| 研究課題/領域番号 |
22K11030
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| 研究種目 |
基盤研究(C)
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| 配分区分 | 基金 |
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| 応募区分 | 一般 |
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| 審査区分 |
小区分58070:生涯発達看護学関連
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| 研究機関 | 高知大学 |
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研究代表者 |
JP NawAwn 高知大学, 医学部, 特任助教 (00835093)
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| 研究分担者 |
滿田 直美 高知大学, 医学部, 特任助教 (30611389)
菅沼 成文 高知大学, 教育研究部医療学系連携医学部門, 教授 (50313747)
栄徳 勝光 高知大学, 教育研究部医療学系連携医学部門, 講師 (50552733)
山崎 慶子 高知大学, 医学部, 特任研究員 (90930446)
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| 研究期間 (年度) |
2022-04-01 – 2025-03-31
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| 研究課題ステータス |
交付 (2023年度)
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| 配分額 *注記 |
4,030千円 (直接経費: 3,100千円、間接経費: 930千円)
2024年度: 1,040千円 (直接経費: 800千円、間接経費: 240千円)
2023年度: 1,170千円 (直接経費: 900千円、間接経費: 270千円)
2022年度: 1,820千円 (直接経費: 1,400千円、間接経費: 420千円)
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| キーワード | chest circumference / head circumference / NAFLD / fetal growth restriction / metabolic syndrome |
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| 研究開始時の研究の概要 |
During intrauterine life, placental insufficiency will cause differential redistribution of fetal cardiac output in favour of the developing brain. The affected fetus will become small overall, but size reduction can be more marked in the body than the head. Thus, the relative size of the chest and head at birth (chest/head circumference ratio) could provide retrospective information of intrauterine growth. We designed this longitudinal birth cohort study to examine how chest/head circumference ratio at birth and catch-up growth during infancy is associated with NAFLD in 8-year-old children.
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| 研究実績の概要 |
In the first fiscal year of this project, we collected comprehensive health information, anthropometric data, and blood samples from 2190 children. In the second fiscal year, we analyzed a range of biomarkers collected during the initial year. These include levels of liver enzymes (ALT, AST, and GGT), lipids (triglycerides, total cholesterol, HDL, LDL), HbA1c, adiponectin, uric acid, creatinine, and hs-CRP. Additionally, we successfully linked the information obtained at this project and the health data gathered during the stages of pregnancy through infancy. By using this merged dataset, we investigated the relationships between anthropometric data collected during these different stages and analyze how they correlate with liver and cardio-metabolic health outcomes in later childhood.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
We are in the process of investigating the relationship between anthropometric fetal growth indicators at birth, height and weight growth in early childhood, markers of adiposity, and liver enzymes in later childhood.
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| 今後の研究の推進方策 |
The integrated information, i.e., collected during pregnancy and infancy with the data obtained at the 8-year follow-up, presents a unique opportunity to explore the long-term effects and developmental trajectories of liver and cardio-metabolic health in children. Specifically, we will examine the relationships between anthropometric data collected during these different stages and analyze how they correlate with liver and cardio-metabolic health outcomes in later childhood.
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