| 研究課題/領域番号 |
22K05330
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| 研究種目 |
基盤研究(C)
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| 配分区分 | 基金 |
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| 応募区分 | 一般 |
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| 審査区分 |
小区分37020:生物分子化学関連
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| 研究機関 | 香川大学 |
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研究代表者 |
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| 研究期間 (年度) |
2022-04-01 – 2027-03-31
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| 研究課題ステータス |
交付 (2022年度)
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| 配分額 *注記 |
4,290千円 (直接経費: 3,300千円、間接経費: 990千円)
2026年度: 130千円 (直接経費: 100千円、間接経費: 30千円)
2025年度: 130千円 (直接経費: 100千円、間接経費: 30千円)
2024年度: 130千円 (直接経費: 100千円、間接経費: 30千円)
2023年度: 390千円 (直接経費: 300千円、間接経費: 90千円)
2022年度: 3,510千円 (直接経費: 2,700千円、間接経費: 810千円)
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| キーワード | nanopore |
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| 研究開始時の研究の概要 |
Efficient discovery of new biological nanopores and conversion of existing ones into new ones is of most significance in technology development. The proposed multidisciplinary research program is to explore new strategies to expand the scope of biological nanopores for sensing biomolecules.
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| 研究実績の概要 |
Most of the expected research goals have been achieved. Particularly, designed proteins have been expressed and purified in small scales. Larger scale production is in progress. The chemical syntheses have been repeated. The purity of the chemicals is being further improved. The establishment of a UPLC-MS system is delayed but it is currently significantly improving the purity and characterisation of the chemicals. On the other hand, the delivery of the AKTAgo FPLC system was much delayed due to the devaluation of the Japanese Yen and difficulties in international delivery during the COVID pandemic. However, it has been set up and the purity of the proteins is being greatly improved. The preparation of novel nanopores are currently in progress. The establishments of the above-mentioned instruments together with a Benchtop NMR system will accelerate the progress of the project greatly.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
3: やや遅れている
理由
The delayed deliveries of essential instruments caused some slight delays in the progress of the project. However, the successful establishments of these devices will greatly accelerate the progress of the project from now on.
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| 今後の研究の推進方策 |
The project is expected to progress smoothly from now on.
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