抗リン脂質抗体症候群の発症メカニズムの分子病態論的解析

• 研究課題/領域番号: 22390198
• 研究種目: 基盤研究(B)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 膠原病・アレルギー内科学
• 研究機関: 北海道大学
• 研究代表者: 小池 隆夫 北海道大学, 大学院・医学研究科, 教授 (80146795)
• 研究分担者: 渥美 達也 北海道大学, 大学院・医学研究科, 教授 (20301905)
• 研究期間 (年度): 2010 – 2012
• 研究課題ステータス: 完了 (2012年度)
• 配分額: 18,720千円 (直接経費: 14,400千円、間接経費: 4,320千円); 2012年度: 5,850千円 (直接経費: 4,500千円、間接経費: 1,350千円); 2011年度: 5,850千円 (直接経費: 4,500千円、間接経費: 1,350千円); 2010年度: 7,020千円 (直接経費: 5,400千円、間接経費: 1,620千円)
• キーワード: 抗リン脂質抗体症候群 / β2GPI / プロテオミクス / 抗β2-GPI抗体 / 酸化LDL / 自己抗体 / 抗リン脂質抗体 / 血栓症 / 単球 / 質量分析 / プロテオーム

研究概要

β2GPIのヒト血清中における主要な結合タンパクは酸化LDLであり、酸化LDLが抗リン脂質抗体症候群(APS)における血栓形成病態に関与する可能性がある。酸化LDL関連分子LpPLA2はAPSに高発現しており、欧米のGWASで明らかにされたLpPLA2関連SNPについて検討したところ、APS患者にこのSNPの異常が認められた。APS患者に酸化LDLが多い理由の一つにSNPの関与が示された。

研究成果

• [雑誌論文] Overexpression of TNF-α-converting enzyme in fibroblasts augments dermal fibrosis after inflammation (2013)
  • 著者名/発表者名: K Fukaya S, Matsui Y, Tomaru U, Kawakami A, Sogo S, Bohgaki T, AtsumiT, Koike T, Kasahara M, Ishizu A
  • 雑誌名: Lab Invest 巻: 93(1) ページ: 72-80
  • NAID: 120005301697
  • 査読あり
• [雑誌論文] A retrospective study of serum KL-6 levels during treatment with biological disease-modifyingantirheumatic drugs in rheumatoid arthritis patients: a report from the Ad Hoc Committee for Safety of Biological DMARDs of the Japan College of Rheumatology (2013)
  • 著者名/発表者名: Takamura A, Hirata S, Nagasawa H, Kameda H, Seto Y, Atsumi T, Dohi M, Koike T, Miyasaka N, Harugau M
  • 雑誌名: Mod Rheumatol 巻: 23(2) 号: 2 ページ: 297-303
  • DOI: 10.1007/s10165-012-0658-1
  • 査読あり
• [雑誌論文] Elevation of KL-6 serum levels in clinical trials of tumor necrosis factor inhibitors in patients withrheumatoid arthritis: a report from the Japan College of Rheumatology Ad Hoc Committee for Safety of Biological DMARDs (2013)
  • 著者名/発表者名: Harigai M, Takamura A, Atsumi T, Dohi M, Hirata S, Kameda H, Nagasawa H, Seto Y, Koike T, Miyasaka N
  • 雑誌名: Mod Rheumatol 巻: 23(2) 号: 2 ページ: 284-96
  • DOI: 10.1007/s10165-012-0657-2
  • NAID: 10031167700
  • 査読あり
• [雑誌論文] Contrast-enhanced whole body joint MR Imaging in rheumatoid patients on tumour necrosis factor-alpha agents: a pilot study to evaluate novel scoring system forMR synovitis (2013)
  • 著者名/発表者名: Kamishima T, Kato M, Atsumi T, Koike T, Onodera Y, Terae S
  • 雑誌名: Clin Exp Rheumatol 巻: 31(1) ページ: 154-154
  • 査読あり
• [雑誌論文] Contrast-enhanced whole body joint MR Imaging in rheumatoid patients on tumour necrosis factor-alpha agents: a pilot study to evaluate novel scoring system for MR synovitis (2013)
  • 著者名/発表者名: Kamishima T
  • 雑誌名: Clin Exp Rheumatol. 巻: 31 ページ: 154-154
  • 査読あり
• [雑誌論文] Overexpression of TNF-α-converting enzyme in fibroblasts augments dermal fibrosis after inflammation. (2013)
  • 著者名/発表者名: Fukaya S
  • 雑誌名: Lab Invest. 巻: 93 号: 1 ページ: 72-80
  • DOI: 10.1038/labinvest.2012.153
  • 査読あり
• [雑誌論文] Phospholipid scramblase 1 expression is enhanced in patients with antiphospholipid syndrome (2012)
  • 著者名/発表者名: Amengual O, Atsumi T, Oku K, Suzuki E, Horita T, Yasuda S, Koike T
  • 雑誌名: Mod Rheumatol 巻: 23(1) 号: 1 ページ: 81-8
  • DOI: 10.1007/s10165-012-0642-9
  • NAID: 10031167669
  • 査読あり
• [雑誌論文] Predominant prevalence of arterial thrombosis in Japanese patients with antiphospholipid (2012)
  • 著者名/発表者名: Fujieda Y, Atsumi T, Amengual O, Odani T, Otomo K, Kato M, Oku K, Kon Y, Horita T, Yasuda S, Koike T
  • 雑誌名: syndromeLupus 巻: 21(14) 号: 14 ページ: 1506-14
  • DOI: 10.1177/0961203312458469
  • 査読あり
• [雑誌論文] A case of adefovir-inducedmembranous nephropathy related to hepatitis B caused by lamivudine-resistant virus after liver transplant due to Byler's disease (2012)
  • 著者名/発表者名: Ebata S, Hashimoto S, Suzuki A, Ito M, Maoka T, Ishikawa Y, Mochizuki T, Koike T
  • 雑誌名: Clin Exp Nephrol 巻: 16(5) 号: 5 ページ: 805-10
  • DOI: 10.1007/s10157-012-0680-9
  • 査読あり
• [雑誌論文] Up-regulated expression of HLA-DRB5 transcripts and high frequency of the HLA-DRB5*01:05 allele in scleroderma patients withinterstitial lung disease (2012)
  • 著者名/発表者名: Odani T, Yasuda S, Ota Y, Fujieda Y, Kon Y, Horita T, Kawaguchi Y, Atsumi T, Yamanaka H, Koike T
  • 雑誌名: Rheumatology(Oxford) 巻: 51(10) ページ: 1765-74
  • 査読あり
• [雑誌論文] Factor XI is a substrate for oxidoreductases: enhanced activation of reduced FXI and its role in antiphospholipid syndrome thrombosis (2012)
  • 著者名/発表者名: Giannakopoulod B, Gao L, Qi M, Wong JW, Yu DM, Vlachoyiannopoulos PG, Moutsopoulos HM, Atsumi T, Koike T, Hogg P, Qi JC, Krilis SA
  • 雑誌名: J Autoimmun 巻: 39(3) 号: 3 ページ: 121-9
  • DOI: 10.1016/j.jaut.2012.05.005
  • 査読あり
• [雑誌論文] Inhibition of plasma IL-6 in addition to maintenance of an efficacious trough level of infliximab associated with clinical remission in patients with rheumatoid arthritis: analysis of the RISING Study (2012)
  • 著者名/発表者名: Takeuchi T, Miyasaka N, Tatsuki Y, Yano T, Yoshinari T, Abe T, Koike T
  • 雑誌名: Ann Rheum Dis 巻: 71(9) 号: 9 ページ: 1583-5
  • DOI: 10.1136/annrheumdis-2011-201069
  • 査読あり
• [雑誌論文] Drug retention rates and relevant risk factors for drug discontinuation due to adverse events in rheumatoid arthritis patients receiving anticytokine therapy with different target molecules. (2012)
  • 著者名/発表者名: Sakai R, Tanaka M, Nanki T, Watanabe K, Yamazaki H, Koike R, Nagasawa H, Amano K, Saito K,Tanaka Y, Ito S, Sumida T,Ihata A, Ishigatsubo Y, Atsumi T, Koike T, Nakajima A, Tamura N, Fujii T, Dobashi H, Tohma S, Sugihara T, Ueki Y, Hashiramoto A, Kawakami A, Hagino N, Miyasaka N, Harigai M
  • 雑誌名: Ann Rheum 巻: 71(11) ページ: 1820-6
  • NAID: 120006985490
  • 査読あり
• [雑誌論文] Drug retention rates and relevant risk factors for drug discontinuation due to adverse events in rheumatoid arthritis patients receiving anticytokine therapy with different target molecules (2012)
  • 著者名/発表者名: Sakai R, Komano Y, Tanaka M, Nanki T, Koike R, Nagasawa H, Amano K,Nakajima A, Atsumi T, Koike T, Ihata A, Ishigatsubo Y, Saito K,Tanaka Y, Ito S, Sumida T, Tohma S,Tamura N, Fujii T, Sugihara T, Kawakami A, Hagino N, Ueki Y, Hashiramoto A, Nagasawa K,Miyasaka N, Harigai M
  • 雑誌名: Arthritis Care Res 巻: 71 号: 11 ページ: 1820
  • DOI: 10.1136/annrheumdis-2011-200838
  • NAID: 120006985490
  • URL: https://pure.teikyo.jp/en/publications/3970fbcf-802b-43fa-b286-5e590ceb9904
  • 査読あり
• [雑誌論文] Impaired expression of Act1mRNA in B cells of patients with Sjogren's syndrome (2012)
  • 著者名/発表者名: Nakagawa Y, Kataoka H, Kurita T, Nakagawa H, Yasuda S, Horita T, Atsumi T, Koike T
  • 雑誌名: Nihon Rinsho Meneki Gakkai Kaishi 巻: 35(1) ページ: 75-80
  • NAID: 10030465739
  • 査読あり
• [雑誌論文] Safety and effectiveness of switching from infliximab to etanercept in patientswith rheumatoid arthritis: results from a large Japanese postmarketing surveillance stud (2012)
  • 著者名/発表者名: Koike T, Harigai M, Inokuma S, Ishiguro N, Ryu J, Takeuchi T, Tanaka Y, Yamanaka H, Fujii K, Yoshinaga T, Freundlich B, Suzukawa M
  • 雑誌名: Rheumatol Int 巻: 32(6) 号: 6 ページ: 1617-24
  • DOI: 10.1007/s00296-011-1807-0
  • 査読あり
• [雑誌論文] Safety and effectiveness responses to etanercept for rheumatoid arthritis in Japan: a sub-analysis of a post-marketing surveillance studyfocusing on the duration of rheumatoid arthritis (2012)
  • 著者名/発表者名: Koike T, Harigai M, Inokuma S, Ishiguro N, Ryu J, Takeuchi T, Tanaka Y, Yamanaka H, Fujii K, Yoshinaga T, Freundlich B, Suzukawa M
  • 雑誌名: Rheumatol Int 巻: 32(6) 号: 6 ページ: 1511-9
  • DOI: 10.1007/s00296-010-1784-8
  • 査読あり
• [雑誌論文] A case of catastrophic antiphospholipid antibody syndrome complicated with systemic lupus erythematosus, double positive for anti-cardiolipin/β(2) glycoprotei I and anti-phosphatidylserine/prothrombin autoantibodies (2012)
  • 著者名/発表者名: Hirakawa E, Saito K, Hirata S, Atsumi T, Koike T, Tanaka Y
  • 雑誌名: Mod Rheumatol 巻: 22(5) 号: 5 ページ: 769-73
  • DOI: 10.1007/s10165-011-0563-z
  • 査読あり
• [雑誌論文] Golimumab in combination with methotrexate in Japanese patients with active rheumatoid arthritis: results of the GO-FORTH study (2012)
  • 著者名/発表者名: Tanaka Y, Harigai M, Takeuchi T, Yamanaka H, Ishiguro N, Yamamoto K, Miyasaka N, Koike T, Kanazawa M, Oba T, Yoshinari T, Baker D;
  • 雑誌名: Ann Rheum Dis 巻: 71(6) 号: 6 ページ: 817-24
  • DOI: 10.1136/ard.2011.200317
  • NAID: 120005906861
  • 査読あり
• [雑誌論文] The efficacy of antiphospholipid score for the diagnosis of antiphospholipid syndrome and its predictive value for thrombotic events (2012)
  • 著者名/発表者名: Otomo K, Atsumi T, Amengual O, Fujieda Y, Kato M, Oku K, Horita T, Yasuda S, Koike T
  • 雑誌名: Arthritis Rheum 巻: 64 号: 2 ページ: 504-512
  • DOI: 10.1002/art.33340
  • 査読あり
• [雑誌論文] Positive synovial vascularity in patients with low disease activity indicates smouldering inflammation leading to joint damage in rheumatoid arthritis: time-integrated joint inflammation estimated by synovialvascularity in each finger joint (2012)
  • 著者名/発表者名: Fukae J, Isobe M, Kitano A, Henmi M, Sakamoto F, Narita A, Ito T, Mitsuzaki A, Shimizu M, Tanimura K, Matsuhashi M, Kamishima T, Atsumi T, Koike T
  • 雑誌名: Rheumatology 巻: 52(3) 号: 3 ページ: 523-8
  • DOI: 10.1093/rheumatology/kes310
  • 査読あり
• [雑誌論文] Time-dependent increased risk for serious infection from continuous use of tumor necrosis factor antagonists over three years in patients with rheumatoid arthritis (2012)
  • 著者名/発表者名: Sakai R
  • 雑誌名: Arthritis Care Res 巻: 64 号: 8 ページ: 1125
  • DOI: 10.1002/acr.21666
  • 査読あり
• [雑誌論文] Up-regulated expression of HLA-DRB5 transcripts and high frequency of the HLA-DRB5*01:05 allele in scleroderma patients with interstitial lung disease (2012)
  • 著者名/発表者名: Odani T
  • 雑誌名: Rheumatology 巻: 51 ページ: 1765-1774
  • 査読あり
• [雑誌論文] Impaired expression of Act1mRNA in B cells of patients with Sjogren's syndrome (2012)
  • 著者名/発表者名: Nakagawa Y
  • 雑誌名: Nihon Rinsho Meneki Gakkai Kaishi 巻: 35 ページ: 75-80
  • 査読あり
• [雑誌論文] Safety and effectiveness of adalimumab in Japanese rheumatoid arthritis patients: postmarketing surveillance report of the first 3,000 patients. (2012)
  • 著者名/発表者名: Koike T
  • 雑誌名: Mod Rheumatol. 巻: 22 号: 4 ページ: 498-508
  • DOI: 10.1007/s10165-011-0541-5
  • NAID: 10031026861
  • 査読あり
• [雑誌論文] IFNγ independent suppression of Th-17 differentiation by T-bet expression in autoimmune arthritis mice (2011)
  • 著者名/発表者名: Koike T
  • 雑誌名: Arthritis Rheum. 巻: 64(1) ページ: 40-41
  • 査読あり
• [雑誌論文] The new era of autoimmune disease research (2011)
  • 著者名/発表者名: Koike T
  • 雑誌名: Arthritis Research&Therapy 巻: 13 ページ: 113-113
  • NAID: 120006352194
  • 査読あり
• [雑誌論文] Plasma gelsolin facilitates interaction between β2 glycoprotein I and α5β1 integrin (2011)
  • 著者名/発表者名: Bohgaki M, Matsumoto M, Koike T, et al.
  • 雑誌名: J Cell Mol Med 巻: 15(1) ページ: 141-151
  • NAID: 120003660581
  • 査読あり
• [雑誌論文] Hapatitis B Virus Reactivation by Immunosuppressive Therapy in Patients with Autoimmune Diseases : Risk Analysis in Hepatitis B Surface Antigen-negative Cases (2011)
  • 著者名/発表者名: Kato M, Atsumi T, Koike T, et al.
  • 雑誌名: Jounal of Rheumatology 巻: 38 ページ: 2209-14
  • 査読あり
• [雑誌論文] Pathopbysiology of thrombosis and potential targeted therapies in antiphospholipid syndrome (2011)
  • 著者名/発表者名: Amengual O, Atsumi T, Koike
  • 雑誌名: Current Vascular Pharacology 巻: 9 ページ: 606-18
  • 査読あり
• [雑誌論文] A case of catastrophic antiphospholipid antibody syndrome complicated with systemic lupus erythematosus, double positive for anti-cardiolipin/β(2) glycoprotein I and anti-phosphatidylserine/prothrombin autoantibodies (2011)
  • 著者名/発表者名: Hirakawa E, Saito K, Hirata S, Atsumi T, Koike T, Tanaka Y
  • 雑誌名: Mod Rheumatol 巻: 13 ページ: 113-113
  • 査読あり
• [雑誌論文] The efficacy of Antiphospholipid Score for the diagnosis of antiphospholipid syndrome and its predictive value for thrombotic events (2011)
  • 著者名/発表者名: Otomo K, Atsumi T, Amengual O, et al.
  • 雑誌名: Arthritis Rheum 巻: 64 ページ: 504-12
  • 査読あり
• [雑誌論文] Plasma gelsolin facilitates interaction between β2 glycoprotein I and α5β1 integrin. (2011)
  • 著者名/発表者名: Bohgaki M, Matsumoto M, Koike T, et al.
  • 雑誌名: J Cell Mol Med 巻: in press
  • NAID: 120003660581
  • 査読あり
• [雑誌論文] Increased expression of Phospholipid Scramblase 1 in monocytes from patients with systemic lupus erythematosus. (2010)
  • 著者名/発表者名: Suzuki E, Amengual O, Koike T, et al.
  • 雑誌名: J Rheumatol 巻: 37 ページ: 1639-1645
  • 査読あり
• [雑誌論文] Antiprothrombin antibody : why do we need more assays? (2010)
  • 著者名/発表者名: Atsumi T, Koike T.
  • 雑誌名: Lupus 巻: 19 ページ: 436-439
  • 査読あり
• [学会発表] Catastrophic Antiphospholipid Syndrome;CAPS (2012)
  • 著者名/発表者名: Koike,T
  • 学会等名: Manila, Philippines, Asian Lupus Summit 2012
  • 発表場所: Shangri-La Hotel(Philippines)
• [学会発表] New Concepts in Antiphospholipid syndrome (2012)
  • 著者名/発表者名: Koike,T
  • 学会等名: Asian Lupus Summit2012
  • 発表場所: Shangri-LaHotel(Philippines)
• [学会発表] Catastrophic Antiphospholipid Syndrome;CAPS (2012)
  • 著者名/発表者名: Koike,T.
  • 学会等名: Asian Lupus Summit 2012
  • 発表場所: Shangri-la Hotel,Manila,Filipin
  • 招待講演
• [学会発表] New Concepts in Antiphospholipid syndrome (2012)
  • 著者名/発表者名: Koike,T.
  • 学会等名: Asian Lupus Summit 2012
  • 発表場所: Shangri-la Hotel,Manila,Filipin
  • 招待講演
• [学会発表] The efficacy of "partial" Antiphospholipid Score for diagnosing antiphospholipid syndrome and for a predictive marker of developing thrombosis in autoimmune diseases (2011)
  • 著者名/発表者名: Otomo K, Atsumi T, Koike T, et al.
  • 学会等名: The 4th East Asian Group of Rheumatology
  • 発表場所: PlazaTokyo (Tokyo Japan)
  • 年月日: 2011-10-15
• [学会発表] Hypertension as a risk for cerebral infarction in patients with antiphospholipid syndrome (2011)
  • 著者名/発表者名: Fujieda Y, Atsumi T, Koike T, et al.
  • 学会等名: The 4th East Asian Group of Rheumatology
  • 発表場所: PlazaTokyo (Tokyo, Japan)
  • 年月日: 2011-10-15
• [学会発表] T cells from patients with systemic lupus erythematosus (2011)
  • 著者名/発表者名: Yasuda S, Kono M, Koike, et al.
  • 学会等名: 5th Asian congress on autoimmunity
  • 発表場所: Internal Convention&Exhibision Center (SuntecCity Singapore)
• [学会発表] Platelet activation and paradoxical inhibition of ADP aggregation by antiphospholipid antibodies in vitro (2011)
  • 著者名/発表者名: Oku K, Atsumi T, Koike T, et al.
  • 学会等名: The 23rd Congress of the International Society on Thrombosis and Haemostasis
  • 発表場所: Kyoto International Conference center (Kyoto Japan)
• [学会発表] Phosphatidylserine-dependent antiprothrombin antibodies(aPS/PT) is a useful predictive marker of thrombosis in patients with autoimmune diseases (2011)
  • 著者名/発表者名: Otomo K, Amengual, Koike T, et al.
  • 学会等名: The 23rd Congress of the International Society on Thrombosis and Haemostasis
  • 発表場所: Kyoto International Conference center (Kyoto Japan)
• [学会発表] Role of apolipoprotein B100 and oxidized low-density lipoprotein in anti-beta2 glycoprotein I induced tissue factor expression on monocytes (2011)
  • 著者名/発表者名: Otomo K, Atsumi T, Koike T, et al.
  • 学会等名: The 75th annual meeting of the American College of Rheumatology
  • 発表場所: McCormick' s Place West, Chicago, (Illinois, USA)
• [学会発表] Predominant prevalence of stroke in Japanese patients with antiphospholipid syndrome (2011)
  • 著者名/発表者名: Fujieda Y, Atsumi T, AKoike T, et al.
  • 学会等名: The 23rd Congress of the International Society on Thrombosis and Haemostasis
  • 発表場所: Kyoto International Conference center (Kyoto, Japan)
• [学会発表] HLA-DRB5* 01:05 is a Risk Factor for Systemic Sclerosis especially with Interstitial Lung Disease (2011)
  • 著者名/発表者名: Odani T, Yasuda S, Koike T, et al.
  • 学会等名: 12th Annual European congress of rheumatology (EULAR)
  • 発表場所: ExCeL London (London, UK)
• [学会発表] HLA-DRB5* 01:05 is a Risk Factor for Systemic Sclerosis with Interstitial Lung Disease (2011)
  • 著者名/発表者名: Odani T, Atsumi T, Koike T, et al
  • 学会等名: The 75th annual meeting of the American College of Rheumatology (ACR)
  • 発表場所: McCormick's Place West, Chicago (Illinois, USA)
• [学会発表] Post-steroid neruropsychiatric manifestations in patients with systemic lupus erythematosus (2011)
  • 著者名/発表者名: Shimizu Y, Atsumi T, Koike T, et al.
  • 学会等名: 12th Annual European congress of rheumatology (EULAR)
  • 発表場所: ExCeL London (London, UK)
• [学会発表] Antiphospholipid Syndrome ; 25 Years. (2010)
  • 著者名/発表者名: Koike T.
  • 学会等名: The 10th International Symposium of Rheumatism Research Center
  • 発表場所: COEX Convention Center, Seoul, Korea 招待講演
  • 年月日: 2010-12-02
• [学会発表] The Involvement of CD36 in the Monocyte Activation by Antiphospholipid Antibodies. (2010)
  • 著者名/発表者名: Kato M, Atsumi T, Koike T, et al.
  • 学会等名: The 74th annual meeting of the American College of Rheumatology
  • 発表場所: McCormick's Place Convention Center, Atlanta, Georgia, USA
  • 年月日: 2010-11-11
• [学会発表] Platelet Activation and Paradoxical Inhibition of ADP Induced Aggregation by Antiphospholipid Antibodies. (2010)
  • 著者名/発表者名: Oku K, Atsumi T, Koike T, et al.
  • 学会等名: The 74th annual meeting of the American College of Rheumatology
  • 発表場所: McCormick's Place Convention Center, Atlanta, Georgia, USA
  • 年月日: 2010-11-11
• [学会発表] Antiphospholipid Score (aPL-S) : A Comprehensive Predictive Marker of Developing Thrombosis in Autoimmune Diseases. (2010)
  • 著者名/発表者名: Otomo K, Atsumi T, Koike T, et al.
  • 学会等名: The 74th annual meeting of the American College of Rheumatology
  • 発表場所: McCormick's Place Convention Center, Atlanta, Georgia, USA
  • 年月日: 2010-11-11
• [学会発表] AGTRL1 and PRKCH Are Genetic Risk Factors for Antiphospholipid Syndrome. (2010)
  • 著者名/発表者名: Nakagawa H, Atsumi T, Koike T, et al.
  • 学会等名: The 74th annual meeting of the American College of Rheumatology
  • 発表場所: McCormick's Place Convention Center, Atlanta, Georgia, USA
  • 年月日: 2010-11-11
• [学会発表] Post-Marketing Surveillance Program of Tocilizumab for RA in Japan-Interim Analyses of 3,881 Patients. (2010)
  • 著者名/発表者名: Koike T
  • 学会等名: The 74th annual meeting of the American College of Rheumatology
  • 発表場所: McCormick's Place Convention Center, Atlanta, Georgia, USA
  • 年月日: 2010-11-11
• [学会発表] Antiphospholipid antibodies : from bench to bedside. (2010)
  • 著者名/発表者名: Koike T.
  • 学会等名: 4th Congress of Asia Pacific League of Associations for Rheumatology (APLAR 2010)
  • 発表場所: Hongkong Convention and Exhibition Center, Hong Kong, China. 招待講演
  • 年月日: 2010-07-13
• [学会発表] Novel Lupus Susceptible Gene Polymorphisms in Patients with Sjogren's Syndrome in Japanese Population. (2010)
  • 著者名/発表者名: Horita T, Atsumi T, Koike T, et al.
  • 学会等名: he 74th annual meeting of the American College of Rheumatology
  • 発表場所: McCormick's Place Convention Center, Atlanta, Georgia, USA
• [学会発表] A comparative analysis of the methods to detect phosphatidylserine-dependent antiprothrombin antibodies. (2010)
  • 著者名/発表者名: Amengual O, Atsumi T, Koike T, et al.
  • 学会等名: 6th Congress of the Asia Pacific Society on Thrombosis and Haemostasis
  • 発表場所: Grand hyatt Hotel, Bali, Indonesia
• [学会発表] High expression of gene transcripts in peripheral blood mononuclear cells from systemic sclerosis with interstitial lung disease. (2010)
  • 著者名/発表者名: Odani T, Atsumi T, Koike T, et al.
  • 学会等名: 14^<th> International Congress of Immunology
  • 発表場所: Kobe Convention Center Complex Overview, Kobe, Japan
• [学会発表] Retrospetive analysis of interstitial lung disease in patients with autoimmune diseases using High-Resolution Computed Tomography. (2010)
  • 著者名/発表者名: Kurita T, Atsumi T, Koike T, et al.
  • 学会等名: 14^<th> International International Congress of Immunology, Kobe
  • 発表場所: Kobe Convention Center Complex Overview, Kobe, Japan
• [学会発表] High-resolution CT analysis of pulmonary complications in 103 patients with rheumatoid arthritis. (2010)
  • 著者名/発表者名: Fujieda Y, Atsumi T, Koike T, et al.
  • 学会等名: 14^<th> International Congress of Immunology, Kobe
  • 発表場所: Kobe Convention Center Complex Overview, Kobe, Japan
• [学会発表] IL-4 and IL-21 inversely regulate CXCR4 expression on activated B cells. (2010)
  • 著者名/発表者名: Yoshida N, Atsumi T, Koike T, et al.
  • 学会等名: 14^<th> International Congress of Immunology, Kobe
  • 発表場所: Kobe Convention Center Complex Overview, Kobe, Japan
• [学会発表] Impaired expression of Id3 mRNA in B cells related to sialoadenitis of Sjogren's syndrome. (2010)
  • 著者名/発表者名: Nakagawa Y, Atsumi T, Koike T, et al.
  • 学会等名: 14^<th> International Congress of Immunology, Kobe
  • 発表場所: Kobe Convention Center Complex Overview, Kobe, Japan
• [学会発表] AGTRL1 and PRKCH are genetic risk factors for antiphospholipid syndrome. (2010)
  • 著者名/発表者名: Nakagawa H, Atsumi T, Koike T, et al.
  • 学会等名: 14^<th> International Congress of Immunology, Kobe
  • 発表場所: Kobe Convention Center Complex Overview, Kobe, Japan
• [学会発表] The role of immunosuppressive therapy for pulmonary arterial hypertension complicated with connective tissue disease : long-term follow-up of 5 cases. (2010)
  • 著者名/発表者名: Kato M, Atsumi T, Koike T, et al.
  • 学会等名: 14^<th> International Congress of Immunology, Kobe
  • 発表場所: Kobe Convention Center Complex Overview, Kobe, Japan
• [学会発表] AGTRL1 and PRKCH single nucleotide polymorphisms in patients with antiphospholipid syndrome. (2010)
  • 著者名/発表者名: Nakagawa H, Atsumi T, Koike T, et al.
  • 学会等名: 14^<th> Asia Pacific League of Associations for Rheumatology
  • 発表場所: Hongkong Convention and Exhibition Center, Hong Kong, China
• [学会発表] Lupus susceptible gene polymorphisms in patients with Sjogren's syndrome in Japanese population. (2010)
  • 著者名/発表者名: Nakagawa H, Atsumi T, Koike T, et al.
  • 学会等名: 9th International Congress on Systemic Lupus Erythematosus
  • 発表場所: Vancouver Convention Centre, Vancouver, Canada
• [学会発表] High Expression of HLA-DRB5 Transcripts in Peripheral Blood Mononuclear Cells from Systemic Sclerosis with Interstitial Lung Disease. (2010)
  • 著者名/発表者名: Odani T, Atsumi T, Koike T, et al.
  • 学会等名: he Annual European Congress of Rheumatology
  • 発表場所: Fiera Roma, Rome, Italy
• [学会発表] RA-Associated Pulmonary Complications As Risks for Infectious Pneumonia. (2010)
  • 著者名/発表者名: Fujieda Y, Atsumi T, Koike T, et al.
  • 学会等名: The Annual European Congress of Rheumatology
  • 発表場所: Fiera Roma, Rome, Italy
• [学会発表] Up-regulated expression of Phospholipid Scramblase 1 in antiphospholipid syndrome : a novel pathogenic mechanism of thrombosis. (2010)
  • 著者名/発表者名: Amengual O, Atsumi T, Koike T, et al.
  • 学会等名: The 7th International Congress on Autoimmunity
  • 発表場所: GR Ljubljana Exhibition and Convention Centre, Ljubljana, Slovenia
• [学会発表] Retrospective Analysis of Interstitial Lung Disease in Patients with Autoimmune Disease Using High-Resolution Computed Tomography. (2010)
  • 著者名/発表者名: Kurita T, Atsumi T, Koike T, et al.
  • 学会等名: The 7th International Congress on Autoimmunity
  • 発表場所: GR Ljubljana Exhibition and Convention Centre, Ljubljana, Slovenia
• [学会発表] Aberrant Splicing of the Transcript of RasGRP4 in the Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis. (2010)
  • 著者名/発表者名: Hashimoto T, Atsumi T, Koike T, et al.
  • 学会等名: The 7th international Congress on Autoimmunity
  • 発表場所: GR Ljubljana Exhibition and Convention Centre, Ljubljana, Slovenia
• [学会発表] Lupus Susceptible Gene Polymorphisms in Patients with Antiphospholipid Syndrome in Japanese Population (2010)
  • 著者名/発表者名: Horita T, Atsumi T, Koike T, et al.
  • 学会等名: 13^<th> International Congress on Antiphospholipid Antibodies
  • 発表場所: Galveston Isrands convention center, Galveston, TX, USA
• [学会発表] Association between CD36 single nucleotide polymorphism and antiphospholipid syndrome. (2010)
  • 著者名/発表者名: Kato M, Atsumi T, Koike T, et al.
  • 学会等名: 13^<th> International Congress on Antiphospholipid Antibodies
  • 発表場所: Galveston Isrands convention center, Galveston, TX, USA
• [学会発表] The diagnostic significance and predictive value of Antiphospholipid-Score (aPL-S) (2010)
  • 著者名/発表者名: Otomo K, Atsumi T, Koike T, et al.
  • 学会等名: The 13th International Congress on Antiphospholipid Antibodies
  • 発表場所: Galveston Isrands convention center, Galveston, TX, USA
• [学会発表] Risk factors to affect the mortality and morbidity in patients with antiphospholipid syndrome : a longitudinal follow-up study of 95 Japanese patients. (2010)
  • 著者名/発表者名: Fujieda Y, Atsumi T, Koike T, et al.
  • 学会等名: The 13th International Congress on Antiphospholipid Antibodies
  • 発表場所: Galveston Isrands convention center, Galveston, TX, USA
• [図書] Antiphospholipid syndrome : pathogenesis.(Lahita RG, editor. Systemic Lupus Erythematosus 5th edition.) (2010)
  • 著者名/発表者名: Atsumi T, Amengual O, Koike T
  • 総ページ数: 22
  • 出版者: San Diego : Academic Press