研究課題/領域番号 |
22H03922
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研究種目 |
基盤研究(B)
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配分区分 | 補助金 |
応募区分 | 一般 |
審査区分 |
小区分90110:生体医工学関連
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研究機関 | 千葉大学 |
研究代表者 |
ゴメスタメス ホセデビツト 千葉大学, フロンティア医工学センター, 准教授 (60772902)
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研究分担者 |
兪 文偉 千葉大学, フロンティア医工学センター, 教授 (20312390)
大鶴 直史 新潟医療福祉大学, リハビリテーション学部, 教授 (50586542)
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研究期間 (年度) |
2022-04-01 – 2025-03-31
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研究課題ステータス |
交付 (2023年度)
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配分額 *注記 |
17,940千円 (直接経費: 13,800千円、間接経費: 4,140千円)
2023年度: 4,810千円 (直接経費: 3,700千円、間接経費: 1,110千円)
2022年度: 11,570千円 (直接経費: 8,900千円、間接経費: 2,670千円)
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キーワード | Brain Stimulation / Neural Engineering / Computational Biophysics / Medical Imaging / Interferential / Brain stimulation |
研究開始時の研究の概要 |
Brain stimulation is a therapeutic modality that uses electrical stimulation to control/regulate brain functions. There is high interest in targetting deep brain parts as a potential treatment of neurological disorders using non-invasive electrical stimulation. However, deep brain stimulation is difficult without superficial stimulation. A multiscale electrophysiological model will be developed to investigate interferential stimulation as a method for achieving focal stimulation together with experimental measurements.
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研究実績の概要 |
Based on the aim of developing a personalized computational physical model for focal and deep brain stimulation, we investigated stimulation dose characteristics using a combined approach of numerical and experimental techniques. The experiments showed the possibility of focal stimulation of individual hand fingers that are condensed in a small area of the brain demonstrating focality with high resolution. In addition, new insight into the dual-hemisphere transcranial stimulation application was presented for deep cortical stimulation of the lower limb. Finally, progress in the development of a micro-physical neuron model integrated with the personalized brain stimulation simulator was achieved to investigate interferential phenomena.
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現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
The developed personalized computational physical model for investigating focal and deep brain stimulation characteristics is in place. Simulation and experiments were conducted showing the feasibility of focal and deep stimulation providing a better understanding of the characteristics of the generated electric currents in the brain in terms of focality and depth. The model integrated the micro-physical brain neuron to investigate independent kilohertz stimulation and a combination of two-kilohertz stimulation (i.e., interferential stimulation) for further characterization of deep and focal brain stimulations. Publications in recognized journals and top conferences in the field demonstrate the progress of the work.
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今後の研究の推進方策 |
In FY2023, the multiscale electrophysiological model will be further improved and validated to investigate focal and deep stimulation. For validation, we will conduct an extended revision of stimulation parameters to achieve personalized focal stimulation. Further, the mechanism of stimulation of kilohertz electric currents (including interferential) will be investigated based on simulations together with experimental measurements. The original plan included brain stimulation at kilohertz currents but they became prohibitive considering the required high electric currents in the brain for evoked responses in recent reports (Wang et.al., 2023, Neural Eng). In substitution, mechanisms of kilohertz stimulation will be investigated in experiments of the peripheral nervous system.
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