| 研究課題/領域番号 |
22K11030
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| 研究種目 |
基盤研究(C)
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| 配分区分 | 基金 |
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| 応募区分 | 一般 |
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| 審査区分 |
小区分58070:生涯発達看護学関連
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| 研究機関 | 高知大学 |
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研究代表者 |
JP NawAwn 高知大学, 医学部, 特任助教 (00835093)
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| 研究分担者 |
滿田 直美 高知大学, 医学部, 特任助教 (30611389)
菅沼 成文 高知大学, 教育研究部医療学系連携医学部門, 教授 (50313747)
栄徳 勝光 高知大学, 教育研究部医療学系連携医学部門, 講師 (50552733)
山崎 慶子 高知大学, 医学部, 特任助教 (90930446)
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| 研究期間 (年度) |
2022-04-01 – 2026-03-31
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| 研究課題ステータス |
交付 (2024年度)
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| 配分額 *注記 |
4,030千円 (直接経費: 3,100千円、間接経費: 930千円)
2024年度: 1,040千円 (直接経費: 800千円、間接経費: 240千円)
2023年度: 1,170千円 (直接経費: 900千円、間接経費: 270千円)
2022年度: 1,820千円 (直接経費: 1,400千円、間接経費: 420千円)
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| キーワード | NAFLD / birth weight / adiposity / obesity / chest circumference / head circumference / fetal growth restriction / metabolic syndrome |
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| 研究開始時の研究の概要 |
During intrauterine life, placental insufficiency will cause differential redistribution of fetal cardiac output in favour of the developing brain. The affected fetus will become small overall, but size reduction can be more marked in the body than the head. Thus, the relative size of the chest and head at birth (chest/head circumference ratio) could provide retrospective information of intrauterine growth. We designed this longitudinal birth cohort study to examine how chest/head circumference ratio at birth and catch-up growth during infancy is associated with NAFLD in 8-year-old children.
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| 研究実績の概要 |
In first fiscal year, we collected comprehensive health information, anthropometric data, blood samples from 2190 children. In second fiscal year, we assayed a range of biomarkers including liver enzymes ALT, AST, and GGT. Currently, by using these information, we evaluated the relationships between anthropometric data collected during different developmental stages and the liver outcome in later childhood.
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| 現在までの達成度 |
現在までの達成度
3: やや遅れている
理由
We are in the process of evaluating the association between fetal growth indicator at birth, adiposity gain across early childhood and liver enzymes in later childhood.
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| 今後の研究の推進方策 |
The integrated information, i.e., collected during pregnancy, birth through early childhood with the data obtained at the 8-year follow-up, present a unique opportunity to explore the long-term effects and developmental trajectories of liver and cardio metabolic health in children. Specifically, we will examine the relationships between anthropometric data collected during these different developmental stages and analyze how they correlate with liver and cardio metabolic health outcomes in later childhood.
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