deason, Noriyuki Fuku, Motohiko Miyachi, Koji Kaneoka, Haruka Murakami, Masashi Tanaka, Ling-Ling Hsieh, Sandy S Hsieh, Daniela Caporossi, Fabio Pigozzi, Alan Hilley, Rob Lee, Stuart D R Galloway, Jason Gulbin, Viktor A Rogozkin, Ildus I Ahmetov, Nan Yang, Kathryn N North, Saraslanidis Ploutarhos, Hugh E Montgomery, Mark E S Bailey, Yannis P Pitsiladis
  • 雑誌名: Med Sci Sports Exerc 巻: 45: 5 ページ: 892-900
• [雑誌論文] Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes (2013)
  • 著者名/発表者名: Kumpei Tanisawa, Eri Mikami, Noriyuki Fuku, Yoko Honda, Shuji Honda, Ikuro Ohsawa, Masafumi Ito, Shogo Endo, Kunio Ihara, Kinji Ohno, Yuki Kishimoto, Akihito Ishigami, Naoki Maruyama, Motoji Sawabe, Hiroyoshi Iseki, Yasushi Okazaki, Sanae Hasegawa-Ishii, Shiro Takei, Atsuyoshi Shimada, Masanori Hosokawa, Masayuki Mori, Keiichi Higuchi, Toshio Takeda, Mitsuru Higuchi, Masashi Tanaka
  • 雑誌名: BMC Genomics 巻: 14: 1 ページ: 248-248
  • NAID: 120007100717
• [雑誌論文] Association Analysis of ACE and ACTN3 in Elite Caucasian and East Asian Swimmers (2013)
  • 著者名/発表者名: Guan Wang
  • 雑誌名: Med Sci Sports Exerc 巻: 45 号: 5 ページ: 892-900
  • DOI: 10.1249/mss.0b013e31827c501f
  • 査読あり
• [雑誌論文] Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes. (2013)
  • 著者名/発表者名: Tanisawa K., Mikami E., Fuku N., Honda Y., Honda S., Ohsawa I., Ito M., Endo S., Ihara K., Ohno K., Kishimoto Y., Ishigami A., Maruyama N., Sawabe M., Iseki H., Okazaki Y., Hasegawa-Ishii S., Takei S., Shimada A., Hosokawa M., Mori M., Higuchi K., Takeda T., Higuchi M., Tanaka M.
  • 雑誌名: BMC Genomics. 巻: 14(1): 号: 1 ページ: 248-248
  • DOI: 10.1186/1471-2164-14-248
  • 査読あり / オープンアクセス
• [雑誌論文] An alternative model for the early peopling of southern South america revealed by analyses of three mitochondrial DNA haplogroups (2012)
  • 著者名/発表者名: Michelle de Pierre, Claudio M Bravi, Josefina M B Motti, Noriyuki Fuku, Masashi Tanaka, Elena Llop, Sandro L Bonatto, Mauricio Moraga
  • 雑誌名: PLoS One 巻: 7: 9 ページ: 9-9
• [雑誌論文] Metabolomic profiling rationalized pyruvate efficacy in cybrid cells harboring MELAS mitochondrial DNA mutations (2012)
  • 著者名/発表者名: Kenjiro Kami, Yasunori Fujita, Saori Igarashi, Sayaka Koike, Shoko Sugawara, Satsuki Ikeda, Naomi Sato, Masafumi Ito, Masashi Tanaka, Masaru Tomita, Tomoyoshi Soga
  • 雑誌名: Mitochondrion 巻: 12: 6 ページ: 644-653
• [雑誌論文] Extended screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss (2012)
  • 著者名/発表者名: Tomofumi Kato, Yutaka Nishigaki, Yoshihiro Noguchi, Noriyuki Fuku, Taku Ito, Eri Mikami, Ken Kitamura,Masashi Tanaka
  • 雑誌名: J Hum Genet 巻: 57: 12 ページ: 772-775
  • NAID: 10031145884
• [雑誌論文] Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans (2012)
  • 著者名/発表者名: Yoko Honda, Akira Higashibata, Yohei Matsunaga, Yukiko Yonezawa, Tsuyoshi Kawano, Atsushi Higashitani, Kana Kuriyama, Toru Shimazu, Masashi Tanaka, Nathaniel J Szewczyk, Noriaki Ishioka, Shuji Honda
  • 雑誌名: Sci Rep 巻: 2: 7
• [雑誌論文] Association of 29C>T polymorphism in the transforming growth factor-61 gene with lean body mass in community-dwelling Japanese population (2012)
  • 著者名/発表者名: Noriyuki Fuku, Seijiro Mori, Haruka Murakami, Yuko Gando, Heying Zhou, Hideki Ito, Masashi Tanaka, Motohiko Miyachi
  • 雑誌名: Geriatr Gerontol Int 巻: 12: 2 ページ: 292-297
• [雑誌論文] Synergistic effects of genetic variants of APOA5 and BTN2A1on dyslipidemia or metabolic syndrome (2012)
  • 著者名/発表者名: Mizuho Hiramatsu, Mitsutoshi Oguri, Kimihiko Kato, Hideki Horibe, Tetsuo Fujimaki, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Dong-Jik Shin, Jong Ho Lee, Yangsoo Jang, Yoshiji Yamada
  • 雑誌名: Int J Mol Med 巻: 30: 1 ページ: 185-192
• [雑誌論文] Importance of mitochondrial haplotypes and maternal lineage in sprint performance among individuals of West African ancestry (2012)
  • 著者名/発表者名: M Deason, R Scott, L Irwin, V Macaulay, N Fuku, M Tanaka, R Irving, V Charlton, E Morrison, K Austin, Y P Pitsiladis
  • 雑誌名: Scand J Med Sci Sports 巻: 22: 2 ページ: 217-223
• [雑誌論文] Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH Ela gene (2012)
  • 著者名/発表者名: Yasutoshi Koga, Nataliya Povalko, Koujyu Katayama, Noriko Kakimoto, Toyojiro Matsuishi, Etsuo Naito, Masashi Tanaka
  • 雑誌名: Brain Dev 巻: 34: 2 ページ: 87-91
• [雑誌論文] mtDNA T8993G mutation-induced mitochondrial complex V inhibition augments cardiolipin-dependent alterations in mitochondrial dynamics during oxidative, Ca(2+), and lipid insults in NARP cybrids:a potential therapeutic target for melatonin (2012)
  • 著者名/発表者名: Tsung-I Peng, Chia-Wei Hsiao, Russel J Reiter, Masashi Tanaka, Yiu-Kay Lai, Mei-Jie Jou
  • 雑誌名: J Pineal Res 巻: 52: 1 ページ: 93-106
• [雑誌論文] Pyruvate therapy for mitochondrial DNA depletion syndrome (2012)
  • 著者名/発表者名: Keiko Saito, Nobusuke Kimura, Nozomi Oda, Hideki Shimomura, Tomohiro Kumada, Tomoko Miyajima, Kei Murayama, Masashi Tanaka, Tatsuya Fujii
  • 雑誌名: Biochim Biophys Acta 巻: 1820: 5 ページ: 632-636
• [雑誌論文] Polymorphisms in the control region of mitochondrial DNA associated with elite Japanese athlete status (2012)
  • 著者名/発表者名: E Mikami, N Fuku, H Takahashi, N Ohiwa, Y P Pitsiladis, M Higuchi, T Kawahara, M Tanaka
  • 雑誌名: Scand J Med Sci Sports Jan
• [雑誌論文] Mitochondrial macrohaplogroup associated with muscle power in healthy adults (2012)
  • 著者名/発表者名: N Fuku, H Murakami, M Iemitsu, K Sanada, M Tanaka, M Miyachi
  • 雑誌名: Int J Sports Med 巻: 33: 5 ページ: 410-414
• [雑誌論文] Biochemistry of mitochondria, life and intervention 2010 (2012)
  • 著者名/発表者名: Yasutoshi Koga, Masashi Tanaka, Shigeo Ohta, Yau-Huei Wei
  • 雑誌名: Biochim Biophys Acta 巻: 1820: 5 ページ: 551-552
• [雑誌論文] The mitochondrial T1095C mutation increases gentamicin-mediatedapoptosis (2012)
  • 著者名/発表者名: Hakan Muyderman, Neil R Sims, Masashi Tanaka, Noriyuki Fuku, Ravinarayan Raghupathi, Dominic Thyagarajan
  • 雑誌名: Mitochondrion 巻: 12: 4 ページ: 465-471
• [雑誌論文] Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1a gene (2012)
  • 著者名/発表者名: Koga Y, Povalko N, Katayama K, Kakimoto N, Matsuishi T, Naito E, Tanaka M
  • 雑誌名: Brain Dev 巻: 34 号: 2 ページ: 87-91
  • DOI: 10.1016/j.braindev.2011.03.003
  • 査読あり
• [雑誌論文] mtDNA T8993G mutation-induced mitochondrial complex V inhibition augments cardiolipin-dependent alterations in mitochondrial dynamics during oxidative, Ca(2+), and lipid insults in NARP cybrids: a potential therapeutic target for melatonin (2012)
  • 著者名/発表者名: Tsung-I Peng, Chia-Wei Hsiao, Russel J Reiter, Masashi Tanaka, Yiu-Kay Lai, Mei-Jie Jou
  • 雑誌名: J Pineal Res 巻: 52 号: 1 ページ: 93-106
  • DOI: 10.1111/j.1600-079x.2011.00923.x
  • 査読あり
• [雑誌論文] An alternative model for the early peopling of southern South america revealed by analyses of three mitochondrial DNA haplogroups. (2012)
  • 著者名/発表者名: Michelle de de Pierre, Claudio M Bravi, Josefina M B Motti, Noriyuki Fuku, Masashi Tanaka, Elena Llop, Sandro L Bonatto, Mauricio Moraga
  • 雑誌名: PLoS One 巻: 7 号: 9 ページ: e43486-e43486
  • DOI: 10.1371/journal.pone.0043486
  • 査読あり
• [雑誌論文] Association of 29C T Polymorphism in the Transforming Growth Factor-β1 Gene with Lean Body Mass in Community-Dwelling Japanese Population (2012)
  • 著者名/発表者名: Fuku N, Mori S, Murakami H, Gando Y, Zhou H, Ito H, Tanaka M, Miyachi M
  • 雑誌名: Geriatr Gerontol Int 巻: 12 号: 2 ページ: 292-297
  • DOI: 10.1111/j.1447-0594.2011.00768.x
  • NAID: 10031147995
  • 査読あり
• [雑誌論文] The mitochondrial T1095C mutation increases gentamicin-mediated apoptosis (2012)
  • 著者名/発表者名: Hakan Muyderman, Neil R Sims, Masashi Tanaka, Noriyuki Fuku, Ravinarayan Raghupathi, Dominic Thyagarajan
  • 雑誌名: Mitochondrion 巻: 12 号: 4 ページ: 465-471
  • DOI: 10.1016/j.mito.2012.06.006
  • 査読あり
• [雑誌論文] Extended screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss. (2012)
  • 著者名/発表者名: Kato T, Nishigaki Y, Noguchi Y, Fuku N, Ito T, Mikami E, Kitamura K, Tanaka M.
  • 雑誌名: J Hum Genet 巻: 57 号: 12 ページ: 772-775
  • DOI: 10.1038/jhg.2012.109
  • 査読あり
• [雑誌論文] Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome (2012)
  • 著者名/発表者名: Mizuho Hiramatsu, Mitsutoshi Oguri, Kimihiko Kato, Hideki Horibe, Tetsuo Fujimaki, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Dong-Jik Shin, Jong Ho Lee, Yangsoo Jang, Yoshiji Yamada
  • 雑誌名: Int J Mol Med 巻: 30 ページ: 185-192
  • DOI: 10.3892/ijmm.2012.976
  • 査読あり
• [雑誌論文] Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans (2011)
  • 著者名/発表者名: Yoko Honda, Yasunori Fujita, Hiroe Maruyama, Yoko Araki, Kenji Ichihara, Akira Sato, Toshio Kojima, Masashi Tanaka, Yoshinori Nozawa, Masafumi Ito, Shuji Honda
  • 雑誌名: PLoS One 巻: 6: 8 ページ: 8-8
• [雑誌論文] Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations (2011)
  • 著者名/発表者名: Yoshiji Yamada, Tamotsu Nishida, Sahoko Ichihara, Motoji Sawabe, Noriyuki Fuku, Yutaka Nishigaki, Yukitoshi Aoyagi, Masashi Tanaka, Yoshinori Fujiwara, Hiroto Yoshida, Shoji Shinkai, Kei Satoh, Kimihiko Kato, Tetsuo Fujimaki, Kiyoshi Yokoi, Mitsutoshi Oguri, Tetsuro Yoshida, Sachiro Watanabe, Yoshinori Nozawa, Aki Hasegawa, Toshio Kojima, Bok-Ghee Han, Younjin Ahn, Meehee Lee, Dong-Jik Shin, Jong Ho Lee, Yangsoo Jang
  • 雑誌名: Atherosclerosis 巻: 215: 1 ページ: 145-152
• [雑誌論文] Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with or without hypertension, diabetes mellitus or chronic kidney disease (2011)
  • 著者名/発表者名: Tetsuro Yoshida, Kimihiko Kato, Mitsutoshi Oguri, Hideki Horibe, Toshiki Kawamiya, Kiyoshi Yokoi, Tetsuo Fujimaki, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Hiroto Yoshida, Shoji Shinkai, Yoshinori Nozawa, Yoshiji Yamada
  • 雑誌名: Int J Mol Med 巻: 27: 5 ページ: 745-752
• [雑誌論文] Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with different lipid profiles (2011)
  • 著者名/発表者名: Tetsuro Yoshida, Kimihiko Kato, Mitsutoshi Oguri, Hideki Horibe, Toshiki Kawamiya, Kiyoshi Yokoi, Tetsuo Fujimaki, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Hiroto Yoshida, Shoji Shinkai, Yoshinori Nozawa, Yoshiji Yamada
  • 雑誌名: Mol Med Report 巻: 4: 3 ページ: 511-518
• [雑誌論文] Association of a polymorphism of BTN2A1 with hypertension in Japanese individuals (2011)
  • 著者名/発表者名: Hideki Horibe, Kimihiko Kato, Mitsutoshi Oguri, Tetsuro Yoshida, Tetsuo Fujimaki, Toshiki Kawamiya, Kiyoshi Yokoi, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Hiroto Yoshida, Shoji Shinkai, Yoshinori Nozawa, Toyoaki Murohara, Yoshiji Yamada
  • 雑誌名: Am J Hypertens 巻: 24: 8 ページ: 924-929
• [雑誌論文] Association of a polymorphism of BTN2A1 with type 2 diabetes mellitus in Japanese individuals (2011)
  • 著者名/発表者名: M Hiramatsu, M Oguri, K Kato, T Yoshida, T Fujimaki, H Horibe, K Yokoi, S Watanabe, K Satoh, Y Aoyagi, M Tanaka, H Yoshida, S Shinkai, Y Nozawa, T Murohara, Y Yamada
  • 雑誌名: Diabet Med 巻: 28: 11 ページ: 1381-1387
• [雑誌論文] Association of a genetic variant of BTN2A1 with metabolic syndrome in East Asian populations (2011)
  • 著者名/発表者名: Mitsutoshi Oguri, Kimihiko Kato, Tetsuro Yoshida, Tetsuo Fujimaki, Hideki Horibe, Kiyoshi Yokoi, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Hiroto Yoshida, Shoji Shinkai, Yoshinori Nozawa, Dong-jik Shin, Jon Ho Lee, Yangsoo Jang, Yoshiji Yamada
  • 雑誌名: J Med Genet 巻: 48: 11 ページ: 787-792
• [雑誌論文] Mitochondrial haplogroups associated with elite Japanese athlete status (2011)
  • 著者名/発表者名: Eri Mikami, Noriyuki Fuku, Hideyuki Takahashi, Nao Ohiwa, Robert A Scott, Yannis P Pitsiladis, Mitsuru Higuchi, Takashi Kawahara, Masashi Tanaka
  • 雑誌名: Br J Sports Med 巻: 45: 15 ページ: 1179-1183
• [雑誌論文] Mitochondrial haplogroups A and M7a confer a genetic risk for coronary atherosclerosis in the Japanese elderly: an autopsy study of 1,536 patients (2011)
  • 著者名/発表者名: Motoji Sawabe, Masashi Tanaka, Kouji Chida, Tomio Arai, Yutaka Nishigaki, Noriyuki Fuku, Makiko Naka Mieno, Aya Kuchiba, Noriko Tanaka
  • 雑誌名: J Atheroscler Thromb 巻: 18: 2 ページ: 166-175
  • NAID: 130004444492
• [雑誌論文] Stability of mitochondrial membrane proteins in terrestrial vertebrates predicts aerobic capacity and longevity (2011)
  • 著者名/発表者名: Yasuhiro Kitazoe, Hirohisa Kishino, Masami Hasegawa, Atsushi Matsui, Nick Lane, Masashi Tanaka
  • 雑誌名: Genome Biol Evol 巻: 3 ページ: 1233-1244
• [雑誌論文] Mitochondrial DNA analysis of Hokkaido Jomon skeletons: remnants of archaic maternal lineages at the southwestern edge of former Beringia (2011)
  • 著者名/発表者名: Noboru Adachi, Ken-ichi Shinoda, Kazuo Umetsu, Takashi Kitano, Hirofumi Matsumura, Ryuzo Fujiyama, Junmei Sawada, Masashi Tanaka
  • 雑誌名: Am J Phys Anthropol 巻: 146: 3 ページ: 346-360
• [雑誌論文] Polymorphisms in the control region of mitochondrial DNA associated with elite Japanese athlete status (2011)
  • 著者名/発表者名: Eri Mikami
  • 雑誌名: Scand J Med Sci Sports 巻: (Epub ahead of print) 号: 5 ページ: 593-599
  • DOI: 10.1111/j.1600-0838.2011.01424.x
  • 査読あり
• [雑誌論文] Mitochondrial haplogroups associated with elite Japanese athlete status (2011)
  • 著者名/発表者名: Mikami E, Fuku N, Takahashi H, Ohiwa N, Scott RA, Pitsiladis YP, Higuchi M, Kawahara T, Tanaka M
  • 雑誌名: Br J Sports Med 巻: 45 号: 15 ページ: 1179-83
  • DOI: 10.1136/bjsm.2010.072371
  • 査読あり
• [雑誌論文] Mitochondrial haplogroups A and M7a confer a genetic risk for coronary atherosclerosis in the Japanese elderly : An autopsy study of 1,536 patients (2011)
  • 著者名/発表者名: Sawabe M., et al.
  • 雑誌名: J Atheroscler Thromb 巻: 18 ページ: 166-175
  • 査読あり
• [雑誌論文] Mitochondrial DNA analysis of Hokkaido Jomon skeletons : Remnants of archaic maternal lineages at the southwestern edge of former Beringia (2011)
  • 著者名/発表者名: Adachi N., et al.
  • 雑誌名: Am J Phys Anthropol 巻: 印刷中
  • 査読あり
• [雑誌論文] Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations (2011)
  • 著者名/発表者名: Fujimaki T., et al.
  • 雑誌名: Exp Ther Med 巻: 2 ページ: 745-749
  • 査読あり
• [雑誌論文] Importance of mitochondrial haplotypes and maternal lineage in sprint performance among individuals of West African ancestry (2011)
  • 著者名/発表者名: Deason M., et al.
  • 雑誌名: Scand J Med Sci Sports 巻: 印刷中
  • 査読あり
• [雑誌論文] Mitochondrial haplogroups associated with elite Japanese athlete status (2011)
  • 著者名/発表者名: Mikami E., et al.
  • 雑誌名: Scand J Med Sci Sports 巻: 印刷中
  • 査読あり
• [雑誌論文] Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E 1α gene (2011)
  • 著者名/発表者名: Koga Y., et al.
  • 雑誌名: Brain Dev 巻: 印刷中
  • 査読あり
• [雑誌論文] Association of a polymorphism of BTN2A1 with type 2 diabetes mellitus in Japanese individuals (2011)
  • 著者名/発表者名: Hiramatsu M., et al.
  • 雑誌名: Diabetic Med 巻: 印刷中
  • 査読あり
• [雑誌論文] Association of a polymorphism of BTN2A1 with hypertension in Japanese individuals (2011)
  • 著者名/発表者名: Horibe H., et al.
  • 雑誌名: Am J Hypertens 巻: 印刷中
  • 査読あり
• [雑誌論文] Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with or without hypertension, diabetes mellitus, or chronic kidney disease (2011)
  • 著者名/発表者名: Yoshida T., et al.
  • 雑誌名: Int J Mol Med 巻: 27 ページ: 745-752
  • 査読あり
• [雑誌論文] Association of a polymorphism of BTN2A1 with chronic kidney disease in Japanese individuals with or without hypertension or diabetes mellitus (2011)
  • 著者名/発表者名: Yoshida T., et al.
  • 雑誌名: Mol Med Rep 巻: 4 ページ: 511-518
  • 査読あり
• [雑誌論文] Association of a polymorphism of BTN2A 1 with chronic kidney disease in Japanese individuals with or without hypertension or diabetes mellitus (2011)
  • 著者名/発表者名: Yoshida T., et al.
  • 雑誌名: Exp Ther Med 巻: 印刷中
  • 査読あり
• [雑誌論文] Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations (2011)
  • 著者名/発表者名: Yamada Y., et al.
  • 雑誌名: Atherosclerosis 巻: 215 ページ: 145-152
  • 査読あり
• [雑誌論文] 人類の遺伝的多様性と運動能力 (2011)
  • 著者名/発表者名: 田中雅嗣
  • 雑誌名: 体育の科学 巻: 61 ページ: 351-356
• [雑誌論文] ミトコンドリア病ならびにシトリン欠損症に対するピルビン酸ナトリウム療法 (2011)
  • 著者名/発表者名: 田中雅嗣
  • 雑誌名: 日本先天性代謝異常学会雑誌 巻: 27 印刷中
  • NAID: 10031002727
• [雑誌論文] Trehalose extends longevity in the nematode Caenorhabditis elegans (2010)
  • 著者名/発表者名: Yoko Honda, Masashi Tanaka, Shuji Honda
  • 雑誌名: Aging Cell 巻: 9: 4 ページ: 558-569
• [雑誌論文] Redox regulation, gene expression and longevity (2010)
  • 著者名/発表者名: Yoko Honda, Masashi Tanaka, Shuji Honda
  • 雑誌名: Geriatr Gerontol Int 巻: 10 Suppl 1
  • NAID: 10027273063
• [雑誌論文] SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5KgammaActivity through Deacetylation of Specific LysineResidues in Mammals (2010)
  • 著者名/発表者名: Sayaka Akieda-Asai, Nobuhiro Zaima, Koji Ikegami, Tomoaki Kahyo, Ikuko Yao, Takahiro Hatanaka, Shun-Ichiro Iemura, Rika Sugiyama, Takeaki Yokozeki, Yoshinobu Eishi, Morio Koike, Kyoji Ikeda, Takuya Chiba, Haruyoshi Yamaza, Isao Shimokawa, Si-Young Song, Akira Matsuno, Akiko Mizutani, Motoji Sawabe, Moses V Chao, Masashi Tanaka, Yasunori Kanaho, Tohru Natsume, Haruhiko Sugimura, Yukari Date, Michael W McBurney, Leonard Guarente, Mitsutoshi Setou
  • 雑誌名: PLoS One 巻: 5: 7 ページ: 7-7
• [雑誌論文] Cooperative effect of serum 25-hydroxyvitamin D concentration and a polymorphism of transforming growth factor-beta1 gene on the prevalence of vertebral fractures in postmenopausal osteoporosis (2010)
  • 著者名/発表者名: Seijiro Mori, Noriyuki Fuku, Yuko Chiba, Fumiaki Tokimura, Takayuki Hosoi, Yoshiyuki Kimbara, Yoshiaki Tamura, Atsushi Araki, Masashi Tanaka, Hideki Ito
  • 雑誌名: J Bone Miner Metab 巻: 28: 4 ページ: 446-450
• [雑誌論文] FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males (2010)
  • 著者名/発表者名: Robert A Scott, Mark E S Bailey, Colin N Moran, Richard H Wilson, Noriyuki Fuku, Masashi Tanaka, Athanasios Tsiokanos, Athanasios Z Jamurtas, Evangelia Grammatikaki, George Moschonis, Yannis Manios, Yannis P Pitsiladis
  • 雑誌名: Eur J Hum Genet 巻: 18: 12 ページ: 1339-1343
• [雑誌論文] Pyruvate therapy for Leigh syndrome due to cytochrome c oxidase deficiency (2010)
  • 著者名/発表者名: Hirofumi Komaki, Yutaka Nishigaki, Noriyuki Fuku, Hiroko Hosoya, Kei Murayama, Akira Ohtake, Yu-Ichi Goto, Hiroyuki Wakamoto, Yasutoshi Koga, Masashi Tanaka
  • 雑誌名: Biochim Biophys Acta 巻: 1800: 3 ページ: 313-315
• [雑誌論文] Mitochondrial DNA variants in a Japanese population of patients with Alzheimer's disease (2010)
  • 著者名/発表者名: Noriko Tanaka, Yu-ichi Goto, Jun Akanuma, Mayuko Kato, Toru Kinoshita, Fumio Yamashita, Masashi Tanaka, Takashi Asada
  • 雑誌名: Mitochondrion 巻: 10: 1 ページ: 32-37
• [雑誌論文] Loss of mutant mitochondrial DNA harboring the MELAS A3243G mutation in human cybrid cells after cell-cell fusion with normal tissue-derived fibroblast cells (2010)
  • 著者名/発表者名: Takamitsu Yano, Masashi Tanaka, Noboru Fukuda, Takuya Ueda, Hiroki Nagase
  • 雑誌名: Int J Mol Med 巻: 25: 1 ページ: 153-158
• [雑誌論文] Extensive screening system using suspension array technology to detect mitochondrial DNA point mutations (2010)
  • 著者名/発表者名: Yutaka Nishigaki, Hitomi Ueno, Jorida Coku, Yasutoshi Koga, Tatsuya Fujii, Ko Sahashi, Kazutoshi Nakano, Makoto Yoneda, Michiko Nonaka, Linya Tang, Chia-Wei Liou, Veronique Paquis-Flucklinger, Yasuo Harigaya, Tohru Ibi, Yu-ichi Goto, Hiroko Hosoya, Salvatore DiMauro, Michio Hirano, Masashi Tanaka
  • 雑誌名: Mitochondrion 巻: 10: 3 ページ: 300-308
• [雑誌論文] Extensive and rapid screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss (2010)
  • 著者名/発表者名: Tomofumi Kato, Yutaka Nishigaki, Yoshihiro Noguchi, Hitomi Ueno, Hiroko Hosoya, Taku Ito, Yurika Kimura, Ken Kitamura, Masashi Tanaka
  • 雑誌名: J Hum Genet 巻: 55: 3 ページ: 147-154
  • NAID: 10030733907
• [雑誌論文] Macrophages that survive hyperoxia exposure have higher superoxide dismutase activities in their mitochondria (2010)
  • 著者名/発表者名: Kenichi Kokubo, Saki Soeda, Toshihiro Shinbo, Minoru Hirose, Noriyuki Fuku, Yutaka Nishigaki, Masashi Tanaka, Hirosuke Kobayashi
  • 雑誌名: Adv Exp Med Biol 巻: 662 ページ: 63-69
• [雑誌論文] Mitochondrial haplogroups associated with lifestyle-related diseases and longevity in the Japanese population (2010)
  • 著者名/発表者名: Yutaka Nishigaki, Noriyuki Fuku, Masashi Tanaka
  • 雑誌名: Geriatr Gerontol Int 巻: 10 Suppl 1
  • NAID: 10027274092
• [雑誌論文] Metabolic analysis of 13C-labeled pyruvate for noninvasive assessment of mitochondrial function (2010)
  • 著者名/発表者名: I-Chien Wu, Ikuroh Ohsawa, Noriyuki Fuku, Masashi Tanaka
  • 雑誌名: Ann N Y Acad Sci 巻: 1201 ページ: 111-120
• [雑誌論文] Energy States in mitochondrial cardiomyopathy. In vivo functional imaging and L-arginine therapy (2010)
  • 著者名/発表者名: Masamichi Ikawa, Makoto Yoneda, Masashi Tanaka
  • 雑誌名: Circ J 巻: 74: 12 ページ: 2560-2561
  • NAID: 10027424125
• [雑誌論文] Trehalose extends longevity in the nematode Caenorhabditis elegans (2010)
  • 著者名/発表者名: Honda Y., et al.
  • 雑誌名: Aging Cell 巻: 9 ページ: 145-152
  • 査読あり
• [雑誌論文] Mitochondrial haplogroups associated with lifestyle-related diseases and longevity in the Japanese population (2010)
  • 著者名/発表者名: Nishigaki Y., et al.
  • 雑誌名: Geriatr Gerontol Int 巻: 10 Suppl 1
  • 査読あり
• [雑誌論文] Redox regulation, gene expression and longevity (2010)
  • 著者名/発表者名: Honda Y., et al.
  • 雑誌名: Geriatr Gerontol Int 巻: 10 Suppl 1
  • 査読あり
• [雑誌論文] Extensive screening system using suspension array technology to detect mitochondrial DNA point mutations (2010)
  • 著者名/発表者名: Komaki H., et al.
  • 雑誌名: Biochim Biophys Acta 巻: 1800 ページ: 313-315
  • 査読あり
• [雑誌論文] Extensive screening system using suspension array technology to detect mitochondrial DNA point mutations (2010)
  • 著者名/発表者名: Nishigaki Y., et al.
  • 雑誌名: Mitochondrion 巻: 10 ページ: 300-308
  • 査読あり
• [雑誌論文] Extensive and rapid screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss (2010)
  • 著者名/発表者名: Kato T., et al.
  • 雑誌名: J Hum Genet 巻: 55 ページ: 300-308
  • 査読あり
• [雑誌論文] Loss of mutant mitochondrial DNA harboring the MELAS A3243G mutation in human cybrid cells after cell-cell fusion with normal tissue-derived fibroblast cells (2010)
  • 著者名/発表者名: Yano T., et al.
  • 雑誌名: Int J Mol Med 巻: 25 ページ: 153-158
  • 査読あり
• [雑誌論文] ミトコンドリアゲノム多型と健康・長寿 (2010)
  • 著者名/発表者名: 福典之・田中雅嗣
  • 雑誌名: 公衆衛生 巻: 9 ページ: 754-760
• [学会発表] Mitochondrial DNA in human longevity and in age-associated diseases (2010)
  • 著者名/発表者名: Tanaka M.
  • 学会等名: The 6th Conference of Asian Society of Mitochondrial Research and Medicine
  • 発表場所: Fukuoka
  • 年月日: 2010-12-17
• [学会発表] ピルビン酸療法 (2010)
  • 著者名/発表者名: 田中雅嗣
  • 学会等名: 第52回日本先天性代謝異常学会
  • 発表場所: 大阪
  • 年月日: 2010-10-22
• [学会発表] Mitopenia contributes to sarcopenia, osteopenia, diabetes, and metabolic syndrome : Practical approaches to verify this hypothesis (2010)
  • 著者名/発表者名: Tanaka M.
  • 学会等名: The 12th Asian-Pacific Conference of Clinical Biochemistry
  • 発表場所: Seoul
  • 年月日: 2010-10-04
• [学会発表] ミトコンドリアと光感受性 (2010)
  • 著者名/発表者名: 田中雅嗣
  • 学会等名: 第32回日本光医学・光生物学会
  • 発表場所: 東京
  • 年月日: 2010-07-31
• [備考]
  • URL: http://publicationslist.org/masashi.tanaka
• [備考] Masashi Tanaka Journal articles
  • URL: http://publicationslist.org/masashi.tanaka
• [備考] Human Mitochondrial Genome Polymorphism Database
  • URL: http://mtsnp.tmig.or.jp/mtsnp/index_e.shtml
• [備考] 健康長寿ゲノム探索研究チーム
  • URL: http://www.tmig.or.jp/J_TMIG/j_research/A40.html
• [備考]
  • URL: http://mtsnp.tmig.or.jp/mtsnp/index.shtml