| 研究課題/領域番号 |
22K12774
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| 研究種目 |
基盤研究(C)
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| 配分区分 | 基金 |
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| 応募区分 | 一般 |
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| 審査区分 |
小区分90110:生体医工学関連
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| 研究機関 | 早稲田大学 |
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研究代表者 |
朱 暁冬 早稲田大学, 理工学術院, 次席研究員(研究院講師) (90813650)
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| 研究分担者 |
岩崎 清隆 早稲田大学, 理工学術院, 教授 (20339691)
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| 研究期間 (年度) |
2022-04-01 – 2025-03-31
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| 研究課題ステータス |
交付 (2023年度)
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| 配分額 *注記 |
4,160千円 (直接経費: 3,200千円、間接経費: 960千円)
2024年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
2023年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
2022年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円)
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| キーワード | cracking failure / concrete damaged / numerical simulation / CDP model / fracture behavior / EMBC / compression test / calcification / finite element analysis / numerical cracking model / cutting/scoring balloon |
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| 研究開始時の研究の概要 |
Refinements of lesion preparation devices with effectively fracturing calcification and reducing arterial injury is necessary.
We aim to reveal the mechanics of calcification fracture with experimental tests and computational simulations to promote the development of the devices.
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| 研究実績の概要 |
To assist in conducting the tensile test, a dedicated tensile fixture model was originally designed and made by a 3D printer. The fixture model was used to fix the calcification sample on the tensile testing machine. Strain-stress data of the calcification samples were obtained and used in the cracking material model.
The numerical simulations were successfully performed for both cutting balloon model and non-compliant balloon models in a calcified artery model system. The pressures of expanding the calcification model and the results of the first principal stresses occurred in the artery models were obtained.
The outcomes have been presented at the international conference EMBC2023 and also will be presented at the 47th Annual Meeting of The Japanese Society of Biorheology.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
The strain-stress data of the calcification model has been obtained from both tensile and compression test. Concrete damaged plasticity model was used to mimic the fracture failure of the calcification model in the numerical simulations. Both cutting balloon model and non-compliant balloon model were pressurized to expand and fracture the calcification model.
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| 今後の研究の推進方策 |
The simulations of deflation of the cutting balloon model and non-compliant balloon model and thereafter stent deployment will be implemented. The deflated cutting/non-compliant balloon model will be removed, and a stent model will be arranged in the calcified artery model. The simulation of stent deployment will be carried out. The lumen gain, such as diameter and area in the calcified artery model, will be used to evaluate the treatment of using both cutting/non-compliant balloon and stent.
Furthermore, the dimensions of blades or wires, which are key roles of the cutting balloons, will be discussed to contribute the improvement of these medical devices via the artery-calcification system with the cracking model.
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