都市部一般住民における代謝性疾患と頚動脈硬化の進展に関する追跡研究

• 研究課題/領域番号: 22390138
• 研究種目: 基盤研究(B)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 公衆衛生学・健康科学
• 研究機関: 独立行政法人国立循環器病研究センター
• 研究代表者: 小久保 喜弘 独立行政法人国立循環器病研究センター, 病院, 医長 (20393217)
• 研究分担者: 中村 敏子 (独)国立循環器病研究センター, 病院, 医長 (70533008) ; 神出 計 大阪大学, 大学院・医学系研究科, 講師 (80393239)
• 連携研究者: 宮本 恵宏 (独)国立循環器病研究センター, 病院, 部長 (10312224) ; 渡邊 至 (独)国立循環器病研究センター, 病院, 医長 (40343446)
• 研究期間 (年度): 2010 – 2012
• 研究課題ステータス: 完了 (2012年度)
• 配分額: 20,410千円 (直接経費: 15,700千円、間接経費: 4,710千円); 2012年度: 3,120千円 (直接経費: 2,400千円、間接経費: 720千円); 2011年度: 3,120千円 (直接経費: 2,400千円、間接経費: 720千円); 2010年度: 14,170千円 (直接経費: 10,900千円、間接経費: 3,270千円)
• キーワード: 頚動脈硬化 / 代謝性疾患 / 追跡研究 / 危険因子 / 地域住民 / 頸動脈硬化 / 交互作用 / 生活習慣病 / 生活習慣 / 炎症マーカー / 進展

研究概要

市部一般住民における代謝性疾患と頚動脈硬化の進展に関する追跡研究と血管内膜中膜肥厚(IMT)の進展との追跡研究について、生活習慣要因から検討した。正常高値血圧以上で最大IMT値が有意に厚かった。女性の最大IMT値は、血圧と高感度CRP高値との間に交互作用が見られた。また、女性の糖尿病型、男性の境界型以上で平均・最大IMTは有意に厚かった。頸動脈狭窄は血糖が高くなるとリスクが高く、さらに血圧上昇と交互作用が見られた。慢性腎障害は頸動脈硬化の危険因子であり、頸動脈硬化は慢性腎障害の正常高値血圧、高血圧群でさらに進展していた。頸動脈硬化症の予防に、慢性腎障害への進展抑止と血圧のコントロールが重要であるごとがわかった。さらに、追跡研究では頸動脈IMT、特に総頸動脈最大IMTは循環器病発症の予測因子であることが分かった。正常高値血圧、糖尿病型、non-HDLコレステロール高値、喫煙、BMIが保健指導において動脈硬化進展の予防に有効な指標であることが分かった。

研究成果

• [雑誌論文] The Effect of Age on the Association between Waist-to-height Ratio and the Incidence of Cardiovascular Disease : The Suita Study. (2013)
  • 著者名/発表者名: Tatsumi Y, Watanabe M, Kokubo Y, Nishimura K, Higashiyama A, Okamura T, Okayama A, Miyamoto Y.
  • 雑誌名: J Epidemiol. 巻: (in press)
  • NAID: 10031194273
  • 査読あり
• [雑誌論文] Alcohol consumption and cardiovascular disease incidence in men with and without hypertension : the Suita study (2013)
  • 著者名/発表者名: Higashiyama A, Okamura T, Watanabe M, Kokubo Y, Wakabayashi I, Okayama A, Miyamoto Y.
  • 雑誌名: Hypertens Res. 巻: 36 ページ: 58-64
  • NAID: 10031163286
  • 査読あり
• [雑誌論文] TIA as Acute Cerebrovascular Syndrome. (2013)
  • 著者名/発表者名: Kokubo Y. Epidemiology of TIA. In : Uchiyama S, Amarenco P, Minematsu K, Wong KS, eds.
  • 雑誌名: Basel, Swiss : Karger 巻: (in press)
  • 査読あり
• [雑誌論文] Carotid atherosclerosis in kidney disease (2013)
  • 著者名/発表者名: Kokubo Y
  • 雑誌名: Contrib Nephrol. 巻: 179 ページ: 35-41
  • DOI: 10.1159/000346720
  • 査読あり
• [雑誌論文] Comparison of Western and Oriental Studies on Cardiovascular Prevention. (2013)
  • 著者名/発表者名: Kokubo Y
  • 雑誌名: Hypertens 巻: 62
  • 査読あり
• [雑誌論文] Impact of chronic kidney disease on carotid atherosclerosis according to blood pressure category in a general urban Japanese population: The Suita Study. (2013)
  • 著者名/発表者名: Ohara T and Kokubo Y
  • 雑誌名: Stroke 巻: 44
  • 査読あり
• [雑誌論文] A prospective study on waist circumference and the risk of all-cause and cardiovascular mortality : a pooled analysis of Japanese communitybased studies (2012)
  • 著者名/発表者名: Saito I, Kokubo Y, Kiyohara Y, Doi Y, Saito S, Ohnishi H, Miyamoto Y.
  • 雑誌名: Circ J. 巻: 76 ページ: 2867-74
  • 査読あり
• [雑誌論文] Weight Reduction in Primary Care : Comprehensive Dietary Counseling-and the Use of Healthy Delivered "Bento (Lunch Boxes)". (2012)
  • 著者名/発表者名: Kokubo Y.
  • 雑誌名: Circ J. 巻: 76 ページ: 1322-1323
  • NAID: 10030315845
  • 査読あり
• [雑誌論文] The Mutual Exacerbation of Decreased Kidney Function and Hypertension. (2012)
  • 著者名/発表者名: Kokubo Y.
  • 雑誌名: J Hypertens. 巻: 30 ページ: 468-469
  • 査読あり
• [雑誌論文] Traditional risk factor management for stroke : a never-ending challenge for health behaviors of diet and physical activity. (2012)
  • 著者名/発表者名: Kokubo Y.
  • 雑誌名: Curr Opinion Neurol. 巻: 25 ページ: 11-17
  • 査読あり
• [雑誌論文] Weight Reduction in Primary Care (2012)
  • 著者名/発表者名: Kokubo Y
  • 雑誌名: Circulation Journal 巻: 76 号: 6 ページ: 1322-1323
  • DOI: 10.1253/circj.CJ-12-0554
  • NAID: 10030315845
  • ISSN: 1346-9843, 1347-4820
  • 査読あり
• [雑誌論文] Traditional risk factor management for stroke : a never-ending challenge for health behaviors of diet and physical activity (2012)
  • 著者名/発表者名: Kokubo Y
  • 雑誌名: Curr Opinion Neurol 巻: 25 号: 1 ページ: 11-17
  • DOI: 10.1097/wco.0b013e32834eb58e
  • 査読あり
• [雑誌論文] A revised definition of the metabolic syndrome predicts coronary artery disease and ischemic stroke after adjusting for low density lipoprotein cholesterol in a 13-year cohort study of Japanese : the Suita study. (2011)
  • 著者名/発表者名: Okamura T, Kokubo Y, Watanabe M, Higashiyama A, Ono Y, Nishimura K, Okayama A, Miyamoto Y.
  • 雑誌名: Atherosclerosis. 巻: 217 ページ: 201-206
  • 査読あり
• [雑誌論文] Serum 1,5-Anhydro-d-glucitol Levels Predict First-ever Cardiovascular Disease : An 11-year Population-based Cohort Study in Japan, the Suita Study. (2011)
  • 著者名/発表者名: Watanabe M, Kokubo Y, Higashiyama A, Ono Y, Miyamoto Y, Okamura T.
  • 雑誌名: Atherosclerosis. 巻: 216 ページ: 477-483
  • 査読あり
• [雑誌論文] Association of intimamedia thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population. (2011)
  • 著者名/発表者名: Kamide K, Kokubo Y, Yang J, Takiuchi S, Horio T, Matsumoto S, Banno M, Matayoshi T, Yasuda H, Miwa Y, Yoshihara F, Nakamura S, Nakahama H, Iwashima Y, Oguro R, Ohishi M, Rakugi H, Okamura T, Miyata T, Kawano Y.
  • 雑誌名: Hypertens Res. 巻: 34 ページ: 740-746
  • NAID: 10031163246
  • 査読あり
• [雑誌論文] Association with Serum Gamma-glutamyltransferase Levels and Alcohol Consumption on Stroke and Coronary Artery Disease : the Suita Study. (2011)
  • 著者名/発表者名: Higashiyama A, Wakabayashi I, Ono Y, Watanabe M, Kokubo Y, Okayama A, Miyamoto Y, Okamura T.
  • 雑誌名: Stroke. 巻: 42 ページ: 1764-1767
  • 査読あり
• [雑誌論文] Associations of impaired glucose metabolism and dyslipidemia with cardiovascular disease : What have we learned from Japanese cohort studies for individualized prevention and treatment? (2011)
  • 著者名/発表者名: Kokubo Y.
  • 雑誌名: EPMA Journal. 巻: 2 ページ: 75-71
  • 査読あり
• [雑誌論文] Associations of impaired glucose metabolism and dyslipidemia with cardiovascular disease : What have we learned from Japanese cohort studies for individualized prevention and treatment? (2011)
  • 著者名/発表者名: Yoshihiro Kokubo
  • 雑誌名: EPMA Journal. 巻: 2 ページ: 75-81
  • 査読あり
• [雑誌論文] Impact of Insulin Resistance and Postprandial Hyperglycemia on Incidence of Stroke in a General Urban Japanese Cohort : The Suita Study. (2011)
  • 著者名/発表者名: Kokubo Y, Watanabe M, Higashiyama A, Ono Y, Furukawa Y, Makino H, Miyamoto Y, Okamura T.
  • 雑誌名: Stroke 巻: 42
  • 査読あり
• [雑誌論文] Prediction of Stroke and Ischemic Heart Disease by Carotid Intima-Media Thickness in Japanese Urban Cohort : The Suita Study. (2011)
  • 著者名/発表者名: Kokubo Y, Toyoda K, Watanabe M, Higashiyama A, Ono Y, Nagatsuka K, Okamura T.
  • 雑誌名: Stroke 巻: 42
  • 査読あり
• [雑誌論文] Association of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population. (2011)
  • 著者名/発表者名: Kamide K, Kokubo Y, Yang J, Takiuchi S, Horio T, Matsumoto S, Banno M, Matayoshi T, Yasuda H, Miwa Y, Yoshihara F, Nakamura S, Nakahama H, Iwashima Y, Oguro R, Ohishi M, Rakugi H, Okamura T, Miyata T, Kawano Y.
  • 雑誌名: Hypertens Res. 巻: 33(印刷中)
  • NAID: 10031163246
  • 査読あり
• [雑誌論文] The Combined Impact of Blood Pressure Categories and Glucose Abnormalities on the Incidence of Cardiovascular Diseases in a Japanese Urban Cohort : The Suita Study. (2010)
  • 著者名/発表者名: Kokubo Y, Okamura T, Watanabe M, Higashiyama A, Ono Y, Miyamoto Y, Furukawa Y, Kamide K, Kawanishi K, Okayama A, Yoshimasa Y
  • 雑誌名: Hypertens Res. 巻: 33 ページ: 1238-1243
  • NAID: 10027682073
  • 査読あり
• [雑誌論文] Lifetime risk of acute myocardial infarction in Japan. (2010)
  • 著者名/発表者名: Turin TC, Kokubo Y, Murakami Y, Higashiyama A, Rumana N, Watanabe M, Okamura T.
  • 雑誌名: Circulation : Cardiovascular Quality and Outcomes. 巻: 3 ページ: 701-3
  • 査読あり
• [雑誌論文] Lifetime Risk of Stroke in Japan. (2010)
  • 著者名/発表者名: Turin TC, Kokubo Y, Murakami Y, Higashiyama A, Rumana N, Watanabe M, Okamura T.
  • 雑誌名: Stroke. 巻: 41 ページ: 1552-4
  • 査読あり
• [雑誌論文] Date C. The Relationship between Waist Circumference and the Risk of Stroke and Myocardial Infarction in a Japanese Urban Cohort : The Suita Study. (2010)
  • 著者名/発表者名: Furukawa Y, Kokubo Y, Okamura T, Watanabe M, Higashiyama A, Ono Y, Kawanishi K, Okayama A
  • 雑誌名: Stroke. 巻: 41 ページ: 550-3
  • 査読あり
• [雑誌論文] New diagnosis criteria for diabetes with hemoglobin A1c and risks of macro-vascular complications in an urban Japanese cohort: the Suita study. (2010)
  • 著者名/発表者名: Watanabe M, Kokubo Y, Higashiyama A, Ono Y, Okayama A, Okamura T.
  • 雑誌名: Diabetes Res Clin Pract. 巻: 88
  • 査読あり
• [雑誌論文] Triglycerides and non-high-density lipoprotein cholesterol and the incidence of cardiovascular disease in an urban Japanese cohort: The Suita study. (2010)
  • 著者名/発表者名: Okamura T, Kokubo Y, Watanabe M, Higashiyama A, Ono Y, Miyamoto Y, Yoshimasa Y, Okayama A.
  • 雑誌名: Atherosclerosis. 巻: 209 ページ: 290-4
  • 査読あり
• [雑誌論文] 都市部一般住民を対象とした循環器病コホート研究 吹田研究 (2010)
  • 著者名/発表者名: 小久保喜弘
  • 雑誌名: 循環器病研究の進歩 巻: XXXI1 ページ: 34-46
• [雑誌論文] Small dense low-density lipoproteins cholesterol can predict incident cardiovascular disease in an urban Japanese cohort : The Suita study.
  • 著者名/発表者名: Arai H, Kokubo Y, Watanabe M, Sawamura T, Ito Y, Minagawa A, Okamura T, Miyamoto Y.
  • 雑誌名: J Atheroscler Thromb. 巻: (in press)
  • NAID: 130004845433
  • 査読あり
• [学会発表] Cut-off Points of Carotid Intima-Media Thickness for Prediction of Incidence and Mortality of Cardiovascular Disease and All-cause Mortality in Japanese Urban Cohort : The Suita Study. (2013)
  • 著者名/発表者名: Kokubo Y, Koga M, Watanabe M, Toyoda K, Nagatsuka K, Miyamoto Y.
  • 学会等名: International Stroke Confrence 2013
  • 発表場所: London
• [学会発表] Age Differences in the Association between Waist-to-height Ratio and Risk of Cardiovascular Disease : The Suita Study. (2013)
  • 著者名/発表者名: Tatsumi Y, Watanabe M, Kokubo Y, Kunihiro Nishimura, Okamura T, Okamura A, Miyamoto Y
  • 学会等名: AHA EPI/NPAM 2013
  • 発表場所: New Orleans, LA.
• [学会発表] Prediction of All-cause and Stroke Mortality by Carotid Intima-Media Thickness in Japanese Urban Cohort : The Suita Study. (2013)
  • 著者名/発表者名: Kokubo Y, Watanabe M, Toyoda K, Miyamoto Y.
  • 学会等名: AHA International Stroke Conference
  • 発表場所: Honolulu, Hawai
• [学会発表] Relationship between carotid intima-media thickness and periodontal disease in an urban Japanese population : The Suita Study. (2013)
  • 著者名/発表者名: Kida M, Kokubo Y, Ono T, Yoshimuta Y, Takemura K, Kosaka T, Maeda Y, Miyamoto Y.
  • 学会等名: AHA International Stroke Conference 2013
  • 発表場所: Honolulu, Hawai
• [学会発表] Prediction of All-cause and Stroke Mortality by Carotid Intima-Media Thickness in Japanese Urban Cohort: The Suita Study. (2013)
  • 著者名/発表者名: Kokubo Y
  • 学会等名: International Stroke Conference 2013: American Stroke Association
  • 発表場所: Honolulu, Hawaii, USA
• [学会発表] Relationship between carotid intima-media thickness and periodontal disease in an urban Japanese population: The Suita Study. (2013)
  • 著者名/発表者名: Kida M and Kokubo Y
  • 学会等名: International Stroke Conference 2013: American Stroke Association
  • 発表場所: Honolulu, Hawaii, USA
• [学会発表] Cut-off Points of Carotid Intima-Media Thickness for Prediction of Incidence and Mortality of Cardiovascular Disease and All-cause Mortality in Japanese Urban Cohort: The Suita Study. (2013)
  • 著者名/発表者名: Kokubo Y
  • 学会等名: European Stroke Conference 2013
  • 発表場所: London UK
• [学会発表] The 8.7-year Follow-up for Prediction of Stroke by Enlargement of Carotid Arteries in General Urban Cohort : The Suita Study (2012)
  • 著者名/発表者名: Kokubo Y, Koga M, Watanabe M, Toyoda K, Nagatsuka K, Miyamoto Y
  • 学会等名: International Stroke Conference 2012
  • 発表場所: New Orleans, USA
  • 年月日: 2012-02-02
• [学会発表] The Combined Impact of Glucose Abnormality and Blood Pressure Category on Carotid Atherosclerosis in a General Urban Japanese Population : The Suita Study (2012)
  • 著者名/発表者名: Endo K, Kokubo Y, Toyoda K, Koga M, Minematsu K, Miyamoto Y
  • 学会等名: International Stroke Conference 2012
  • 発表場所: New Orleans, USA
  • 年月日: 2012-02-01
• [学会発表] The impact of chronic kidney disease on carotid atherosclerosis in a general Japanese urban population : the Suita (2012)
  • 著者名/発表者名: Ohara T, Kokubo Y, Toyoda K, Koga M, Nagatsuka K, Nakamura S, Minematsu K, Miyamoto Y
  • 学会等名: International Stroke Conference 2012
  • 発表場所: New Orleans, USA
  • 年月日: 2012-02-01
• [学会発表] Cut-Off Points of Carotid Intima-Media Thickness for Prediction of Cardiovascular Disease in Japanese Urban Cohort : The Suita Study. (2012)
  • 著者名/発表者名: Kokubo Y, Koga M, Watanabe M, Toyoda K, Nagatsuka K, Miyamoto Y.
  • 学会等名: European Stroke Conference. 2012.
  • 発表場所: Lisbon, Portugal
• [学会発表] Carotid Artery Diameter is Positively Associated with Stroke in a General Urban Cohort : The Suita Study. (2012)
  • 著者名/発表者名: Kokubo Y, Watanabe M, Koga M, Toyoda K, Nagatsuka K, Miyamoto Y.
  • 学会等名: European Stroke Conference. 2012.
  • 発表場所: Lisbon, Portugal.
• [学会発表] The 8.7-year Follow-up for Prediction of Stroke by Enlargement of Carotid Arteries in General Urban Cohort : The Suita Study. (2012)
  • 著者名/発表者名: Kokubo Y, Koga M, Watanabe M, Toyoda K, Nagatsuka K, Miyamoto Y.
  • 学会等名: International Stroke Conference 2012.
  • 発表場所: New Orleans, Louisiana
• [学会発表] The Combined Impact of Glucose Abnormality and Blood Pressure Category on Carotid Atherosclerosis in a General Urban Japanese Population : The Suita Study. (2012)
  • 著者名/発表者名: Endo K, Kokubo Y, Toyoda K, Koga M, Minematsu K, Miyamoto Y.
  • 学会等名: International Stroke Conference 2012.
  • 発表場所: New Orleans, Louisiana
• [学会発表] The impact of chronic kidney disease on carotid atherosclerosis in a general Japanese urban population : the Suita Study. (2012)
  • 著者名/発表者名: Ohara T, Kokubo Y, Toyoda K, Koga M, Nagatsuka K, Nakamura S, Minematsu K, Miyamoto Y.
  • 学会等名: International Stroke Conference 2012.
  • 発表場所: New Orleans, Louisiana
• [学会発表] Elevated serum soluble Lectin-like oxidized LDL receptor-1(sLOX1)is associated with increased ischemic stroke risk : A case-control study. (2012)
  • 著者名/発表者名: Fukuda M, Yokota C, Kokubo Y, Sawamura T, Miyamoto Y, Minematsu K, Toyoda K.
  • 学会等名: International Stroke Conference 2012.
  • 発表場所: New Orleans, Louisiana
• [学会発表] Small dense low-density lipoprotein is a risk for coronary artery disease in an urban Japanese cohort : the Suita study. (2012)
  • 著者名/発表者名: Arai H, Kokubo Y, Watanabe M, Miyamoto Y, Sawamura T, Okamura T.
  • 学会等名: The European Society of Cardiology Congress 2012.
  • 発表場所: Munich, Germany
• [学会発表] Renal Dysfunction Associated with Incident Hypertension According to Blood Pressure Categories in a Non-hypertensive Population in the Suita Study: an Urban Cohort Study. (2012)
  • 著者名/発表者名: Kokubo Y
  • 学会等名: High Blood Pressure Research 2012, American Heart Association
  • 発表場所: Washington DC. , USA
• [学会発表] Carotid Artery Diameter is Positively Associated with Stroke in a General Urban Cohort: The Suita Study. (2012)
  • 著者名/発表者名: Kokubo Y
  • 学会等名: European Stroke Conference 2012
  • 発表場所: . Lisbon, Portugal
• [学会発表] Cut-Off Points of Carotid Intima-Media Thickness for Prediction of Cardiovascular Disease in Japanese Urban Cohort: The Suita Study. (2012)
  • 著者名/発表者名: Kokubo Y
  • 学会等名: Asian Pacific Stroke Conference 2012
  • 発表場所: Tokyo, Japan
• [学会発表] Cardiovascular Risk Factors Associated With Incident Hypertension According to Blood Pressure Categories in Non-hypertensive Population in the Suita Study : An Urban Cohort Study (2011)
  • 著者名/発表者名: Kokubo Y, Nakamura S, Watanabe M, Kamide K, Kawano Y, Kawanishi K, Miyamoto Y
  • 学会等名: American Heart Association, High Blood pressure Research Council
  • 発表場所: Orlando, USA
  • 年月日: 2011-09-21
• [学会発表] Associations of impaired glucose metabolism and dyslipidemia with cardiovascular disease : What have we learned from Japanese cohort studies for individualized prevention and treatment? (2011)
  • 著者名/発表者名: Kokubo Y
  • 学会等名: The EPMA World Congress 2011
  • 発表場所: Bonn, Germany
  • 年月日: 2011-09-17
• [学会発表] Impact of Carotid Plaque on the Risk of Stroke and Ischemic Heart Disease in a Japanese Urban Population : The Suita Study (2011)
  • 著者名/発表者名: Kokubo Y, Toyoda K, Watanabe M, Ono Y, Miyamoto Y, Nagatsuka K
  • 学会等名: European Stroke Conference 2011
  • 発表場所: Hamburg, Germany
  • 年月日: 2011-05-23
• [学会発表] The association between plasma fibrinogen and coronary heart disease in a Japanese urban cohort : the Suita study. (2011)
  • 著者名/発表者名: Kokubo Y, Miyata T, Sakata T, Okamoto A, Watanabe M, Ono Y, Banno M, Miyamoto Y.
  • 学会等名: XXIII Congress of the International Society on Thrombosis and Haemostasis.
  • 発表場所: Kyoto
• [学会発表] Association of platelet reactivity with lipid and PAI-1 levels in a Japanese general population, the Suita study. (2011)
  • 著者名/発表者名: Kameda S, Sakata T, Kokubo Y, Mitsuguro M, Okamoto A, Sano M, Miyata T.
  • 学会等名: XXIII Congress of the International Society on Thrombosis and Haemostasis.
  • 発表場所: Kyoto
• [学会発表] Age- and gender-related differences in PAI-1 antigen levels in a Japanese general population, the Suita study. (2011)
  • 著者名/発表者名: Akira O, Sakata T, Kokubo Y, Sano M, Miyata T.
  • 学会等名: XXIII Congress of the International Society on Thrombosis and Haemostasis.
  • 発表場所: Kyoto
• [学会発表] Estimation of the number of individuals with a congenital adamts13 deficiency in Japan. (2011)
  • 著者名/発表者名: Kokame K, Kokubo Y, Miyata T.
  • 学会等名: XXIII Congress of the International Society on Thrombosis and Haemostasis.
  • 発表場所: Kyoto
• [学会発表] Cystatin C as a marker of kidney injury and cardiovascular diseases in an urban cohort -the Suita Study. (2011)
  • 著者名/発表者名: Nakamura S, Kokubo Y, Makino H, Takata H, Fujii T, Yoshihara F, Horio T, Kawano Y.
  • 学会等名: Clinical Kidney Journal
• [学会発表] Impact of Carotid Plaque on the Risk of Stroke and Ischemic Heart Disease in a Japanese Urban Population : The Suita Study. (2011)
  • 著者名/発表者名: Kokubo Y, Toyoda K, Watanabe M, Ono Y, Miyamoto Y, Nagatsuka K.
  • 学会等名: European Stroke Conference 2011
  • 発表場所: Hamburg, Germany
• [学会発表] Impact of Insulin Resistance and Postprandial Hyperglycemia on Incidence of Stroke in a General Urban Japanese Cohort : The Suita Study. (2011)
  • 著者名/発表者名: Kokubo Y, Watanabe M, Higashiyama A, Ono Y, Furukawa Y, Makino H, Miyamoto Y, Okamura T.
  • 学会等名: American Stroke Association : International Stroke Conference 2011.
  • 発表場所: Los Angeles, California
• [学会発表] Prediction of Stroke and Ischemic Heart Disease by Carotid Intima-Media Thickness in Japanese Urban Cohort : The Suita Study. (2011)
  • 著者名/発表者名: Kokubo Y, Toyoda K, Watanabe M, Higashiyama A, Ono Y, Nagatsuka K, Okamura T.
  • 学会等名: American Stroke Association : International Stroke Conference 2011.
  • 発表場所: Los Angeles, California
• [学会発表] Prediction of Stroke and Ischemic Heart Disease by Carotid Intima-Media Thickness in Japanese Urban Cohort : The Suita Study. (2011)
  • 著者名/発表者名: Kokubo Y
  • 学会等名: International Stroke Conference 2011
  • 発表場所: Los Angels, USA
• [学会発表] Impact of Insulin Resistance and Postprandial Hyperglycemia on Incidence of Stroke in a General Urban Japanese Cohort : The Suita Study. (2011)
  • 著者名/発表者名: Kokubo Y
  • 学会等名: International Stroke Conference 2011
  • 発表場所: Los Angels, USA
• [図書] Carotid atherosclerosis in kidney disease. In : Toyoda K (ed) : Brain, Stroke, and Kidney. Contrib Nephrol. Risk of Clinical and Subclinical Brain Damage in Kidney Disease. (2013)
  • 著者名/発表者名: Kokubo Y.
  • 出版者: Basel, Swiss : Karger
• [図書] Epidemiology of TIA. (2013)
  • 著者名/発表者名: Kokubo Y
  • 総ページ数: 8
  • 出版者: Karger