| 研究課題/領域番号 |
22K06490
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| 研究種目 |
基盤研究(C)
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| 配分区分 | 基金 |
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| 応募区分 | 一般 |
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| 審査区分 |
小区分46030:神経機能学関連
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| 研究機関 | 沖縄科学技術大学院大学 |
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研究代表者 |
Lindeman Sander 沖縄科学技術大学院大学, 知覚と行動の神経科学ユニット, ポストドクトラルスカラー (50866192)
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| 研究分担者 |
フクナガ イズミ 沖縄科学技術大学院大学, 知覚と行動の神経科学ユニット, 准教授 (90801259)
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| 研究期間 (年度) |
2022-04-01 – 2025-03-31
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| 研究課題ステータス |
交付 (2022年度)
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| 配分額 *注記 |
4,030千円 (直接経費: 3,100千円、間接経費: 930千円)
2024年度: 1,820千円 (直接経費: 1,400千円、間接経費: 420千円)
2023年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
2022年度: 780千円 (直接経費: 600千円、間接経費: 180千円)
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| キーワード | Neurosicence / State-dependent / Inhibition / Sensory Processing / olfaction / inhibition / neuroscience |
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| 研究開始時の研究の概要 |
How sensory information is processed in the brain needs to change dynamically, as it is subject to constant changes in the sensory environment and behavioural demands. Crucial to this is the involvement of inhibitory neurons, which exerts powerful regulation of neurons throughout the brain. This study seeks to unravel the inhibitory source of dynamic neural modulation. Using a novel behavioural paradigm combined with two-photon microscopy and circuit perturbations, we aim to reveal how local inhibition and long-range inputs together may implement dynamic neural modulation.
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| 研究実績の概要 |
In FY 2022 we have successfully ran experiments to identify subcellular specificity of sate-dependent inhibition. We have recorded neural activity from different compartments of two types of output neurons in the olfactory bulb. With these data we were able to identify where in these cells (in which compartments) inhibition occurred in a behavioural relevant context. We thus have successfully reach our milestone for this fiscal year. In addition, we started to run experiments to identify the source of this inhibition. The preliminary results were shared at a major international neuroscience conference in November and have been positively received by our peers.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
Research progress is according to initial plan. No major set-backs encountered.
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| 今後の研究の推進方策 |
We set out to identify the source of the inhibition that we observed in the output neurons in the olfactory bulb. For this, we recently have started to record activity from the inhibitory granule cells, located deep in the olfactory bulb. These neurons mediate feedback information from a specific higher order brain region into the olfactory bulb. These data will shed light on which higher order brain regions are potentially involved in modulating state-dependent sensory processing in the olfactory bulb.
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